←Back to structures

RNA-dependent_RNA_polymerase

Euk-Vir

Louping_ill_virus

RNA-dependent_RNA_polymerase__NP_740729__Louping_ill_virus__11086

Identity

Accession:
NP_740729 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

85.7 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Louping_ill_virus

TaxID: 11086

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 731-887
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF20483.4 best Flavi_NS5_thumb 184.7 1.70e-54 87.9% 82.3%
D2 medium residues 6-70_171-262
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_776009__Yellow_fever_virus__11089__D6-81_163-264
D3 medium residues 71-170
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01728.26 best FtsJ 43.4 5.10e-11 99.0% 50.8%
CATH (98)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1r6aA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.98 95.0 6.63e-01 100.0% 38.2%
4fzvA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.80 74.0 5.58e-01 100.0% 57.1%
3egiA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.78 72.0 5.70e-01 100.0% 55.4%
1ej0A00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.77 72.0 5.82e-01 100.0% 59.4%
1fl2A02 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.76 57.0 5.30e-01 78.0% 82.3%
3v97A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.76 69.0 5.78e-01 100.0% 60.9%
5uzxA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.76 68.0 5.11e-01 97.0% 51.9%
3pvzB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.76 68.0 4.82e-01 99.0% 40.7%
3a27A00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.75 66.0 5.02e-01 100.0% 43.4%
3s55E00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.75 67.0 4.90e-01 99.0% 50.0%
3ftdA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.74 64.0 5.22e-01 100.0% 52.0%
6yu8A01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.74 69.0 4.98e-01 100.0% 48.3%
3ll7A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.74 68.0 5.45e-01 100.0% 54.7%
3vvbA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.74 66.0 4.74e-01 97.0% 40.0%
3mggB01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.73 66.0 5.57e-01 100.0% 59.8%
7e52A01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.73 55.0 5.03e-01 78.0% 82.0%
2h00B00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.73 67.0 5.22e-01 100.0% 53.3%
5ilgB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.73 66.0 4.85e-01 99.0% 44.6%
1mg5A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.73 66.0 4.89e-01 100.0% 45.9%
5icsF00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.73 66.0 4.81e-01 98.0% 46.3%
3jwhA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.73 67.0 5.33e-01 100.0% 55.5%
2qrvA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.73 64.0 5.04e-01 97.0% 51.9%
3aw9A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.73 62.0 4.93e-01 96.0% 47.4%
3uwpA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 67.0 5.10e-01 100.0% 50.0%
3dhnA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.72 62.0 4.80e-01 98.0% 43.1%
2q1sA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.72 66.0 4.92e-01 100.0% 45.3%
6qmmA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 68.0 5.11e-01 100.0% 46.1%
2o07A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 65.0 4.96e-01 100.0% 44.7%
3htxD03 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 65.0 5.01e-01 100.0% 48.9%
3gnlA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 63.0 5.29e-01 100.0% 57.6%
1inlD01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.72 65.0 4.95e-01 100.0% 44.5%
6kv9A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.72 63.0 5.00e-01 96.0% 48.7%
1mldA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.72 63.0 5.57e-01 96.0% 72.4%
4f6cB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.71 65.0 4.34e-01 99.0% 29.9%
2dulA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.71 66.0 4.57e-01 100.0% 36.0%
3mtiB00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.71 66.0 5.35e-01 100.0% 57.2%
1bxkA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.71 62.0 4.65e-01 97.0% 71.4%
1g38A01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.71 65.0 4.94e-01 100.0% 53.4%
1m6yA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.70 65.0 5.25e-01 100.0% 59.3%
5yw4A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.70 62.0 4.28e-01 97.0% 32.3%
5ygqA02 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.70 52.0 4.83e-01 77.0% 84.4%
2p8jA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.70 63.0 4.98e-01 100.0% 50.0%
3ay3A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.70 61.0 4.63e-01 98.0% 41.9%
2dtxA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.70 63.0 4.64e-01 99.0% 43.9%
3dtnA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.70 62.0 5.05e-01 100.0% 52.9%
3ic5A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.70 56.0 5.39e-01 97.0% 75.7%
5cvdB00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.69 63.0 4.83e-01 100.0% 77.4%
4lvuA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.69 62.0 4.63e-01 99.0% 67.1%
3g5tA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.69 64.0 4.47e-01 100.0% 35.5%
3t37A01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.69 61.0 4.52e-01 96.0% 70.7%
4e4yA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.69 61.0 4.56e-01 97.0% 44.2%
1ceqA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.69 61.0 5.47e-01 97.0% 93.4%
1npdB02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.68 62.0 5.41e-01 100.0% 89.9%
2dc1A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.68 47.0 4.29e-01 96.0% 53.3%
1pjqA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.68 56.0 5.43e-01 100.0% 79.5%
1jqbA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.68 59.0 5.28e-01 100.0% 68.1%
4k7zA01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.68 60.0 4.60e-01 97.0% 72.3%
3un1C00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.68 60.0 4.53e-01 97.0% 47.0%
2xveA02 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.67 49.0 4.96e-01 76.0% 81.0%
4h15A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.67 60.0 4.43e-01 99.0% 43.3%
3nksA00 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.67 59.0 3.76e-01 96.0% 62.4%
3jyoA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.66 61.0 5.35e-01 100.0% 70.6%
3o4fH02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.66 61.0 4.68e-01 100.0% 60.6%
4p22A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.66 59.0 4.55e-01 99.0% 52.0%
5nmxB02 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.65 48.0 4.98e-01 76.0% 81.7%
5ji5A00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.65 58.0 4.13e-01 100.0% 66.6%
3h8vB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.65 58.0 4.50e-01 99.0% 49.1%
7q1bA01 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.64 57.0 3.90e-01 100.0% 56.1%
1kolA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.64 58.0 4.88e-01 100.0% 65.3%
4xrpC01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.63 56.0 4.70e-01 100.0% 58.3%
5g0gA00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.63 56.0 3.87e-01 100.0% 58.6%
1evyA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.63 57.0 4.53e-01 99.0% 68.7%
3menB00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.63 55.0 3.87e-01 100.0% 48.2%
1vg0A01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.63 54.0 4.29e-01 95.0% 80.5%
6fu1A00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.63 55.0 3.73e-01 100.0% 42.3%
6z6fA01 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.62 55.0 3.78e-01 100.0% 56.8%
2v5wB00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.62 55.0 3.78e-01 100.0% 44.1%
5dzsB02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.62 55.0 5.07e-01 100.0% 90.2%
5g0xA00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.62 54.0 3.73e-01 100.0% 45.9%
2vqmA00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.61 54.0 3.70e-01 100.0% 44.5%
1c3pA00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.61 54.0 3.72e-01 100.0% 54.6%
4uejA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.61 54.0 4.91e-01 100.0% 89.9%
16pkA02 3.40.50.1260 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate kinase, N-terminal domain 0.61 53.0 4.28e-01 100.0% 78.4%
1d1tA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.60 54.0 4.84e-01 100.0% 90.6%
5k1sB00 3.90.180.10 Alpha Beta › Alpha-Beta Complex › Quinone Oxidoreductase; Chain A, domain 1 › Medium-chain alcohol dehydrogenases, catalytic domain 0.60 54.0 3.73e-01 100.0% 36.3%
1o89A02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.60 54.0 4.54e-01 100.0% 70.7%
3t38A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.59 48.0 4.49e-01 97.0% 69.5%
1s3iA01 3.40.50.170 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Formyl transferase, N-terminal domain 0.59 52.0 4.13e-01 97.0% 47.3%
3qtgA03 3.40.1380.20 Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain 0.59 52.0 4.96e-01 100.0% 83.5%
5ib9A02 3.50.30.30 Alpha Beta › 3-Layer(bba) Sandwich › Glucose Oxidase; domain 1 › 0.59 42.0 3.96e-01 100.0% 59.8%
6rqaA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.58 52.0 4.37e-01 99.0% 64.7%
2w2kA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.58 51.0 4.17e-01 100.0% 62.2%
2jfvA01 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.58 47.0 4.05e-01 97.0% 55.4%
4n7bA03 3.40.1010.20 Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain 0.58 44.0 4.45e-01 88.0% 83.5%
2jfzB01 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.57 45.0 4.18e-01 96.0% 65.4%
4dvjA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.56 49.0 4.42e-01 100.0% 69.2%
4e21A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.56 49.0 4.06e-01 97.0% 62.8%
3qy9B01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 46.0 4.25e-01 95.0% 94.1%
ECOD (97)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
321243 2003.1.5.15 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.97 94.0 6.57e-01 100.0% 38.3%
4868697 2003.1.5.15 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.95 91.0 6.43e-01 100.0% 38.9%
None — 0.80 74.0 5.45e-01 100.0% 55.1%
None — 0.80 74.0 5.42e-01 100.0% 53.4%
4259464 2003.1.5.15 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.79 74.0 5.86e-01 100.0% 54.7%
3194406 2003.1.5.70 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_15 0.78 72.0 5.11e-01 100.0% 48.4%
4987784 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.78 68.0 4.82e-01 100.0% 33.8%
5013470 2003.1.5.82 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_31 0.77 67.0 5.23e-01 100.0% 46.0%
5025172 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.77 67.0 4.80e-01 100.0% 34.8%
3591987 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.77 68.0 4.56e-01 100.0% 27.5%
4991373 2003.1.5.46 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS 0.77 70.0 5.31e-01 100.0% 48.5%
4072844 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.76 68.0 4.92e-01 100.0% 36.9%
5011559 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.76 68.0 4.92e-01 100.0% 37.2%
4300350 2003.1.5.46 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS 0.76 70.0 5.24e-01 100.0% 50.0%
4974737 2003.1.5.66 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 0.76 70.0 5.09e-01 100.0% 41.7%
3355727 2003.1.5.13 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Spermine_synth 0.75 70.0 5.19e-01 100.0% 45.8%
3386329 2003.1.5.46 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS 0.75 69.0 5.21e-01 100.0% 50.4%
3699676 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.75 68.0 4.60e-01 100.0% 53.5%
4931836 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.75 68.0 4.85e-01 100.0% 35.6%
4979585 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.75 68.0 4.83e-01 100.0% 35.1%
3949961 2003.1.1.61 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › KR 0.75 68.0 5.00e-01 100.0% 50.6%
1900401 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.75 66.0 5.24e-01 100.0% 49.5%
5043444 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.75 68.0 4.78e-01 100.0% 34.4%
3967100 2003.1.5.13 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Spermine_synth 0.74 70.0 5.12e-01 100.0% 42.1%
3458057 2003.1.5.15 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.74 64.0 5.97e-01 90.0% 80.8%
3963365 2003.1.5.13 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Spermine_synth 0.74 69.0 4.93e-01 100.0% 39.6%
4933693 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.74 68.0 4.79e-01 100.0% 34.4%
5059196 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.74 66.0 4.72e-01 100.0% 34.3%
4990482 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.74 67.0 4.80e-01 100.0% 35.9%
5043258 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.74 68.0 4.98e-01 100.0% 40.3%
4088620 2003.1.5.13 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Spermine_synth 0.74 69.0 5.13e-01 100.0% 46.4%
5033545 2003.1.2.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › Pyr_redox_2 0.74 54.0 4.75e-01 75.0% 87.1%
5034603 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.74 67.0 4.81e-01 100.0% 35.6%
4133826 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.74 67.0 4.91e-01 99.0% 45.0%
1684299 2003.1.5.13 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Spermine_synth 0.74 69.0 5.19e-01 100.0% 48.0%
5028098 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.74 68.0 4.79e-01 100.0% 34.7%
4120064 2003.1.5.62 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Eco57I 0.74 67.0 4.85e-01 100.0% 44.0%
3183115 2003.1.5.79 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 0.74 68.0 4.88e-01 100.0% 46.6%
3464761 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.74 69.0 4.72e-01 100.0% 34.5%
3255463 2003.1.1.67 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NAD_binding_10 0.73 66.0 5.02e-01 97.0% 45.0%
4313955 2003.1.5.13 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Spermine_synth 0.73 68.0 5.10e-01 100.0% 46.1%
5041637 2003.1.5.19 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › TRM 0.73 68.0 4.80e-01 100.0% 36.1%
5001313 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.73 65.0 4.70e-01 100.0% 35.9%
4367611 2003.1.5.13 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Spermine_synth 0.73 68.0 5.17e-01 100.0% 49.3%
4969811 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.73 67.0 4.73e-01 100.0% 34.7%
5062190 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.73 67.0 4.76e-01 100.0% 36.0%
4679950 2003.1.5.8 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Ubie_methyltran 0.72 67.0 4.94e-01 100.0% 80.0%
168640 2003.1.1.143 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA, NAD_binding_10 0.72 62.0 4.83e-01 98.0% 44.1%
4937816 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.72 66.0 4.88e-01 100.0% 40.8%
4434568 102.1.1.6 ↗ alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like › Methyltransf_5 0.72 67.0 5.26e-01 100.0% 52.5%
5026623 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.72 66.0 4.73e-01 100.0% 37.9%
3426735 2003.1.5.19 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › TRM 0.72 67.0 5.60e-01 100.0% 66.9%
4998190 2003.1.5.82 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_31 0.72 64.0 4.74e-01 100.0% 39.2%
3287115 2003.1.5.55 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PrmA 0.72 66.0 5.92e-01 100.0% 73.3%
3813351 2003.1.5.66 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 0.72 65.0 4.96e-01 100.0% 44.8%
5049017 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.72 66.0 4.71e-01 100.0% 36.1%
3952711 2003.1.1.160 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD, NmrA 0.72 65.0 4.38e-01 99.0% 29.2%
4974380 2003.1.5.79 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 0.72 58.0 4.47e-01 100.0% 39.1%
4093457 2003.1.5.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_2 0.72 65.0 4.73e-01 100.0% 37.7%
3690072 2003.1.5.79 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 0.71 66.0 4.71e-01 100.0% 63.6%
4611556 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.71 65.0 4.42e-01 100.0% 29.6%
4941791 2003.1.5.82 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_31 0.71 65.0 5.16e-01 100.0% 56.1%
4306905 2003.1.2.30 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › Pyr_redox_3 0.71 56.0 5.07e-01 84.0% 80.7%
4291137 2003.1.5.17 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.71 65.0 5.07e-01 99.0% 93.5%
3994498 2003.1.5.65 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › DOT1 0.70 65.0 4.33e-01 100.0% 31.3%
4511915 2003.1.5.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_2 0.70 63.0 4.62e-01 100.0% 37.8%
4285308 2003.1.8.4 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › MurCD/PglD N-terminal domain-like › MurD-like_N 0.70 59.0 5.91e-01 99.0% 90.0%
4482793 2003.1.5.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_2 0.70 64.0 4.66e-01 100.0% 66.8%
4098294 101.1.2.546 ↗ alpha arrays › HTH › HTH › winged helix domain › Methyltransf_2 0.70 63.0 4.10e-01 100.0% 25.1%
2777343 2003.1.2.30 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › Pyr_redox_3 0.69 51.0 5.08e-01 76.0% 80.4%
2527100 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.69 60.0 4.35e-01 98.0% 34.5%
3760704 2003.1.5.52 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_PK 0.69 63.0 4.52e-01 100.0% 62.5%
3403369 2003.1.5.73 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16 0.68 61.0 4.39e-01 100.0% 36.6%
1270114 2003.1.2.5 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › FMO-like 0.68 49.0 4.94e-01 76.0% 79.4%
4363289 2003.1.5.67 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12 0.67 60.0 4.11e-01 100.0% 30.4%
4329191 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.67 61.0 4.32e-01 100.0% 43.4%
3176510 2006.1.5.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.65 57.0 3.77e-01 100.0% 45.6%
5011929 2006.1.5.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.64 57.0 3.97e-01 100.0% 60.6%
2443842 2006.1.5.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.63 57.0 4.03e-01 100.0% 64.6%
5056851 2003.1.11.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Formate/glycerate dehydrogenase catalytic domain-like 0.63 57.0 4.41e-01 100.0% 57.3%
4833623 2487.1.1.7 ↗ a/b three-layered sandwiches › "The ""swivelling"" beta/beta/alpha domains" › "The ""swivelling"" beta/beta/alpha domain" › "The ""swivelling"" beta/beta/alpha domain" › PA 0.63 43.0 4.46e-01 70.0% 88.0%
2390984 2006.1.5.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.63 55.0 3.71e-01 100.0% 41.7%
4023150 2003.1.7.2 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › IF-2B 0.62 55.0 4.45e-01 99.0% 79.5%
4027784 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.62 54.0 3.92e-01 96.0% 56.5%
3603055 2006.1.5.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.62 55.0 3.87e-01 100.0% 59.5%
4854889 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.62 53.0 4.28e-01 100.0% 88.4%
5049617 2006.1.5.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.61 54.0 3.72e-01 100.0% 57.5%
4595350 2003.1.1.25 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Shikimate_DH,SDH_C 0.61 55.0 4.31e-01 100.0% 66.2%
4883164 2006.1.5.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.60 54.0 3.93e-01 100.0% 56.3%
3412965 2004.1.1.211 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › CLP1_P 0.60 53.0 4.01e-01 100.0% 54.9%
3075489 2003.1.5.1 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › DNA_methylase 0.59 51.0 4.37e-01 97.0% 92.1%
4198949 2007.1.5.0 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › ATC-like 0.57 45.0 3.92e-01 97.0% 54.8%
None — 0.57 51.0 4.19e-01 100.0% 76.2%
None — 0.57 50.0 3.76e-01 100.0% 50.8%
3757892 2487.1.1.7 ↗ a/b three-layered sandwiches › "The ""swivelling"" beta/beta/alpha domains" › "The ""swivelling"" beta/beta/alpha domain" › "The ""swivelling"" beta/beta/alpha domain" › PA 0.56 41.0 4.19e-01 100.0% 82.1%
4933320 2003.6.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Ribokinase-like › Ribokinase-like 0.54 48.0 3.62e-01 99.0% 44.0%
3441261 7516.1.1.105 ↗ a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Fringe, DUF604 0.54 46.0 3.72e-01 98.0% 91.9%
D4 medium residues 291-504_565-595
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase__YP_009337183__Beihai_weivirus-like_virus_12__1922741__D286-574_646-655
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 347.2 1.80e-103 88.6% 47.9%
D5 medium residues 505-564_596-691
PDB
Domain cluster: rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 139.2 2.20e-40 62.2% 21.5%
PF00972.26 Flavi_NS5 61.2 1.10e-16 39.1% 13.3%