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RNA-dependent_RNA_polymerase_NS5B
Euk-VirNon-primate_hepacivirus_NZP1
RNA-dependent_RNA_polymerase_NS5B__YP_009664202__Non-primate_hepacivirus_NZP1__1605403
Identity
- Accession:
- YP_009664202 ↗
- Protein ID:
- RNA-dependent_RNA_polymerase_NS5B
- Kingdom:
- euk
Quality
84.5
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Non-primate_hepacivirus_NZP1
TaxID: 1605403
Cluster
View cluster (450 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 364-548
Domain cluster:
rep: NS5B_RNA-dependent_RNA_polymerase__YP_009272656__Hepatitis_C_virus_genotype_5__33746__D391-472_498-585
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 97.5 | 1.10e-27 | 80.5% | 28.2% |
D2
medium
residues 22-49_78-186_231-272
Domain cluster:
rep: hypothetical_protein_3__YP_009345007__Wuhan_spider_virus_8__1923757__D1-105_147-200
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 54.0 | 1.70e-14 | 67.6% | 20.8% |
D3
medium
residues 50-77_187-230_273-363
Domain cluster:
rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 85.2 | 6.20e-24 | 56.4% | 17.5% |
| PF00998.29 | RdRP_3 | 59.1 | 4.90e-16 | 41.7% | 10.7% |
CATH (22)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1gx5A03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 1.00 | 72.0 | 8.48e-01 | 82.8% | 98.4% |
| 1s48A04 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.80 | 52.0 | 6.35e-01 | 82.8% | 96.4% |
| 1bqnA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.78 | 46.0 | 5.89e-01 | 78.5% | 100.0% |
| 1khvA03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.76 | 58.0 | 6.53e-01 | 82.2% | 98.5% |
| 7uinD01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.73 | 61.0 | 6.08e-01 | 87.1% | 92.2% |
| 7e6gA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.69 | 51.0 | 5.32e-01 | 76.1% | 91.3% |
| 6d9mA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.66 | 51.0 | 5.36e-01 | 81.0% | 91.4% |
| 5xgbA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.66 | 52.0 | 5.06e-01 | 82.8% | 82.1% |
| 3ezuA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.63 | 49.0 | 5.20e-01 | 82.8% | 90.5% |
| 3hvwA00 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.61 | 48.0 | 4.91e-01 | 82.8% | 84.9% |
| 5abxA00 | 3.30.760.10 | Alpha Beta › 2-Layer Sandwich › RNA Cap, Translation Initiation Factor Eif4e › RNA Cap, Translation Initiation Factor Eif4e | 0.60 | 47.0 | 4.68e-01 | 88.3% | 78.6% |
| 1s5jA03 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.59 | 47.0 | 4.86e-01 | 84.0% | 97.5% |
| 4dmzA02 | 3.30.70.2880 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.57 | 44.0 | 4.71e-01 | 82.8% | 94.9% |
| 3c1mA02 | 3.30.2130.10 | Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like | 0.57 | 40.0 | 4.07e-01 | 72.4% | 75.0% |
| 1whuA00 | 1.10.10.400 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain | 0.56 | 27.0 | 3.38e-01 | 74.8% | 72.1% |
| 3f56A01 | 3.30.70.1710 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain | 0.56 | 36.0 | 4.26e-01 | 90.2% | 98.1% |
| 3hxiA01 | 3.30.760.10 | Alpha Beta › 2-Layer Sandwich › RNA Cap, Translation Initiation Factor Eif4e › RNA Cap, Translation Initiation Factor Eif4e | 0.54 | 46.0 | 4.59e-01 | 92.0% | 97.7% |
| 1waaC00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.53 | 30.0 | 3.74e-01 | 93.9% | 93.5% |
| 3dpuB03 | 3.30.310.200 | Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › | 0.52 | 34.0 | 4.08e-01 | 81.0% | 100.0% |
| 2q5wE00 | 3.90.1170.40 | Alpha Beta › Alpha-Beta Complex › Aldehyde Oxidoreductase; domain 3 › Molybdopterin biosynthesis MoaE subunit | 0.52 | 37.0 | 3.96e-01 | 72.4% | 87.6% |
| 1i7qA00 | 3.60.120.10 | Alpha Beta › 4-Layer Sandwich › Anthranilate synthase › Anthranilate synthase | 0.51 | 40.0 | 2.86e-01 | 81.6% | 91.5% |
| 3popA02 | 3.40.462.20 | Alpha Beta › 3-Layer(aba) Sandwich › Vanillyl-alcohol Oxidase; Chain A, domain 3 › | 0.51 | 40.0 | 3.51e-01 | 83.4% | 86.9% |
ECOD (46)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 217141 | 304.48.1.15 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 | 1.00 | 98.0 | 7.21e-01 | 100.0% | 87.4% |
| 1411401 | 304.48.1.7 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flu_PB1 | 0.80 | 72.0 | 5.05e-01 | 96.3% | 91.1% |
| 223786 | 304.48.1.16 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_4 | 0.79 | 72.0 | 5.61e-01 | 95.7% | 99.4% |
| 3927049 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.79 | 73.0 | 5.37e-01 | 100.0% | 85.6% |
| 1697857 | 304.48.1.30 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › CPV_RdRP_pol_dom | 0.78 | 71.0 | 5.43e-01 | 95.7% | 98.6% |
| 4859811 | 304.48.1.7 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flu_PB1 | 0.78 | 74.0 | 5.24e-01 | 100.0% | 90.8% |
| 3989356 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.77 | 64.0 | 6.17e-01 | 87.1% | 91.9% |
| 3928372 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.76 | 70.0 | 4.88e-01 | 100.0% | 72.4% |
| 3574984 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.75 | 70.0 | 5.28e-01 | 100.0% | 90.7% |
| 1827765 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.73 | 61.0 | 4.94e-01 | 87.1% | 58.5% |
| 4361688 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.72 | 67.0 | 5.03e-01 | 100.0% | 89.6% |
| 3654976 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.71 | 59.0 | 4.62e-01 | 86.5% | 66.4% |
| 3934202 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.71 | 54.0 | 5.75e-01 | 79.1% | 91.7% |
| 3889441 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.69 | 64.0 | 4.64e-01 | 100.0% | 75.9% |
| 3984781 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.68 | 52.0 | 5.25e-01 | 77.9% | 88.7% |
| 3280378 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.66 | 52.0 | 5.27e-01 | 82.8% | 86.7% |
| 2841957 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.66 | 60.0 | 4.79e-01 | 98.8% | 88.5% |
| 3282366 | 304.48.1.14 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF | 0.66 | 53.0 | 5.11e-01 | 84.7% | 78.4% |
| 3708776 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.66 | 61.0 | 4.81e-01 | 100.0% | 95.4% |
| 4014158 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.65 | 61.0 | 4.95e-01 | 100.0% | 82.0% |
| 3931851 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.65 | 61.0 | 5.07e-01 | 100.0% | 86.0% |
| 1175882 | 304.154.1.1 ↗ | a+b two layers › Alpha-beta plaits › Regulator of polyketide synthase expression N-terminal domain › Regulator of polyketide synthase expression N-terminal domain › GGDEF_2 | 0.65 | 46.0 | 4.80e-01 | 82.8% | 78.4% |
| 3286351 | 304.154.1.1 ↗ | a+b two layers › Alpha-beta plaits › Regulator of polyketide synthase expression N-terminal domain › Regulator of polyketide synthase expression N-terminal domain › GGDEF_2 | 0.63 | 47.0 | 5.02e-01 | 87.1% | 86.9% |
| 3278063 | 304.48.1.48 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF_2 | 0.62 | 49.0 | 5.00e-01 | 87.7% | 83.1% |
| 5006874 | 5067.1.1.4 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL | 0.62 | 45.0 | 2.88e-01 | 75.5% | 58.5% |
| 3460962 | 327.11.2.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_1 | 0.61 | 32.0 | 4.15e-01 | 76.7% | 90.0% |
| 3937440 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.61 | 57.0 | 4.78e-01 | 100.0% | 86.8% |
| 3927796 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.61 | 56.0 | 4.75e-01 | 100.0% | 83.4% |
| 5072243 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.59 | 46.0 | 3.88e-01 | 81.0% | 81.5% |
| 5070890 | 5067.1.1.4 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL | 0.59 | 49.0 | 3.26e-01 | 88.3% | 88.6% |
| 4017396 | 317.1.1.1 ↗ | a+b two layers › Translation initiation factor eIF4e and phosphothreonine lyase › Translation initiation factor eIF4e and phosphothreonine lyase › Translation initiation factor eIF4e and phosphothreonine lyase › IF4E | 0.58 | 47.0 | 4.26e-01 | 85.9% | 82.3% |
| 3699127 | 317.1.1.1 ↗ | a+b two layers › Translation initiation factor eIF4e and phosphothreonine lyase › Translation initiation factor eIF4e and phosphothreonine lyase › Translation initiation factor eIF4e and phosphothreonine lyase › IF4E | 0.58 | 46.0 | 4.38e-01 | 87.7% | 71.3% |
| 5042464 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.58 | 45.0 | 3.88e-01 | 81.0% | 80.0% |
| 3618884 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.58 | 45.0 | 3.95e-01 | 82.2% | 80.4% |
| 5048812 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.57 | 44.0 | 3.69e-01 | 79.8% | 82.5% |
| 5075991 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.57 | 43.0 | 3.67e-01 | 79.8% | 82.6% |
| 141693 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.57 | 44.0 | 3.83e-01 | 81.6% | 81.5% |
| 5065955 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.56 | 45.0 | 3.94e-01 | 82.8% | 82.1% |
| 4996208 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.56 | 45.0 | 3.87e-01 | 84.7% | 95.0% |
| 5039561 | 865.1.1.1 ↗ | beta complex topology › PheT/TilS domain › PheT/TilS domain › PheT/TilS domain › B3_4 | 0.55 | 39.0 | 3.58e-01 | 73.0% | 99.5% |
| 3974758 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.55 | 43.0 | 3.78e-01 | 82.2% | 81.2% |
| 4133570 | 304.54.1.2 ↗ | a+b two layers › Alpha-beta plaits › CcmK-like › CcmK-like › CsoS1D_N | 0.54 | 36.0 | 4.19e-01 | 89.6% | 94.8% |
| 5047861 | 304.6.1.1 ↗ | a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain › FAD-oxidase_C | 0.54 | 42.0 | 3.68e-01 | 81.6% | 81.5% |
| 5045666 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.54 | 37.0 | 3.98e-01 | 70.6% | 100.0% |
| 4995246 | 5104.1.1.1 ↗ | a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA1 | 0.53 | 33.0 | 3.76e-01 | 87.7% | 82.9% |
| 3280631 | 323.1.1.15 ↗ | a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › WS_DGAT_C | 0.52 | 38.0 | 3.29e-01 | 75.5% | 94.8% |