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RNA-dependent_RNA_polymerase

Euk-Vir

Tick-borne_encephalitis_virus

RNA-dependent_RNA_polymerase__NP_775511__Tick-borne_encephalitis_virus__11084

Identity

Accession:: NP_775511 ↗
Protein ID:: RNA-dependent_RNA_polymerase
Kingdom:: euk

Quality

85.9 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Tick-borne_encephalitis_virus

TaxID: 11084

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 714-887

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	216.7	2.50e-64	89.1%	92.7%

D2 medium residues 29-60_178-267

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009329957__Saint_Louis_encephalitis_virus__11080__D147-245

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1r6aA00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.95	92.0	6.86e-01	100.0%	90.5%
7qh2C03	3.30.70.2740	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.51	27.0	3.26e-01	84.4%	79.5%

ECOD (5)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
321243	2003.1.5.15 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ	0.94	90.0	6.72e-01	99.2%	90.8%
4868697	2003.1.5.15 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ	0.93	88.0	6.65e-01	98.4%	91.4%
4024084	2003.1.5.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases	0.67	59.0	4.13e-01	94.3%	85.1%
3600323	2003.1.5.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases	0.62	48.0	3.65e-01	79.5%	97.4%
3204920	2003.1.5.15 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ	0.60	49.0	3.58e-01	85.2%	94.6%

D3 medium residues 61-177

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_740729__Louping_ill_virus__11086__D71-170

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	53.0	5.80e-14	98.3%	62.4%

D4 medium residues 268-317_346-368_450-471_578-603

PDB

Domain cluster: rep: NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071__D315-356_368-395_444-456_471-503_597-617

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	43.2	3.00e-11	41.3%	9.8%
PF00972.26	Flavi_NS5	30.8	1.70e-07	22.3%	5.1%

CATH (3)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2hfzA01	3.30.70.2840	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain	0.88	64.0	7.44e-01	92.6%	100.0%
5bmnA04	3.30.310.50	Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Alpha-D-phosphohexomutase, C-terminal domain	0.64	26.0	3.08e-01	90.1%	51.8%
6lgqC01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.51	40.0	3.92e-01	95.0%	76.3%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.87	84.0	5.49e-01	100.0%	76.2%

D5 medium residues 369-392_500-543_604-688

PDB

Domain cluster: rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	118.1	5.80e-34	56.9%	18.9%
PF00972.26	Flavi_NS5	49.4	3.90e-13	30.1%	9.8%

D6 medium residues 393-449_472-499_544-577

PDB

Domain cluster: rep: RdRp__YP_009329892__Hubei_diptera_virus_18__1922879__D81-159_189-211_249-288

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	75.6	4.40e-21	48.7%	12.9%
PF00972.26	Flavi_NS5	53.2	2.70e-14	26.9%	6.4%