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RNA-dependent_RNA_polymerase

Euk-Vir

Trichomonas_vaginalis_virus_2

RNA-dependent_RNA_polymerase__NP_624323__Trichomonas_vaginalis_virus_2__674954

Identity

Accession:
NP_624323 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

52.5 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 454-580
PDB
D2 medium residues 331-386
PDB
D3 medium residues 581-670
PDB
D4 medium residues 796-923
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02123.22 best RdRP_4 69.9 3.00e-19 98.4% 26.7%
CATH (5)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2hpiA03 1.10.10.1600 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Bacterial DNA polymerase III alpha subunit, thumb domain 0.59 31.0 4.12e-01 73.4% 93.0%
4ae4A00 1.20.120.1920 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › UBAP1 SOUBA domain 0.57 38.0 4.01e-01 89.8% 74.6%
3pqaB01 3.40.605.10 Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 0.52 44.0 3.46e-01 91.4% 65.1%
5jazA03 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.51 35.0 4.05e-01 93.0% 100.0%
1szhA02 1.10.150.370 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Caenorhabditis elegans Her-1, C-terminal domain 0.51 29.0 3.35e-01 82.8% 81.7%
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5032432 7014.1.1.2 alpha bundles › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › TauE 0.53 30.0 3.15e-01 76.6% 60.0%
3257900 103.1.1.0 alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain 0.51 35.0 3.75e-01 70.3% 99.1%
D5 medium residues 1055-1088_1143-1214
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02123.22 best RdRP_4 68.1 1.10e-18 69.8% 17.6%
CATH (39)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1hi8A03 3.30.70.1600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.77 71.0 5.91e-01 100.0% 88.1%
4ol8A01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.70 62.0 5.72e-01 96.2% 80.7%
6lpnA03 3.30.70.2190 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.68 47.0 4.64e-01 71.7% 96.5%
2d1cA02 3.30.70.1570 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.67 47.0 4.70e-01 72.6% 96.4%
1a9nD00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.65 47.0 5.04e-01 75.5% 96.8%
4mt1A02 3.30.70.1430 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain 0.65 44.0 4.53e-01 70.8% 92.2%
2dgvA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.64 45.0 4.84e-01 71.7% 98.9%
1rkiA01 3.30.70.1650 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › PDO, CxxC motif 0.64 47.0 4.93e-01 77.4% 99.0%
2dhaA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.63 50.0 4.78e-01 84.9% 83.7%
2e5jA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.63 45.0 4.93e-01 80.2% 90.9%
1x4hA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.62 45.0 4.46e-01 74.5% 82.0%
1vq3B00 3.30.1280.10 Alpha Beta › 2-Layer Sandwich › Mth169; Chain: A , › Phosphoribosylformylglycinamidine synthase subunit PurS 0.62 29.0 3.21e-01 71.7% 53.6%
3c1mA02 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.62 49.0 4.26e-01 84.9% 89.6%
2mgzA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.62 45.0 4.79e-01 76.4% 91.5%
1mg7A01 3.30.70.1000 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Switch protein XOL-1, GHMP-like 0.62 47.0 4.04e-01 82.1% 84.0%
4aukA01 3.30.70.2810 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 44.0 4.92e-01 79.2% 100.0%
4pwuC00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.61 44.0 4.94e-01 76.4% 100.0%
4mt1A06 3.30.70.1430 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain 0.61 44.0 4.52e-01 74.5% 100.0%
2wbrA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 46.0 4.96e-01 80.2% 95.5%
2cpdA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.60 41.0 4.71e-01 78.3% 100.0%
2b4vA03 3.30.70.1970 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 45.0 4.68e-01 80.2% 90.9%
1kohA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.60 46.0 4.81e-01 82.1% 94.8%
2cpzA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.60 47.0 5.04e-01 84.9% 100.0%
2kviA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.59 42.0 4.74e-01 74.5% 100.0%
3im8A02 3.30.70.250 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Malonyl-CoA ACP transacylase, ACP-binding 0.59 40.0 4.55e-01 78.3% 100.0%
2cqhA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.59 44.0 4.61e-01 77.4% 88.2%
4f67A01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 41.0 4.12e-01 71.7% 88.7%
1bgxT05 3.30.70.370 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 52.0 4.98e-01 100.0% 99.2%
1r6yA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 42.0 4.27e-01 75.5% 100.0%
1itpA00 3.30.70.80 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Peptidase S8 propeptide/proteinase inhibitor I9 0.58 40.0 4.57e-01 76.4% 98.7%
2cyyA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.58 44.0 4.68e-01 82.1% 92.6%
1vjqA00 3.30.70.340 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Metallocarboxypeptidase-like 0.58 39.0 4.44e-01 76.4% 100.0%
2g4bA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.57 42.0 4.48e-01 78.3% 95.7%
1mwqA00 3.30.70.1060 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel 0.57 42.0 4.29e-01 77.4% 98.0%
2cqiA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.57 42.0 4.29e-01 78.3% 82.5%
2mzqA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.55 44.0 4.57e-01 89.6% 97.0%
8owfA01 2.60.40.290 Mainly Beta › Sandwich › Immunoglobulin-like › 0.53 36.0 3.54e-01 74.5% 65.8%
3thdA03 2.60.120.260 Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like 0.52 41.0 3.81e-01 84.9% 98.5%
5jpnC01 2.60.40.690 Mainly Beta › Sandwich › Immunoglobulin-like › Alpha-macroglobulin, receptor-binding domain 0.51 37.0 3.49e-01 76.4% 61.7%
ECOD (46)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5019341 304.7.1.0 a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors 0.69 45.0 5.34e-01 79.2% 98.6%
5040248 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.67 46.0 5.30e-01 76.4% 100.0%
3656887 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.66 47.0 5.22e-01 78.3% 95.2%
3786390 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.66 48.0 4.94e-01 76.4% 88.0%
3739756 304.7.1.2 a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › Inhibitor_I9 0.65 43.0 4.96e-01 79.2% 96.0%
3670856 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.65 47.0 4.94e-01 78.3% 84.2%
3726627 304.7.1.0 a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors 0.65 44.0 4.63e-01 81.1% 77.9%
3617948 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.64 48.0 4.78e-01 78.3% 82.7%
3671637 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.64 44.0 4.42e-01 71.7% 76.4%
3346483 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.64 45.0 4.98e-01 74.5% 95.3%
3383967 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.64 47.0 5.17e-01 81.1% 97.6%
2813751 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.64 45.0 5.08e-01 76.4% 100.0%
3709243 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.63 50.0 5.11e-01 88.7% 86.7%
3339604 304.9.1.47 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › DUF4283 0.63 46.0 4.34e-01 75.5% 68.0%
3227692 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.63 45.0 4.85e-01 80.2% 88.9%
3973622 304.28.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain 0.63 46.0 4.64e-01 78.3% 95.5%
3619277 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.62 45.0 4.85e-01 81.1% 90.0%
4980947 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.62 46.0 4.95e-01 77.4% 96.7%
5055913 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.62 47.0 4.67e-01 80.2% 88.2%
3481563 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.62 45.0 4.18e-01 78.3% 61.5%
3715104 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.62 45.0 4.24e-01 81.1% 62.3%
3973848 304.154.1.1 a+b two layers › Alpha-beta plaits › Regulator of polyketide synthase expression N-terminal domain › Regulator of polyketide synthase expression N-terminal domain › GGDEF_2 0.61 52.0 4.69e-01 94.3% 86.0%
3195848 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.61 44.0 4.83e-01 84.9% 100.0%
4978620 304.4.1.1 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › AsnC_trans_reg 0.60 44.0 4.70e-01 79.2% 90.0%
3891298 304.9.1.77 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › PF28441 0.60 44.0 4.22e-01 75.5% 70.8%
5035580 304.4.1.1 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › AsnC_trans_reg 0.60 43.0 4.86e-01 77.4% 100.0%
3449952 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.60 44.0 4.71e-01 80.2% 91.1%
3415955 304.126.1.2 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C › V-ATPase_C 0.59 44.0 4.28e-01 77.4% 100.0%
3728157 304.7.1.0 a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors 0.59 39.0 4.53e-01 77.4% 100.0%
5082753 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.59 43.0 4.39e-01 77.4% 84.8%
4452423 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.59 46.0 4.62e-01 86.8% 83.8%
3886756 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.59 46.0 4.74e-01 84.0% 92.0%
3897640 304.9.1.18 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › Tap-RNA_bind 0.59 44.0 4.70e-01 79.2% 93.3%
3683605 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.59 41.0 4.52e-01 76.4% 91.8%
3824051 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.58 47.0 4.79e-01 87.7% 90.5%
4929272 304.22.1.0 a+b two layers › Alpha-beta plaits › Urease metallochaperone UreE, C-terminal domain › Urease metallochaperone UreE, C-terminal domain 0.58 40.0 4.50e-01 77.4% 95.0%
3223173 304.9.1.17 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › DUF1866 0.58 42.0 4.61e-01 75.5% 94.1%
5029940 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.58 40.0 4.39e-01 70.8% 97.5%
5033398 304.4.1.1 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › AsnC_trans_reg 0.58 44.0 4.73e-01 81.1% 97.8%
5083386 304.12.1.0 a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 0.58 44.0 4.64e-01 82.1% 97.9%
3289145 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.57 42.0 4.64e-01 84.9% 96.5%
4033451 301.13.1.6 a+b three layers › Bacillus chorismate mutase-like › DAK1/DegV C-terminal domain › DAK1/DegV C-terminal domain › FakA-like_M 0.57 41.0 4.53e-01 77.4% 94.1%
5072361 304.4.1.1 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › AsnC_trans_reg 0.57 43.0 4.52e-01 83.0% 89.5%
3397652 2004.1.1.5 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran 0.57 43.0 2.73e-01 80.2% 55.2%
3016421 304.4.1.5 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › Dyp_perox_N 0.54 47.0 4.40e-01 96.2% 100.0%
3560979 11.1.5.27 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Common fold of diphtheria toxin/transcription factors/cytochrome f › A2M_recep 0.52 38.0 3.48e-01 76.4% 59.3%
D6 medium residues 1215-1312_1352-1368
PDB
D7 medium residues 1369-1436
PDB