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RNA-dependent_RNA_polymerase

Euk-Vir

Penaeus_vannamei_nodavirus

RNA-dependent_RNA_polymerase__YP_004207810__Penaeus_vannamei_nodavirus__430911

Identity

Accession:: YP_004207810 ↗
Protein ID:: RNA-dependent_RNA_polymerase
Kingdom:: euk

Quality

70.2 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Magsaviricetes› Nodamuvirales› Nodaviridae› Penaeus_vannamei_nodavirus

TaxID: 430911

Cluster

View cluster (6 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 19-83

PDB

D2 medium residues 203-230_314-391

PDB

Domain cluster: rep: hypothetical_protein__YP_009329958__Beihai_noda-like_virus_18__1922471__D201-230_309-395

CATH (10)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2nvnA00	2.30.31.10	Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A	0.60	42.0	4.07e-01	73.6%	87.5%
3cm1A00	2.30.31.20	Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Sporulation-specific cell division protein SsgB	0.59	42.0	3.84e-01	73.6%	69.9%
2kc8A00	3.30.2310.20	Alpha Beta › 2-Layer Sandwich › YaeB-like fold › RelE-like	0.55	34.0	3.64e-01	71.7%	70.5%
7ob9B01	3.90.1110.10	Alpha Beta › Alpha-Beta Complex › Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3 › RNA polymerase Rpb2, domain 2	0.54	44.0	3.59e-01	85.8%	76.6%
7ne4A01	2.130.10.120	Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › Prolyl oligopeptidase, N-terminal domain	0.54	37.0	2.67e-01	71.7%	38.6%
1ob8A00	3.40.1350.10	Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 ›	0.52	36.0	3.49e-01	98.1%	63.0%
1qw2A00	3.30.1980.10	Alpha Beta › 2-Layer Sandwich › Hypothetical protein Ta1206 fold › Hypothetical protein YunC	0.52	37.0	3.76e-01	73.6%	92.2%
6vp6A03	2.130.10.10	Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase	0.51	44.0	3.14e-01	94.3%	76.1%
3k44B00	3.30.2450.30	Alpha Beta › 2-Layer Sandwich › Secreted effector protein pipB2 fold ›	0.51	46.0	4.23e-01	100.0%	88.6%
8hpoK01	2.130.10.10	Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase	0.51	43.0	2.95e-01	95.3%	81.3%

ECOD (16)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4966836	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.66	35.0	4.74e-01	70.8%	100.0%
5001101	7089.1.1.0 ↗	a+b two layers › Methane monooxygenase hydroxylase, MmoD › Methane monooxygenase hydroxylase, MmoD › Methane monooxygenase hydroxylase, MmoD	0.62	32.0	4.01e-01	71.7%	85.0%
3589620	4312.1.1.11 ↗	a+b two layers › RelE-like › RelE-like › RelE-like › ParE-like_toxin	0.61	37.0	4.03e-01	94.3%	72.2%
3673032	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.57	33.0	3.92e-01	71.7%	85.7%
4078775	331.1.1.0 ↗	a+b two layers › TBP-like › TATA-box binding protein-like › TATA-box binding protein-like	0.57	32.0	3.75e-01	82.1%	78.7%
3519803	4041.1.1.1 ↗	a+b complex topology › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › RNA_pol_Rpb2_2	0.56	45.0	3.72e-01	85.8%	79.5%
4641867	277.1.1.0 ↗	a+b two layers › PX domain › PX domain › PX domain	0.55	40.0	3.45e-01	75.5%	86.9%
3936608	220.1.1.0 ↗	beta barrels › PH domain-like › PH domain-like › PH domain-like	0.55	38.0	3.81e-01	72.6%	79.1%
3234295	4292.2.1.2 ↗	a+b two layers › FlaG-like › MAGUK binding stalk (MBS) domain › MAGUK binding stalk (MBS) domain › KIF1B	0.54	37.0	3.80e-01	70.8%	81.9%
4677426	4041.1.1.1 ↗	a+b complex topology › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › RNA_pol_Rpb2_2	0.54	43.0	3.56e-01	85.8%	80.0%
3603731	295.1.1.0 ↗	a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain	0.54	38.0	3.52e-01	73.6%	82.9%
3544618	4292.2.1.0 ↗	a+b two layers › FlaG-like › MAGUK binding stalk (MBS) domain › MAGUK binding stalk (MBS) domain	0.54	36.0	4.02e-01	70.8%	85.9%
3558557	330.16.1.0 ↗	a+b two layers › dsRBD-like › ODA16 N-terminal domain › ODA16 N-terminal domain	0.51	32.0	3.65e-01	99.1%	88.0%
3224052	4041.1.1.1 ↗	a+b complex topology › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › RNA_pol_Rpb2_2	0.51	44.0	3.61e-01	94.3%	70.0%
4945471	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.50	29.0	3.56e-01	73.6%	92.3%
3881962	4041.1.1.1 ↗	a+b complex topology › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › RNA_pol_Rpb2_2	0.50	43.0	3.60e-01	94.3%	70.8%

D3 medium residues 231-271_293-313

PDB

Domain cluster: representative

CATH (16)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1ov3A02	2.30.30.40	Mainly Beta › Roll › SH3 type barrels. › SH3 Domains	0.71	40.0	4.21e-01	80.6%	61.8%
6ghmC02	2.30.30.40	Mainly Beta › Roll › SH3 type barrels. › SH3 Domains	0.67	41.0	4.08e-01	80.6%	57.8%
2bzyA00	2.30.30.40	Mainly Beta › Roll › SH3 type barrels. › SH3 Domains	0.63	39.0	4.00e-01	83.9%	62.9%
2egeA00	2.30.30.40	Mainly Beta › Roll › SH3 type barrels. › SH3 Domains	0.59	37.0	3.48e-01	82.3%	50.7%
1wu7A03	3.40.50.800	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Anticodon-binding domain	0.59	44.0	3.87e-01	82.3%	100.0%
6epkA02	3.30.67.10	Alpha Beta › 2-Layer Sandwich › Viral Envelope Glycoprotein; domain 2 › Viral Envelope Glycoprotein, domain 2	0.56	42.0	4.06e-01	83.9%	71.8%
3p54A02	3.30.67.10	Alpha Beta › 2-Layer Sandwich › Viral Envelope Glycoprotein; domain 2 › Viral Envelope Glycoprotein, domain 2	0.56	41.0	4.01e-01	83.9%	71.8%
4x9cD00	2.30.30.100	Mainly Beta › Roll › SH3 type barrels. ›	0.54	36.0	3.74e-01	88.7%	71.7%
1okeB02	3.30.67.10	Alpha Beta › 2-Layer Sandwich › Viral Envelope Glycoprotein; domain 2 › Viral Envelope Glycoprotein, domain 2	0.54	39.0	3.73e-01	88.7%	64.9%
3d3rA00	2.30.30.140	Mainly Beta › Roll › SH3 type barrels. ›	0.53	40.0	3.62e-01	80.6%	62.7%
2w5eA01	2.40.10.10	Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases	0.53	38.0	3.82e-01	77.4%	100.0%
3qr8A01	2.40.50.230	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Gp5 N-terminal domain	0.52	39.0	3.61e-01	82.3%	83.3%
1g29102	2.40.50.140	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins	0.52	35.0	4.03e-01	74.2%	97.8%
2k4yA00	2.30.30.90	Mainly Beta › Roll › SH3 type barrels. › Ferrous iron transport protein A (FeoA)	0.52	43.0	3.88e-01	93.5%	89.5%
7afrX02	2.30.30.180	Mainly Beta › Roll › SH3 type barrels. › Ribosome maturation factor RimP, C-terminal domain	0.51	37.0	3.78e-01	88.7%	80.0%
4epsA02	2.60.40.3570	Mainly Beta › Sandwich › Immunoglobulin-like ›	0.51	36.0	2.93e-01	75.8%	60.8%

ECOD (27)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3218217	4.1.1.54 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_2	0.71	42.0	4.35e-01	82.3%	61.7%
3575243	4.1.1.1 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_1	0.69	40.0	4.18e-01	82.3%	61.0%
3417443	4.1.1.1 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_1	0.69	41.0	3.94e-01	82.3%	52.2%
3524378	4.1.1.92 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_9	0.68	42.0	4.31e-01	82.3%	63.3%
4013671	4.1.1.0 ↗	beta barrels › SH3 › SH3 › SH3	0.67	38.0	3.99e-01	79.0%	61.8%
3522979	4.1.1.1 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_1	0.67	41.0	4.66e-01	80.6%	82.2%
3366511	4.1.1.92 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_9	0.67	40.0	4.00e-01	82.3%	56.9%
3596004	4.1.1.0 ↗	beta barrels › SH3 › SH3 › SH3	0.66	40.0	3.17e-01	82.3%	28.8%
1698227	2.1.1.103 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › PHA02142	0.65	39.0	4.05e-01	80.6%	62.7%
3436022	4.1.1.175 ↗	beta barrels › SH3 › SH3 › SH3 › MSSS	0.65	40.0	4.20e-01	82.3%	69.1%
3675341	4.1.1.175 ↗	beta barrels › SH3 › SH3 › SH3 › MSSS	0.65	39.0	4.17e-01	82.3%	69.1%
4194684	507.1.1.6 ↗	alpha arrays › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB_C	0.63	47.0	2.79e-01	79.0%	17.5%
3914833	4.1.1.54 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_2	0.63	40.0	3.88e-01	82.3%	57.1%
3585452	4.1.1.334 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_1, SH3_2	0.58	41.0	3.94e-01	82.3%	64.3%
5042869	4.6.1.0 ↗	beta barrels › SH3 › PRC-barrel domain › PRC-barrel domain	0.58	40.0	3.99e-01	72.6%	73.8%
4467360	4.1.1.0 ↗	beta barrels › SH3 › SH3 › SH3	0.56	38.0	3.93e-01	79.0%	73.3%
3386763	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.56	44.0	4.33e-01	85.5%	93.8%
3407841	4.1.1.0 ↗	beta barrels › SH3 › SH3 › SH3	0.53	37.0	3.46e-01	82.3%	60.0%
2441971	4.1.1.40 ↗	beta barrels › SH3 › SH3 › SH3 › FeoA	0.52	42.0	3.91e-01	90.3%	81.0%
3164388	2.4.1.0 ↗	beta barrels › OB-fold › MOP-like › MOP-like	0.52	36.0	3.58e-01	72.6%	75.4%
3225762	4.1.1.92 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_9	0.51	41.0	3.90e-01	88.7%	77.3%
4200822	4.1.1.92 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_9	0.51	42.0	4.24e-01	91.9%	96.8%
3525376	4.1.1.54 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_2	0.51	42.0	4.19e-01	91.9%	92.3%
4282509	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.51	41.0	2.46e-01	95.2%	45.1%
4632138	4.1.1.1 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_1	0.51	42.0	4.16e-01	91.9%	93.8%
4994226	2.4.1.2 ↗	beta barrels › OB-fold › MOP-like › MOP-like › TOBE_2	0.50	38.0	3.05e-01	82.3%	51.2%
3224250	220.1.1.8 ↗	beta barrels › PH domain-like › PH domain-like › PH domain-like › GRAM	0.50	35.0	2.82e-01	77.4%	60.0%

D4 medium residues 459-485_570-754

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00680.26 best	RdRP_1	32.3	6.60e-08	93.9%	37.6%

CATH (5)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3h5xA03	3.30.70.270	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain	0.78	43.0	5.82e-01	78.3%	100.0%
5jxsA02	3.30.70.270	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain	0.74	48.0	5.87e-01	87.3%	97.2%
6qwtA02	3.30.70.270	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain	0.73	47.0	5.78e-01	87.3%	97.2%
1mw7A03	3.30.70.980	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YebC, transcriptional regulation domain	0.70	27.0	4.51e-01	76.9%	100.0%
2bm0A03	3.30.70.870	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Elongation Factor G (Translational Gtpase), domain 3	0.57	16.0	3.21e-01	89.2%	100.0%

ECOD (34)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4875416	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.88	84.0	6.65e-01	100.0%	87.2%
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.87	75.0	5.76e-01	89.6%	78.5%
5366	304.48.1.15 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3	0.87	76.0	5.96e-01	90.1%	79.1%
217141	304.48.1.15 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3	0.83	77.0	6.29e-01	96.2%	99.4%
1789314	304.48.1.8 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1	0.82	72.0	5.70e-01	90.6%	75.6%
3810170	304.48.1.43 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mitovir_RNA_pol	0.80	66.0	7.12e-01	90.6%	100.0%
1875037	304.48.1.8 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1	0.80	71.0	5.67e-01	92.5%	82.3%
3306901	304.48.1.43 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mitovir_RNA_pol	0.78	56.0	6.32e-01	84.4%	94.5%
2541763	304.48.1.8 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1	0.76	70.0	5.69e-01	97.2%	100.0%
3927049	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.75	68.0	5.42e-01	96.2%	85.6%
3589612	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.75	58.0	4.97e-01	80.2%	94.8%
3336938	304.48.1.43 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mitovir_RNA_pol	0.75	71.0	6.65e-01	100.0%	92.4%
3068775	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.74	57.0	5.83e-01	88.2%	82.3%
3928372	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.74	69.0	5.11e-01	100.0%	84.5%
3983816	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.74	62.0	5.83e-01	87.3%	75.2%
None	—		0.73	68.0	5.55e-01	97.2%	100.0%
3939572	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.73	63.0	6.24e-01	91.0%	96.9%
3451410	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.73	68.0	5.17e-01	100.0%	77.2%
None	—		0.72	61.0	5.07e-01	88.2%	62.5%
3899435	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.72	67.0	5.21e-01	99.5%	80.4%
4188583	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.72	65.0	5.13e-01	96.2%	82.7%
4108146	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.71	60.0	5.06e-01	89.2%	69.6%
3884315	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.71	66.0	4.63e-01	100.0%	55.1%
4152428	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.70	60.0	5.01e-01	91.0%	54.9%
3968281	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.69	55.0	5.28e-01	88.2%	73.2%
3923013	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.69	64.0	5.40e-01	98.6%	100.0%
3258201	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.69	54.0	5.19e-01	80.2%	83.0%
3650065	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.67	58.0	5.42e-01	91.0%	82.3%
3495499	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.67	63.0	5.48e-01	99.5%	90.8%
5032235	304.24.1.0 ↗	a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like	0.65	27.0	4.30e-01	75.5%	97.6%
3927490	304.7.1.0 ↗	a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors	0.65	28.0	4.28e-01	76.9%	95.6%
5032014	304.7.1.0 ↗	a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors	0.64	28.0	4.15e-01	75.5%	93.3%
4589829	304.24.1.0 ↗	a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like	0.60	27.0	4.07e-01	75.0%	98.9%
4122730	304.1.1.1 ↗	a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C	0.50	29.0	3.76e-01	80.2%	100.0%

D5 medium residues 486-569

PDB

Domain cluster: rep: hypothetical_protein_2__YP_009333161__Hubei_tombus-like_virus_32__1923280__D105-190

CATH (6)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2dqlA00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.56	42.0	3.77e-01	79.8%	75.7%
5umbA02	3.90.640.10	Alpha Beta › Alpha-Beta Complex › Actin; Chain A, domain 4 › ATPase, substrate binding domain, subdomain 4	0.54	33.0	3.43e-01	92.9%	66.7%
7b1xA01	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.53	39.0	2.80e-01	82.1%	87.1%
6rzqA04	3.90.640.10	Alpha Beta › Alpha-Beta Complex › Actin; Chain A, domain 4 › ATPase, substrate binding domain, subdomain 4	0.52	32.0	3.29e-01	94.0%	61.2%
3aeiA00	1.10.287.370	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.51	33.0	3.26e-01	85.7%	58.5%
3p9aF00	1.10.132.80	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 ›	0.51	31.0	2.70e-01	92.9%	37.3%

ECOD (5)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5050894	1075.3.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1	0.55	41.0	3.03e-01	79.8%	82.5%
3233208	5067.1.1.3 ↗	alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched	0.54	42.0	2.43e-01	84.5%	62.7%
3978692	101.1.9.143 ↗	alpha arrays › HTH › HTH › Putative DNA-binding domain › Virulence_RhuM	0.52	37.0	3.15e-01	77.4%	62.0%
3215753	3226.1.1.1 ↗	alpha complex topology › Uracil Transporter UraA › Uracil Transporter UraA › Uracil Transporter UraA › Xan_ur_permease	0.51	39.0	2.50e-01	85.7%	50.1%
5022945	302.4.1.0 ↗	a+b two layers › Reverse ferredoxin › a+b domain in Acetophenone carboxylase (Apc) alpha subunit › a+b domain in Acetophenone carboxylase (Apc) alpha subunit	0.50	35.0	3.29e-01	72.6%	72.4%

D6 medium residues 755-779_835-893

PDB

Domain cluster: representative

CATH (1)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4us5C00	3.20.20.30	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Luciferase-like domain	0.50	35.0	2.38e-01	72.6%	81.3%

D7 medium residues 780-834

PDB