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RNA-dependent_RNA_polymerase_NS5

Euk-Vir

Mercadeo_virus

RNA-dependent_RNA_polymerase_NS5__YP_009259288__Mercadeo_virus__1708574

Identity

Accession:
YP_009259288 ↗
Protein ID:
RNA-dependent_RNA_polymerase_NS5
Kingdom:
euk

Quality

85.8 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Mercadeo_virus

TaxID: 1708574

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 698-880
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF20483.4 best Flavi_NS5_thumb 199.8 4.10e-59 85.8% 95.1%
D2 medium residues 6-62_202-237
PDB
Domain cluster: representative
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2f22A00 1.20.120.450 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain 0.57 52.0 4.47e-01 100.0% 88.7%
6ncvA00 1.10.533.10 Mainly Alpha › Orthogonal Bundle › Death Domain, Fas › Death Domain, Fas 0.56 43.0 4.35e-01 100.0% 83.5%
6zzx601 1.10.3460.10 Mainly Alpha › Orthogonal Bundle › Chlorophyll a-b binding protein › Chlorophyll a/b binding protein domain 0.53 40.0 3.10e-01 82.8% 43.8%
6sl5601 1.10.3460.10 Mainly Alpha › Orthogonal Bundle › Chlorophyll a-b binding protein › Chlorophyll a/b binding protein domain 0.52 40.0 3.42e-01 82.8% 50.3%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3714391 101.1.1.0 ↗ alpha arrays › HTH › HTH › Three-helical HTH 0.52 28.0 3.04e-01 97.8% 60.0%
4031846 101.1.8.1 ↗ alpha arrays › HTH › HTH › DNA breaking-rejoining enzymes › Phage_integrase 0.51 40.0 3.68e-01 86.0% 97.6%
4016140 620.1.1.4 ↗ alpha bundles › YfiT-like putative metal-dependent hydrolases › YfiT-like putative metal-dependent hydrolases › YfiT-like putative metal-dependent hydrolases › DUF1993 0.51 45.0 3.69e-01 100.0% 84.6%
D3 medium residues 63-201
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01728.26 best FtsJ 45.8 9.20e-12 100.0% 76.8%
CATH (62)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1r6aA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.95 91.0 7.10e-01 100.0% 52.3%
3rkuA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.77 71.0 5.65e-01 100.0% 70.1%
1mg5A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.76 71.0 5.71e-01 100.0% 92.2%
2oo3A00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.76 71.0 5.65e-01 100.0% 83.9%
6vloD01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.76 70.0 6.06e-01 100.0% 91.4%
4dmgA03 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.75 70.0 6.00e-01 100.0% 75.8%
3t4xA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.75 69.0 5.54e-01 100.0% 84.2%
1u9jA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.75 69.0 5.68e-01 100.0% 79.1%
2q1sA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.75 69.0 5.68e-01 100.0% 74.1%
2fpoC00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.74 65.0 5.91e-01 100.0% 71.3%
1bxkA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.74 68.0 5.58e-01 100.0% 75.0%
4bluB00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.74 69.0 5.42e-01 100.0% 72.5%
1ej6A03 3.40.50.10760 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Reovirus core 0.73 67.0 5.36e-01 100.0% 52.1%
1mldA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.73 65.0 6.46e-01 96.4% 100.0%
6jh7B00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.73 67.0 5.41e-01 100.0% 84.9%
3wj7A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.73 67.0 5.02e-01 100.0% 52.1%
7mdhA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.73 64.0 6.25e-01 95.7% 98.0%
2dulA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 67.0 5.11e-01 100.0% 57.8%
2v6fA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.72 67.0 4.87e-01 100.0% 67.9%
3uj9A00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 67.0 5.38e-01 100.0% 61.2%
3gu3A01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 65.0 6.13e-01 100.0% 81.4%
4id9A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.70 65.0 5.58e-01 99.3% 76.8%
3a27A00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.70 65.0 5.56e-01 100.0% 64.8%
2efjA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.70 64.0 5.56e-01 100.0% 80.4%
3uwpA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.70 65.0 5.54e-01 100.0% 70.0%
3vpgA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.70 63.0 6.29e-01 97.1% 100.0%
5h02A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.70 65.0 5.95e-01 100.0% 80.9%
4ilkA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.69 57.0 5.83e-01 96.4% 90.3%
3ip3A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.68 56.0 5.92e-01 96.4% 99.2%
3o9zA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.68 58.0 6.04e-01 99.3% 100.0%
3hbmA02 3.40.50.2000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; 0.67 55.0 5.56e-01 100.0% 86.5%
7cluA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.67 61.0 5.18e-01 100.0% 71.1%
1hyhA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.66 59.0 5.95e-01 97.8% 99.3%
3fzgA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.65 59.0 5.23e-01 100.0% 70.4%
1ygpA02 3.40.50.2000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; 0.64 59.0 4.39e-01 100.0% 64.4%
2wabA02 3.40.50.1110 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase 0.64 59.0 5.06e-01 100.0% 82.7%
3h5nD02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.64 59.0 4.81e-01 99.3% 81.7%
4k05A01 3.40.50.12170 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Uncharacterised protein PF07075, DUF1343 0.64 58.0 4.90e-01 100.0% 81.3%
3pg5A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.63 56.0 4.42e-01 100.0% 94.6%
16pkA02 3.40.50.1260 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate kinase, N-terminal domain 0.62 56.0 4.93e-01 100.0% 93.8%
3h8vB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.62 57.0 4.81e-01 98.6% 83.3%
2z0mA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.62 54.0 4.85e-01 94.2% 79.6%
4m8kA00 3.40.50.1110 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase 0.61 56.0 4.84e-01 100.0% 84.5%
6iubA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.60 53.0 4.37e-01 100.0% 84.8%
8alzB05 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.60 50.0 4.46e-01 92.1% 76.6%
1h6vA01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.58 53.0 4.46e-01 100.0% 89.7%
3ug7C00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.58 51.0 4.06e-01 100.0% 94.0%
7nn3B01 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.58 53.0 3.99e-01 100.0% 73.5%
3c7tA01 3.40.50.1240 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate mutase-like 0.57 50.0 4.19e-01 96.4% 67.8%
1di0A00 3.40.50.960 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Lumazine/riboflavin synthase 0.57 46.0 4.59e-01 100.0% 82.4%
3u7iA00 3.40.50.360 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain 0.56 51.0 4.41e-01 100.0% 91.3%
3l23A00 3.20.20.150 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Divalent-metal-dependent TIM barrel enzymes 0.56 47.0 3.75e-01 91.4% 68.4%
3kqxL01 3.40.220.10 Alpha Beta › 3-Layer(aba) Sandwich › Leucine Aminopeptidase, subunit E; domain 1 › Leucine Aminopeptidase, subunit E, domain 1 0.55 46.0 4.24e-01 92.1% 80.3%
2yfkA01 3.40.50.1370 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Aspartate/ornithine carbamoyltransferase 0.53 37.0 3.38e-01 70.5% 57.1%
7uqyB01 3.90.550.10 Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A 0.53 48.0 4.18e-01 100.0% 93.0%
7exfA01 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.53 45.0 3.53e-01 94.2% 83.1%
4o1eB00 3.20.20.20 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Dihydropteroate synthase-like 0.53 44.0 3.60e-01 91.4% 58.1%
3cqjA00 3.20.20.150 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Divalent-metal-dependent TIM barrel enzymes 0.52 43.0 3.52e-01 91.4% 76.4%
4lusA02 3.20.20.10 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Alanine racemase 0.51 44.0 3.81e-01 92.8% 76.7%
2o3rA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 37.0 3.94e-01 99.3% 85.5%
1e6pB01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.51 42.0 3.25e-01 92.1% 75.6%
1a3wA02 3.20.20.60 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Phosphoenolpyruvate-binding domains 0.50 43.0 3.66e-01 95.0% 64.3%
ECOD (57)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
321243 2003.1.5.15 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.95 91.0 7.11e-01 100.0% 52.9%
4868697 2003.1.5.15 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.92 87.0 6.88e-01 100.0% 53.3%
3955553 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.76 70.0 5.19e-01 100.0% 61.8%
3296522 2003.1.1.2 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Ldh_1_N 0.76 68.0 6.18e-01 97.1% 78.9%
3633643 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.75 69.0 4.89e-01 100.0% 61.9%
1873097 2003.1.5.74 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltrans_SAM 0.75 70.0 5.27e-01 100.0% 50.8%
3962239 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.75 69.0 6.15e-01 100.0% 88.2%
3595652 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.75 70.0 4.97e-01 100.0% 55.3%
4319341 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.75 69.0 6.04e-01 100.0% 78.0%
3253828 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.74 68.0 4.72e-01 100.0% 46.5%
4948483 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.74 65.0 6.20e-01 100.0% 82.9%
5064244 2003.1.5.5 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 0.73 68.0 6.16e-01 100.0% 78.3%
None — 0.73 68.0 4.86e-01 100.0% 58.7%
3287115 2003.1.5.55 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PrmA 0.73 54.0 5.55e-01 95.7% 79.3%
3386329 2003.1.5.46 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS 0.73 67.0 5.61e-01 99.3% 81.6%
3593840 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.73 65.0 6.25e-01 96.4% 98.1%
3330430 2003.1.5.19 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › TRM 0.72 68.0 5.32e-01 100.0% 61.5%
None — 0.72 57.0 6.18e-01 82.7% 99.1%
1088385 2003.1.1.153 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase, GDP_Man_Dehyd 0.72 56.0 6.15e-01 82.7% 99.1%
3292313 2003.1.1.2 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Ldh_1_N 0.72 64.0 6.28e-01 96.4% 100.0%
3198609 2003.1.5.67 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12 0.71 66.0 5.19e-01 100.0% 84.7%
4586005 2003.1.5.67 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12 0.71 66.0 5.32e-01 100.0% 79.2%
4372224 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.70 64.0 4.71e-01 100.0% 54.2%
3722802 2003.1.1.53 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA 0.69 64.0 4.91e-01 100.0% 49.5%
3693730 2003.1.5.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_2 0.69 63.0 5.05e-01 100.0% 61.5%
4093457 2003.1.5.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_2 0.69 63.0 5.08e-01 100.0% 62.6%
4019380 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.68 52.0 4.06e-01 80.6% 75.3%
4477670 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.67 53.0 4.39e-01 82.7% 87.9%
3263363 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.67 54.0 4.89e-01 86.3% 88.4%
3290122 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.63 59.0 5.11e-01 100.0% 84.9%
3287584 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.63 50.0 4.11e-01 83.5% 81.6%
3696926 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.63 48.0 3.95e-01 79.9% 69.1%
5013075 2004.1.1.1200 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF835 0.63 50.0 4.98e-01 95.0% 81.2%
4991683 2004.1.1.194 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C_2 0.63 52.0 4.83e-01 90.6% 89.4%
869081 2003.1.6.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Tubulin nucleotide-binding domain-like 0.61 55.0 5.02e-01 100.0% 86.5%
3459195 2005.1.1.3 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp 0.60 52.0 4.89e-01 93.5% 84.1%
3415146 2004.1.1.186 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12 0.60 54.0 4.54e-01 100.0% 81.3%
3222773 2005.1.1.36 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › SLC12 0.59 55.0 5.12e-01 100.0% 82.4%
4022630 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.59 51.0 4.27e-01 94.2% 71.7%
4001806 2005.1.1.36 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › SLC12 0.58 53.0 4.95e-01 100.0% 85.7%
3175558 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.57 49.0 4.17e-01 93.5% 61.7%
3479417 2005.1.1.36 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › SLC12 0.57 51.0 5.09e-01 97.1% 100.0%
3638394 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.57 49.0 3.91e-01 94.2% 70.0%
3721955 2004.1.1.73 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › MMR_HSR1 0.57 50.0 4.04e-01 99.3% 60.0%
3590138 2005.1.1.22 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › QueH 0.57 51.0 4.27e-01 100.0% 65.8%
4936487 7543.1.1.3 ↗ a/b three-layered sandwiches › Methylglyoxal synthase-like › Methylglyoxal synthase-like › Methylglyoxal synthase-like › AICARFT_IMPCHas 0.55 47.0 4.76e-01 95.7% 92.9%
3923356 300.1.1.9 ↗ a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease › MIT_C 0.55 42.0 3.94e-01 87.1% 64.6%
None — 0.54 49.0 3.23e-01 100.0% 42.9%
3387513 2004.1.1.159 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Mur_ligase_M 0.53 48.0 4.44e-01 100.0% 81.7%
4639471 2004.1.1.73 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › MMR_HSR1 0.53 48.0 4.46e-01 100.0% 91.4%
3816687 207.1.1.0 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats 0.53 44.0 3.13e-01 89.9% 46.9%
3471006 7516.1.1.21 ↗ a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glyco_transf_64 0.53 48.0 3.97e-01 100.0% 83.6%
4826516 2002.1.1.8 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Cellulase 0.53 45.0 4.00e-01 95.0% 84.8%
3681732 2004.1.1.56 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › NB-ARC 0.53 48.0 3.81e-01 100.0% 60.7%
3941347 2004.1.1.163 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › KTI12 0.52 45.0 4.13e-01 92.8% 81.1%
3510301 7516.1.1.37 ↗ a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › CHGN 0.52 45.0 3.72e-01 97.1% 93.8%
3321664 207.1.1.0 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats 0.50 46.0 3.25e-01 99.3% 36.8%
D4 medium residues 259-303_333-355
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D258-306_330-351
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 35.6 6.20e-09 67.7% 9.3%
D5 medium residues 442-466_530-597
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 39.5 4.00e-10 74.2% 14.2%
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2a26B01 4.10.860.10 Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › UVR domain 0.64 32.0 4.33e-01 72.0% 97.7%
1zpyA00 6.10.140.1960 Special › Helix non-globular › Helix Hairpins › 0.53 36.0 3.71e-01 87.1% 71.4%
7k3zG01 3.50.7.10 Alpha Beta › 3-Layer(bba) Sandwich › GroEL › GroEL 0.51 39.0 3.06e-01 83.9% 91.1%
ECOD (5)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4261003 192.6.1.0 ↗ alpha bundles › Long alpha-hairpin › Epsilon subunit of F1F0-ATP synthase C-terminal domain › Epsilon subunit of F1F0-ATP synthase C-terminal domain 0.63 32.0 4.38e-01 91.4% 100.0%
3173834 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 57.0 3.66e-01 100.0% 32.2%
4984140 4070.1.1.2 ↗ alpha arrays › FtsH protease domain-like › FtsH protease domain-like › FtsH protease domain-like › Peptidase_M50 0.55 46.0 3.45e-01 90.3% 85.9%
3592115 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.53 36.0 2.45e-01 71.0% 24.8%
3589429 4159.1.1.0 ↗ alpha arrays › SP0561-like › SP0561-like › SP0561-like 0.51 32.0 3.47e-01 87.1% 76.0%
D6 medium residues 498-529_598-609_623-697
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009259365__Quang_Binh_virus__643132__D492-530_608-683