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RNA-dependent_RNA_polymerase_NS5B
Euk-VirHepacivirus_L
RNA-dependent_RNA_polymerase_NS5B__YP_009679023__Hepacivirus_L__2008771
Identity
- Accession:
- YP_009679023 ↗
- Protein ID:
- RNA-dependent_RNA_polymerase_NS5B
- Kingdom:
- euk
Quality
91.5
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Hepacivirus_vittatae
TaxID: 2008771
Cluster
View cluster (450 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 373-548
Domain cluster:
rep: NS5B_RNA-dependent_RNA_polymerase__YP_009272656__Hepatitis_C_virus_genotype_5__33746__D391-472_498-585
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 62.6 | 4.20e-17 | 83.0% | 27.4% |
D2
medium
residues 1-60
Domain cluster:
rep: RNA-dependent_RNA_polymerase_NS5B__YP_009679003__Hepacivirus_F__2008765__D1-52
D3
medium
residues 61-288
Domain cluster:
rep: hypothetical_protein_3__YP_009345007__Wuhan_spider_virus_8__1923757__D1-105_147-200
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 137.0 | 1.20e-39 | 100.0% | 43.2% |
D4
medium
residues 289-359
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 52.9 | 3.90e-14 | 100.0% | 13.0% |
CATH (55)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1gx5A03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 1.00 | 96.0 | 7.65e-01 | 98.6% | 57.4% |
| 2id1A01 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.74 | 62.0 | 5.49e-01 | 93.0% | 74.0% |
| 2fyxA00 | 3.30.70.1290 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Transposase IS200-like | 0.74 | 64.0 | 5.26e-01 | 97.2% | 63.8% |
| 2ewhA01 | 3.30.70.1710 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain | 0.74 | 59.0 | 5.57e-01 | 87.3% | 77.6% |
| 2o5aA01 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.73 | 60.0 | 5.37e-01 | 91.5% | 73.5% |
| 1y10B02 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.73 | 64.0 | 4.71e-01 | 97.2% | 55.2% |
| 2kyzA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.73 | 54.0 | 5.53e-01 | 93.0% | 83.6% |
| 6liuC02 | 3.90.1150.10 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 | 0.71 | 57.0 | 4.91e-01 | 88.7% | 56.9% |
| 7e6gA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.71 | 62.0 | 4.91e-01 | 100.0% | 76.5% |
| 5llwA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.70 | 61.0 | 5.01e-01 | 100.0% | 75.9% |
| 3upsA00 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.70 | 57.0 | 5.05e-01 | 93.0% | 72.2% |
| 1f2uB00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.70 | 54.0 | 4.39e-01 | 87.3% | 54.5% |
| 4lhpF00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.69 | 58.0 | 4.86e-01 | 95.8% | 74.6% |
| 4dezA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.69 | 60.0 | 5.37e-01 | 97.2% | 85.9% |
| 3cgiA00 | 3.30.70.1710 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain | 0.69 | 62.0 | 5.28e-01 | 100.0% | 92.0% |
| 2fltA00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.68 | 57.0 | 4.96e-01 | 97.2% | 82.1% |
| 2xmjA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.68 | 48.0 | 5.01e-01 | 87.3% | 85.7% |
| 3mahA02 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.68 | 51.0 | 5.20e-01 | 97.2% | 85.5% |
| 4e1oA03 | 3.90.1150.10 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 | 0.67 | 50.0 | 4.53e-01 | 81.7% | 62.2% |
| 3onqA02 | 3.30.70.2730 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.66 | 54.0 | 5.20e-01 | 91.5% | 79.0% |
| 1eh7A01 | 3.30.160.70 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Methylated DNA-protein cysteine methyltransferase domain | 0.66 | 34.0 | 3.49e-01 | 77.5% | 50.0% |
| 1u9dA00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.66 | 53.0 | 4.51e-01 | 91.5% | 67.2% |
| 1ghhA00 | 3.30.910.10 | Alpha Beta › 2-Layer Sandwich › Protein Binding, DinI Protein; Chain A › DinI-like | 0.66 | 50.0 | 4.88e-01 | 84.5% | 79.0% |
| 2hfsA02 | 3.30.70.890 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain | 0.65 | 54.0 | 4.39e-01 | 95.8% | 84.2% |
| 1s5jA03 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.65 | 51.0 | 4.09e-01 | 100.0% | 40.8% |
| 2ja9A02 | 3.30.1370.10 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 | 0.65 | 48.0 | 4.60e-01 | 80.3% | 72.6% |
| 6j09A04 | 3.10.20.310 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac | 0.65 | 43.0 | 4.21e-01 | 90.1% | 63.6% |
| 2oi2A02 | 3.30.70.890 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain | 0.64 | 55.0 | 4.52e-01 | 97.2% | 85.8% |
| 3eo7A02 | 3.40.109.10 | Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › NADH Oxidase | 0.64 | 53.0 | 3.67e-01 | 93.0% | 66.7% |
| 3ewgA00 | 3.30.70.940 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain | 0.64 | 49.0 | 4.74e-01 | 95.8% | 75.0% |
| 1vx4407 | 3.30.70.240 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.63 | 48.0 | 4.88e-01 | 91.5% | 87.0% |
| 2cdqA03 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.63 | 47.0 | 4.52e-01 | 84.5% | 69.0% |
| 6tznA01 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.63 | 52.0 | 4.59e-01 | 93.0% | 80.6% |
| 2f1fA02 | 3.30.70.1150 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT-like. Chain A, domain 2 | 0.63 | 46.0 | 4.52e-01 | 93.0% | 73.1% |
| 3znuA00 | 3.30.70.1060 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel | 0.62 | 47.0 | 4.28e-01 | 84.5% | 61.7% |
| 4dmzA02 | 3.30.70.2880 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.62 | 52.0 | 4.28e-01 | 97.2% | 55.5% |
| 1vq8E01 | 3.90.930.12 | Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 | 0.60 | 47.0 | 4.53e-01 | 83.1% | 89.9% |
| 1zp2A02 | 1.10.472.10 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like | 0.60 | 51.0 | 4.48e-01 | 98.6% | 83.9% |
| 2f7aA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.60 | 47.0 | 4.05e-01 | 88.7% | 83.5% |
| 5gaeG01 | 3.90.930.12 | Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 | 0.59 | 45.0 | 4.38e-01 | 83.1% | 86.4% |
| 3h4rA00 | 3.90.320.10 | Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A › | 0.59 | 44.0 | 3.09e-01 | 78.9% | 89.5% |
| 1oaoC03 | 3.30.1650.10 | Alpha Beta › 2-Layer Sandwich › Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3 › Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3 | 0.59 | 50.0 | 3.86e-01 | 98.6% | 42.0% |
| 1u02A02 | 3.30.70.1020 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Trehalose-6-phosphate phosphatase related protein; domain 2 | 0.59 | 49.0 | 4.89e-01 | 98.6% | 94.7% |
| 4trkA00 | 3.30.900.10 | Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain | 0.59 | 50.0 | 3.43e-01 | 93.0% | 86.0% |
| 3tcrA00 | 3.40.980.10 | Alpha Beta › 3-Layer(aba) Sandwich › Molybdenum Cofactor Biosythetic Enzyme; Chain A › MoaB/Mog-like domain | 0.58 | 45.0 | 3.53e-01 | 87.3% | 38.6% |
| 5jeaD00 | 3.30.230.70 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain | 0.58 | 47.0 | 3.35e-01 | 90.1% | 86.6% |
| 3thxB04 | 1.10.1420.10 | Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › | 0.57 | 47.0 | 3.95e-01 | 94.4% | 57.8% |
| 5esyA01 | 3.30.540.10 | Alpha Beta › 2-Layer Sandwich › Fructose-1,6-Bisphosphatase; Chain A, domain 1 › Fructose-1,6-Bisphosphatase, subunit A, domain 1 | 0.55 | 47.0 | 3.36e-01 | 94.4% | 62.6% |
| 6nifA01 | 3.30.900.10 | Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain | 0.55 | 46.0 | 3.44e-01 | 100.0% | 61.3% |
| 1wp1B01 | 1.20.1600.10 | Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) | 0.54 | 46.0 | 2.88e-01 | 91.5% | 71.3% |
| 1s12A00 | 3.30.70.1490 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Cysteine protease Prp | 0.53 | 45.0 | 4.15e-01 | 95.8% | 96.8% |
| 6t8qA00 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.53 | 41.0 | 2.61e-01 | 88.7% | 21.3% |
| 3akcA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 43.0 | 3.14e-01 | 93.0% | 75.5% |
| 1kafA00 | 3.90.1150.20 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Transcription regulator MotA, C-terminal domain | 0.52 | 44.0 | 3.85e-01 | 95.8% | 96.3% |
| 1yjgA00 | 1.20.120.240 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Lipoprotein, type 6 | 0.50 | 42.0 | 3.28e-01 | 93.0% | 68.2% |
ECOD (73)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 217141 | 304.48.1.15 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 | 1.00 | 97.0 | 5.88e-01 | 100.0% | 19.9% |
| 3621728 | 304.18.1.0 ↗ | a+b two layers › Alpha-beta plaits › Anticodon-binding domain of PheRS › Anticodon-binding domain of PheRS | 0.81 | 73.0 | 7.05e-01 | 98.6% | 96.2% |
| 3571539 | 304.47.1.1 ↗ | a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA | 0.78 | 68.0 | 6.08e-01 | 97.2% | 83.0% |
| 4429067 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.76 | 68.0 | 5.11e-01 | 100.0% | 64.1% |
| 3927940 | 304.36.1.2 ↗ | a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › RVT_1 | 0.75 | 66.0 | 5.86e-01 | 100.0% | 75.2% |
| 5070538 | 3501.1.1.1 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › Pcc1 | 0.75 | 56.0 | 5.64e-01 | 88.7% | 81.4% |
| 4999908 | 3501.1.1.0 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 | 0.74 | 56.0 | 5.77e-01 | 83.1% | 87.7% |
| 3931851 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.74 | 66.0 | 4.43e-01 | 100.0% | 27.2% |
| 5027879 | 304.120.1.6 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer | 0.74 | 58.0 | 5.79e-01 | 98.6% | 82.7% |
| 5004123 | 3501.1.1.0 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 | 0.73 | 54.0 | 5.26e-01 | 81.7% | 71.8% |
| 5060909 | 3501.1.1.1 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › Pcc1 | 0.73 | 55.0 | 5.56e-01 | 87.3% | 82.9% |
| 3935908 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.73 | 62.0 | 5.21e-01 | 100.0% | 55.2% |
| 3957901 | 304.121.1.1 ↗ | a+b two layers › Alpha-beta plaits › SP0830-like › SP0830-like › DUF1697 | 0.72 | 56.0 | 5.21e-01 | 93.0% | 66.7% |
| 4382937 | 1.1.5.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel | 0.72 | 61.0 | 3.99e-01 | 100.0% | 22.3% |
| 3282366 | 304.48.1.14 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF | 0.71 | 62.0 | 4.61e-01 | 98.6% | 62.7% |
| 5079596 | 309.1.2.1 ↗ | a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › ThrRS/AlaRS editing domain › tRNA_SAD | 0.71 | 61.0 | 4.74e-01 | 97.2% | 99.4% |
| 4662505 | 304.28.1.4 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD_1st | 0.70 | 56.0 | 5.34e-01 | 97.2% | 74.1% |
| 3838269 | 304.28.1.1 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › ACR_tran | 0.70 | 60.0 | 5.50e-01 | 97.2% | 77.9% |
| 3983718 | 304.48.1.14 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF | 0.70 | 62.0 | 5.32e-01 | 100.0% | 64.3% |
| 4070661 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.70 | 52.0 | 5.39e-01 | 80.3% | 92.3% |
| 4949239 | 3501.1.1.0 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 | 0.69 | 51.0 | 5.17e-01 | 83.1% | 80.0% |
| 4929334 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.69 | 53.0 | 5.34e-01 | 91.5% | 84.3% |
| 3596282 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.69 | 58.0 | 5.36e-01 | 95.8% | 90.5% |
| 4959470 | 873.1.1.12 ↗ | a+b complex topology › H-NOX domain › H-NOX domain › H-NOX domain › PF27313 | 0.69 | 55.0 | 4.63e-01 | 87.3% | 54.2% |
| 3284992 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.69 | 52.0 | 4.85e-01 | 81.7% | 70.5% |
| 3726512 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.68 | 55.0 | 5.34e-01 | 95.8% | 78.8% |
| 3164241 | 304.28.1.4 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD_1st | 0.68 | 57.0 | 5.37e-01 | 100.0% | 75.6% |
| 3828762 | 304.3.1.0 ↗ | a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain | 0.68 | 52.0 | 5.23e-01 | 93.0% | 84.3% |
| 3448881 | 304.3.1.0 ↗ | a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain | 0.68 | 54.0 | 5.33e-01 | 91.5% | 82.7% |
| 4507561 | 3012.1.1.9 ↗ | a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain › SecD_1st | 0.68 | 58.0 | 4.58e-01 | 100.0% | 45.2% |
| 3803472 | 304.3.1.1 ↗ | a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain › HMA | 0.67 | 50.0 | 5.03e-01 | 81.7% | 80.0% |
| 5077796 | 304.104.1.1 ↗ | a+b two layers › Alpha-beta plaits › Sulfolobus fructose-1,6-bisphosphatase-like › Sulfolobus fructose-1,6-bisphosphatase-like › FBPase_3 | 0.67 | 57.0 | 3.69e-01 | 98.6% | 26.8% |
| 5057340 | 3012.1.1.0 ↗ | a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain | 0.67 | 58.0 | 5.56e-01 | 100.0% | 87.1% |
| 4100501 | 1.1.5.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel | 0.67 | 58.0 | 3.76e-01 | 100.0% | 75.4% |
| 3738318 | 327.11.2.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) | 0.67 | 52.0 | 5.06e-01 | 85.9% | 77.5% |
| 4040528 | 304.24.1.16 ↗ | a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like › PrmA | 0.67 | 56.0 | 5.21e-01 | 93.0% | 75.6% |
| 3667031 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.67 | 53.0 | 5.28e-01 | 88.7% | 86.7% |
| 5017294 | 3501.1.1.1 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › Pcc1 | 0.67 | 52.0 | 5.21e-01 | 88.7% | 84.0% |
| 5065044 | 304.120.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI | 0.66 | 56.0 | 5.40e-01 | 95.8% | 85.0% |
| 3592723 | 304.151.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase | 0.66 | 57.0 | 5.19e-01 | 97.2% | 82.1% |
| 3586965 | 304.48.1.48 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF_2 | 0.66 | 56.0 | 4.91e-01 | 98.6% | 94.5% |
| 1157676 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.65 | 54.0 | 4.38e-01 | 95.8% | 83.7% |
| 3302107 | 2006.1.1.3 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Trehalose_PPase | 0.65 | 55.0 | 4.20e-01 | 98.6% | 41.1% |
| 4201723 | 327.16.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system | 0.65 | 44.0 | 4.85e-01 | 81.7% | 100.0% |
| 3516510 | 304.48.1.6 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_A | 0.65 | 56.0 | 4.76e-01 | 98.6% | 70.6% |
| 4934048 | 304.4.1.1 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › AsnC_trans_reg | 0.65 | 49.0 | 4.82e-01 | 91.5% | 77.3% |
| 3586929 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.64 | 55.0 | 4.45e-01 | 97.2% | 85.0% |
| 3285164 | 1.1.5.44 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › SecDF_P1_head | 0.64 | 55.0 | 3.83e-01 | 97.2% | 93.9% |
| 4931677 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.64 | 47.0 | 4.42e-01 | 85.9% | 64.0% |
| 3280699 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.64 | 54.0 | 4.30e-01 | 97.2% | 80.0% |
| 5076912 | 304.4.1.3 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › YCII | 0.64 | 49.0 | 4.90e-01 | 85.9% | 80.0% |
| 5063669 | 327.11.2.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) | 0.63 | 46.0 | 4.56e-01 | 78.9% | 74.7% |
| 3958915 | 3012.1.1.0 ↗ | a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain | 0.62 | 52.0 | 5.07e-01 | 97.2% | 88.7% |
| 4968322 | 304.126.1.0 ↗ | a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C | 0.61 | 42.0 | 4.60e-01 | 90.1% | 94.5% |
| 3612638 | 304.126.1.0 ↗ | a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C | 0.60 | 49.0 | 4.39e-01 | 93.0% | 81.0% |
| 5020988 | 267.1.1.3 ↗ | a+b complex topology › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Cation_ATPase | 0.60 | 46.0 | 3.33e-01 | 83.1% | 42.5% |
| 4593130 | 601.7.1.40 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › Cas13a_C | 0.59 | 51.0 | 3.36e-01 | 100.0% | 74.5% |
| 5075945 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.59 | 50.0 | 5.03e-01 | 94.4% | 100.0% |
| 4236584 | 3433.1.2.1 ↗ | a+b duplicates or obligate multimers › ParB dimerization domain › ParB dimerization domain › Chromosome-encoded ParB dimerization domain › ParB_dimer | 0.58 | 39.0 | 4.38e-01 | 73.2% | 100.0% |
| 3511708 | 859.1.1.1 ↗ | a+b two layers › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › HORMA | 0.58 | 50.0 | 3.62e-01 | 98.6% | 96.3% |
| 4522790 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.58 | 49.0 | 4.25e-01 | 100.0% | 70.0% |
| 3621782 | 859.1.1.1 ↗ | a+b two layers › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › HORMA | 0.57 | 49.0 | 3.44e-01 | 97.2% | 86.8% |
| 3359387 | 5051.1.1.6 ↗ | alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Aa_trans | 0.56 | 42.0 | 2.59e-01 | 80.3% | 89.8% |
| 4075008 | 633.21.1.18 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CASP_dom | 0.56 | 42.0 | 3.27e-01 | 81.7% | 86.1% |
| 4928856 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.55 | 46.0 | 4.25e-01 | 98.6% | 71.0% |
| 2541233 | 3819.1.1.3 ↗ | alpha complex topology › CRISPR-associated endonuclease Cas9 alpha-helical lobe › CRISPR-associated endonuclease Cas9 alpha-helical lobe › CRISPR-associated endonuclease Cas9 alpha-helical lobe › Cas9_a | 0.54 | 44.0 | 2.77e-01 | 90.1% | 41.4% |
| 3969345 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.54 | 44.0 | 3.13e-01 | 90.1% | 60.5% |
| 4385210 | 633.21.1.18 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CASP_dom | 0.53 | 44.0 | 3.27e-01 | 91.5% | 75.1% |
| 3643228 | 633.21.1.18 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CASP_dom | 0.52 | 44.0 | 3.45e-01 | 94.4% | 86.7% |
| 3752375 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.52 | 46.0 | 3.35e-01 | 100.0% | 85.1% |
| 3288303 | 5051.1.1.3 ↗ | alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › SSF | 0.51 | 43.0 | 2.64e-01 | 97.2% | 74.8% |
| 5011884 | 3563.1.1.1 ↗ | alpha bundles › Twin arginine protein translocation system component TatC › Twin arginine protein translocation system component TatC › Twin arginine protein translocation system component TatC › TatC | 0.51 | 44.0 | 3.02e-01 | 100.0% | 83.8% |
| 5024728 | 3563.1.1.1 ↗ | alpha bundles › Twin arginine protein translocation system component TatC › Twin arginine protein translocation system component TatC › Twin arginine protein translocation system component TatC › TatC | 0.50 | 44.0 | 3.06e-01 | 100.0% | 70.9% |