←Back to structures
PreM_protein
Euk-VirPowassan_virus
PreM_protein__NP_775514__Powassan_virus__11083
Identity
- Accession:
- NP_775514 ↗
- Protein ID:
- PreM_protein
- Kingdom:
- euk
Quality
75.6
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Powassan_virus
TaxID: 11083
Cluster
View cluster (4 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 6-83
Domain cluster:
rep: propep__YP_009553725__Kampung_Karu_virus__2045186__D2-68
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01570.23 best | Flavi_propep | 61.5 | 8.50e-17 | 96.2% | 65.9% |
CATH (7)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3c5xC00 | 2.60.260.50 | Mainly Beta › Sandwich › HSP40/DNAj peptide-binding domain › Flavivirus polyprotein propeptide domain | 0.87 | 81.0 | 8.00e-01 | 100.0% | 97.5% |
| 6y2kA03 | 2.60.40.1180 | Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II | 0.54 | 32.0 | 3.76e-01 | 91.0% | 90.0% |
| 4djmA02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.54 | 34.0 | 3.44e-01 | 89.7% | 62.5% |
| 7nn3B01 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.53 | 41.0 | 2.77e-01 | 85.9% | 39.9% |
| 2omkA00 | 3.40.50.10240 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin pyrophosphokinase, catalytic domain | 0.51 | 40.0 | 2.96e-01 | 87.2% | 55.9% |
| 3wy2A03 | 2.60.40.1180 | Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II | 0.51 | 37.0 | 3.80e-01 | 93.6% | 80.8% |
| 3picA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.51 | 40.0 | 2.58e-01 | 85.9% | 31.5% |
ECOD (7)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2410038 | 67.1.1.2 ↗ | beta sandwiches › HSP40/DnaJ peptide-binding domain › HSP40/DnaJ peptide-binding domain › HSP40/DnaJ peptide-binding domain › Flavi_propep | 0.94 | 89.0 | 8.81e-01 | 100.0% | 96.2% |
| 2721993 | 67.1.1.2 ↗ | beta sandwiches › HSP40/DnaJ peptide-binding domain › HSP40/DnaJ peptide-binding domain › HSP40/DnaJ peptide-binding domain › Flavi_propep | 0.92 | 82.0 | 8.27e-01 | 97.4% | 94.8% |
| 2720279 | 67.1.1.2 ↗ | beta sandwiches › HSP40/DnaJ peptide-binding domain › HSP40/DnaJ peptide-binding domain › HSP40/DnaJ peptide-binding domain › Flavi_propep | 0.92 | 87.0 | 7.87e-01 | 100.0% | 79.2% |
| 5025112 | 4272.1.1.1 ↗ | a+b two layers › Nqo5-like › Nqo5-like › Nqo5-like › Complex1_30kDa | 0.59 | 47.0 | 3.97e-01 | 100.0% | 53.6% |
| 4301634 | 11.1.1.42 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › PapD_C | 0.54 | 34.0 | 3.44e-01 | 91.0% | 61.3% |
| 4180426 | 11.1.1.42 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › PapD_C | 0.54 | 34.0 | 3.34e-01 | 91.0% | 58.8% |
| 4964155 | 1.1.9.31 ↗ | beta barrels › cradle loop barrel › RIFT-related › PUA domain › SRA_ScoMcrA | 0.52 | 40.0 | 3.33e-01 | 83.3% | 75.0% |
D2
high
residues 116-166
Domain cluster:
representative
CATH (28)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3j27B00 | 1.10.8.970 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Flavivirus envelope glycoprotein M-like | 0.87 | 77.0 | 6.81e-01 | 98.0% | 70.8% |
| 1zoyD00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.80 | 54.0 | 4.26e-01 | 70.6% | 37.3% |
| 4i9oA00 | 1.10.246.20 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › Coactivator CBP, KIX domain | 0.80 | 61.0 | 5.24e-01 | 82.4% | 71.8% |
| 2l37A00 | 6.10.250.890 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.77 | 54.0 | 5.82e-01 | 76.5% | 88.4% |
| 2lqxA00 | 6.10.250.1700 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.76 | 54.0 | 5.80e-01 | 78.4% | 92.7% |
| 6xxvC00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.76 | 52.0 | 4.03e-01 | 72.5% | 34.2% |
| 4j0eA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.75 | 55.0 | 3.62e-01 | 78.4% | 20.8% |
| 1f05A00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.73 | 57.0 | 3.55e-01 | 92.2% | 18.9% |
| 2o4cA03 | 3.30.1370.170 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › Erythronate-4-phosphate dehydrogenase, dimerisation domain | 0.72 | 46.0 | 3.90e-01 | 70.6% | 38.6% |
| 1w0bA01 | 1.20.58.420 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › AHSP | 0.70 | 47.0 | 3.90e-01 | 70.6% | 43.5% |
| 2hxiB02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.66 | 49.0 | 3.73e-01 | 90.2% | 32.1% |
| 2pkeA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.63 | 49.0 | 4.33e-01 | 94.1% | 57.7% |
| 1k32A03 | 3.30.750.44 | Alpha Beta › 2-Layer Sandwich › Transcription Regulator spoIIAA › | 0.63 | 47.0 | 4.32e-01 | 96.1% | 61.1% |
| 3dzvA00 | 3.40.1190.20 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase | 0.62 | 51.0 | 3.28e-01 | 96.1% | 87.1% |
| 3qvmB00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.62 | 50.0 | 3.20e-01 | 94.1% | 91.1% |
| 2oauA01 | 1.10.287.1260 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 44.0 | 3.64e-01 | 80.4% | 42.2% |
| 1dqeA00 | 1.10.238.20 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain | 0.61 | 52.0 | 3.85e-01 | 98.0% | 88.3% |
| 7m2wE01 | 1.20.120.1900 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain | 0.61 | 50.0 | 3.19e-01 | 100.0% | 45.2% |
| 1b5lA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.59 | 49.0 | 3.63e-01 | 100.0% | 88.2% |
| 3x0uB01 | 1.20.190.10 | Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain | 0.58 | 46.0 | 3.01e-01 | 90.2% | 86.0% |
| 4pt1B00 | 1.10.238.20 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain | 0.58 | 49.0 | 3.68e-01 | 96.1% | 61.7% |
| 5jrcA00 | 1.20.58.2140 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 42.0 | 2.92e-01 | 80.4% | 23.1% |
| 4gf0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.57 | 39.0 | 3.08e-01 | 70.6% | 49.6% |
| 2aj6A00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.56 | 40.0 | 3.14e-01 | 86.3% | 33.3% |
| 3axjB02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.54 | 37.0 | 3.16e-01 | 70.6% | 47.1% |
| 1pu6A01 | 1.10.1670.10 | Mainly Alpha › Orthogonal Bundle › Endonuclease Iii, domain 2 › Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) | 0.54 | 45.0 | 3.75e-01 | 96.1% | 66.0% |
| 2glzA00 | 3.30.1330.130 | Alpha Beta › 2-Layer Sandwich › 60s Ribosomal Protein L30; Chain: A; › | 0.53 | 42.0 | 3.26e-01 | 100.0% | 85.9% |
| 3ivpD01 | 1.10.260.40 | Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › lambda repressor-like DNA-binding domains | 0.52 | 38.0 | 3.37e-01 | 74.5% | 68.0% |
ECOD (27)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4861326 | 3544.1.1.1 ↗ | extended segments › Small envelope protein M › Small envelope protein M › Small envelope protein M › Flavi_M | 0.93 | 84.0 | 7.76e-01 | 98.0% | 78.1% |
| 2720280 | 3544.1.1.1 ↗ | extended segments › Small envelope protein M › Small envelope protein M › Small envelope protein M › Flavi_M | 0.91 | 79.0 | 8.01e-01 | 94.1% | 96.0% |
| 3314379 | 4953.1.1.0 ↗ | beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like | 0.79 | 55.0 | 4.91e-01 | 72.5% | 78.6% |
| 3912794 | 2004.1.1.118 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AIG1 | 0.78 | 70.0 | 4.34e-01 | 100.0% | 65.1% |
| 4931046 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.76 | 51.0 | 4.41e-01 | 70.6% | 78.8% |
| 3331967 | 397.7.1.3 ↗ | few secondary structure elements › Toxic hairpin › Ribosome-inactivating protein luffin P1 › Ribosome-inactivating protein luffin P1 › DUF842 | 0.75 | 52.0 | 5.27e-01 | 72.5% | 78.0% |
| 5072135 | 2498.1.1.10 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M48 | 0.75 | 52.0 | 3.49e-01 | 78.4% | 19.5% |
| 3163576 | 5076.2.1.0 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ | 0.71 | 63.0 | 4.11e-01 | 100.0% | 96.9% |
| 3597909 | 5094.1.1.0 ↗ | a+b duplicates or obligate multimers › OmpH-like › OmpH-like › OmpH-like | 0.71 | 53.0 | 4.05e-01 | 84.3% | 35.0% |
| 3347379 | 3470.1.1.26 ↗ | extended segments › Glycophorin-A transmembrane domain › Glycophorin-A transmembrane domain › Glycophorin-A transmembrane domain › DUF543 | 0.70 | 53.0 | 4.91e-01 | 84.3% | 64.6% |
| 3596791 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.69 | 50.0 | 3.32e-01 | 80.4% | 19.0% |
| 4964132 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.68 | 51.0 | 4.13e-01 | 84.3% | 41.0% |
| 3453796 | 7519.1.1.11 ↗ | a/b three-layered sandwiches › ATP synthase (F1-ATPase), gamma subunit › ATP synthase (F1-ATPase), gamma subunit › ATP synthase (F1-ATPase), gamma subunit › Rick_17kDa_Anti, PF29034 | 0.67 | 50.0 | 4.01e-01 | 84.3% | 40.0% |
| 3574388 | 103.9.1.0 ↗ | alpha arrays › RuvA-C › RanGAP2 N-terminal domain › RanGAP2 N-terminal domain | 0.65 | 54.0 | 4.55e-01 | 96.1% | 56.7% |
| 5051457 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.64 | 43.0 | 3.92e-01 | 70.6% | 72.0% |
| 3602986 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.64 | 46.0 | 3.81e-01 | 78.4% | 44.2% |
| 4951179 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.63 | 45.0 | 3.77e-01 | 80.4% | 42.0% |
| 5047182 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.63 | 44.0 | 4.19e-01 | 78.4% | 64.6% |
| 3603687 | 632.2.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains | 0.62 | 44.0 | 4.16e-01 | 82.4% | 60.9% |
| 3655557 | 148.1.1.25 ↗ | alpha arrays › Histone-like › Histone-related › Histone › Tim17 | 0.62 | 47.0 | 3.59e-01 | 84.3% | 34.4% |
| 2832654 | 5058.1.1.1 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st_1,MS_channel_1st | 0.62 | 47.0 | 3.93e-01 | 84.3% | 45.7% |
| 3320952 | 2006.1.4.33 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › Tim17 | 0.62 | 49.0 | 3.63e-01 | 92.2% | 33.3% |
| 5054424 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.60 | 44.0 | 3.91e-01 | 84.3% | 52.5% |
| 2791544 | 568.1.1.0 ↗ | few secondary structure elements › p8-MTCP1-related › p8-MTCP1-related › p8-MTCP1-related | 0.58 | 48.0 | 4.73e-01 | 98.0% | 88.9% |
| 3250253 | 633.6.1.12 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACOX+ACOX_C_alpha1 | 0.57 | 47.0 | 2.89e-01 | 100.0% | 52.3% |
| 3478615 | 5076.1.1.1 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Mitochondrial ADP/ATP carrier › Mitochondrial ADP/ATP carrier › Mito_carr | 0.55 | 47.0 | 2.96e-01 | 100.0% | 34.2% |
| 3483392 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.53 | 41.0 | 2.94e-01 | 92.2% | 27.4% |