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RNA-dependent_RNA_polymerase_NS5

Euk-Vir

Hanko_virus

RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677

Identity

Accession:: YP_009268628 ↗
Protein ID:: RNA-dependent_RNA_polymerase_NS5
Kingdom:: euk

Quality

85.9 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Hanko_virus

TaxID: 1125677

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 40-241

PDB

Domain cluster: rep: IMGVR_UViG_3300009616_000257-3300009616-Ga0116111_100275611__D486-632

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	86.8	2.40e-24	86.1%	99.5%

D2 high residues 698-878

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	199.9	3.80e-59	86.7%	95.1%

CATH (4)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2vyiA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.56	29.0	3.36e-01	89.0%	67.2%
2fo7A00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.52	26.0	2.97e-01	79.6%	60.3%
4dloB02	1.25.40.610	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.52	34.0	4.03e-01	84.5%	100.0%
4n5cD06	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.52	30.0	3.70e-01	100.0%	90.3%

ECOD (5)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
None	—		0.94	87.0	8.24e-01	98.9%	83.5%
3010831	4967.1.1.14 ↗	alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › Flavi_NS5_thumb	0.90	85.0	8.00e-01	100.0%	83.8%
3781	4967.1.1.0 ↗	alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases	0.76	62.0	6.10e-01	100.0%	80.0%
3863082	109.4.1.1147 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_INTS8_2	0.51	33.0	3.44e-01	90.1%	69.4%
3907391	109.25.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A	0.50	31.0	3.81e-01	77.9%	100.0%

D3 medium residues 258-306_330-351

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	42.4	5.10e-11	70.4%	9.1%

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2hfzA01	3.30.70.2840	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain	0.93	71.0	6.47e-01	95.8%	62.9%
6wczB02	3.30.70.2840	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain	0.87	54.0	5.89e-01	70.4%	75.0%

ECOD (2)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.93	87.0	5.13e-01	97.2%	20.8%
2702788	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.88	83.0	6.02e-01	100.0%	52.6%

D4 medium residues 384-486_532-597

PDB

Domain cluster: rep: NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071__D315-356_368-395_444-456_471-503_597-617

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	136.0	2.10e-39	63.3%	23.1%
PF00972.26	Flavi_NS5	41.5	9.50e-11	39.1%	13.5%

D5 medium residues 487-531_598-697

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009259365__Quang_Binh_virus__643132__D492-530_608-683

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	72.9	2.90e-20	62.8%	21.1%
PF00972.26	Flavi_NS5	39.2	4.80e-10	31.7%	10.2%