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RNA-dependent_RNA_polymerase_NS5

Euk-Vir

Saint_Louis_encephalitis_virus

RNA-dependent_RNA_polymerase_NS5__YP_009329957__Saint_Louis_encephalitis_virus__11080

Identity

Accession:: YP_009329957 ↗
Protein ID:: RNA-dependent_RNA_polymerase_NS5
Kingdom:: euk

Quality

85.1 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› St._Louis_encephalitis_virus

TaxID: 11080

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 715-894

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	246.3	2.00e-73	87.8%	94.5%

D2 medium residues 1-50

PDB

Domain cluster: representative

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4957618	5060.1.1.1 ↗	alpha bundles › V-type ATP synthase subunit C › V-type ATP synthase subunit C › V-type ATP synthase subunit C › vATP-synt_AC39	0.50	39.0	3.05e-01	86.0%	91.2%

D3 medium residues 51-146

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_740729__Louping_ill_virus__11086__D71-170

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	55.6	9.20e-15	96.9%	53.6%

D4 medium residues 147-245

PDB

Domain cluster: representative

CATH (10)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1r6aA00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.98	95.0	6.59e-01	100.0%	37.4%
5mmjh01	3.30.1370.30	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 ›	0.67	42.0	4.71e-01	77.8%	82.7%
3evzA01	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.64	46.0	3.91e-01	78.8%	45.2%
2lxrA00	3.30.110.40	Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › TusA-like domain	0.59	41.0	4.49e-01	78.8%	94.7%
2ob0C01	3.40.630.30	Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT)	0.55	40.0	3.47e-01	78.8%	80.9%
3p0lD00	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.53	39.0	3.17e-01	77.8%	92.4%
6wnsA01	3.40.630.30	Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT)	0.51	36.0	2.99e-01	78.8%	39.1%
1yreC00	3.40.630.30	Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT)	0.51	37.0	3.14e-01	78.8%	44.0%
3c0wA02	3.10.28.10	Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases	0.50	35.0	3.49e-01	71.7%	77.7%
3mwbA01	3.40.190.10	Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II	0.50	37.0	3.80e-01	79.8%	94.8%

ECOD (15)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
321243	2003.1.5.15 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ	0.99	97.0	6.74e-01	100.0%	37.9%
4868697	2003.1.5.15 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ	0.96	92.0	6.45e-01	100.0%	38.1%
4999042	328.5.1.1 ↗	a+b two layers › IF3-like › SirA-like › SirA-like › TusA	0.71	47.0	5.36e-01	78.8%	90.5%
3204920	2003.1.5.15 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ	0.68	61.0	4.30e-01	100.0%	48.7%
3609798	320.1.1.0 ↗	a+b two layers › R3H domain-like › R3H domain › R3H domain	0.66	47.0	4.50e-01	73.7%	87.0%
4029853	2003.1.5.6 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltr_RsmB-F	0.65	48.0	3.15e-01	78.8%	30.1%
1900987	2003.1.5.81 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25	0.64	46.0	3.71e-01	78.8%	38.1%
None	—		0.63	48.0	3.52e-01	80.8%	41.2%
3992039	320.1.1.0 ↗	a+b two layers › R3H domain-like › R3H domain › R3H domain	0.61	41.0	4.27e-01	72.7%	73.4%
3701239	320.1.1.0 ↗	a+b two layers › R3H domain-like › R3H domain › R3H domain	0.60	43.0	4.68e-01	75.8%	96.2%
3625370	2003.1.5.73 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16	0.59	46.0	3.53e-01	83.8%	76.6%
3726634	327.11.2.0 ↗	a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I)	0.58	35.0	3.83e-01	78.8%	73.8%
3792947	2003.1.5.73 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16	0.58	46.0	3.53e-01	84.8%	78.9%
3464409	304.8.1.0 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like	0.56	32.0	3.59e-01	78.8%	73.3%
3318862	304.8.1.45 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant	0.54	35.0	3.79e-01	74.7%	77.6%

D5 medium residues 271-363_420-463_544-597

PDB

Domain cluster: rep: NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071__D315-356_368-395_444-456_471-503_597-617

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	157.0	8.90e-46	49.2%	20.2%
PF00972.26	Flavi_NS5	67.4	1.30e-18	29.3%	12.2%
PF00972.26	Flavi_NS5	74.5	9.40e-21	25.7%	10.4%

D6 medium residues 364-390_500-543_598-714

PDB

Domain cluster: rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	171.6	3.40e-50	58.0%	23.5%
PF00972.26	Flavi_NS5	71.6	7.30e-20	26.1%	9.8%

D7 medium residues 391-419_464-499

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268580__Ilomantsi_virus__1445557__D396-441_479-493

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	76.5	2.40e-21	61.5%	8.6%
PF00972.26	Flavi_NS5	32.3	6.10e-08	46.2%	6.4%