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PH2015_22_scaffold_1_prodigal-single.1__X__X__00198
Bact-VirPH2015_22_scaffold_1_prodigal-single.1__X__X__00198
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 77-197
Domain cluster:
rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D669-796
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00521.27 best | DNA_topoisoIV | 57.0 | 2.30e-15 | 92.6% | 23.9% |
D2
high
residues 419-509
Domain cluster:
rep: IMGVR_UViG_3300022161_001637-3300022161-Ga0213931_10010881__D368-463
CATH (33)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4z4qA04 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.87 | 79.0 | 8.00e-01 | 97.8% | 100.0% |
| 4gycA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.84 | 43.0 | 3.13e-01 | 100.0% | 20.9% |
| 2yw6B00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.83 | 45.0 | 3.76e-01 | 100.0% | 33.3% |
| 3lpxA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.80 | 72.0 | 6.90e-01 | 97.8% | 99.0% |
| 3vbbE01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.78 | 49.0 | 4.36e-01 | 100.0% | 48.7% |
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.74 | 42.0 | 3.58e-01 | 100.0% | 36.4% |
| 1zvuA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.73 | 66.0 | 5.70e-01 | 100.0% | 67.1% |
| 8a1gC01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.65 | 43.0 | 3.38e-01 | 100.0% | 33.7% |
| 4nswB01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.65 | 39.0 | 2.80e-01 | 100.0% | 21.1% |
| 7p2yd01 | 1.10.520.20 | Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › N-terminal domain of the delta subunit of the F1F0-ATP synthase | 0.63 | 47.0 | 4.65e-01 | 81.3% | 87.9% |
| 4rajA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.62 | 42.0 | 3.19e-01 | 100.0% | 29.6% |
| 7ccmB01 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.61 | 41.0 | 3.61e-01 | 70.3% | 55.9% |
| 1abvA00 | 1.10.520.20 | Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › N-terminal domain of the delta subunit of the F1F0-ATP synthase | 0.60 | 47.0 | 4.58e-01 | 86.8% | 91.4% |
| 1rz4A01 | 1.25.40.250 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › ARM repeat; domain 1 | 0.60 | 30.0 | 2.77e-01 | 97.8% | 33.3% |
| 5yk4A03 | 1.10.1420.10 | Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › | 0.59 | 44.0 | 3.81e-01 | 79.1% | 100.0% |
| 1io1A01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.59 | 55.0 | 4.40e-01 | 100.0% | 84.0% |
| 2h7fX02 | 3.90.15.10 | Alpha Beta › Alpha-Beta Complex › Topoisomerase I; Chain A, domain 3 › Topoisomerase I; Chain A, domain 3 | 0.59 | 45.0 | 3.43e-01 | 85.7% | 99.6% |
| 3ihuA02 | 1.20.120.530 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like | 0.57 | 44.0 | 3.93e-01 | 84.6% | 87.1% |
| 6nsjA00 | 1.25.40.600 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › AmiS/UreI transporter | 0.57 | 51.0 | 4.06e-01 | 100.0% | 99.5% |
| 1a41A02 | 1.20.120.380 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Type 1-topoisomerase catalytic fragment, domain 2 | 0.55 | 42.0 | 4.25e-01 | 83.5% | 91.5% |
| 2vwaA00 | 1.20.58.1330 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Plasmodium falciparum UIS3 membrane protein | 0.55 | 39.0 | 3.81e-01 | 74.7% | 75.8% |
| 3ckyA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.54 | 46.0 | 4.04e-01 | 96.7% | 64.2% |
| 5je8B02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.54 | 46.0 | 4.11e-01 | 96.7% | 67.2% |
| 3vprA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.53 | 43.0 | 3.78e-01 | 91.2% | 72.4% |
| 5z7qA00 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.53 | 47.0 | 3.81e-01 | 100.0% | 72.2% |
| 3ccyA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 42.0 | 3.66e-01 | 89.0% | 68.7% |
| 2g7sA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 36.0 | 2.87e-01 | 72.5% | 44.7% |
| 3lwjA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 41.0 | 3.34e-01 | 90.1% | 58.5% |
| 2p1aB01 | 1.20.120.450 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain | 0.51 | 40.0 | 3.47e-01 | 84.6% | 75.3% |
| 3onqA03 | 1.10.10.2840 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › PucR C-terminal helix-turn-helix domain | 0.51 | 35.0 | 3.22e-01 | 72.5% | 85.5% |
| 1z6oM00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.51 | 45.0 | 3.57e-01 | 100.0% | 60.7% |
| 4nx9A01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.50 | 47.0 | 3.86e-01 | 100.0% | 71.0% |
| 5mmjn01 | 1.10.287.1480 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.50 | 35.0 | 3.62e-01 | 92.3% | 74.2% |
ECOD (51)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1302406 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.87 | 81.0 | 6.78e-01 | 100.0% | 61.9% |
| 4883080 | 101.1.2.9 ↗ | alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV | 0.87 | 80.0 | 6.97e-01 | 100.0% | 67.9% |
| 1297277 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.85 | 79.0 | 6.15e-01 | 100.0% | 50.3% |
| 4218225 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.83 | 77.0 | 6.33e-01 | 100.0% | 58.7% |
| 4945340 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.82 | 43.0 | 3.06e-01 | 100.0% | 19.6% |
| 1780091 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.81 | 74.0 | 6.13e-01 | 100.0% | 57.6% |
| 4024264 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.81 | 73.0 | 6.39e-01 | 100.0% | 67.4% |
| 3345589 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.80 | 74.0 | 5.71e-01 | 100.0% | 51.6% |
| 4299749 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.80 | 73.0 | 6.22e-01 | 100.0% | 62.8% |
| 4174306 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.80 | 71.0 | 5.97e-01 | 100.0% | 58.7% |
| 4373100 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.80 | 73.0 | 6.18e-01 | 100.0% | 62.8% |
| 4043618 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.79 | 72.0 | 6.07e-01 | 100.0% | 60.7% |
| 5083298 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.78 | 71.0 | 6.01e-01 | 100.0% | 64.7% |
| 4946213 | 4016.1.1.18 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_gyraseA_C | 0.78 | 71.0 | 6.06e-01 | 100.0% | 66.9% |
| 5024978 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.78 | 70.0 | 6.01e-01 | 100.0% | 62.8% |
| 4932829 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.78 | 70.0 | 5.97e-01 | 100.0% | 66.9% |
| 4552385 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.76 | 68.0 | 5.70e-01 | 100.0% | 60.6% |
| 3965596 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.75 | 67.0 | 5.36e-01 | 98.9% | 75.6% |
| 3959880 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.73 | 65.0 | 6.53e-01 | 96.7% | 100.0% |
| 3404270 | 377.1.1.0 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like | 0.72 | 35.0 | 3.08e-01 | 100.0% | 32.3% |
| 3708939 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.71 | 66.0 | 5.42e-01 | 100.0% | 58.7% |
| 3600354 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.70 | 65.0 | 5.43e-01 | 100.0% | 60.7% |
| 5010816 | 5060.2.1.0 ↗ | alpha bundles › V-type ATP synthase subunit C › Toxin coregulated pilus biosynthesis protein E cytoplasmic domain › Toxin coregulated pilus biosynthesis protein E cytoplasmic domain | 0.63 | 53.0 | 4.90e-01 | 94.5% | 96.7% |
| 4456963 | 563.1.1.1 ↗ | alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP | 0.61 | 48.0 | 3.97e-01 | 90.1% | 48.6% |
| 3345966 | 4133.1.1.0 ↗ | alpha arrays › Emsy N terminal (ENT) domain-like › Emsy N terminal (ENT) domain-like › Emsy N terminal (ENT) domain-like | 0.61 | 40.0 | 4.32e-01 | 73.6% | 81.3% |
| 3797393 | 5067.1.1.42 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Na_H_Exchanger | 0.60 | 39.0 | 2.90e-01 | 100.0% | 26.2% |
| 2986816 | 563.1.1.0 ↗ | alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase | 0.60 | 47.0 | 3.89e-01 | 85.7% | 54.9% |
| 4451042 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 53.0 | 3.35e-01 | 100.0% | 84.9% |
| 4937972 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.58 | 48.0 | 3.46e-01 | 91.2% | 85.6% |
| 4294975 | 563.1.1.1 ↗ | alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP | 0.58 | 45.0 | 3.71e-01 | 86.8% | 53.3% |
| 5024277 | 1079.1.1.19 ↗ | alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › DUF2162 | 0.56 | 47.0 | 3.71e-01 | 94.5% | 75.5% |
| 3707590 | 5079.1.1.4 ↗ | alpha duplicates or obligate multimers › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › TM_HPP | 0.56 | 47.0 | 4.04e-01 | 100.0% | 93.3% |
| 4476645 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.55 | 50.0 | 3.90e-01 | 100.0% | 89.2% |
| 5030340 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.55 | 40.0 | 3.24e-01 | 78.0% | 80.0% |
| 4029940 | 604.5.1.44 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › EMC6 | 0.54 | 38.0 | 3.83e-01 | 73.6% | 88.4% |
| 3993676 | 3919.1.1.0 ↗ | alpha duplicates or obligate multimers › N-terminal domain of COMMD9 › N-terminal domain of COMMD9 › N-terminal domain of COMMD9 | 0.54 | 40.0 | 3.86e-01 | 79.1% | 85.7% |
| 4646391 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.54 | 48.0 | 3.73e-01 | 100.0% | 88.8% |
| 5026254 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.53 | 40.0 | 3.09e-01 | 78.0% | 69.8% |
| 4125652 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.53 | 50.0 | 3.15e-01 | 100.0% | 31.1% |
| 3948493 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.53 | 41.0 | 3.24e-01 | 85.7% | 74.1% |
| 2330599 | 601.51.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-helical domain in phase 1 flagellin › alpha-helical domain in phase 1 flagellin › Flagellin_N,Flagellin_C | 0.53 | 47.0 | 3.81e-01 | 100.0% | 72.2% |
| 3722700 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.53 | 48.0 | 3.66e-01 | 100.0% | 89.9% |
| 4947169 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.52 | 48.0 | 3.69e-01 | 100.0% | 87.2% |
| 3921752 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.52 | 45.0 | 3.42e-01 | 100.0% | 89.4% |
| 4535879 | 5050.1.1.18 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › PUCC | 0.52 | 45.0 | 3.54e-01 | 100.0% | 92.7% |
| 4948141 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.52 | 47.0 | 3.68e-01 | 100.0% | 89.5% |
| 3998516 | 5050.1.1.6 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP | 0.51 | 45.0 | 3.41e-01 | 96.7% | 96.3% |
| 3753760 | 5082.1.1.0 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like | 0.51 | 47.0 | 3.48e-01 | 100.0% | 64.1% |
| 4946929 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 45.0 | 3.43e-01 | 100.0% | 88.4% |
| 3336590 | 5050.1.1.8 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › FPN1 | 0.51 | 45.0 | 3.32e-01 | 100.0% | 78.0% |
| 3784891 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.50 | 35.0 | 3.01e-01 | 71.4% | 79.3% |
D3
medium
residues 198-304_368-418_510-533
Domain cluster:
representative
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2xcqA02 | 3.90.199.10 | Alpha Beta › Alpha-Beta Complex › Topoisomerase II; domain 5 › Topoisomerase II, domain 5 | 0.85 | 63.0 | 5.34e-01 | 100.0% | 50.2% |
| 1bjtA05 | 3.90.199.10 | Alpha Beta › Alpha-Beta Complex › Topoisomerase II; domain 5 › Topoisomerase II, domain 5 | 0.80 | 49.0 | 4.33e-01 | 98.9% | 44.2% |
| 4he8D00 | 1.20.120.1200 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ | 0.57 | 23.0 | 2.45e-01 | 97.8% | 41.2% |
ECOD (16)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 396210 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.81 | 59.0 | 5.31e-01 | 74.2% | 78.8% |
| 4624017 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.80 | 58.0 | 5.87e-01 | 73.6% | 100.0% |
| 4024263 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.80 | 59.0 | 5.51e-01 | 74.7% | 100.0% |
| 3962339 | 4014.1.1.0 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase | 0.80 | 57.0 | 5.67e-01 | 72.0% | 100.0% |
| 3965475 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.78 | 56.0 | 5.41e-01 | 73.6% | 100.0% |
| 3590557 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.78 | 57.0 | 5.60e-01 | 74.7% | 94.9% |
| 4266765 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.72 | 52.0 | 5.50e-01 | 74.2% | 100.0% |
| 3096551 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.71 | 51.0 | 5.12e-01 | 73.1% | 100.0% |
| 3998667 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.70 | 57.0 | 5.62e-01 | 85.7% | 100.0% |
| 3220665 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.69 | 51.0 | 5.21e-01 | 74.7% | 100.0% |
| 3789606 | 4014.1.1.0 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase | 0.69 | 50.0 | 5.23e-01 | 74.2% | 100.0% |
| 4887990 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.65 | 46.0 | 4.92e-01 | 72.0% | 100.0% |
| 3409703 | 192.2.1.2 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin | 0.55 | 25.0 | 2.97e-01 | 86.8% | 59.2% |
| 4945806 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.52 | 26.0 | 3.18e-01 | 86.8% | 70.8% |
| 3950576 | 6094.1.1.0 ↗ | a+b two layers › KS-MAT linker domain in fatty acid synthase › KS-MAT linker domain in fatty acid synthase › KS-MAT linker domain in fatty acid synthase | 0.50 | 24.0 | 2.84e-01 | 97.8% | 64.8% |
| 3960654 | 239.4.1.2 ↗ | beta barrels › Ribosomal protein L25-like › Glutamine synthetase, N-terminal domain › Glutamine synthetase, N-terminal domain › GSIII_N | 0.50 | 20.0 | 2.51e-01 | 84.6% | 54.3% |
D4
medium
residues 305-367
D5
medium
residues 534-590
Domain cluster:
representative
CATH (18)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3m4iA02 | 3.30.1490.440 | Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › | 0.78 | 54.0 | 5.16e-01 | 73.7% | 70.6% |
| 2xcqA01 | 3.40.50.670 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.77 | 52.0 | 3.55e-01 | 75.4% | 21.3% |
| 3tiiA03 | 3.30.1490.20 | Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › ATP-grasp fold, A domain | 0.74 | 48.0 | 4.62e-01 | 70.2% | 58.5% |
| 5c17A00 | 3.30.450.410 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › | 0.70 | 61.0 | 4.16e-01 | 100.0% | 61.7% |
| 4d05A01 | 3.30.1490.70 | Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › | 0.66 | 52.0 | 4.77e-01 | 87.7% | 76.3% |
| 1x9nA02 | 3.30.1490.70 | Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › | 0.66 | 51.0 | 4.58e-01 | 87.7% | 75.0% |
| 3dtdD00 | 2.60.40.1880 | Mainly Beta › Sandwich › Immunoglobulin-like › Invasion associated locus B (IalB) protein | 0.65 | 51.0 | 3.87e-01 | 87.7% | 49.0% |
| 4gi3C00 | 3.30.60.30 | Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › | 0.62 | 41.0 | 4.15e-01 | 70.2% | 68.4% |
| 3aqoA02 | 3.30.1360.200 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.61 | 49.0 | 3.80e-01 | 93.0% | 85.1% |
| 5ucoA02 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.60 | 44.0 | 3.36e-01 | 80.7% | 57.5% |
| 5m3nA03 | 2.30.42.10 | Mainly Beta › Roll › Pdz3 Domain › PDZ domain | 0.60 | 47.0 | 4.01e-01 | 89.5% | 70.1% |
| 4flnA02 | 3.20.190.20 | Alpha Beta › Alpha-Beta Barrel › N-terminal domain of MutM-like DNA repair proteins › | 0.59 | 50.0 | 3.79e-01 | 100.0% | 53.3% |
| 4mqdA00 | 2.60.34.30 | Mainly Beta › Sandwich › Substrate Binding Domain Of DNAk; Chain A, domain 1 › Competence, DNA-entry nuclease inhibitor, ComJ | 0.58 | 45.0 | 3.51e-01 | 87.7% | 66.9% |
| 2p3wB01 | 2.30.42.10 | Mainly Beta › Roll › Pdz3 Domain › PDZ domain | 0.57 | 44.0 | 3.85e-01 | 89.5% | 70.8% |
| 6vgwA01 | 2.170.16.10 | Mainly Beta › Beta Complex › Endonuclease - Pi-scei; Chain A, domain 1 › Hedgehog/Intein (Hint) domain | 0.55 | 43.0 | 3.38e-01 | 93.0% | 82.3% |
| 7chkB01 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.52 | 42.0 | 3.23e-01 | 87.7% | 47.0% |
| 1h8eH00 | 2.60.15.10 | Mainly Beta › Sandwich › ATP Synthase; domain 1 › F0F1 ATP synthase delta/epsilon subunit, N-terminal | 0.52 | 41.0 | 3.69e-01 | 94.7% | 95.5% |
| 3kzqA00 | 3.40.30.10 | Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Glutaredoxin | 0.51 | 38.0 | 2.68e-01 | 82.5% | 36.9% |
ECOD (30)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2452014 | 2006.1.3.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › DNA_gyraseB_C,Toprim | 0.77 | 54.0 | 3.56e-01 | 75.4% | 20.5% |
| 3300493 | 2004.1.1.26 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Kinesin | 0.73 | 55.0 | 3.91e-01 | 84.2% | 56.1% |
| 4028488 | 224.1.1.0 ↗ | a+b three layers › Gelsolin-like › Gelsolin-like › Gelsolin-like | 0.70 | 59.0 | 4.47e-01 | 96.5% | 71.4% |
| 4981224 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.69 | 56.0 | 4.87e-01 | 87.7% | 65.9% |
| 3394204 | 379.1.1.0 ↗ | few secondary structure elements › Kazal-type serine protease inhibitors-like › Kazal-type serine protease inhibitors › Kazal-type serine protease inhibitors | 0.67 | 45.0 | 4.65e-01 | 70.2% | 81.5% |
| 4979979 | 224.1.1.0 ↗ | a+b three layers › Gelsolin-like › Gelsolin-like › Gelsolin-like | 0.67 | 56.0 | 4.65e-01 | 94.7% | 82.5% |
| 3218303 | 379.1.1.3 ↗ | few secondary structure elements › Kazal-type serine protease inhibitors-like › Kazal-type serine protease inhibitors › Kazal-type serine protease inhibitors › Kazal_2 | 0.67 | 43.0 | 4.64e-01 | 70.2% | 84.4% |
| 3259145 | 224.1.1.2 ↗ | a+b three layers › Gelsolin-like › Gelsolin-like › Gelsolin-like › Gelsolin | 0.66 | 54.0 | 4.55e-01 | 93.0% | 82.0% |
| 3518462 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.65 | 52.0 | 4.70e-01 | 91.2% | 91.3% |
| 4957226 | 7.1.1.10 ↗ | beta barrels › PDZ domain › PDZ domain › PDZ domain › PDZ_6 | 0.65 | 55.0 | 4.59e-01 | 96.5% | 76.0% |
| 3612291 | 207.1.1.0 ↗ | beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats | 0.64 | 55.0 | 3.46e-01 | 96.5% | 36.1% |
| 4086511 | 7.1.1.0 ↗ | beta barrels › PDZ domain › PDZ domain › PDZ domain | 0.63 | 52.0 | 4.30e-01 | 94.7% | 70.9% |
| 3539447 | 4070.1.1.0 ↗ | alpha arrays › FtsH protease domain-like › FtsH protease domain-like › FtsH protease domain-like | 0.63 | 52.0 | 4.46e-01 | 94.7% | 82.1% |
| 3900452 | 11.1.1.15 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › PKD | 0.62 | 47.0 | 4.25e-01 | 86.0% | 65.9% |
| 3276497 | 11.1.1.29 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › TIG | 0.62 | 48.0 | 4.18e-01 | 86.0% | 70.0% |
| 3895014 | 376.1.1.3 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › ZZ | 0.60 | 47.0 | 4.17e-01 | 93.0% | 57.8% |
| 4126406 | 2005.1.1.40 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › tRNA-synt_1+tRNA-synt_1g | 0.60 | 43.0 | 2.61e-01 | 77.2% | 26.4% |
| 3844612 | 376.1.1.3 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › ZZ | 0.59 | 45.0 | 4.50e-01 | 91.2% | 85.0% |
| 3482810 | 11.2.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › C2 domain › C2 domain | 0.58 | 41.0 | 3.10e-01 | 78.9% | 97.1% |
| 3619679 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.58 | 46.0 | 3.86e-01 | 87.7% | 66.0% |
| 3470932 | 11.2.1.10 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › C2 domain › C2 domain › DUF3668 | 0.58 | 41.0 | 3.08e-01 | 78.9% | 97.1% |
| 166194 | 7.1.1.5 ↗ | beta barrels › PDZ domain › PDZ domain › PDZ domain › PDZ_2 | 0.57 | 44.0 | 3.70e-01 | 89.5% | 61.8% |
| 4015953 | 7.1.1.0 ↗ | beta barrels › PDZ domain › PDZ domain › PDZ domain | 0.57 | 45.0 | 3.76e-01 | 93.0% | 67.3% |
| 3016553 | 822.1.1.2 ↗ | a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF_2 | 0.56 | 47.0 | 4.64e-01 | 100.0% | 93.4% |
| 5018095 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.55 | 43.0 | 3.50e-01 | 89.5% | 50.0% |
| 5011273 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.55 | 42.0 | 3.65e-01 | 86.0% | 60.0% |
| 3535221 | 7.1.1.10 ↗ | beta barrels › PDZ domain › PDZ domain › PDZ domain › PDZ_6 | 0.54 | 43.0 | 3.74e-01 | 94.7% | 83.0% |
| 3629768 | 7.1.1.0 ↗ | beta barrels › PDZ domain › PDZ domain › PDZ domain | 0.54 | 44.0 | 3.86e-01 | 94.7% | 93.3% |
| 5006740 | 7.1.1.0 ↗ | beta barrels › PDZ domain › PDZ domain › PDZ domain | 0.53 | 43.0 | 3.51e-01 | 93.0% | 51.3% |
| 4089702 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.53 | 40.0 | 3.41e-01 | 87.7% | 63.8% |
D6
medium
residues 591-679
D7
medium
residues 680-783
Domain cluster:
representative
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1wr2A01 | 3.30.470.20 | Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › ATP-grasp fold, B domain | 0.59 | 43.0 | 3.77e-01 | 76.9% | 67.5% |
| 3s6pA03 | 2.60.270.70 | Mainly Beta › Sandwich › Mutm (Fpg) Protein; Chain: A, domain 2 › | 0.54 | 38.0 | 3.51e-01 | 74.0% | 91.5% |
| 2f2hA01 | 2.60.40.1760 | Mainly Beta › Sandwich › Immunoglobulin-like › glycosyl hydrolase (family 31) | 0.52 | 42.0 | 3.29e-01 | 89.4% | 90.6% |
| 7bsbI01 | 2.100.10.30 | Mainly Beta › Aligned Prism › Vitelline Membrane Outer Layer Protein I, subunit A › Jacalin-like lectin domain | 0.52 | 43.0 | 4.06e-01 | 91.3% | 89.8% |
| 2c9kA03 | 2.100.10.10 | Mainly Beta › Aligned Prism › Vitelline Membrane Outer Layer Protein I, subunit A › Pesticidal crystal protein, central domain | 0.52 | 43.0 | 3.59e-01 | 93.3% | 81.0% |
| 1mg2A00 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.52 | 39.0 | 2.69e-01 | 98.1% | 22.0% |
| 1mdaH00 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.51 | 38.0 | 2.69e-01 | 98.1% | 22.8% |
| 4jg5A01 | 2.60.40.2580 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.51 | 35.0 | 3.01e-01 | 72.1% | 54.3% |
ECOD (5)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4943675 | 12.3.1.73 ↗ | beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Glyco_hydro_31_2nd | 0.56 | 46.0 | 3.62e-01 | 89.4% | 95.1% |
| 3197107 | 76.1.1.2 ↗ | beta duplicates or obligate multimers › beta-Prism I › beta-Prism I › beta-Prism I › Jacalin | 0.55 | 43.0 | 3.77e-01 | 84.6% | 78.0% |
| 3814287 | 5.1.3.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed | 0.54 | 39.0 | 2.70e-01 | 75.0% | 99.4% |
| 3823805 | 76.1.1.0 ↗ | beta duplicates or obligate multimers › beta-Prism I › beta-Prism I › beta-Prism I | 0.51 | 34.0 | 3.37e-01 | 93.3% | 63.6% |
| 3815901 | 76.1.1.2 ↗ | beta duplicates or obligate multimers › beta-Prism I › beta-Prism I › beta-Prism I › Jacalin | 0.51 | 42.0 | 3.70e-01 | 92.3% | 75.6% |