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RNA-dependent_RNA-polymerase_-RdRp-
Euk-VirGrapevine_Bulgarian_latent_virus
RNA-dependent_RNA-polymerase_-RdRp-__YP_004429254__Grapevine_Bulgarian_latent_virus__748667
Identity
- Accession:
- YP_004429254 ↗
- Protein ID:
- RNA-dependent_RNA-polymerase_-RdRp-
- Kingdom:
- euk
Quality
86.2
mean pLDDT
Cluster
View cluster (32 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 525-669
Domain cluster:
rep: RNA-dependent_RNA_polymerase__YP_054443__Arabis_mosaic_virus__12271__D540-681
CATH (24)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7ncyB01 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.74 | 58.0 | 6.34e-01 | 90.3% | 99.2% |
| 2hcmA01 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.73 | 64.0 | 6.34e-01 | 91.7% | 89.3% |
| 1i9sA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.72 | 65.0 | 5.91e-01 | 95.9% | 84.7% |
| 4r30A00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.72 | 63.0 | 5.87e-01 | 93.1% | 88.3% |
| 4d3pA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.72 | 63.0 | 6.33e-01 | 93.1% | 92.5% |
| 2j16A00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.72 | 58.0 | 6.11e-01 | 93.8% | 93.2% |
| 1yz4B01 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.72 | 61.0 | 6.05e-01 | 90.3% | 85.6% |
| 2esbA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.72 | 62.0 | 5.99e-01 | 91.7% | 82.7% |
| 2g6zA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.71 | 63.0 | 6.31e-01 | 100.0% | 93.2% |
| 4ki9A00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.70 | 60.0 | 5.83e-01 | 90.3% | 82.8% |
| 4jmjA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.70 | 62.0 | 5.77e-01 | 95.9% | 91.7% |
| 1d5rA01 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.70 | 65.0 | 6.12e-01 | 100.0% | 92.5% |
| 2r0bA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.70 | 63.0 | 6.28e-01 | 97.2% | 94.0% |
| 2nlkA02 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.69 | 64.0 | 5.21e-01 | 100.0% | 84.2% |
| 2p4dA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.69 | 63.0 | 6.08e-01 | 98.6% | 88.3% |
| 1oheA01 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.67 | 59.0 | 5.84e-01 | 94.5% | 97.3% |
| 1jbwA02 | 3.90.190.20 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain | 0.62 | 47.0 | 5.27e-01 | 87.6% | 100.0% |
| 7q1bA01 | 3.40.800.20 | Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain | 0.56 | 50.0 | 3.78e-01 | 100.0% | 95.7% |
| 6llwB01 | 3.40.50.2000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; | 0.54 | 47.0 | 3.98e-01 | 95.2% | 70.7% |
| 1d5wA00 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.53 | 32.0 | 3.52e-01 | 71.0% | 71.5% |
| 5gizA01 | 3.40.50.1980 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain | 0.52 | 34.0 | 3.57e-01 | 91.7% | 72.9% |
| 4qboA00 | 3.40.1350.10 | Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 › | 0.52 | 26.0 | 3.20e-01 | 77.2% | 75.0% |
| 3ct6A00 | 3.40.50.510 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphotransferase system, mannose-type IIA component | 0.51 | 36.0 | 3.79e-01 | 72.4% | 97.7% |
| 2vliB00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 41.0 | 3.86e-01 | 85.5% | 82.1% |
ECOD (31)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5065614 | 2007.2.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II | 0.75 | 54.0 | 6.02e-01 | 91.0% | 93.0% |
| 3221179 | 2007.2.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II | 0.73 | 69.0 | 6.22e-01 | 100.0% | 78.4% |
| 4000139 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.73 | 59.0 | 6.23e-01 | 84.8% | 100.0% |
| 5049258 | 2007.2.3.12 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Tc-R-P | 0.73 | 64.0 | 6.59e-01 | 100.0% | 96.4% |
| 3740233 | 2007.2.3.14 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Init_tRNA_PT | 0.73 | 64.0 | 6.06e-01 | 93.8% | 92.9% |
| 3850992 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.73 | 64.0 | 6.18e-01 | 93.1% | 85.0% |
| 3725576 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.72 | 64.0 | 5.89e-01 | 95.9% | 89.2% |
| 4948530 | 2007.2.3.12 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Tc-R-P | 0.72 | 63.0 | 6.27e-01 | 93.1% | 91.3% |
| 3239957 | 2007.2.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II | 0.71 | 61.0 | 5.81e-01 | 91.7% | 85.9% |
| 3906453 | 2007.2.3.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase | 0.71 | 65.0 | 5.09e-01 | 99.3% | 67.8% |
| 3507735 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.71 | 63.0 | 5.73e-01 | 95.9% | 91.5% |
| 3274884 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.71 | 62.0 | 5.91e-01 | 93.1% | 82.4% |
| 3514292 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.70 | 61.0 | 6.35e-01 | 95.9% | 99.3% |
| 3733761 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.70 | 61.0 | 5.68e-01 | 93.8% | 82.8% |
| 3705897 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.69 | 63.0 | 5.93e-01 | 97.9% | 86.9% |
| 3631982 | 2007.2.3.8 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase3 | 0.69 | 63.0 | 5.08e-01 | 98.6% | 88.1% |
| 3599998 | 2007.2.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II | 0.69 | 62.0 | 5.98e-01 | 97.2% | 89.7% |
| 2099531 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.67 | 62.0 | 5.83e-01 | 99.3% | 86.8% |
| 2100287 | 2007.2.3.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPn | 0.67 | 58.0 | 5.62e-01 | 91.7% | 88.7% |
| 3483990 | 2007.2.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II | 0.67 | 61.0 | 4.78e-01 | 98.6% | 70.3% |
| 3743443 | 7525.1.1.1 ↗ | a/b three-layered sandwiches › Phosphoglycerate mutase-like › Phosphoglycerate mutase-like › Phosphoglycerate mutase-like › His_Phos_1 | 0.66 | 50.0 | 4.43e-01 | 80.7% | 80.9% |
| 4148948 | 2007.2.3.5 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › BLH_phosphatase | 0.66 | 57.0 | 5.84e-01 | 93.1% | 97.1% |
| 4939913 | 2004.1.1.103 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Sua5_C | 0.61 | 40.0 | 4.50e-01 | 75.9% | 87.0% |
| 147093 | 2004.1.1.229 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TraI_hel_assoc_N | 0.53 | 42.0 | 3.88e-01 | 84.1% | 85.7% |
| 3252815 | 2004.1.1.23 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SNF2-rel_dom | 0.53 | 45.0 | 3.71e-01 | 93.8% | 79.6% |
| 5049820 | 2002.1.1.79 ↗ | a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › DUF72 | 0.53 | 46.0 | 3.84e-01 | 97.9% | 95.9% |
| 3393414 | 7515.1.1.6 ↗ | a/b three-layered sandwiches › Alkaline phosphatase-like › Alkaline phosphatase-like › Alkaline phosphatase-like › Phosphodiest | 0.51 | 44.0 | 3.25e-01 | 96.6% | 43.7% |
| 4107405 | 2007.1.14.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Chelatase-like › Oxidored_nitro | 0.51 | 33.0 | 3.60e-01 | 97.9% | 79.2% |
| 5015080 | 2004.1.1.1200 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF835 | 0.50 | 41.0 | 4.30e-01 | 89.0% | 96.2% |
| 4423007 | 2002.1.1.29 ↗ | a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › DHDPS | 0.50 | 44.0 | 3.53e-01 | 97.2% | 89.8% |
| 4383522 | 2004.1.1.42 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE | 0.50 | 42.0 | 3.04e-01 | 91.0% | 33.8% |
D2
medium
residues 1-65
Domain cluster:
representative
D3
medium
residues 66-229_264-320
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00680.26 best | RdRP_1 | 51.0 | 1.40e-13 | 63.8% | 24.9% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2pggA01 | 3.90.1730.10 | Alpha Beta › Alpha-Beta Complex › Infectious bursal virus vp1 polymerase fold › Infectious bursal virus vp1 polymerase domain | 0.71 | 68.0 | 5.73e-01 | 100.0% | 72.6% |
| 2r7rA05 | 1.10.357.80 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › | 0.68 | 50.0 | 5.61e-01 | 100.0% | 94.9% |
| 2a3vB01 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.56 | 25.0 | 3.64e-01 | 78.3% | 92.6% |
| 6bmeA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.54 | 29.0 | 3.71e-01 | 80.5% | 88.2% |
| 2wy4A00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.53 | 30.0 | 3.64e-01 | 81.0% | 85.6% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2541763 | 304.48.1.8 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 | 0.85 | 82.0 | 6.67e-01 | 100.0% | 63.2% |
| 1173784 | 304.48.1.8 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 | 0.81 | 78.0 | 6.36e-01 | 100.0% | 61.8% |
| None | — | 0.79 | 77.0 | 6.28e-01 | 100.0% | 61.5% | |
| 4871000 | 304.48.1.8 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 | 0.79 | 64.0 | 6.00e-01 | 83.3% | 74.0% |
| 217141 | 304.48.1.15 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 | 0.74 | 70.0 | 5.86e-01 | 100.0% | 63.6% |
| 1789314 | 304.48.1.8 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 | 0.72 | 69.0 | 5.56e-01 | 100.0% | 58.4% |
| 1411401 | 304.48.1.7 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flu_PB1 | 0.68 | 65.0 | 4.90e-01 | 100.0% | 74.7% |
| 3258406 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.68 | 64.0 | 4.64e-01 | 100.0% | 42.8% |
| 3789227 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.67 | 62.0 | 5.50e-01 | 98.2% | 77.1% |
| 1695458 | 304.48.1.7 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flu_PB1 | 0.67 | 63.0 | 4.86e-01 | 100.0% | 74.4% |
| 3928372 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.66 | 63.0 | 4.68e-01 | 100.0% | 47.2% |
| 3589612 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.65 | 56.0 | 4.82e-01 | 90.0% | 62.7% |
| 3945039 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.64 | 55.0 | 4.76e-01 | 91.0% | 60.3% |
| 3792091 | 304.48.1.25 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 | 0.64 | 55.0 | 4.70e-01 | 94.1% | 58.3% |
| 4516798 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.63 | 55.0 | 4.24e-01 | 91.0% | 43.7% |
| 4071235 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.63 | 55.0 | 4.10e-01 | 91.0% | 39.4% |
| 4004424 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.63 | 55.0 | 4.53e-01 | 91.4% | 55.7% |
| 3615272 | 304.48.1.25 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 | 0.62 | 55.0 | 4.55e-01 | 95.0% | 58.7% |
| 3598902 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.61 | 55.0 | 4.51e-01 | 94.1% | 58.9% |
| 5002351 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.60 | 52.0 | 4.31e-01 | 91.0% | 55.2% |
| 5029718 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.56 | 46.0 | 3.98e-01 | 87.3% | 57.6% |
| 4138932 | 304.48.1.72 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_N | 0.55 | 47.0 | 4.24e-01 | 90.0% | 68.0% |
| 2995051 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.54 | 46.0 | 3.94e-01 | 91.0% | 58.3% |
D4
medium
residues 230-263_321-414
Domain cluster:
rep: KR816341.1__AKQ06880.1__X__00021__D162-195_238-325
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00680.26 best | RdRP_1 | 55.8 | 5.00e-15 | 73.4% | 18.0% |
CATH (52)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6qwtA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.87 | 76.0 | 7.37e-01 | 100.0% | 83.0% |
| 3h5xA03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.86 | 75.0 | 7.95e-01 | 97.7% | 100.0% |
| 1khvA03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.86 | 81.0 | 8.10e-01 | 100.0% | 96.9% |
| 1ra6A02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.86 | 69.0 | 7.57e-01 | 92.2% | 100.0% |
| 5jxsA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.86 | 76.0 | 7.30e-01 | 100.0% | 83.1% |
| 2ckwA03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.85 | 74.0 | 7.81e-01 | 96.1% | 100.0% |
| 1s48A04 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.81 | 63.0 | 6.75e-01 | 100.0% | 93.7% |
| 1gx5A03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.78 | 68.0 | 6.95e-01 | 100.0% | 95.9% |
| 7pliA03 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.70 | 42.0 | 5.22e-01 | 78.9% | 100.0% |
| 1in0A01 | 3.30.70.860 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.69 | 39.0 | 5.00e-01 | 78.1% | 100.0% |
| 6ahuH01 | 3.30.70.3250 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribonuclease P, Pop5 subunit | 0.69 | 49.0 | 5.65e-01 | 81.2% | 100.0% |
| 1hi8A03 | 3.30.70.1600 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.69 | 64.0 | 5.67e-01 | 100.0% | 86.4% |
| 2g0cA00 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.67 | 37.0 | 4.76e-01 | 78.9% | 100.0% |
| 4ol8A01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.67 | 49.0 | 4.82e-01 | 100.0% | 71.9% |
| 3trgA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.66 | 40.0 | 4.51e-01 | 80.5% | 80.9% |
| 3u5eU00 | 3.30.1360.210 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.63 | 44.0 | 4.93e-01 | 78.1% | 92.0% |
| 1vx7X00 | 3.30.1360.210 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.62 | 43.0 | 4.79e-01 | 78.9% | 92.8% |
| 4c98A01 | 3.30.70.1890 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.62 | 45.0 | 4.93e-01 | 79.7% | 93.3% |
| 4zmuA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.60 | 52.0 | 4.94e-01 | 95.3% | 98.7% |
| 2qv6A01 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.60 | 45.0 | 4.57e-01 | 78.9% | 96.9% |
| 3otdA00 | 3.30.70.3000 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › tRNA(His) guanylyltransferase (Thg1) | 0.60 | 47.0 | 3.80e-01 | 82.8% | 52.5% |
| 3hvwA00 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.60 | 53.0 | 4.92e-01 | 96.1% | 95.0% |
| 2c5sA01 | 3.30.2130.30 | Alpha Beta › 2-Layer Sandwich › VC0802-like › | 0.60 | 46.0 | 4.20e-01 | 81.2% | 92.3% |
| 3pjxA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.59 | 52.0 | 4.66e-01 | 96.1% | 85.6% |
| 5axmB00 | 3.30.70.3000 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › tRNA(His) guanylyltransferase (Thg1) | 0.59 | 47.0 | 3.79e-01 | 82.8% | 49.0% |
| 7e6gA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.58 | 50.0 | 4.79e-01 | 93.8% | 100.0% |
| 4er8A00 | 3.30.70.1290 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Transposase IS200-like | 0.58 | 46.0 | 4.21e-01 | 83.6% | 90.9% |
| 1q8bA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.58 | 39.0 | 4.44e-01 | 79.7% | 94.6% |
| 2rkvA01 | 3.30.559.10 | Alpha Beta › 2-Layer Sandwich › Chloramphenicol Acetyltransferase › Chloramphenicol acetyltransferase-like domain | 0.58 | 45.0 | 3.77e-01 | 81.2% | 90.7% |
| 5kfnA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.58 | 46.0 | 4.11e-01 | 83.6% | 93.8% |
| 2xliA01 | 3.30.70.2540 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › CRISPR-associated endoribonuclease Cas6/Csy4 | 0.57 | 45.0 | 4.23e-01 | 84.4% | 100.0% |
| 6wubf01 | 3.30.70.60 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B | 0.57 | 40.0 | 4.53e-01 | 79.7% | 100.0% |
| 4mt1A06 | 3.30.70.1430 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain | 0.56 | 42.0 | 4.66e-01 | 82.0% | 100.0% |
| 3w9iD03 | 3.30.70.1320 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain like | 0.56 | 42.0 | 4.56e-01 | 78.9% | 99.0% |
| 2efpA02 | 3.30.70.920 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain | 0.56 | 38.0 | 4.22e-01 | 87.5% | 90.8% |
| 5t0oA03 | 3.30.70.1320 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain like | 0.56 | 41.0 | 4.50e-01 | 77.3% | 100.0% |
| 3ungC03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.56 | 42.0 | 4.18e-01 | 79.7% | 88.7% |
| 5o6uB00 | 3.30.70.2540 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › CRISPR-associated endoribonuclease Cas6/Csy4 | 0.55 | 43.0 | 3.84e-01 | 82.8% | 100.0% |
| 1yirA00 | 3.20.140.10 | Alpha Beta › Alpha-Beta Barrel › nicotinate phosphoribosyltransferase › nicotinate phosphoribosyltransferase | 0.55 | 43.0 | 3.06e-01 | 82.8% | 87.9% |
| 3c19A01 | 3.30.70.1380 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Transcriptional regulatory protein pf0864 domain like | 0.55 | 36.0 | 4.00e-01 | 80.5% | 86.9% |
| 3k85A00 | 3.30.230.120 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › | 0.54 | 41.0 | 3.18e-01 | 80.5% | 98.7% |
| 2a6mA00 | 3.30.70.1290 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Transposase IS200-like | 0.54 | 43.0 | 4.32e-01 | 84.4% | 87.7% |
| 2oo4A02 | 3.30.70.3310 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.54 | 43.0 | 4.61e-01 | 85.9% | 100.0% |
| 2im5A00 | 3.20.140.10 | Alpha Beta › Alpha-Beta Barrel › nicotinate phosphoribosyltransferase › nicotinate phosphoribosyltransferase | 0.54 | 42.0 | 3.02e-01 | 83.6% | 90.5% |
| 3cx5A01 | 3.30.830.10 | Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like | 0.54 | 41.0 | 3.58e-01 | 82.0% | 82.2% |
| 1g71A01 | 3.90.920.10 | Alpha Beta › Alpha-Beta Complex › DNA primase, PRIM domain › DNA primase, PRIM domain | 0.53 | 46.0 | 3.79e-01 | 95.3% | 73.7% |
| 1vdhA01 | 3.30.70.1030 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Apc35880; domain 1 | 0.53 | 39.0 | 3.99e-01 | 81.2% | 80.2% |
| 1oaoC03 | 3.30.1650.10 | Alpha Beta › 2-Layer Sandwich › Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3 › Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3 | 0.53 | 43.0 | 3.87e-01 | 87.5% | 76.7% |
| 4f67A01 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.52 | 37.0 | 4.01e-01 | 83.6% | 87.7% |
| 1s12A00 | 3.30.70.1490 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Cysteine protease Prp | 0.52 | 34.0 | 3.86e-01 | 76.6% | 90.4% |
| 2r15A01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.51 | 35.0 | 3.74e-01 | 83.6% | 82.0% |
| 3fmbA01 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.50 | 37.0 | 4.05e-01 | 80.5% | 99.0% |
ECOD (76)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1875037 | 304.48.1.8 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 | 0.86 | 77.0 | 5.26e-01 | 93.8% | 44.4% |
| 2994348 | 304.48.1.9 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N | 0.83 | 79.0 | 4.59e-01 | 100.0% | 24.3% |
| 3664456 | 304.7.1.2 ↗ | a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › Inhibitor_I9 | 0.71 | 46.0 | 5.35e-01 | 82.0% | 94.4% |
| 3939861 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.69 | 56.0 | 5.76e-01 | 100.0% | 92.5% |
| 3651505 | 304.3.1.1 ↗ | a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain › HMA | 0.68 | 41.0 | 4.96e-01 | 78.1% | 95.0% |
| 3185440 | 304.48.1.10 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › IMS | 0.66 | 53.0 | 4.30e-01 | 84.4% | 92.6% |
| 3192747 | 304.57.1.2 ↗ | a+b two layers › Alpha-beta plaits › Rpp14/Pop5-like › Rpp14/Pop5-like › Pop8 | 0.66 | 50.0 | 5.12e-01 | 84.4% | 82.4% |
| 3983816 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.65 | 59.0 | 4.74e-01 | 100.0% | 70.0% |
| 3408148 | 304.57.1.1 ↗ | a+b two layers › Alpha-beta plaits › Rpp14/Pop5-like › Rpp14/Pop5-like › RNase_P_Rpp14 | 0.65 | 50.0 | 4.91e-01 | 85.2% | 75.0% |
| 5018583 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.64 | 57.0 | 4.29e-01 | 98.4% | 54.6% |
| 4886155 | 304.57.1.1 ↗ | a+b two layers › Alpha-beta plaits › Rpp14/Pop5-like › Rpp14/Pop5-like › RNase_P_Rpp14 | 0.63 | 51.0 | 4.84e-01 | 85.2% | 72.7% |
| 3231858 | 304.8.1.72 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › SCVP | 0.63 | 47.0 | 5.19e-01 | 86.7% | 99.0% |
| 3595281 | 3715.1.1.0 ↗ | a+b two layers › Ribosomal protein L22e › Ribosomal protein L22e › Ribosomal protein L22e | 0.62 | 45.0 | 4.64e-01 | 78.9% | 80.0% |
| 4176318 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.62 | 56.0 | 4.65e-01 | 100.0% | 71.6% |
| 3934872 | 3122.1.1.2 ↗ | a+b complex topology › MESD › MESD › MESD › SCVP | 0.62 | 46.0 | 4.99e-01 | 83.6% | 94.3% |
| 4976338 | 304.20.1.4 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › CAA_C | 0.61 | 53.0 | 4.66e-01 | 93.8% | 91.1% |
| 4116969 | 304.48.1.14 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF | 0.61 | 55.0 | 4.73e-01 | 98.4% | 83.5% |
| 4588604 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.61 | 54.0 | 4.29e-01 | 98.4% | 53.0% |
| 4928720 | 304.20.1.4 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › CAA_C | 0.61 | 50.0 | 4.54e-01 | 87.5% | 91.8% |
| 3940836 | 304.8.1.72 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › SCVP | 0.61 | 44.0 | 4.78e-01 | 78.9% | 92.4% |
| 4927492 | 304.51.1.11 ↗ | a+b two layers › Alpha-beta plaits › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › Cas6b_N | 0.61 | 43.0 | 4.87e-01 | 79.7% | 98.9% |
| 3571315 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.61 | 55.0 | 4.51e-01 | 100.0% | 59.1% |
| 4883269 | 304.51.1.5 ↗ | a+b two layers › Alpha-beta plaits › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › Cas_Csy4 | 0.61 | 43.0 | 4.91e-01 | 80.5% | 98.9% |
| 4928490 | 304.48.1.22 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GCH_III | 0.61 | 53.0 | 4.28e-01 | 96.1% | 88.0% |
| 4033553 | 304.26.1.1 ↗ | a+b two layers › Alpha-beta plaits › MTH1187/YkoF-like › MTH1187/YkoF-like › Thiamine_BP | 0.61 | 39.0 | 4.25e-01 | 79.7% | 79.0% |
| 3591115 | 304.163.1.0 ↗ | a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain | 0.60 | 45.0 | 4.96e-01 | 82.0% | 100.0% |
| 4055479 | 304.20.1.5 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › tRNA_synt_2f | 0.60 | 47.0 | 3.92e-01 | 82.8% | 94.7% |
| 4316367 | 304.55.2.7 ↗ | a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like › tRNA_synt_2f | 0.60 | 47.0 | 3.97e-01 | 82.8% | 91.2% |
| 3601534 | 309.1.1.0 ↗ | a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › LuxS/MPP-like metallohydrolase | 0.60 | 44.0 | 3.82e-01 | 77.3% | 83.4% |
| 3839917 | 304.28.1.4 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD_1st | 0.60 | 43.0 | 4.73e-01 | 78.9% | 91.4% |
| 5053407 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.60 | 41.0 | 4.71e-01 | 79.7% | 100.0% |
| 3258201 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.60 | 49.0 | 4.05e-01 | 89.1% | 77.4% |
| 4126752 | 304.20.1.5 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › tRNA_synt_2f | 0.60 | 47.0 | 3.92e-01 | 82.8% | 90.5% |
| 3283852 | 304.48.1.10 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › IMS | 0.60 | 47.0 | 4.77e-01 | 82.0% | 96.8% |
| 3388863 | 304.9.1.1 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 | 0.59 | 46.0 | 4.51e-01 | 83.6% | 74.3% |
| 4554584 | 304.20.1.5 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › tRNA_synt_2f | 0.59 | 47.0 | 3.93e-01 | 82.8% | 91.2% |
| 5018198 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.59 | 45.0 | 3.84e-01 | 81.2% | 63.2% |
| 4395692 | 304.48.1.22 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GCH_III | 0.59 | 44.0 | 4.64e-01 | 78.1% | 100.0% |
| 3186355 | 304.48.1.21 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Thg1,Thg1C | 0.59 | 46.0 | 3.57e-01 | 82.8% | 47.8% |
| 3826050 | 304.48.1.21 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Thg1,Thg1C | 0.59 | 46.0 | 3.59e-01 | 82.8% | 45.8% |
| 4974674 | 309.1.2.0 ↗ | a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › ThrRS/AlaRS editing domain | 0.59 | 44.0 | 4.11e-01 | 78.1% | 91.9% |
| 4484241 | 304.55.2.7 ↗ | a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like › tRNA_synt_2f | 0.59 | 46.0 | 3.85e-01 | 82.8% | 94.1% |
| 4255066 | 304.20.1.5 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › tRNA_synt_2f | 0.58 | 46.0 | 3.76e-01 | 83.6% | 90.2% |
| 4104229 | 304.7.1.2 ↗ | a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › Inhibitor_I9 | 0.58 | 39.0 | 4.36e-01 | 80.5% | 88.0% |
| 4401417 | 304.7.1.2 ↗ | a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › Inhibitor_I9 | 0.58 | 39.0 | 4.37e-01 | 81.2% | 88.0% |
| 3839960 | 140.1.1.23 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › tRNA_synt_2f | 0.58 | 45.0 | 3.75e-01 | 82.8% | 91.7% |
| 3164246 | 131.1.1.24 ↗ | alpha complex topology › PDEase-like › HD-domain/PDEase-like › HD-domain/PDEase-like › tRNA_synt_2f | 0.58 | 45.0 | 3.78e-01 | 82.8% | 92.0% |
| 3607581 | 304.48.1.6 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_A | 0.58 | 47.0 | 4.82e-01 | 87.5% | 90.4% |
| 4273051 | 304.7.1.2 ↗ | a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › Inhibitor_I9 | 0.58 | 39.0 | 4.34e-01 | 81.2% | 88.0% |
| 4948011 | 304.28.1.38 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › CAA_C | 0.57 | 49.0 | 4.40e-01 | 93.8% | 91.8% |
| 3937694 | 862.1.1.0 ↗ | a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain | 0.57 | 44.0 | 3.53e-01 | 82.8% | 52.8% |
| 4366330 | 304.20.1.5 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › tRNA_synt_2f | 0.57 | 45.0 | 4.13e-01 | 83.6% | 96.4% |
| 4936768 | 304.20.1.4 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › CAA_C | 0.57 | 49.0 | 4.43e-01 | 93.8% | 93.7% |
| 3234644 | 304.166.1.1 ↗ | a+b two layers › Alpha-beta plaits › Nup54 ferredoxin-like domain › Nup54 ferredoxin-like domain › DAG1 | 0.57 | 46.0 | 4.87e-01 | 85.9% | 98.3% |
| 3164241 | 304.28.1.4 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD_1st | 0.57 | 39.0 | 4.49e-01 | 80.5% | 100.0% |
| 3601349 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.56 | 45.0 | 2.71e-01 | 85.2% | 40.5% |
| 4576635 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.56 | 44.0 | 3.99e-01 | 83.6% | 97.7% |
| 4168568 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.56 | 43.0 | 3.92e-01 | 82.0% | 97.1% |
| 3963252 | 304.28.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain | 0.56 | 42.0 | 4.56e-01 | 84.4% | 97.1% |
| 5006874 | 5067.1.1.4 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL | 0.56 | 47.0 | 2.91e-01 | 90.6% | 62.3% |
| 3366481 | 3715.1.1.1 ↗ | a+b two layers › Ribosomal protein L22e › Ribosomal protein L22e › Ribosomal protein L22e › Ribosomal_L22e | 0.55 | 37.0 | 4.24e-01 | 76.6% | 95.6% |
| 5039708 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.55 | 47.0 | 4.09e-01 | 94.5% | 62.3% |
| 4940399 | 5104.1.1.1 ↗ | a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA1 | 0.55 | 34.0 | 3.52e-01 | 96.1% | 65.3% |
| 4021804 | 304.7.1.0 ↗ | a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors | 0.55 | 37.0 | 4.16e-01 | 79.7% | 91.6% |
| 5058023 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.55 | 46.0 | 4.15e-01 | 91.4% | 96.6% |
| 3193678 | 304.60.1.9 ↗ | a+b two layers › Alpha-beta plaits › Ribosomal protein L10-like › Ribosomal protein L10-like › PF28227 | 0.55 | 45.0 | 3.70e-01 | 90.6% | 76.0% |
| 4659364 | 304.55.2.7 ↗ | a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like › tRNA_synt_2f | 0.55 | 42.0 | 3.58e-01 | 82.8% | 92.0% |
| 4443361 | 304.55.2.7 ↗ | a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like › tRNA_synt_2f | 0.54 | 42.0 | 3.56e-01 | 84.4% | 96.0% |
| 4063750 | 5067.1.1.26 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL, Sterol-sensing | 0.54 | 45.0 | 2.80e-01 | 91.4% | 59.6% |
| 4164391 | 304.55.2.7 ↗ | a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like › tRNA_synt_2f | 0.53 | 42.0 | 3.54e-01 | 84.4% | 92.0% |
| 3640423 | 304.48.1.21 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Thg1,Thg1C | 0.53 | 40.0 | 3.22e-01 | 80.5% | 43.8% |
| 3626314 | 862.1.1.11 ↗ | a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain › AEP_C962R | 0.52 | 44.0 | 3.60e-01 | 93.0% | 57.2% |
| 4276570 | 304.53.1.1 ↗ | a+b two layers › Alpha-beta plaits › DOPA dioxygenase-like › DOPA dioxygenase-like › DOPA_dioxygen | 0.52 | 41.0 | 3.72e-01 | 82.8% | 63.5% |
| 3956294 | 3755.3.1.527 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › MMPL | 0.52 | 42.0 | 3.93e-01 | 87.5% | 91.9% |
| 3724729 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.50 | 41.0 | 4.16e-01 | 97.7% | 88.5% |
| 3733394 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.50 | 41.0 | 4.30e-01 | 97.7% | 99.1% |
D5
medium
residues 415-524
Domain cluster:
representative
CATH (16)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1ra6A03 | 1.20.960.20 | Mainly Alpha › Up-down Bundle › Mitochondrial Import Receptor Subunit Tom20; Chain A › | 0.79 | 60.0 | 6.62e-01 | 81.8% | 100.0% |
| 1sqgA01 | 1.10.940.10 | Mainly Alpha › Orthogonal Bundle › N-utilizing Substance Protein B Homolog; Chain A › NusB-like | 0.65 | 46.0 | 4.25e-01 | 72.7% | 96.5% |
| 2ysiA01 | 2.20.70.10 | Mainly Beta › Single Sheet › Ubiquitin Ligase Nedd4; Chain: W; › | 0.61 | 19.0 | 3.28e-01 | 90.0% | 90.9% |
| 2ifuD00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.59 | 49.0 | 3.68e-01 | 94.5% | 36.7% |
| 2yshA01 | 2.20.70.10 | Mainly Beta › Single Sheet › Ubiquitin Ligase Nedd4; Chain: W; › | 0.57 | 19.0 | 2.93e-01 | 82.7% | 84.8% |
| 6u3wB00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.56 | 47.0 | 3.42e-01 | 88.2% | 67.7% |
| 5jjxA01 | 1.25.40.1040 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.56 | 46.0 | 3.41e-01 | 90.0% | 72.7% |
| 2kxqA01 | 2.20.70.10 | Mainly Beta › Single Sheet › Ubiquitin Ligase Nedd4; Chain: W; › | 0.55 | 18.0 | 2.82e-01 | 81.8% | 90.0% |
| 3myvA01 | 1.25.40.390 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.54 | 43.0 | 3.36e-01 | 84.5% | 48.9% |
| 4b0zA00 | 1.25.40.990 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.54 | 45.0 | 3.54e-01 | 92.7% | 43.2% |
| 2fonA04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.53 | 36.0 | 3.49e-01 | 70.0% | 93.0% |
| 3vvmA02 | 1.10.1740.110 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › | 0.52 | 32.0 | 3.33e-01 | 89.1% | 65.7% |
| 4gtnA01 | 1.20.970.10 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C | 0.52 | 34.0 | 3.87e-01 | 81.8% | 97.3% |
| 1j5sA02 | 1.10.2020.10 | Mainly Alpha › Orthogonal Bundle › uronate isomerase, domain 2, chain A › uronate isomerase, domain 2, chain A | 0.51 | 29.0 | 3.17e-01 | 91.8% | 65.9% |
| 2gw1A02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.51 | 39.0 | 2.71e-01 | 80.9% | 81.7% |
| 3wl5A00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.51 | 43.0 | 3.08e-01 | 94.5% | 75.7% |
ECOD (30)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1792583 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.72 | 49.0 | 5.28e-01 | 70.0% | 93.5% |
| 4101911 | 109.4.1.888 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HAT_Syf1_CNRKL1_N | 0.71 | 49.0 | 2.95e-01 | 76.4% | 12.0% |
| 4804034 | 304.48.1.12 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mononeg_RNA_pol | 0.67 | 49.0 | 4.73e-01 | 76.4% | 96.8% |
| 3805461 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.67 | 42.0 | 4.29e-01 | 75.5% | 63.6% |
| 1680487 | 4967.1.1.3 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › Mononeg_RNA_pol | 0.66 | 48.0 | 4.67e-01 | 76.4% | 96.8% |
| 3318512 | 109.4.1.420 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR | 0.66 | 44.0 | 4.07e-01 | 78.2% | 53.6% |
| 3443406 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.66 | 51.0 | 4.22e-01 | 88.2% | 48.1% |
| 3599625 | 109.4.1.1284 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF29978 | 0.63 | 43.0 | 3.61e-01 | 76.4% | 42.2% |
| 3622849 | 109.4.1.218 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SNAP | 0.62 | 47.0 | 3.47e-01 | 80.0% | 66.0% |
| 4387694 | 109.4.1.142 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CSN8_PSD8_EIF3K | 0.62 | 48.0 | 4.40e-01 | 82.7% | 77.9% |
| 3700092 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.61 | 46.0 | 3.84e-01 | 78.2% | 60.5% |
| 3316895 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.61 | 48.0 | 3.81e-01 | 84.5% | 67.2% |
| 3347410 | 109.4.1.189 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_2 | 0.61 | 44.0 | 4.15e-01 | 75.5% | 85.9% |
| 3830087 | 109.4.1.1292 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_1, PPR_2, PPR_3 | 0.61 | 45.0 | 3.34e-01 | 76.4% | 41.9% |
| 3355418 | 109.4.1.1262 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_1, PPR_2, PPR_long | 0.60 | 45.0 | 2.96e-01 | 78.2% | 25.4% |
| 3633516 | 109.4.1.1434 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TRAPPC9-Trs120, PF26251 | 0.59 | 43.0 | 3.21e-01 | 76.4% | 48.8% |
| 1789315 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.59 | 50.0 | 4.78e-01 | 92.7% | 84.6% |
| 3441172 | 109.4.1.883 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 | 0.59 | 43.0 | 3.40e-01 | 75.5% | 50.5% |
| 3175706 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.58 | 43.0 | 3.41e-01 | 76.4% | 57.2% |
| 3248894 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.58 | 43.0 | 3.81e-01 | 77.3% | 73.5% |
| 3646235 | 101.1.10.7 ↗ | alpha arrays › HTH › HTH › Cyclin-like › Cyclin_C | 0.56 | 36.0 | 4.03e-01 | 77.3% | 83.5% |
| 5050143 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.56 | 46.0 | 3.38e-01 | 90.0% | 63.8% |
| 3594415 | 4015.1.1.0 ↗ | alpha complex topology › alpha-helical domain in sec1/munc18-like (SM) proteins › alpha-helical domain in sec1/munc18-like (SM) proteins › alpha-helical domain in sec1/munc18-like (SM) proteins | 0.55 | 37.0 | 3.03e-01 | 74.5% | 35.7% |
| 3706334 | 109.4.1.850 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RPN2_N | 0.54 | 40.0 | 3.61e-01 | 76.4% | 64.8% |
| 4004781 | 3355.1.1.1 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp | 0.53 | 46.0 | 3.03e-01 | 94.5% | 85.4% |
| 3660695 | 109.4.1.1599 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, DYW_deaminase | 0.53 | 42.0 | 2.86e-01 | 84.5% | 47.3% |
| 3934037 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 40.0 | 2.96e-01 | 79.1% | 40.4% |
| 3931153 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.52 | 45.0 | 3.65e-01 | 94.5% | 63.9% |
| 3207611 | 109.4.1.1587 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MOR2-PAG1_N, MOR2-PAG1_mid | 0.52 | 40.0 | 2.44e-01 | 84.5% | 35.6% |
| 3608419 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.50 | 39.0 | 3.17e-01 | 83.6% | 47.9% |