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RNA-dependent_RNA_polymerase_NS5

Euk-Vir

Aedes_flavivirus

RNA-dependent_RNA_polymerase_NS5__YP_009259331__Aedes_flavivirus__390845

Identity

Accession:: YP_009259331 ↗
Protein ID:: RNA-dependent_RNA_polymerase_NS5
Kingdom:: euk

Quality

86.3 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Aedes_flavivirus

TaxID: 390845

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 48-231

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009259288__Mercadeo_virus__1708574__D63-201

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	82.8	4.20e-23	92.4%	97.2%

D2 high residues 699-867

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	181.9	1.20e-53	93.5%	95.1%

D3 medium residues 6-47_232-242

PDB

Domain cluster: representative

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1r6aA00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.84	72.0	4.49e-01	94.3%	93.5%
5w87A01	3.30.2410.10	Alpha Beta › 2-Layer Sandwich › Hect, E3 ligase catalytic fold › Hect, E3 ligase catalytic domain	0.58	48.0	3.92e-01	88.7%	60.6%

ECOD (4)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3189481	70.3.1.1 ↗	beta barrels › beta-clip › SET domain-like › SET domain-like › SET	0.63	55.0	3.60e-01	96.2%	35.0%
4013445	70.3.1.0 ↗	beta barrels › beta-clip › SET domain-like › SET domain-like	0.61	55.0	3.54e-01	100.0%	63.5%
3181227	70.3.1.1 ↗	beta barrels › beta-clip › SET domain-like › SET domain-like › SET	0.61	53.0	3.44e-01	98.1%	30.9%
4016856	70.3.1.1 ↗	beta barrels › beta-clip › SET domain-like › SET domain-like › SET	0.60	52.0	3.36e-01	98.1%	33.1%

D4 medium residues 265-306_332-359_383-485_577-588

PDB

Domain cluster: rep: NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071__D315-356_368-395_444-456_471-503_597-617

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	149.4	1.80e-43	61.6%	23.9%

D5 medium residues 360-382_520-576_589-636

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268612__Nakiwogo_virus__667516__D468-494_526-579_598-632

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	84.8	6.90e-24	91.4%	23.9%

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2psmA00	1.20.1250.70	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-15/Interleukin-21	0.53	31.0	3.21e-01	70.3%	61.5%
2fdrA02	1.10.150.240	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2	0.51	27.0	3.60e-01	81.2%	100.0%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3651060	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.69	50.0	4.31e-01	73.4%	68.9%

D6 medium residues 486-519_637-698

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009259365__Quang_Binh_virus__643132__D492-530_608-683