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RNA-dependent_RNA_polymerase_NS5

Euk-Vir

Quang_Binh_virus

RNA-dependent_RNA_polymerase_NS5__YP_009259365__Quang_Binh_virus__643132

Identity

Accession:
YP_009259365 ↗
Protein ID:
RNA-dependent_RNA_polymerase_NS5
Kingdom:
euk

Quality

86.1 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 42-240
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01728.26 best FtsJ 75.7 6.10e-21 87.4% 98.3%
D2 medium residues 258-350_436-469_558-607
PDB
Pfam (3)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 76.0 3.30e-21 53.7% 19.3%
PF00972.26 Flavi_NS5 37.4 1.80e-09 28.8% 10.6%
PF00972.26 Flavi_NS5 48.8 5.90e-13 27.1% 8.0%
D3 medium residues 351-435_470-491_531-557
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 45.0 8.70e-12 64.9% 18.0%
PF00972.26 Flavi_NS5 31.7 9.00e-08 32.1% 6.7%
D4 medium residues 492-530_608-683
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 27.5 1.70e-06 66.1% 12.0%
PF00972.26 Flavi_NS5 25.2 8.90e-06 49.6% 9.3%
CATH (22)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3h5xA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.73 64.0 6.46e-01 95.7% 93.1%
1hi8A03 3.30.70.1600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.71 63.0 5.45e-01 95.7% 76.1%
1khvA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.69 63.0 6.04e-01 97.4% 91.5%
7uinD01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.62 57.0 5.00e-01 100.0% 85.0%
1earA02 3.30.70.790 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › UreE, C-terminal domain 0.62 32.0 3.95e-01 78.3% 81.2%
1lfpA03 3.30.70.980 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YebC, transcriptional regulation domain 0.60 35.0 4.21e-01 81.7% 90.4%
4hkqA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.60 49.0 4.56e-01 96.5% 70.1%
1konA03 3.30.70.980 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YebC, transcriptional regulation domain 0.59 34.0 4.08e-01 80.9% 86.7%
3rrkA03 3.30.70.2750 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 37.0 4.52e-01 80.0% 100.0%
1mw7A03 3.30.70.980 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YebC, transcriptional regulation domain 0.59 36.0 4.32e-01 80.9% 94.7%
1in0A01 3.30.70.860 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 35.0 4.17e-01 73.0% 94.3%
1vk8A00 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 37.0 4.06e-01 74.8% 79.6%
4ol8A01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.58 45.0 4.25e-01 100.0% 69.6%
5xgbA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.56 50.0 4.37e-01 100.0% 90.5%
1yqhA00 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 36.0 3.74e-01 74.8% 72.1%
2kviA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.55 34.0 3.99e-01 80.0% 92.2%
1s7hA01 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.54 34.0 3.99e-01 75.7% 91.3%
3ui3A02 3.30.70.240 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 35.0 3.80e-01 79.1% 81.6%
1vk3A01 3.90.650.10 Alpha Beta › Alpha-Beta Complex › Phosphoribosyl-aminoimidazole Synthetase; Chain A, domain 2 › PurM-like C-terminal domain 0.52 38.0 3.27e-01 77.4% 68.4%
1zavA01 3.30.70.1730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein L10, N-terminal RNA-binding domain 0.52 44.0 4.20e-01 93.9% 97.8%
1ir6A02 3.10.310.30 Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › 0.51 34.0 3.32e-01 80.0% 61.2%
5hmpB02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.50 29.0 3.58e-01 81.7% 100.0%
ECOD (45)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1279063 304.48.1.13 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.97 94.0 6.02e-01 100.0% 45.3%
5033333 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.70 39.0 5.01e-01 75.7% 96.9%
5060568 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.70 37.0 4.96e-01 78.3% 100.0%
4937597 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.68 36.0 4.79e-01 75.7% 98.3%
4388157 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.66 35.0 4.55e-01 73.9% 92.3%
4042122 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.65 35.0 4.37e-01 73.9% 85.7%
4231349 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.65 35.0 4.31e-01 75.7% 85.7%
4215184 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.63 35.0 4.29e-01 75.7% 87.1%
4604805 304.117.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC 0.63 34.0 4.36e-01 73.9% 92.3%
4048587 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.63 37.0 4.53e-01 79.1% 94.3%
4101997 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.63 34.0 4.23e-01 73.9% 85.7%
4295716 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.63 34.0 4.22e-01 75.7% 85.7%
3983816 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 57.0 4.39e-01 100.0% 65.6%
4461494 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.61 34.0 4.20e-01 80.9% 93.8%
4279811 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.61 35.0 4.04e-01 79.1% 80.0%
4310337 304.117.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC 0.61 35.0 4.27e-01 74.8% 92.9%
4990288 304.7.1.0 a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors 0.61 33.0 4.21e-01 76.5% 93.8%
4273411 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.61 35.0 4.35e-01 78.3% 98.5%
4058379 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.60 34.0 4.20e-01 78.3% 96.9%
4156338 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.60 35.0 4.18e-01 81.7% 88.0%
4962984 304.8.1.10 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_7 0.59 36.0 4.13e-01 81.7% 85.0%
4205064 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.59 34.0 4.11e-01 78.3% 92.9%
5445 304.117.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC 0.59 36.0 4.32e-01 80.9% 94.7%
4357399 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.58 34.0 4.09e-01 81.7% 94.3%
4080161 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.58 35.0 4.13e-01 78.3% 92.0%
4173742 304.117.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC 0.58 35.0 4.19e-01 79.1% 93.3%
4033416 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.57 34.0 4.09e-01 84.3% 95.7%
4033471 304.26.1.1 a+b two layers › Alpha-beta plaits › MTH1187/YkoF-like › MTH1187/YkoF-like › Thiamine_BP 0.57 37.0 4.08e-01 75.7% 81.1%
4070496 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.56 34.0 3.95e-01 84.3% 89.3%
3936601 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.56 50.0 3.77e-01 95.7% 46.8%
3518893 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.55 47.0 3.67e-01 92.2% 48.8%
3939082 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.54 49.0 3.69e-01 99.1% 45.6%
3939219 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.53 46.0 3.55e-01 96.5% 48.3%
3926536 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.52 45.0 3.51e-01 95.7% 42.3%
3937211 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.52 47.0 3.57e-01 99.1% 46.3%
3927691 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.52 47.0 3.63e-01 99.1% 50.0%
4246496 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.52 45.0 3.59e-01 94.8% 62.2%
3936323 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.51 47.0 3.62e-01 99.1% 49.4%
3529282 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.51 44.0 3.59e-01 94.8% 63.6%
3678489 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.51 45.0 3.74e-01 96.5% 68.5%
3938275 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.51 46.0 3.57e-01 100.0% 49.4%
3257066 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.51 46.0 3.63e-01 100.0% 52.1%
4940753 5104.1.1.1 a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA1 0.51 36.0 3.67e-01 78.3% 75.5%
3934131 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.51 46.0 3.61e-01 100.0% 50.6%
3934730 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.51 46.0 3.60e-01 100.0% 50.6%
D5 medium residues 684-734_804-827
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF20483.4 best Flavi_NS5_thumb 57.3 2.60e-15 60.0% 26.2%
CATH (5)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1z47A03 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.60 31.0 3.83e-01 90.7% 79.6%
2jz6A01 2.30.170.40 Mainly Beta › Roll › Ribosomal Protein L24e; Chain: T; › Ribosomal protein L28/L24 0.56 33.0 3.84e-01 98.7% 88.0%
6zxfz01 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.51 35.0 3.01e-01 72.0% 80.5%
4f3nA00 3.40.50.12710 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.51 36.0 2.43e-01 78.7% 63.6%
5mj6A03 2.60.40.1910 Mainly Beta › Sandwich › Immunoglobulin-like › 0.50 28.0 2.75e-01 84.0% 48.8%
ECOD (9)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3010831 4967.1.1.14 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › Flavi_NS5_thumb 0.95 91.0 6.28e-01 100.0% 68.6%
None 0.93 89.0 6.21e-01 100.0% 68.9%
2770736 4967.1.1.14 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › Flavi_NS5_thumb 0.67 58.0 4.20e-01 93.3% 58.2%
3781 4967.1.1.0 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.66 56.0 4.14e-01 93.3% 62.1%
150973 4967.1.1.5 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RdRP_3 0.63 57.0 4.08e-01 100.0% 58.3%
3580752 7579.1.1.93 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_1, Abhydro_lipase 0.56 44.0 2.61e-01 86.7% 20.8%
8227 4232.1.1.1 few secondary structure elements › Ribosomal protein bL28-related › Ribosomal protein bL28-related › Ribosomal protein L28 › Ribosomal_L28 0.55 33.0 3.47e-01 98.7% 64.3%
3319006 101.1.2.497 alpha arrays › HTH › HTH › winged helix domain › PF25874 0.54 34.0 2.96e-01 93.3% 42.7%
4046934 4232.1.1.1 few secondary structure elements › Ribosomal protein bL28-related › Ribosomal protein bL28-related › Ribosomal protein L28 › Ribosomal_L28 0.51 25.0 3.09e-01 82.7% 68.9%
D6 medium residues 735-803_828-889
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF20483.4 best Flavi_NS5_thumb 78.4 8.60e-22 55.7% 40.8%