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RNA-dependent_RNA_polymerase

Euk-Vir

Ophiostoma_mitovirus_3a

RNA-dependent_RNA_polymerase__NP_660176__Ophiostoma_mitovirus_3a__198597

Identity

Accession:
NP_660176 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

70.4 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 18-136
PDB
CATH (12)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
6ks6a01 1.10.560.10 Mainly Alpha › Orthogonal Bundle › GROEL; domain 1 › GroEL-like equatorial domain 0.70 63.0 4.80e-01 100.0% 90.6%
3nz4B03 1.10.274.20 Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Phenylalanine ammonia-lyase 1; domain 3 0.62 47.0 4.94e-01 97.5% 90.4%
2qyuA04 1.10.4140.10 Mainly Alpha › Orthogonal Bundle › effector protein (NleL) fold › effector protein (NleL) 0.61 40.0 3.36e-01 85.7% 39.9%
2k73A00 1.20.1550.10 Mainly Alpha › Up-down Bundle › Bromodomain-like › DsbB-like 0.57 51.0 4.48e-01 100.0% 82.5%
3cvvA02 1.25.40.80 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.57 35.0 3.38e-01 82.4% 54.2%
6cnzF00 1.20.59.10 Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase 0.57 41.0 3.72e-01 74.8% 81.6%
1nxuA01 1.10.1530.10 Mainly Alpha › Orthogonal Bundle › Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 › Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel 0.56 35.0 4.15e-01 98.3% 94.9%
2zihC00 1.10.3630.10 Mainly Alpha › Orthogonal Bundle › yeast vps74-n-term truncation variant fold › yeast vps74-n-term truncation variant domain like 0.53 45.0 3.52e-01 95.0% 92.5%
4fb2A00 1.10.630.10 Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 0.53 42.0 2.96e-01 84.9% 72.4%
3vkgA09 1.20.920.30 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › 0.52 41.0 3.92e-01 85.7% 94.4%
3h4cA01 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.51 36.0 3.95e-01 92.4% 89.6%
1i7dA04 1.10.290.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; domain 4 › Topoisomerase I, domain 4 0.51 43.0 4.28e-01 94.1% 99.2%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5004344 593.1.1.1 alpha bundles › GroEL equatorial domain-like › GroEL equatorial domain-like › GroEL equatorial domain-like › Cpn60_TCP1 0.70 64.0 5.01e-01 100.0% 96.8%
3585345 5050.1.1.8 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › FPN1 0.56 51.0 3.92e-01 100.0% 88.9%
3646014 604.1.1.61 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › DUF6857 0.51 37.0 2.98e-01 74.8% 65.7%
D2 medium residues 137-148_178-299
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF05919.17 best Mitovir_RNA_pol 102.5 4.10e-29 94.8% 22.3%
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5x8tT00 3.90.470.10 Alpha Beta › Alpha-Beta Complex › Ribosomal Protein L22; Chain A › Ribosomal protein L22/L17 0.54 28.0 2.79e-01 76.9% 45.1%
6qdws00 3.90.470.10 Alpha Beta › Alpha-Beta Complex › Ribosomal Protein L22; Chain A › Ribosomal protein L22/L17 0.51 26.0 2.90e-01 73.9% 59.6%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5002351 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.54 40.0 2.89e-01 91.0% 26.9%
4497954 304.48.1.73 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1, RVT_N 0.54 40.0 3.01e-01 91.0% 33.2%
3509327 2003.1.2.12 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › DAO 0.52 39.0 2.83e-01 80.6% 96.9%
D3 medium residues 149-177_300-454
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF05919.17 best Mitovir_RNA_pol 262.4 1.40e-77 91.3% 30.2%
D4 medium residues 455-524
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF05919.17 best Mitovir_RNA_pol 61.2 1.40e-16 100.0% 14.1%
CATH (6)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4bucA02 3.40.1190.10 Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain 0.53 39.0 2.90e-01 81.4% 94.6%
3lk7A02 3.40.1190.10 Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain 0.52 39.0 2.84e-01 81.4% 97.6%
3gmiA02 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.52 40.0 2.90e-01 87.1% 70.3%
4mtlA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.52 42.0 3.13e-01 95.7% 97.1%
2gffA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.51 35.0 3.23e-01 72.9% 85.4%
2xp1A01 3.30.505.10 Alpha Beta › 2-Layer Sandwich › SHC Adaptor Protein › SH2 domain 0.50 36.0 3.32e-01 77.1% 100.0%
ECOD (6)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4932734 4959.1.1.1 a+b complex topology › first helical domain in RNA-polymerase beta-prime subunit › first helical domain in RNA-polymerase beta-prime subunit › first helical domain in RNA-polymerase beta-prime subunit › RNA_pol_Rpb1_3 0.62 43.0 3.59e-01 71.4% 50.4%
3265091 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.58 49.0 2.93e-01 98.6% 20.0%
3594603 3012.1.1.0 a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain 0.54 37.0 3.35e-01 71.4% 85.0%
3258201 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.54 45.0 3.22e-01 97.1% 54.0%
3167962 4329.1.1.1 a+b complex topology › ORC1-binding domain › ORC1-binding domain › ORC1-binding domain › Sir1 0.54 44.0 3.82e-01 98.6% 80.0%
4137680 4967.1.1.0 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.52 44.0 3.33e-01 98.6% 89.7%
D5 medium residues 525-591
PDB