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RNA-dependent_RNA_polymerase

Euk-Vir

Broad_bean_true_mosaic_virus

RNA-dependent_RNA_polymerase__YP_008400143__Broad_bean_true_mosaic_virus__649890

Identity

Accession:
YP_008400143 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

86.9 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D2 high residues 545-680
PDB
CATH (23)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
7ncyB01 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.76 53.0 5.60e-01 83.8% 80.2%
4d3pA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.72 55.0 5.43e-01 85.3% 73.5%
2esbA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.72 55.0 5.18e-01 85.3% 66.7%
4ki9A00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.70 54.0 5.18e-01 83.8% 69.4%
2p4dA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.68 58.0 5.43e-01 94.9% 75.5%
1ywfA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.64 52.0 4.27e-01 86.0% 58.5%
3imkA00 3.40.50.450 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.60 47.0 4.51e-01 83.1% 89.9%
5ji5A00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.59 53.0 4.12e-01 100.0% 84.6%
3zl8A03 3.90.190.20 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain 0.59 49.0 4.88e-01 89.0% 99.3%
6fu1A00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.58 52.0 3.76e-01 100.0% 78.5%
1zu4A02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.57 45.0 3.83e-01 82.4% 58.3%
1wyzA01 3.40.1010.10 Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain 0.57 43.0 4.67e-01 80.9% 93.8%
3q9cA00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.57 50.0 3.82e-01 100.0% 94.1%
3menB00 3.40.800.20 Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain 0.56 50.0 3.81e-01 100.0% 91.8%
1vpqA00 3.20.20.410 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Protein of unknown function UPF0759 0.56 49.0 3.99e-01 96.3% 95.8%
5l3qA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.56 42.0 3.64e-01 78.7% 58.7%
2o0aA00 3.40.850.20 Alpha Beta › 3-Layer(aba) Sandwich › Kinesin › 0.55 49.0 3.99e-01 100.0% 87.0%
2xvyA02 3.40.50.1400 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.54 39.0 4.09e-01 75.0% 86.3%
4ydsA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.53 41.0 3.53e-01 82.4% 69.5%
4c91A02 3.20.20.520 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosyl hydrolase family 115 0.53 46.0 3.71e-01 97.8% 95.3%
1wiwA02 3.40.50.10490 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 0.51 37.0 3.78e-01 97.1% 77.4%
7vkkB01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.50 37.0 3.11e-01 75.0% 83.1%
5tnvA00 3.20.20.150 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Divalent-metal-dependent TIM barrel enzymes 0.50 44.0 3.48e-01 100.0% 95.1%
ECOD (27)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3229205 2007.2.3.2 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.73 59.0 5.32e-01 94.9% 63.3%
3901404 2007.2.3.2 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.70 60.0 5.52e-01 92.6% 71.7%
3617108 2007.2.3.2 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.70 56.0 5.15e-01 84.6% 67.1%
4000139 2007.2.3.2 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.69 55.0 5.63e-01 84.6% 86.9%
2050785 2007.2.3.2 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.67 58.0 5.20e-01 94.9% 68.0%
3514292 2007.2.3.2 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.67 57.0 5.74e-01 91.9% 91.1%
3705897 2007.2.3.2 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.63 56.0 5.12e-01 94.9% 73.7%
3599998 2007.2.3.0 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II 0.62 52.0 4.87e-01 95.6% 73.9%
5013218 2007.1.2.5 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Bmp 0.62 51.0 4.82e-01 86.8% 95.0%
4181335 7570.1.1.1 a/b three-layered sandwiches › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › Mur_ligase_C 0.60 49.0 4.79e-01 86.8% 99.3%
119404 7563.1.1.5 a/b three-layered sandwiches › MCP/YpsA-related › MCP/YpsA-related › MCP/YpsA-related › cpYpsA 0.60 47.0 4.51e-01 83.1% 89.9%
4192171 7570.1.1.1 a/b three-layered sandwiches › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › Mur_ligase_C 0.60 49.0 4.74e-01 88.2% 99.4%
5015080 2004.1.1.1200 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF835 0.59 44.0 4.52e-01 83.8% 80.8%
4936410 2004.1.1.201 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_26 0.59 45.0 3.78e-01 80.9% 57.3%
3407744 7570.1.1.0 a/b three-layered sandwiches › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain 0.59 49.0 4.53e-01 91.9% 97.2%
3689211 2006.1.5.2 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.58 52.0 3.77e-01 100.0% 69.0%
3592419 2006.1.5.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase 0.58 52.0 3.82e-01 100.0% 69.9%
3260424 2006.1.5.2 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Arginase/deacetylase › Hist_deacetyl 0.58 52.0 3.82e-01 100.0% 71.4%
5075132 2002.1.1.79 a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › DUF72 0.56 49.0 4.05e-01 96.3% 95.1%
3954343 7550.1.1.1 a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase 0.54 41.0 4.01e-01 79.4% 95.2%
4296001 2004.1.1.50 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin 0.53 41.0 3.63e-01 80.9% 58.5%
5005108 2002.1.1.90 a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › MTHFR 0.52 47.0 3.64e-01 100.0% 89.9%
4411008 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.51 40.0 3.89e-01 84.6% 92.9%
3834882 2002.1.1.30 a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Glyco_hydro_18 0.51 45.0 3.40e-01 100.0% 94.4%
3838032 2007.1.14.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Chelatase-like 0.51 33.0 3.31e-01 94.9% 60.7%
4976305 2002.1.1.79 a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › DUF72 0.51 45.0 3.67e-01 96.3% 96.8%
4227815 2002.1.1.30 a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Glyco_hydro_18 0.50 44.0 3.37e-01 100.0% 94.7%
D3 medium residues 14-113_206-223
PDB
Domain cluster: representative
D4 medium residues 114-171_224-255
PDB
CATH (1)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3bfmA01 3.30.930.10 Alpha Beta › 2-Layer Sandwich › BirA Bifunctional Protein; domain 2 › Bira Bifunctional Protein; Domain 2 0.51 42.0 3.45e-01 93.3% 97.2%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2541763 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.79 75.0 4.78e-01 100.0% 33.9%
D5 medium residues 172-205_284-348
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 57.1 2.00e-15 66.7% 14.4%
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2r7rA05 1.10.357.80 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.68 53.0 4.38e-01 83.8% 76.7%
1f14A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.53 38.0 3.03e-01 73.7% 91.8%
2ntxA01 1.20.58.2010 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › PRONE domain, subdomain 1 0.51 41.0 3.33e-01 89.9% 90.0%
2keyA00 1.10.150.130 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain 0.51 38.0 3.67e-01 84.8% 69.6%
ECOD (32)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
217141 304.48.1.15 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 0.81 75.0 4.97e-01 100.0% 48.7%
4875416 304.48.1.13 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.79 72.0 4.75e-01 100.0% 41.8%
2541763 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.78 73.0 4.77e-01 100.0% 53.3%
4014158 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.75 57.0 4.00e-01 79.8% 56.9%
3983816 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.72 67.0 4.89e-01 100.0% 64.4%
3422064 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.71 65.0 4.27e-01 100.0% 52.4%
3877925 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.71 64.0 4.27e-01 100.0% 53.0%
3574984 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.71 64.0 4.28e-01 100.0% 53.9%
3273928 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.71 64.0 3.94e-01 100.0% 36.8%
4524063 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.70 64.0 3.88e-01 100.0% 29.4%
3915025 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.70 64.0 3.82e-01 100.0% 26.4%
None 0.70 64.0 3.86e-01 100.0% 28.4%
3265091 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 63.0 3.92e-01 100.0% 36.5%
3920615 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 64.0 4.08e-01 100.0% 40.2%
3883010 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 63.0 4.48e-01 100.0% 61.0%
3258406 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.69 63.0 3.89e-01 100.0% 32.7%
3928801 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.69 62.0 4.26e-01 100.0% 51.1%
3878013 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.69 63.0 4.14e-01 100.0% 44.7%
3792091 304.48.1.25 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 0.69 63.0 4.27e-01 100.0% 44.6%
3889441 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.69 62.0 4.01e-01 100.0% 42.0%
4424453 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.68 62.0 3.83e-01 100.0% 37.6%
3454701 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.68 56.0 3.98e-01 87.9% 59.3%
3615272 304.48.1.25 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 0.67 61.0 4.07e-01 100.0% 46.0%
3676014 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.67 60.0 3.72e-01 99.0% 52.0%
3598902 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.67 61.0 4.06e-01 100.0% 46.6%
4361688 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.66 60.0 4.02e-01 100.0% 48.0%
3272030 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 57.0 3.83e-01 100.0% 52.2%
4188583 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 55.0 3.66e-01 100.0% 54.9%
3655168 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 53.0 3.59e-01 100.0% 56.7%
4380832 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 53.0 3.59e-01 100.0% 57.7%
3251965 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.53 47.0 3.46e-01 93.9% 52.5%
3933108 110.1.1.0 alpha arrays › DEATH domain › DEATH domain › DEATH domain 0.53 38.0 3.76e-01 84.8% 69.5%
D6 medium residues 256-283_349-443
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 56.9 2.30e-15 78.0% 19.6%