←Back to structures
RNA-dependent_RNA_polymerase_NS5B
Euk-VirBat_hepacivirus
RNA-dependent_RNA_polymerase_NS5B__YP_009664192__Bat_hepacivirus__1325446
Identity
- Accession:
- YP_009664192 ↗
- Protein ID:
- RNA-dependent_RNA_polymerase_NS5B
- Kingdom:
- euk
Quality
83.5
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Bat_hepacivirus
TaxID: 1325446
Cluster
View cluster (450 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-53
D2
medium
residues 54-73_224-298
Domain cluster:
rep: nonstructural_protein_NS5B__YP_009179227_nonstructural_protein_NS5B__Wenling_shark_virus__1746066__D171-191_226-287
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 73.4 | 2.30e-20 | 83.2% | 15.8% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2w00A02 | 3.90.640.50 | Alpha Beta › Alpha-Beta Complex › Actin; Chain A, domain 4 › | 0.62 | 31.0 | 3.45e-01 | 98.9% | 58.9% |
| 1bw5A00 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.62 | 28.0 | 3.29e-01 | 100.0% | 57.6% |
| 4hehA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.59 | 31.0 | 3.30e-01 | 77.9% | 54.2% |
| 2g80A02 | 1.10.720.60 | Mainly Alpha › Orthogonal Bundle › Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 › | 0.53 | 40.0 | 4.32e-01 | 100.0% | 98.7% |
| 3edgA00 | 3.40.390.10 | Alpha Beta › 3-Layer(aba) Sandwich › Collagenase (Catalytic Domain) › Collagenase (Catalytic Domain) | 0.52 | 36.0 | 2.81e-01 | 78.9% | 34.4% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 217141 | 304.48.1.15 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 | 0.97 | 94.0 | 6.06e-01 | 100.0% | 67.5% |
| 4976528 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.56 | 40.0 | 3.25e-01 | 76.8% | 67.9% |
| 4940232 | 608.1.1.1 ↗ | alpha arrays › AhpD-like › AhpD-like › AhpD-like › CMD | 0.55 | 39.0 | 3.59e-01 | 73.7% | 92.8% |
D3
medium
residues 74-187
Domain cluster:
rep: nonstructural_protein_NS5B__YP_009325411__Norway_rat_hepacivirus_2__1562039__D82-143_155-174
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 33.3 | 3.40e-08 | 98.2% | 18.5% |
D4
medium
residues 188-223_299-397
Domain cluster:
rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 45.6 | 6.30e-12 | 74.8% | 19.1% |
| PF00998.29 | RdRP_3 | 28.1 | 1.30e-06 | 27.4% | 6.8% |
D5
medium
residues 398-590
Domain cluster:
rep: NS5B_RNA-dependent_RNA_polymerase__YP_009272656__Hepatitis_C_virus_genotype_5__33746__D391-472_498-585
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 40.2 | 2.60e-10 | 59.1% | 19.8% |
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5nnpE01 | 1.25.40.1040 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.60 | 31.0 | 2.28e-01 | 72.0% | 19.1% |
| 2wpvE00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.54 | 32.0 | 2.87e-01 | 70.5% | 39.6% |
| 2bvlA01 | 1.20.58.1190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 21.0 | 3.08e-01 | 71.5% | 81.4% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 150973 | 4967.1.1.5 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RdRP_3 | 0.86 | 70.0 | 6.68e-01 | 83.4% | 76.9% |
| 3676107 | 109.4.1.883 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 | 0.51 | 26.0 | 3.11e-01 | 71.0% | 72.5% |
| 3411233 | 109.4.1.1396 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › IBN_N, TPR_IPO5 | 0.51 | 36.0 | 3.15e-01 | 89.6% | 48.1% |