RNA-dependent_RNA_polymerase_NS5

Euk-Vir

West_Nile_virus

RNA-dependent_RNA_polymerase_NS5__NP_776022__West_Nile_virus__11082

Identity

84.4 mean pLDDT

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› West_Nile_virus

TaxID: 11082

View cluster (51 members)

Download PDB Download Scores JSON

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 8-256

PDB

Domain cluster: rep: IMGVR_UViG_3300009616_000257-3300009616-Ga0116111_100275611__D486-632

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	79.5	4.30e-22	69.1%	97.8%

D2 high residues 715-891

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	236.7	1.80e-70	89.3%	96.3%

D3 medium residues 339-361_378-392_453-479_545-600

PDB

Domain cluster: representative

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	68.6	6.00e-19	47.1%	12.6%
PF00972.26	Flavi_NS5	34.3	1.50e-08	32.2%	5.5%
PF00972.26	Flavi_NS5	44.6	1.10e-11	29.8%	6.0%

CATH (8)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1c3gA01	2.60.260.20	Mainly Beta › Sandwich › HSP40/DNAj peptide-binding domain › Urease metallochaperone UreE, N-terminal domain	0.66	25.0	3.10e-01	86.8%	53.8%
2jbrA02	2.40.110.10	Mainly Beta › Beta Barrel › Butyryl-CoA Dehydrogenase, subunit A; domain 2 › Butyryl-CoA Dehydrogenase, subunit A, domain 2	0.61	27.0	3.09e-01	88.4%	52.6%
3gw6A03	3.30.2460.10	Alpha Beta › 2-Layer Sandwich › Endo-n-acetylneuraminidase fold › Endo-n-acetylneuraminidase domain	0.55	19.0	2.65e-01	81.0%	57.9%
5odnC00	2.40.50.140	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins	0.54	23.0	2.47e-01	88.4%	44.1%
3bwlB00	3.30.450.20	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain	0.52	23.0	2.30e-01	90.9%	36.6%
4g79A00	2.170.210.20	Mainly Beta › Beta Complex › Dna Repair Protein Xrcc4; Chain: A, domain 1 › Spindle assembly abnormal protein 6, N-terminal domain	0.52	24.0	2.35e-01	90.9%	39.6%
3mr0A01	3.30.450.20	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain	0.51	23.0	2.44e-01	89.3%	42.7%
3pieB05	2.30.30.30	Mainly Beta › Roll › SH3 type barrels. ›	0.51	22.0	2.85e-01	81.8%	70.3%

ECOD (4)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.90	87.0	5.66e-01	100.0%	60.0%
4986861	223.1.1.2 ↗	a+b three layers › Profilin-like › sensor domains › sensor domains › PAS	0.59	25.0	2.90e-01	90.9%	51.7%
4641382	4099.1.1.32 ↗	a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › PF30019	0.58	23.0	2.14e-01	94.2%	24.8%
4973552	223.1.1.0 ↗	a+b three layers › Profilin-like › sensor domains › sensor domains	0.54	25.0	2.69e-01	90.1%	46.7%

D4 medium residues 362-377_495-544_601-710

PDB

Domain cluster: rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	162.6	1.80e-47	60.2%	22.8%
PF00972.26	Flavi_NS5	82.6	3.40e-23	33.5%	11.3%

D5 medium residues 393-452_480-494

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268580__Ilomantsi_virus__1445557__D396-441_479-493

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	94.8	6.60e-27	80.0%	13.3%