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RNA-dependent_RNA_polymerase

Euk-Vir

Macrobrachium_rosenbergii_nodavirus

RNA-dependent_RNA_polymerase__NP_919036__Macrobrachium_rosenbergii_nodavirus__222557

Identity

Accession:
NP_919036 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

70.5 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 15-84
PDB
D2 high residues 755-885
PDB
D3 medium residues 189-242_306-393
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF19222.6 best Noda_Vmethyltr 60.8 1.70e-16 41.5% 32.4%
D4 medium residues 243-305
PDB
Domain cluster: representative
CATH (19)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5cxoB00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.67 50.0 3.97e-01 95.2% 38.8%
1h6fA00 2.60.40.820 Mainly Beta › Sandwich › Immunoglobulin-like › Transcription factor, T-box 0.63 52.0 3.72e-01 92.1% 60.3%
4jgwA01 1.20.870.10 Mainly Alpha › Up-down Bundle › Son of sevenless (SoS) protein; Chain S, domain 1 › Son of sevenless (SoS) protein Chain: S domain 1 0.63 38.0 2.89e-01 85.7% 25.0%
1ms9A01 2.120.10.10 Mainly Beta › 6 Propeller › Neuraminidase › 0.61 52.0 3.27e-01 100.0% 28.5%
1p97A00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.60 42.0 3.49e-01 90.5% 40.4%
1iicA02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.59 40.0 2.77e-01 87.3% 18.5%
6yfiB01 3.30.380.10 Alpha Beta › 2-Layer Sandwich › MS2 Viral Coat Protein › MS2 Viral Coat Protein 0.57 37.0 2.95e-01 87.3% 30.4%
2bolA03 2.60.40.790 Mainly Beta › Sandwich › Immunoglobulin-like › 0.56 38.0 3.46e-01 100.0% 48.4%
2aj7A00 2.30.290.10 Mainly Beta › Roll › BH3618-like › BH3618-like 0.55 40.0 3.07e-01 92.1% 31.8%
1wv4B00 2.30.110.10 Mainly Beta › Roll › Pnp Oxidase; Chain A › Electron Transport, Fmn-binding Protein; Chain A 0.55 37.0 2.89e-01 87.3% 29.2%
4jf8A00 3.10.450.230 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein 0.54 41.0 3.16e-01 82.5% 38.9%
7b1cD01 2.10.90.10 Mainly Beta › Ribbon › Cystine Knot Cytokines, subunit B › Cystine-knot cytokines 0.53 36.0 3.28e-01 71.4% 53.4%
3qi7A03 3.30.30.130 Alpha Beta › 2-Layer Sandwich › Defensin A-like › 0.53 29.0 3.30e-01 82.5% 71.1%
4o3vA00 3.10.450.230 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein 0.52 39.0 3.16e-01 92.1% 39.1%
1yc9A02 2.20.200.10 Mainly Beta › Single Sheet › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) 0.52 40.0 3.73e-01 87.3% 69.9%
2xvlA05 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.51 34.0 2.87e-01 88.9% 36.1%
2re7A00 2.30.110.10 Mainly Beta › Roll › Pnp Oxidase; Chain A › Electron Transport, Fmn-binding Protein; Chain A 0.51 40.0 3.21e-01 87.3% 47.7%
4kz1A00 3.10.450.230 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein 0.50 38.0 3.11e-01 87.3% 42.2%
2i02A00 2.30.110.10 Mainly Beta › Roll › Pnp Oxidase; Chain A › Electron Transport, Fmn-binding Protein; Chain A 0.50 39.0 3.10e-01 87.3% 45.7%
ECOD (25)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
None 0.66 51.0 2.83e-01 85.7% 6.6%
3605629 2492.1.1.2 a+b three layers › Cytidine deaminase-like › Cytidine deaminase-like › Cytidine deaminase-like › JAB 0.63 45.0 3.19e-01 87.3% 24.6%
3484065 11.1.5.0 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Common fold of diphtheria toxin/transcription factors/cytochrome f 0.63 53.0 3.76e-01 93.7% 58.4%
3312219 706.2.1.5 beta complex topology › Head domain of nucleotide exchange factor GrpE › G5 and E repeats in surface protein G › G5 and E repeats in surface protein G › Tim44 0.62 50.0 4.85e-01 90.5% 94.3%
3203449 3195.1.1.1 extended segments › Mediator of RNA polymerase II transcription subunit 6 › Mediator of RNA polymerase II transcription subunit 6 › Mediator of RNA polymerase II transcription subunit 6 › Med6 0.58 46.0 3.33e-01 88.9% 35.1%
3741194 2484.1.1.1 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › HSP70 0.57 45.0 2.84e-01 92.1% 69.5%
3423894 9.3.1.0 beta barrels › Lipocalins/Streptavidin › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Quinohemoprotein amine dehydrogenase A chain, domain 3-like 0.57 44.0 3.22e-01 87.3% 47.2%
3591503 11.1.1.0 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.56 45.0 3.48e-01 88.9% 66.2%
5000297 4010.1.1.0 a+b complex topology › N-terminal domain in beta subunit of DNA dependent RNA-polymerase › N-terminal domain in beta subunit of DNA dependent RNA-polymerase › N-terminal domain in beta subunit of DNA dependent RNA-polymerase 0.56 48.0 3.07e-01 100.0% 47.5%
4024695 2484.1.1.15 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › GDA1_CD39 0.55 48.0 3.65e-01 100.0% 79.4%
3213184 573.1.1.6 alpha duplicates or obligate multimers › Soluble domain of poliovirus core protein 3a › Soluble domain of poliovirus core protein 3a › Soluble domain of poliovirus core protein 3a › LMF1_C 0.55 45.0 3.52e-01 90.5% 93.5%
3600460 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.54 47.0 2.89e-01 100.0% 52.4%
4030001 5.1.4.621 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Mcl1_mid 0.53 43.0 2.53e-01 100.0% 12.1%
3395786 5.1.4.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 0.53 39.0 2.53e-01 100.0% 15.0%
4023152 5.1.5.115 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed › WD40, Beta-prop_WDR3_2nd 0.53 36.0 2.29e-01 73.0% 93.1%
3452171 2484.1.1.1 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › HSP70 0.52 44.0 3.06e-01 100.0% 75.6%
3442241 5.1.3.118 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › FBA_3 0.51 45.0 2.91e-01 100.0% 27.3%
4236832 230.1.1.1 a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › Uricase 0.51 40.0 3.18e-01 95.2% 81.2%
3675798 883.1.1.20 a+b complex topology › Aha1/BPI domain-like › Aha1/BPI domain-like › Aha1/BPI domain-like › SMP_MUG190-like 0.51 39.0 2.77e-01 87.3% 31.4%
3582462 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.51 39.0 2.94e-01 87.3% 49.1%
3217597 109.6.1.2 alpha superhelices › Repetitive alpha hairpins › Ras GEF › Ras GEF › RasGEF,RasGEF_N 0.51 35.0 2.17e-01 74.6% 84.4%
3894561 221.1.2.16 a+b two layers › beta-Grasp › Ubiquitin-related › Alpha-L RNA-binding motif › MTRES1_C 0.51 36.0 3.24e-01 88.9% 50.0%
4966376 2484.1.1.59 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › NurA 0.50 42.0 2.74e-01 100.0% 27.0%
4484391 230.1.1.5 a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GCHY-1 0.50 39.0 3.20e-01 85.7% 64.0%
5081719 298.1.1.24 a+b two layers › FwdE/GAPDH domain-like › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › GFO_IDH_MocA_C3 0.50 36.0 2.82e-01 82.5% 79.4%
D5 medium residues 452-519_553-569_603-664
PDB