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RNA-dependent_RNA_polymerase

Euk-Vir

Powassan_virus

RNA-dependent_RNA_polymerase__NP_775524__Powassan_virus__11083

Identity

Accession:
NP_775524 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

84.5 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Powassan_virus

TaxID: 11083

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 731-887
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF20483.4 best Flavi_NS5_thumb 189.2 7.20e-56 87.9% 82.3%
D2 medium residues 6-57_245-260
PDB
Domain cluster: rep: nonstructural_protein_NS5__NP_740302__Langat_virus__11085__D6-47_242-264
D3 medium residues 58-93_144-244
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009329957__Saint_Louis_encephalitis_virus__11080__D147-245
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01728.26 best FtsJ 25.5 1.60e-05 27.0% 20.4%
D4 medium residues 94-143
PDB
Domain cluster: representative
CATH (14)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1r6aA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.95 88.0 5.34e-01 100.0% 19.1%
2ewvA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.61 50.0 3.36e-01 100.0% 70.1%
5aunB01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.60 47.0 3.17e-01 92.0% 73.4%
4hutA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.58 48.0 3.34e-01 100.0% 57.1%
1w4rA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.56 44.0 3.49e-01 100.0% 59.8%
3imkA00 3.40.50.450 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.56 44.0 3.22e-01 92.0% 56.3%
2f46A00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.54 41.0 3.28e-01 100.0% 52.8%
3gxhA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.53 42.0 3.17e-01 100.0% 42.9%
4c1bB01 3.40.50.12690 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 40.0 3.79e-01 90.0% 81.5%
2shpB03 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.53 41.0 2.68e-01 94.0% 64.7%
1d5rA01 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.52 42.0 3.05e-01 100.0% 59.2%
2v3uA01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.52 42.0 3.11e-01 94.0% 79.6%
2qzuA01 3.40.720.10 Alpha Beta › 3-Layer(aba) Sandwich › Alkaline Phosphatase, subunit A › Alkaline Phosphatase, subunit A 0.52 39.0 2.52e-01 100.0% 29.9%
2wmfA02 3.30.2330.20 Alpha Beta › 2-Layer Sandwich › arginine biosynthesis bifunctional protein fold › family 98 glycoside hydrolase 0.52 40.0 3.47e-01 94.0% 68.9%
ECOD (10)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
321243 2003.1.5.15 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.95 88.0 5.34e-01 100.0% 19.2%
4868697 2003.1.5.15 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.93 85.0 5.24e-01 100.0% 19.5%
3999600 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.65 55.0 3.81e-01 100.0% 62.2%
1406851 2007.1.2.10 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 0.58 47.0 3.66e-01 100.0% 74.6%
3701790 389.1.1.45 ↗ few secondary structure elements › EGF-like › EGF-related › EGF/Laminin › DGF-1_N 0.57 45.0 3.79e-01 90.0% 55.6%
3705897 2007.2.3.2 ↗ a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.53 41.0 2.95e-01 92.0% 51.4%
4149837 7523.1.1.15 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › LysR_substrate 0.51 42.0 3.48e-01 100.0% 70.0%
3946624 7523.1.1.15 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › LysR_substrate 0.51 40.0 3.44e-01 100.0% 52.0%
4900269 2007.1.14.0 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Chelatase-like 0.50 38.0 2.91e-01 90.0% 59.3%
3176188 109.4.1.3157 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF29173, PF29174, PF29177 0.50 40.0 2.47e-01 94.0% 43.2%
D5 medium residues 344-365_393-498_558-605
PDB
Domain cluster: rep: NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071__D315-356_368-395_444-456_471-503_597-617
Pfam (3)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 203.3 7.80e-60 65.3% 25.1%
PF00972.26 Flavi_NS5 52.3 5.30e-14 27.3% 10.6%
PF00972.26 Flavi_NS5 26.5 3.50e-06 13.1% 4.9%
D6 medium residues 366-392_499-557_606-687
PDB
Domain cluster: rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 116.7 1.50e-33 50.0% 18.4%
PF00972.26 Flavi_NS5 74.2 1.20e-20 38.1% 13.1%