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RNA-dependent_RNA_polymerase_NS5
Euk-VirDonggang_virus
RNA-dependent_RNA_polymerase_NS5__YP_009259536__Donggang_virus__985683
Identity
- Accession:
- YP_009259536 ↗
- Protein ID:
- RNA-dependent_RNA_polymerase_NS5
- Kingdom:
- euk
Quality
85.8
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Donggang_virus
TaxID: 985683
Cluster
View cluster (51 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 719-901
Domain cluster:
rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF20483.4 best | Flavi_NS5_thumb | 210.3 | 2.30e-62 | 84.2% | 93.9% |
D2
medium
residues 5-73_161-270
Domain cluster:
rep: RNA-dependent_RNA_polymerase__NP_776009__Yellow_fever_virus__11089__D6-81_163-264
D3
medium
residues 74-160
Domain cluster:
rep: RNA-dependent_RNA_polymerase__NP_740729__Louping_ill_virus__11086__D71-170
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01728.26 best | FtsJ | 40.2 | 5.10e-10 | 100.0% | 48.1% |
D4
medium
residues 279-312
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00972.26 best | Flavi_NS5 | 50.8 | 1.50e-13 | 100.0% | 7.5% |
CATH (7)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2hfzA01 | 3.30.70.2840 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain | 0.97 | 87.0 | 6.25e-01 | 100.0% | 38.2% |
| 6wczB02 | 3.30.70.2840 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain | 0.92 | 80.0 | 6.62e-01 | 100.0% | 56.7% |
| 1r4qA01 | 3.40.420.10 | Alpha Beta › 3-Layer(aba) Sandwich › Ricin (A subunit); domain 1 › Ricin (A subunit), domain 1 | 0.57 | 44.0 | 2.90e-01 | 91.2% | 92.9% |
| 2k6hA01 | 3.40.420.10 | Alpha Beta › 3-Layer(aba) Sandwich › Ricin (A subunit); domain 1 › Ricin (A subunit), domain 1 | 0.54 | 39.0 | 2.65e-01 | 88.2% | 84.6% |
| 2uv8A06 | 3.30.70.2490 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.52 | 42.0 | 3.51e-01 | 100.0% | 52.2% |
| 6wqbA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.52 | 39.0 | 2.65e-01 | 85.3% | 37.8% |
| 2jugA01 | 1.10.10.1830 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Non-ribosomal peptide synthase, adenylation domain | 0.51 | 41.0 | 3.51e-01 | 91.2% | 72.7% |
ECOD (9)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2702788 | 304.48.1.13 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 | 0.97 | 83.0 | 5.09e-01 | 100.0% | 18.3% |
| 3728370 | 148.1.3.42 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › RCF1-5-like_lid | 0.64 | 44.0 | 3.33e-01 | 73.5% | 91.8% |
| 4992297 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.63 | 45.0 | 2.91e-01 | 100.0% | 16.4% |
| 3722010 | 2003.1.7.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › 5-FTHF_cyc-lig | 0.56 | 40.0 | 2.43e-01 | 76.5% | 70.8% |
| 5051463 | 304.54.1.0 ↗ | a+b two layers › Alpha-beta plaits › CcmK-like › CcmK-like | 0.55 | 45.0 | 3.56e-01 | 100.0% | 46.3% |
| 3735723 | 603.2.1.0 ↗ | alpha bundles › STAT-like › STAT › STAT | 0.52 | 43.0 | 2.67e-01 | 100.0% | 44.8% |
| 3611954 | 198.1.1.4 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › DUF3456 | 0.51 | 39.0 | 2.64e-01 | 94.1% | 21.3% |
| 4947393 | 2.1.1.31 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_ligase_A_C | 0.51 | 41.0 | 2.86e-01 | 94.1% | 55.7% |
| 4012484 | 102.1.1.0 ↗ | alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like | 0.50 | 40.0 | 2.64e-01 | 91.2% | 54.8% |
D5
medium
residues 363-379_500-542_606-718
Domain cluster:
rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00972.26 best | Flavi_NS5 | 139.1 | 2.30e-40 | 58.4% | 21.7% |
| PF00972.26 | Flavi_NS5 | 65.1 | 6.90e-18 | 31.2% | 10.0% |
CATH (9)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1s48A04 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.82 | 52.0 | 6.51e-01 | 86.7% | 100.0% |
| 1gx5A03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.82 | 57.0 | 6.79e-01 | 85.0% | 100.0% |
| 1khvA03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.77 | 57.0 | 6.54e-01 | 84.4% | 100.0% |
| 1ra6A02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.77 | 47.0 | 5.95e-01 | 75.7% | 100.0% |
| 4hkqA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.66 | 47.0 | 5.12e-01 | 100.0% | 86.8% |
| 4ol8A01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.60 | 41.0 | 4.64e-01 | 100.0% | 89.6% |
| 7uinD01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.60 | 51.0 | 5.26e-01 | 90.2% | 94.6% |
| 3smzA01 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.58 | 37.0 | 4.40e-01 | 90.2% | 95.5% |
| 2a7oA00 | 1.10.1740.100 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › Set2, Rpb1 interacting domain | 0.58 | 32.0 | 4.09e-01 | 70.5% | 94.0% |
ECOD (7)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1279063 | 304.48.1.13 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 | 1.00 | 91.0 | 6.38e-01 | 92.5% | 78.5% |
| 4875416 | 304.48.1.13 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 | 0.83 | 81.0 | 5.94e-01 | 100.0% | 83.9% |
| 3794546 | 304.9.1.1 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 | 0.55 | 34.0 | 3.98e-01 | 80.9% | 88.3% |
| 3939082 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.51 | 48.0 | 4.06e-01 | 100.0% | 85.9% |
| 4476428 | 304.20.1.0 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0.50 | 40.0 | 4.00e-01 | 82.7% | 92.6% |
| 3937813 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.50 | 47.0 | 4.01e-01 | 100.0% | 85.2% |
| 3937211 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.50 | 47.0 | 3.99e-01 | 100.0% | 83.3% |
D6
medium
residues 380-499_543-605
Domain cluster:
rep: NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071__D315-356_368-395_444-456_471-503_597-617
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00972.26 best | Flavi_NS5 | 223.5 | 5.80e-66 | 66.7% | 26.6% |
| PF00972.26 | Flavi_NS5 | 80.0 | 2.10e-22 | 34.4% | 14.0% |