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RNA-dependent_RNA_polymerase_NS5B
Euk-VirHepacivirus_M
RNA-dependent_RNA_polymerase_NS5B__YP_009664172__Hepacivirus_M__2008772
Identity
- Accession:
- YP_009664172 ↗
- Protein ID:
- RNA-dependent_RNA_polymerase_NS5B
- Kingdom:
- euk
Quality
87.6
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Hepacivirus_otomopis
TaxID: 2008772
Cluster
View cluster (450 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 385-547
Domain cluster:
rep: NS5B_RNA-dependent_RNA_polymerase__YP_009272656__Hepatitis_C_virus_genotype_5__33746__D391-472_498-585
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 47.3 | 1.80e-12 | 77.9% | 22.8% |
D2
medium
residues 1-58
D3
medium
residues 59-187_220-279
Domain cluster:
rep: hypothetical_protein_3__YP_009345007__Wuhan_spider_virus_8__1923757__D1-105_147-200
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 32.2 | 7.30e-08 | 66.7% | 18.7% |
| PF00998.29 | RdRP_3 | 36.6 | 3.40e-09 | 36.0% | 12.6% |
D4
medium
residues 188-219_360-384
Domain cluster:
representative
CATH (21)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1vwxg01 | 6.20.370.70 | Special › Other non-globular › Rhinovirus 14, subunit 4 › | 0.62 | 33.0 | 3.90e-01 | 77.2% | 78.4% |
| 3cueC00 | 3.30.450.70 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › | 0.60 | 47.0 | 3.55e-01 | 87.7% | 34.3% |
| 2j3tC00 | 3.30.450.70 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › | 0.58 | 45.0 | 3.41e-01 | 87.7% | 34.8% |
| 1vwxP00 | 3.90.470.10 | Alpha Beta › Alpha-Beta Complex › Ribosomal Protein L22; Chain A › Ribosomal protein L22/L17 | 0.58 | 39.0 | 2.86e-01 | 70.2% | 43.8% |
| 1v1aA00 | 3.40.1190.20 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase | 0.58 | 41.0 | 2.64e-01 | 77.2% | 43.2% |
| 1wyuA02 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.57 | 49.0 | 3.23e-01 | 100.0% | 84.0% |
| 3m4aA03 | 3.90.15.10 | Alpha Beta › Alpha-Beta Complex › Topoisomerase I; Chain A, domain 3 › Topoisomerase I; Chain A, domain 3 | 0.57 | 43.0 | 3.44e-01 | 82.5% | 96.6% |
| 4abyD00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.57 | 46.0 | 2.90e-01 | 91.2% | 25.4% |
| 7odyC01 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.56 | 38.0 | 3.22e-01 | 91.2% | 43.5% |
| 3e66A01 | 3.30.420.230 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Prp8 RNase H domain, palm region | 0.55 | 48.0 | 3.44e-01 | 96.5% | 50.9% |
| 1vknA02 | 3.30.360.10 | Alpha Beta › 2-Layer Sandwich › Dihydrodipicolinate Reductase; domain 2 › Dihydrodipicolinate Reductase; domain 2 | 0.55 | 44.0 | 3.31e-01 | 94.7% | 98.2% |
| 2j3tD01 | 3.30.450.70 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › | 0.55 | 42.0 | 3.33e-01 | 91.2% | 38.1% |
| 3t91B00 | 3.60.40.10 | Alpha Beta › 4-Layer Sandwich › Phosphatase 2c; domain 1 › PPM-type phosphatase domain | 0.54 | 46.0 | 3.16e-01 | 100.0% | 38.8% |
| 1jkmA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.54 | 44.0 | 2.80e-01 | 100.0% | 53.6% |
| 6whjD00 | 3.40.1190.20 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase | 0.53 | 40.0 | 2.61e-01 | 98.2% | 16.1% |
| 2v79A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 42.0 | 3.43e-01 | 91.2% | 60.0% |
| 1tg0A00 | 2.30.30.40 | Mainly Beta › Roll › SH3 type barrels. › SH3 Domains | 0.53 | 36.0 | 3.45e-01 | 86.0% | 62.1% |
| 5c40B00 | 3.40.1190.20 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase | 0.52 | 37.0 | 2.34e-01 | 75.4% | 54.8% |
| 1ilvA00 | 3.40.1210.10 | Alpha Beta › 3-Layer(aba) Sandwich › Stationary-phase Survival Protein Sure Homolog; Chain: A, › Survival protein SurE-like phosphatase/nucleotidase | 0.52 | 44.0 | 2.90e-01 | 96.5% | 92.7% |
| 5ja2A01 | 3.30.559.30 | Alpha Beta › 2-Layer Sandwich › Chloramphenicol Acetyltransferase › Nonribosomal peptide synthetase, condensation domain | 0.51 | 38.0 | 2.50e-01 | 82.5% | 56.7% |
| 4mi0A00 | 2.170.270.10 | Mainly Beta › Beta Complex › Beta-clip-like › SET domain | 0.50 | 42.0 | 2.95e-01 | 100.0% | 46.6% |
ECOD (24)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3614862 | 4015.1.1.1 ↗ | alpha complex topology › alpha-helical domain in sec1/munc18-like (SM) proteins › alpha-helical domain in sec1/munc18-like (SM) proteins › alpha-helical domain in sec1/munc18-like (SM) proteins › Sec1 | 0.62 | 44.0 | 2.98e-01 | 77.2% | 22.6% |
| 3203168 | 206.1.1.11 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › APH | 0.59 | 41.0 | 2.62e-01 | 73.7% | 60.3% |
| 3327372 | 2004.1.1.19 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Ras | 0.59 | 42.0 | 2.84e-01 | 75.4% | 76.3% |
| 3620592 | 6155.1.1.15 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › DUF846 | 0.59 | 41.0 | 3.19e-01 | 75.4% | 76.4% |
| 3243753 | 223.2.1.8 ↗ | a+b three layers › Profilin-like › profilin-like › profilin-like › Sybindin | 0.58 | 46.0 | 3.50e-01 | 87.7% | 36.4% |
| 4160831 | 109.4.1.1255 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N, Cnd1 | 0.57 | 45.0 | 2.59e-01 | 91.2% | 19.4% |
| 3586413 | 213.1.1.1 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 | 0.57 | 46.0 | 3.59e-01 | 93.0% | 73.1% |
| 3513179 | 388.1.1.0 ↗ | few secondary structure elements › Huristasin-like › Huristasin-like › Huristasin-like | 0.55 | 39.0 | 3.86e-01 | 96.5% | 70.0% |
| 150973 | 4967.1.1.5 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RdRP_3 | 0.55 | 41.0 | 2.76e-01 | 78.9% | 62.0% |
| 4016440 | 246.2.1.1 ↗ | a+b four layers › Carbon-nitrogen hydrolase-like › Metallo-dependent phosphatases › Metallo-dependent phosphatases › Metallophos | 0.55 | 39.0 | 2.49e-01 | 77.2% | 23.3% |
| 5056146 | 389.1.1.0 ↗ | few secondary structure elements › EGF-like › EGF-related › EGF/Laminin | 0.55 | 31.0 | 3.69e-01 | 70.2% | 91.4% |
| 3599123 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.55 | 43.0 | 2.77e-01 | 91.2% | 71.3% |
| 4107401 | 2004.1.1.790 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › GvpD_P-loop | 0.54 | 42.0 | 2.92e-01 | 91.2% | 28.7% |
| 4443502 | 109.4.1.116 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RIH_assoc | 0.54 | 43.0 | 2.50e-01 | 94.7% | 37.3% |
| 3665034 | 2004.1.1.118 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AIG1 | 0.54 | 46.0 | 2.92e-01 | 100.0% | 78.0% |
| 164474 | 387.1.1.8 ↗ | few secondary structure elements › omega toxin-like › omega toxin-related › omega toxin-related › Omega-toxin | 0.53 | 34.0 | 3.84e-01 | 94.7% | 97.4% |
| 4639306 | 109.4.1.1255 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N, Cnd1 | 0.52 | 45.0 | 2.55e-01 | 100.0% | 13.2% |
| 3585186 | 391.1.1.0 ↗ | few secondary structure elements › Fibronectin type I module-like › Fibronectin type I module-like › Fibronectin type I module | 0.52 | 31.0 | 3.60e-01 | 71.9% | 97.1% |
| 3510113 | 391.1.1.0 ↗ | few secondary structure elements › Fibronectin type I module-like › Fibronectin type I module-like › Fibronectin type I module | 0.52 | 34.0 | 3.69e-01 | 71.9% | 86.7% |
| 4194686 | 2004.1.1.6 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran,oligo_HPY | 0.51 | 43.0 | 2.68e-01 | 94.7% | 38.5% |
| 3718125 | 207.1.1.0 ↗ | beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats | 0.51 | 41.0 | 2.73e-01 | 94.7% | 30.2% |
| 2324017 | 3019.1.1.0 ↗ | beta sandwiches › gp11/flagellar cap protein FliD insertion domain › gp11/flagellar cap protein FliD insertion domain › gp11/flagellar cap protein FliD insertion domain | 0.51 | 34.0 | 2.75e-01 | 70.2% | 78.7% |
| 3894181 | 101.1.2.115 ↗ | alpha arrays › HTH › HTH › winged helix domain › CDC27 | 0.51 | 42.0 | 3.11e-01 | 100.0% | 64.0% |
| 3938900 | 3346.1.1.5 ↗ | a+b two layers › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › ODR4-like | 0.51 | 36.0 | 2.70e-01 | 82.5% | 78.9% |
D5
medium
residues 280-359
Domain cluster:
rep: RNA-dependent_RNA_polymerase_NS5B__YP_009679023__Hepacivirus_L__2008771__D289-359
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 51.5 | 9.80e-14 | 98.8% | 14.4% |
CATH (56)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1gx5A03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.93 | 88.0 | 7.39e-01 | 97.5% | 64.8% |
| 2ewhA01 | 3.30.70.1710 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain | 0.77 | 59.0 | 5.86e-01 | 82.5% | 87.1% |
| 2kjwA00 | 3.30.70.60 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B | 0.77 | 62.0 | 5.80e-01 | 86.3% | 76.0% |
| 2ddzE00 | 3.30.930.10 | Alpha Beta › 2-Layer Sandwich › BirA Bifunctional Protein; domain 2 › Bira Bifunctional Protein; Domain 2 | 0.75 | 56.0 | 4.16e-01 | 77.5% | 54.7% |
| 4wcwA01 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.73 | 60.0 | 5.41e-01 | 90.0% | 92.8% |
| 4kyzA00 | 3.30.70.600 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 | 0.72 | 57.0 | 4.47e-01 | 86.3% | 42.5% |
| 7e6gA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.72 | 63.0 | 5.20e-01 | 100.0% | 63.8% |
| 1mwwB00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.71 | 58.0 | 5.11e-01 | 90.0% | 82.2% |
| 1s5jA03 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.71 | 63.0 | 5.07e-01 | 100.0% | 72.6% |
| 2hfsA02 | 3.30.70.890 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain | 0.70 | 58.0 | 4.74e-01 | 90.0% | 84.2% |
| 1f2uB00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.70 | 51.0 | 4.21e-01 | 77.5% | 54.5% |
| 1vx4407 | 3.30.70.240 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.69 | 51.0 | 5.36e-01 | 83.7% | 91.3% |
| 4lhpF00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.69 | 56.0 | 4.85e-01 | 91.3% | 78.5% |
| 2aajA00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.69 | 56.0 | 4.85e-01 | 91.3% | 78.3% |
| 2f1fA02 | 3.30.70.1150 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT-like. Chain A, domain 2 | 0.68 | 47.0 | 4.79e-01 | 83.7% | 74.4% |
| 2hiyA01 | 3.30.70.1280 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › SP0830-like domains | 0.67 | 53.0 | 5.20e-01 | 100.0% | 79.5% |
| 3cgiA00 | 3.30.70.1710 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain | 0.67 | 58.0 | 5.18e-01 | 95.0% | 95.5% |
| 2xmjA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.67 | 44.0 | 4.82e-01 | 77.5% | 87.3% |
| 4e1oA03 | 3.90.1150.10 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 | 0.66 | 46.0 | 4.32e-01 | 72.5% | 62.2% |
| 1in0A02 | 3.30.70.990 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YajQ-like, domain 2 | 0.66 | 57.0 | 5.51e-01 | 97.5% | 94.6% |
| 2j0wA04 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.66 | 49.0 | 5.07e-01 | 83.7% | 86.7% |
| 3onqA02 | 3.30.70.2730 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.65 | 52.0 | 5.19e-01 | 86.3% | 86.4% |
| 1ghhA00 | 3.30.910.10 | Alpha Beta › 2-Layer Sandwich › Protein Binding, DinI Protein; Chain A › DinI-like | 0.65 | 46.0 | 4.68e-01 | 75.0% | 79.0% |
| 1fjeB01 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.64 | 49.0 | 4.96e-01 | 97.5% | 84.0% |
| 4dh4A00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.64 | 50.0 | 4.56e-01 | 87.5% | 81.6% |
| 4em2A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.64 | 50.0 | 4.06e-01 | 83.7% | 72.0% |
| 3ewgA00 | 3.30.70.940 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain | 0.64 | 46.0 | 4.69e-01 | 90.0% | 78.8% |
| 8dq6A01 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.63 | 50.0 | 4.71e-01 | 88.7% | 93.0% |
| 8p5sA01 | 3.30.559.10 | Alpha Beta › 2-Layer Sandwich › Chloramphenicol Acetyltransferase › Chloramphenicol acetyltransferase-like domain | 0.63 | 50.0 | 3.58e-01 | 86.3% | 82.6% |
| 6tznA01 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.63 | 49.0 | 4.53e-01 | 87.5% | 88.9% |
| 3znuA00 | 3.30.70.1060 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel | 0.63 | 45.0 | 4.32e-01 | 80.0% | 64.9% |
| 2kgsA01 | 3.40.1520.20 | Alpha Beta › 3-Layer(aba) Sandwich › hypothetical protein tt1634 › | 0.62 | 46.0 | 4.19e-01 | 90.0% | 58.2% |
| 1u02A02 | 3.30.70.1020 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Trehalose-6-phosphate phosphatase related protein; domain 2 | 0.62 | 48.0 | 4.97e-01 | 95.0% | 92.1% |
| 2dgkA02 | 3.90.1150.160 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › | 0.62 | 44.0 | 4.05e-01 | 76.2% | 62.6% |
| 3va7A05 | 3.30.1360.40 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.61 | 48.0 | 4.49e-01 | 85.0% | 84.0% |
| 3eo7A02 | 3.40.109.10 | Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › NADH Oxidase | 0.61 | 51.0 | 3.66e-01 | 95.0% | 66.3% |
| 4bujE03 | 1.10.3380.30 | Mainly Alpha › Orthogonal Bundle › Sec63 N-terminal domain-like fold › | 0.61 | 47.0 | 3.45e-01 | 83.7% | 63.2% |
| 8dqaA01 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.61 | 48.0 | 4.56e-01 | 88.7% | 92.9% |
| 1ohvA01 | 3.90.1150.10 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 | 0.61 | 47.0 | 3.76e-01 | 97.5% | 41.0% |
| 3tcrA00 | 3.40.980.10 | Alpha Beta › 3-Layer(aba) Sandwich › Molybdenum Cofactor Biosythetic Enzyme; Chain A › MoaB/Mog-like domain | 0.59 | 41.0 | 3.36e-01 | 73.8% | 40.5% |
| 3oreA01 | 3.30.1360.40 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.59 | 41.0 | 4.37e-01 | 81.2% | 87.9% |
| 1zp2A02 | 1.10.472.10 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like | 0.59 | 48.0 | 4.38e-01 | 92.5% | 94.6% |
| 2cdqA03 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.58 | 44.0 | 4.37e-01 | 83.7% | 98.8% |
| 2f7aA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.58 | 43.0 | 3.75e-01 | 78.8% | 84.3% |
| 5gaeG01 | 3.90.930.12 | Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 | 0.57 | 40.0 | 4.04e-01 | 73.8% | 86.4% |
| 3x1oA00 | 1.20.120.1790 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.56 | 46.0 | 3.74e-01 | 88.7% | 88.6% |
| 3e9lA02 | 1.20.80.40 | Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › Prp8 RNase H domain, fingers region | 0.56 | 40.0 | 3.82e-01 | 75.0% | 75.8% |
| 5jeaD00 | 3.30.230.70 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain | 0.56 | 44.0 | 3.25e-01 | 86.3% | 89.7% |
| 2nn6D00 | 3.30.230.70 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain | 0.55 | 45.0 | 3.46e-01 | 92.5% | 71.7% |
| 3h4rA00 | 3.90.320.10 | Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A › | 0.55 | 43.0 | 3.17e-01 | 85.0% | 42.5% |
| 3pieA02 | 3.30.1370.250 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › | 0.53 | 41.0 | 3.89e-01 | 86.3% | 96.0% |
| 1vq8E01 | 3.90.930.12 | Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 | 0.52 | 39.0 | 3.97e-01 | 85.0% | 83.5% |
| 5kolD00 | 3.90.950.20 | Alpha Beta › Alpha-Beta Complex › Maf protein › CinA-like | 0.52 | 39.0 | 3.04e-01 | 80.0% | 100.0% |
| 1kafA00 | 3.90.1150.20 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Transcription regulator MotA, C-terminal domain | 0.52 | 41.0 | 3.80e-01 | 90.0% | 79.6% |
| 3weoA02 | 3.20.20.80 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases | 0.51 | 44.0 | 2.99e-01 | 100.0% | 63.5% |
| 1pc6A00 | 1.10.3790.10 | Mainly Alpha › Orthogonal Bundle › NinB fold › NinB | 0.51 | 36.0 | 3.04e-01 | 76.2% | 53.9% |
ECOD (75)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 217141 | 304.48.1.15 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 | 0.98 | 95.0 | 5.91e-01 | 100.0% | 22.7% |
| 5055913 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.77 | 62.0 | 5.59e-01 | 86.3% | 63.6% |
| 3959182 | 304.48.1.41 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF2652 | 0.75 | 67.0 | 5.02e-01 | 97.5% | 61.1% |
| 4999908 | 3501.1.1.0 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 | 0.75 | 51.0 | 5.59e-01 | 73.8% | 87.7% |
| 3931851 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.74 | 66.0 | 4.59e-01 | 100.0% | 31.3% |
| 3927940 | 304.36.1.2 ↗ | a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › RVT_1 | 0.74 | 66.0 | 6.02e-01 | 100.0% | 83.8% |
| 5070538 | 3501.1.1.1 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › Pcc1 | 0.73 | 51.0 | 5.38e-01 | 85.0% | 82.9% |
| 3935908 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.73 | 63.0 | 5.47e-01 | 100.0% | 62.4% |
| 3957901 | 304.121.1.1 ↗ | a+b two layers › Alpha-beta plaits › SP0830-like › SP0830-like › DUF1697 | 0.73 | 57.0 | 5.52e-01 | 97.5% | 75.6% |
| 4929334 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.72 | 53.0 | 5.55e-01 | 85.0% | 88.6% |
| 5060909 | 3501.1.1.1 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › Pcc1 | 0.72 | 50.0 | 5.33e-01 | 77.5% | 84.3% |
| 3985106 | 304.55.2.1 ↗ | a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like › Y1_Tnp | 0.71 | 59.0 | 5.27e-01 | 91.3% | 79.1% |
| 3282366 | 304.48.1.14 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF | 0.71 | 63.0 | 4.83e-01 | 100.0% | 55.1% |
| 4070661 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.71 | 48.0 | 5.25e-01 | 71.2% | 92.3% |
| 1157676 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.70 | 58.0 | 4.73e-01 | 90.0% | 83.7% |
| 5000281 | 304.55.2.0 ↗ | a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like | 0.70 | 57.0 | 5.59e-01 | 88.7% | 88.2% |
| 3448881 | 304.3.1.0 ↗ | a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain | 0.70 | 54.0 | 5.59e-01 | 86.3% | 88.0% |
| 3803472 | 304.3.1.1 ↗ | a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain › HMA | 0.70 | 48.0 | 5.06e-01 | 72.5% | 80.0% |
| 3986241 | 304.54.1.1 ↗ | a+b two layers › Alpha-beta plaits › CcmK-like › CcmK-like › BMC | 0.70 | 53.0 | 5.71e-01 | 81.2% | 97.1% |
| 3284992 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.70 | 48.0 | 4.73e-01 | 72.5% | 69.3% |
| 3566248 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.69 | 50.0 | 4.87e-01 | 86.3% | 68.9% |
| 4949239 | 3501.1.1.0 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 | 0.69 | 46.0 | 4.89e-01 | 73.8% | 80.0% |
| 3972831 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.68 | 49.0 | 4.94e-01 | 75.0% | 76.2% |
| 4507561 | 3012.1.1.9 ↗ | a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain › SecD_1st | 0.68 | 58.0 | 4.75e-01 | 96.2% | 87.1% |
| 3980313 | 304.39.1.1 ↗ | a+b two layers › Alpha-beta plaits › Mechanosensitive channel protein MscS (YggB), C-terminal domain › Mechanosensitive channel protein MscS (YggB), C-terminal domain › MS_channel_3rd | 0.68 | 54.0 | 4.98e-01 | 87.5% | 77.1% |
| 3613321 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.67 | 60.0 | 3.64e-01 | 100.0% | 25.2% |
| 3676311 | 314.1.1.0 ↗ | a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases | 0.67 | 58.0 | 3.66e-01 | 98.8% | 60.5% |
| 4056579 | 304.28.1.4 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD_1st | 0.67 | 57.0 | 5.55e-01 | 97.5% | 85.6% |
| 3289468 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.66 | 48.0 | 5.12e-01 | 77.5% | 98.6% |
| 3282344 | 304.20.1.0 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0.66 | 57.0 | 5.35e-01 | 98.8% | 79.0% |
| 3302107 | 2006.1.1.3 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Trehalose_PPase | 0.66 | 54.0 | 4.21e-01 | 91.3% | 40.6% |
| 3596282 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.66 | 56.0 | 5.31e-01 | 93.8% | 93.7% |
| 3738318 | 327.11.2.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) | 0.66 | 48.0 | 4.85e-01 | 77.5% | 77.5% |
| 5017294 | 3501.1.1.1 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › Pcc1 | 0.66 | 48.0 | 4.95e-01 | 83.7% | 84.0% |
| 3413137 | 2006.1.1.3 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Trehalose_PPase | 0.66 | 53.0 | 3.75e-01 | 95.0% | 27.7% |
| 5077796 | 304.104.1.1 ↗ | a+b two layers › Alpha-beta plaits › Sulfolobus fructose-1,6-bisphosphatase-like › Sulfolobus fructose-1,6-bisphosphatase-like › FBPase_3 | 0.66 | 57.0 | 3.74e-01 | 100.0% | 62.7% |
| 5076912 | 304.4.1.3 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › YCII | 0.65 | 49.0 | 5.07e-01 | 81.2% | 85.3% |
| 3513624 | 3261.1.1.1 ↗ | a+b two layers › amino-terminal domain of OmpATb › amino-terminal domain of OmpATb › amino-terminal domain of OmpATb › BON | 0.65 | 54.0 | 5.38e-01 | 92.5% | 89.4% |
| 3667031 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.65 | 51.0 | 5.23e-01 | 86.3% | 90.7% |
| 3343597 | 304.24.1.7 ↗ | a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like › V_ATPase_I | 0.65 | 50.0 | 4.93e-01 | 86.3% | 80.0% |
| 3958915 | 3012.1.1.0 ↗ | a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain | 0.64 | 51.0 | 5.15e-01 | 96.2% | 88.7% |
| 5065044 | 304.120.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI | 0.64 | 52.0 | 5.22e-01 | 90.0% | 91.3% |
| 4939027 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.64 | 49.0 | 4.37e-01 | 83.7% | 71.7% |
| 5007816 | 327.3.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › GMP synthetase C-terminal dimerisation domain › GMP synthetase C-terminal dimerisation domain | 0.64 | 51.0 | 5.07e-01 | 91.3% | 84.7% |
| 5000514 | 304.19.1.1 ↗ | a+b two layers › Alpha-beta plaits › eIF-2-alpha, C-terminal domain › eIF-2-alpha, C-terminal domain › EIF_2_alpha | 0.64 | 55.0 | 5.36e-01 | 96.2% | 87.5% |
| 4974589 | 3501.1.1.1 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › Pcc1 | 0.64 | 45.0 | 4.52e-01 | 75.0% | 75.0% |
| 4973607 | 2006.1.1.0 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like | 0.64 | 52.0 | 3.75e-01 | 91.3% | 44.9% |
| 4968297 | 304.4.1.2 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › MIase | 0.64 | 46.0 | 4.55e-01 | 81.2% | 71.8% |
| 4961490 | 304.8.1.122 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › DmsR_N | 0.64 | 53.0 | 4.41e-01 | 91.3% | 81.4% |
| 3951206 | 3012.1.1.1 ↗ | a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain › Trehalose_PPase | 0.63 | 50.0 | 5.06e-01 | 96.2% | 90.0% |
| 2122949 | 2006.1.1.3 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Trehalose_PPase | 0.63 | 50.0 | 3.67e-01 | 95.0% | 29.9% |
| 4995246 | 5104.1.1.1 ↗ | a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA1 | 0.63 | 42.0 | 3.72e-01 | 83.7% | 45.5% |
| 3612638 | 304.126.1.0 ↗ | a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C | 0.62 | 49.0 | 4.55e-01 | 87.5% | 84.8% |
| 3679516 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.62 | 49.0 | 4.67e-01 | 87.5% | 73.7% |
| 5041410 | 2006.1.1.3 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Trehalose_PPase | 0.61 | 49.0 | 3.54e-01 | 96.2% | 28.5% |
| 3639594 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.61 | 39.0 | 4.37e-01 | 75.0% | 88.3% |
| 3180807 | 320.1.1.0 ↗ | a+b two layers › R3H domain-like › R3H domain › R3H domain | 0.60 | 43.0 | 4.15e-01 | 73.8% | 96.7% |
| 4593130 | 601.7.1.40 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › Cas13a_C | 0.60 | 50.0 | 3.36e-01 | 95.0% | 75.2% |
| 5020988 | 267.1.1.3 ↗ | a+b complex topology › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Cation_ATPase | 0.59 | 41.0 | 3.09e-01 | 73.8% | 42.5% |
| 3289385 | 3433.1.2.1 ↗ | a+b duplicates or obligate multimers › ParB dimerization domain › ParB dimerization domain › Chromosome-encoded ParB dimerization domain › ParB_dimer | 0.58 | 36.0 | 4.17e-01 | 70.0% | 100.0% |
| 3557902 | 101.1.2.580 ↗ | alpha arrays › HTH › HTH › winged helix domain › DEPDC5_CTD | 0.58 | 49.0 | 4.57e-01 | 95.0% | 100.0% |
| 4192214 | 2498.1.1.22 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › YbeY | 0.58 | 45.0 | 3.74e-01 | 86.3% | 89.3% |
| 4522790 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.58 | 48.0 | 4.27e-01 | 95.0% | 70.8% |
| 5051424 | 304.4.1.3 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › YCII | 0.56 | 48.0 | 4.62e-01 | 97.5% | 84.2% |
| 4886439 | 7577.1.1.0 ↗ | a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases | 0.56 | 43.0 | 4.27e-01 | 83.7% | 78.8% |
| 5021023 | 2008.1.1.4 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Cas_Cas4 | 0.56 | 42.0 | 3.02e-01 | 81.2% | 31.6% |
| 4936773 | 2008.1.1.4 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Cas_Cas4 | 0.56 | 42.0 | 3.00e-01 | 81.2% | 31.0% |
| 4555637 | 2008.1.1.4 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Cas_Cas4 | 0.55 | 43.0 | 3.32e-01 | 85.0% | 46.7% |
| 5077420 | 2008.1.1.4 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Cas_Cas4 | 0.54 | 43.0 | 3.11e-01 | 86.3% | 34.2% |
| 3287378 | 601.23.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › DNA repair protein MutS, domain III › DNA repair protein MutS, domain III | 0.54 | 44.0 | 3.14e-01 | 92.5% | 76.2% |
| 3504218 | 377.1.1.10 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › ArfGap | 0.53 | 43.0 | 2.81e-01 | 92.5% | 41.5% |
| 5044199 | 1075.1.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain | 0.52 | 46.0 | 3.23e-01 | 100.0% | 83.0% |
| 5041715 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.52 | 35.0 | 3.14e-01 | 93.8% | 50.0% |
| 4943167 | 2008.1.1.0 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like | 0.51 | 40.0 | 2.93e-01 | 86.3% | 34.8% |
| 2541233 | 3819.1.1.3 ↗ | alpha complex topology › CRISPR-associated endonuclease Cas9 alpha-helical lobe › CRISPR-associated endonuclease Cas9 alpha-helical lobe › CRISPR-associated endonuclease Cas9 alpha-helical lobe › Cas9_a | 0.51 | 41.0 | 2.68e-01 | 91.3% | 37.6% |