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RNA-dependent_RNA_polymerase
Euk-VirBotrytis_cinerea_RNA_virus_1
RNA-dependent_RNA_polymerase__YP_009115498__Botrytis_cinerea_RNA_virus_1__1568973
Identity
- Accession:
- YP_009115498 ↗
- Protein ID:
- RNA-dependent_RNA_polymerase
- Kingdom:
- euk
Quality
78.4
mean pLDDT
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 96-264
Domain cluster:
representative
CATH (24)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3l09A02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.62 | 32.0 | 4.23e-01 | 97.6% | 96.4% |
| 2pg4A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.59 | 32.0 | 4.10e-01 | 98.8% | 94.5% |
| 1yj7B01 | 3.30.70.1530 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Hypothetical protein rpa1041 | 0.59 | 22.0 | 3.26e-01 | 73.4% | 77.5% |
| 2b0lC00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.59 | 30.0 | 3.97e-01 | 94.7% | 89.4% |
| 6teyA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.57 | 28.0 | 3.81e-01 | 93.5% | 100.0% |
| 2bv6A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.57 | 32.0 | 3.47e-01 | 100.0% | 64.7% |
| 2v1nA01 | 1.10.10.2030 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › DNA/RNA-binding protein Kin17, conserved domain | 0.56 | 31.0 | 3.74e-01 | 95.9% | 86.1% |
| 5iceA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.56 | 28.0 | 3.38e-01 | 92.9% | 74.3% |
| 3lfkD00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 29.0 | 3.47e-01 | 100.0% | 74.5% |
| 3pqkA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 30.0 | 3.66e-01 | 98.8% | 84.8% |
| 7xc2A02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 34.0 | 4.16e-01 | 99.4% | 97.2% |
| 4hw0C00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 28.0 | 3.57e-01 | 97.0% | 84.9% |
| 3cjnA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 30.0 | 3.22e-01 | 100.0% | 58.9% |
| 4rs8A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 28.0 | 3.68e-01 | 98.2% | 94.0% |
| 6pcoC00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 30.0 | 3.37e-01 | 99.4% | 67.4% |
| 4g9yA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 30.0 | 3.30e-01 | 100.0% | 63.2% |
| 1yyvB00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 31.0 | 3.60e-01 | 98.8% | 79.5% |
| 2co5A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.54 | 30.0 | 3.82e-01 | 98.2% | 95.7% |
| 1ub9A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 30.0 | 3.67e-01 | 100.0% | 89.0% |
| 4e1oA03 | 3.90.1150.10 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 | 0.53 | 26.0 | 3.33e-01 | 88.2% | 79.6% |
| 2j9lF01 | 3.90.1280.20 | Alpha Beta › Alpha-Beta Complex › CBS domain Like › | 0.51 | 20.0 | 2.88e-01 | 71.6% | 76.7% |
| 2f4nB02 | 2.40.30.90 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Bacterial fluorinating enzyme like | 0.51 | 26.0 | 3.34e-01 | 89.3% | 85.1% |
| 3m8eA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.51 | 29.0 | 3.53e-01 | 98.2% | 90.1% |
| 6t8qA00 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.51 | 44.0 | 3.29e-01 | 93.5% | 66.4% |
ECOD (12)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3778418 | 142.1.1.42 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors › GREB1_2nd | 0.65 | 48.0 | 4.43e-01 | 75.7% | 95.3% |
| 3905834 | 148.1.3.243 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › GREB1_2nd | 0.65 | 48.0 | 4.45e-01 | 75.1% | 99.5% |
| 3806127 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.59 | 28.0 | 4.07e-01 | 81.1% | 100.0% |
| 5042411 | 101.1.2.150 ↗ | alpha arrays › HTH › HTH › winged helix domain › HTH_45 | 0.57 | 30.0 | 3.94e-01 | 98.8% | 96.5% |
| 3578641 | 304.24.1.0 ↗ | a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like | 0.57 | 21.0 | 3.09e-01 | 71.0% | 74.3% |
| 3942501 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.56 | 31.0 | 3.98e-01 | 97.6% | 100.0% |
| 4941413 | 7523.1.1.0 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II | 0.55 | 23.0 | 3.34e-01 | 91.7% | 84.0% |
| 5006536 | 101.1.2.150 ↗ | alpha arrays › HTH › HTH › winged helix domain › HTH_45 | 0.54 | 28.0 | 3.67e-01 | 98.8% | 92.2% |
| 3173661 | 7502.1.1.0 ↗ | a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS | 0.52 | 31.0 | 3.47e-01 | 89.9% | 75.4% |
| 4974378 | 3016.1.1.6 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › DegT_DnrJ_EryC1 | 0.51 | 33.0 | 3.64e-01 | 90.5% | 80.0% |
| 4004813 | 304.28.1.3 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD-TM1 | 0.51 | 25.0 | 3.22e-01 | 78.7% | 80.0% |
| 3954637 | 101.1.2.309 ↗ | alpha arrays › HTH › HTH › winged helix domain › GPAT_C | 0.50 | 30.0 | 3.70e-01 | 97.0% | 97.0% |
D2
high
residues 900-1031
Domain cluster:
rep: VP2__YP_009665170__Eriocheir_sinensis_reovirus__273810__D721-872
D3
medium
residues 622-679
Domain cluster:
representative
CATH (54)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3h6pC00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.81 | 62.0 | 6.35e-01 | 82.8% | 96.4% |
| 4dciA00 | 6.10.140.1110 | Special › Helix non-globular › Helix Hairpins › | 0.81 | 63.0 | 4.63e-01 | 84.5% | 36.7% |
| 2j5iA02 | 6.10.250.2850 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.79 | 51.0 | 5.83e-01 | 79.3% | 100.0% |
| 2hw5A02 | 1.10.12.10 | Mainly Alpha › Orthogonal Bundle › Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 › Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 | 0.78 | 53.0 | 5.34e-01 | 81.0% | 71.9% |
| 3iqcA00 | 1.20.120.340 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS | 0.77 | 59.0 | 4.71e-01 | 84.5% | 41.2% |
| 3besR03 | 6.10.140.1480 | Special › Helix non-globular › Helix Hairpins › | 0.75 | 56.0 | 5.77e-01 | 81.0% | 83.9% |
| 6xz3A01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.75 | 59.0 | 4.72e-01 | 87.9% | 52.1% |
| 1m5iA00 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.75 | 56.0 | 4.60e-01 | 81.0% | 47.6% |
| 4l0rB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 55.0 | 5.15e-01 | 81.0% | 75.3% |
| 4fvmA06 | 1.10.287.690 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain | 0.73 | 52.0 | 5.59e-01 | 77.6% | 91.7% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.72 | 55.0 | 4.55e-01 | 84.5% | 45.4% |
| 4jylA02 | 1.10.12.10 | Mainly Alpha › Orthogonal Bundle › Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 › Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 | 0.72 | 49.0 | 5.29e-01 | 82.8% | 85.7% |
| 3na7A00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.69 | 53.0 | 3.53e-01 | 84.5% | 21.1% |
| 3fcnA00 | 1.20.1220.20 | Mainly Alpha › Up-down Bundle › Malate Synthase G; Chain: A; Domain 4 › Uncharcterised protein PF01724 | 0.69 | 56.0 | 4.12e-01 | 91.4% | 48.1% |
| 1tjlA00 | 1.20.120.910 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain | 0.69 | 60.0 | 4.55e-01 | 100.0% | 59.3% |
| 2f93B00 | 1.10.287.470 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.69 | 53.0 | 5.59e-01 | 100.0% | 98.0% |
| 4nv0A02 | 1.10.150.340 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain | 0.69 | 50.0 | 4.57e-01 | 81.0% | 58.5% |
| 4h63K00 | 1.10.287.3490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.69 | 54.0 | 4.52e-01 | 84.5% | 63.3% |
| 1zpyA00 | 6.10.140.1960 | Special › Helix non-globular › Helix Hairpins › | 0.69 | 51.0 | 4.43e-01 | 81.0% | 60.4% |
| 2rkhA02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.69 | 51.0 | 4.70e-01 | 82.8% | 61.8% |
| 2a26B01 | 4.10.860.10 | Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › UVR domain | 0.69 | 46.0 | 5.06e-01 | 72.4% | 93.2% |
| 2d5wA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.68 | 51.0 | 3.40e-01 | 86.2% | 19.8% |
| 3fxdB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 50.0 | 5.02e-01 | 79.3% | 94.8% |
| 3gnlB02 | 1.10.287.1890 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.68 | 50.0 | 4.79e-01 | 79.3% | 67.6% |
| 2cazC00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.67 | 50.0 | 4.91e-01 | 82.8% | 75.0% |
| 4fppB01 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.67 | 53.0 | 4.98e-01 | 86.2% | 73.2% |
| 2ahmG01 | 6.10.250.2820 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.67 | 51.0 | 4.34e-01 | 84.5% | 53.5% |
| 1wrdA00 | 1.20.58.160 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 53.0 | 4.45e-01 | 86.2% | 53.1% |
| 3eslA01 | 1.20.58.2070 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 48.0 | 4.49e-01 | 79.3% | 60.0% |
| 4dkcB00 | 1.20.1250.80 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-34 | 0.66 | 50.0 | 3.63e-01 | 81.0% | 30.6% |
| 3rkvA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.66 | 50.0 | 3.76e-01 | 82.8% | 32.7% |
| 2rbdA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.66 | 52.0 | 3.92e-01 | 87.9% | 71.3% |
| 2jdiH02 | 1.20.5.440 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › ATP synthase delta/epsilon subunit, C-terminal domain | 0.66 | 45.0 | 5.08e-01 | 74.1% | 100.0% |
| 6jkvA00 | 3.60.40.10 | Alpha Beta › 4-Layer Sandwich › Phosphatase 2c; domain 1 › PPM-type phosphatase domain | 0.66 | 50.0 | 3.40e-01 | 84.5% | 22.2% |
| 2yw5A00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.65 | 48.0 | 3.70e-01 | 81.0% | 76.1% |
| 4ptsB02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.65 | 48.0 | 3.43e-01 | 81.0% | 27.1% |
| 3vm9A02 | 6.10.140.2110 | Special › Helix non-globular › Helix Hairpins › | 0.64 | 50.0 | 5.13e-01 | 86.2% | 87.7% |
| 6tkvA01 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.64 | 53.0 | 5.13e-01 | 100.0% | 82.4% |
| 2lf0A01 | 4.10.860.10 | Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › UVR domain | 0.64 | 48.0 | 4.80e-01 | 82.8% | 86.7% |
| 1zhcA00 | 6.10.280.50 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 48.0 | 4.49e-01 | 86.2% | 76.3% |
| 2wzvA01 | 3.40.109.10 | Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › NADH Oxidase | 0.63 | 47.0 | 3.20e-01 | 81.0% | 64.2% |
| 2bdeA03 | 1.20.58.1160 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 47.0 | 4.40e-01 | 84.5% | 79.2% |
| 2ckoA02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.62 | 51.0 | 3.42e-01 | 100.0% | 59.3% |
| 3pjaJ01 | 1.20.58.190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 | 0.61 | 45.0 | 3.60e-01 | 82.8% | 36.6% |
| 2jdiG01 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.61 | 53.0 | 5.22e-01 | 96.6% | 98.4% |
| 4wzxA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.61 | 45.0 | 4.15e-01 | 81.0% | 60.0% |
| 3b2eF00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.60 | 52.0 | 5.17e-01 | 100.0% | 93.5% |
| 1skvA00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.59 | 50.0 | 4.88e-01 | 96.6% | 85.9% |
| 4nooB00 | 1.10.8.1160 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.59 | 52.0 | 4.44e-01 | 100.0% | 60.0% |
| 1exzB00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.59 | 45.0 | 3.55e-01 | 89.7% | 63.6% |
| 1n1cA02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.58 | 48.0 | 4.32e-01 | 98.3% | 67.1% |
| 1lrzA03 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.56 | 48.0 | 4.80e-01 | 100.0% | 95.2% |
| 2d54A02 | 2.170.220.10 | Mainly Beta › Beta Complex › Methionyl-trna Synthetase; domain 2 › | 0.56 | 36.0 | 3.04e-01 | 72.4% | 35.1% |
| 7b9cA02 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.54 | 47.0 | 2.89e-01 | 100.0% | 17.6% |
ECOD (38)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3779376 | 601.1.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Vinculin | 0.85 | 68.0 | 5.81e-01 | 86.2% | 65.6% |
| 4999868 | 604.1.1.264 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Oxidored_q2 | 0.80 | 63.0 | 5.44e-01 | 86.2% | 61.1% |
| 5044927 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.77 | 60.0 | 5.95e-01 | 82.8% | 91.7% |
| 5048061 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.77 | 58.0 | 5.90e-01 | 81.0% | 98.2% |
| 5081153 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.77 | 59.0 | 4.98e-01 | 84.5% | 60.0% |
| 3988791 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.75 | 59.0 | 5.54e-01 | 86.2% | 72.9% |
| 4876531 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.74 | 59.0 | 4.10e-01 | 87.9% | 52.9% |
| 5002349 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.74 | 57.0 | 5.56e-01 | 84.5% | 96.9% |
| 3191420 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.74 | 56.0 | 5.44e-01 | 82.8% | 90.8% |
| 2323867 | 4970.1.1.1 ↗ | alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.73 | 59.0 | 5.81e-01 | 87.9% | 85.2% |
| 5003516 | 7577.1.1.3 ↗ | a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › Aminotran_5 | 0.73 | 54.0 | 3.24e-01 | 79.3% | 13.2% |
| 3355429 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.72 | 55.0 | 5.31e-01 | 82.8% | 84.6% |
| 2814929 | 150.1.1.14 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › EncFtn-like | 0.72 | 53.0 | 5.12e-01 | 81.0% | 80.9% |
| 4954658 | 632.19.1.7 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A › PF27212 | 0.72 | 54.0 | 5.24e-01 | 100.0% | 73.8% |
| 4613072 | 101.1.2.721 ↗ | alpha arrays › HTH › HTH › winged helix domain › MarR_2, PF27113 | 0.72 | 55.0 | 3.98e-01 | 82.8% | 33.3% |
| 4964878 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.71 | 57.0 | 5.33e-01 | 86.2% | 74.3% |
| 4446039 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.70 | 53.0 | 5.00e-01 | 82.8% | 78.6% |
| 4568335 | 3812.1.1.8 ↗ | alpha bundles › Type III secretion protein YscE › Type III secretion protein YscE › Type III secretion protein YscE › DUF5398 | 0.70 | 54.0 | 5.13e-01 | 84.5% | 73.9% |
| 3588172 | 10.12.1.0 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix | 0.69 | 54.0 | 4.02e-01 | 86.2% | 84.7% |
| 3247204 | 103.1.1.0 ↗ | alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain | 0.69 | 54.0 | 5.41e-01 | 86.2% | 85.0% |
| 4838801 | 3710.1.1.1 ↗ | alpha bundles › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › CHD5 | 0.69 | 52.0 | 5.05e-01 | 82.8% | 78.5% |
| 4223425 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.68 | 53.0 | 4.39e-01 | 84.5% | 47.6% |
| 3237324 | 3710.1.1.1 ↗ | alpha bundles › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › CHD5 | 0.68 | 52.0 | 5.21e-01 | 84.5% | 86.7% |
| 4573348 | 4044.1.1.0 ↗ | alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins | 0.68 | 52.0 | 5.11e-01 | 86.2% | 87.7% |
| 3332966 | 140.1.1.0 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.68 | 51.0 | 4.19e-01 | 82.8% | 43.6% |
| 4930292 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.68 | 60.0 | 5.70e-01 | 100.0% | 84.3% |
| 3925930 | 604.6.1.1 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › GAT | 0.67 | 53.0 | 4.43e-01 | 86.2% | 53.0% |
| 3491310 | 3826.1.1.67 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Med10 | 0.66 | 49.0 | 4.61e-01 | 82.8% | 64.0% |
| 3586442 | 604.6.1.1 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › GAT | 0.66 | 52.0 | 4.22e-01 | 86.2% | 46.4% |
| 4670545 | 3711.1.1.61 ↗ | alpha bundles › LTXXQ motif family protein › LTXXQ motif family protein › LTXXQ motif family protein › CHD5 | 0.65 | 51.0 | 4.46e-01 | 86.2% | 87.8% |
| 4816886 | 5054.1.1.2 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans | 0.65 | 48.0 | 4.77e-01 | 79.3% | 78.3% |
| 3685099 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.64 | 56.0 | 5.44e-01 | 100.0% | 89.2% |
| 4128596 | 3710.1.1.1 ↗ | alpha bundles › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › CHD5 | 0.63 | 47.0 | 4.57e-01 | 81.0% | 76.9% |
| 4939305 | 7577.1.1.13 ↗ | a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › SepSecS | 0.63 | 50.0 | 3.02e-01 | 84.5% | 14.1% |
| 3916884 | 192.29.1.1 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB_dom | 0.61 | 50.0 | 4.86e-01 | 100.0% | 84.6% |
| 4429835 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.61 | 46.0 | 3.97e-01 | 86.2% | 95.0% |
| 3290879 | 3922.1.1.155 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › DUF4349 | 0.60 | 51.0 | 4.84e-01 | 96.6% | 82.9% |
| 4114191 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.60 | 52.0 | 4.34e-01 | 100.0% | 97.1% |
D4
medium
residues 808-899
Domain cluster:
rep: RNA-dependent_RNA_polymerase__YP_009551328__Phytophthora_infestans_RNA_virus_3__1133557__D653-744
CATH (16)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1mukA02 | 3.90.1850.10 | Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3 | 0.62 | 43.0 | 2.68e-01 | 80.4% | 12.9% |
| 2nr4A02 | 1.20.58.290 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hypothetical membrane protein ta0354_69_121. | 0.60 | 37.0 | 4.47e-01 | 80.4% | 96.6% |
| 1i5eA00 | 3.40.50.2020 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.59 | 44.0 | 3.45e-01 | 80.4% | 94.7% |
| 2e55A00 | 3.40.50.2020 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.59 | 43.0 | 3.43e-01 | 80.4% | 93.8% |
| 2p5kA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.58 | 34.0 | 3.84e-01 | 78.3% | 81.0% |
| 4by6D02 | 1.25.40.800 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.56 | 44.0 | 3.40e-01 | 87.0% | 55.1% |
| 2l02A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.56 | 33.0 | 3.46e-01 | 79.3% | 63.4% |
| 3lapA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 32.0 | 3.66e-01 | 77.2% | 76.5% |
| 4gyiA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.54 | 36.0 | 3.63e-01 | 80.4% | 67.7% |
| 1sd4A01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 32.0 | 3.56e-01 | 79.3% | 84.4% |
| 6l2cB00 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.52 | 42.0 | 2.78e-01 | 88.0% | 94.7% |
| 4pkcC00 | 6.20.90.20 | Special › Other non-globular › SH3 type barrels. › Benzylsuccinate synthase gamma subunit | 0.51 | 25.0 | 3.42e-01 | 70.7% | 97.6% |
| 2co5A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.51 | 34.0 | 3.49e-01 | 85.9% | 69.6% |
| 1zcdA00 | 1.20.1530.10 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › Na+/H+ antiporter like domain | 0.51 | 36.0 | 2.42e-01 | 90.2% | 18.1% |
| 1tbxB00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.50 | 36.0 | 3.64e-01 | 81.5% | 75.6% |
| 1u5tB02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.50 | 33.0 | 3.72e-01 | 84.8% | 91.3% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 223787 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.74 | 53.0 | 5.16e-01 | 79.3% | 68.7% |
| 3426986 | 101.1.2.503 ↗ | alpha arrays › HTH › HTH › winged helix domain › PF25875 | 0.62 | 36.0 | 4.06e-01 | 78.3% | 78.5% |
| 4992415 | 192.11.1.2 ↗ | alpha bundles › Long alpha-hairpin › C-terminal UvrC-binding domain of UvrB › C-terminal UvrC-binding domain of UvrB › CysS_C | 0.62 | 33.0 | 4.27e-01 | 80.4% | 94.0% |
| 4636429 | 192.11.1.2 ↗ | alpha bundles › Long alpha-hairpin › C-terminal UvrC-binding domain of UvrB › C-terminal UvrC-binding domain of UvrB › CysS_C | 0.61 | 34.0 | 4.15e-01 | 81.5% | 89.1% |
| 3609410 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.61 | 43.0 | 4.08e-01 | 81.5% | 61.8% |
| 4985657 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.60 | 34.0 | 3.24e-01 | 77.2% | 46.7% |
| 4574231 | 192.11.1.0 ↗ | alpha bundles › Long alpha-hairpin › C-terminal UvrC-binding domain of UvrB › C-terminal UvrC-binding domain of UvrB | 0.59 | 31.0 | 4.00e-01 | 80.4% | 92.0% |
| 4652240 | 140.1.1.17 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › CysS_C | 0.59 | 32.0 | 2.68e-01 | 81.5% | 28.5% |
| 4387219 | 140.1.1.7 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_2 | 0.58 | 32.0 | 2.62e-01 | 82.6% | 26.8% |
| 3898843 | 101.1.2.503 ↗ | alpha arrays › HTH › HTH › winged helix domain › PF25875 | 0.57 | 33.0 | 3.72e-01 | 75.0% | 75.4% |
| 4399502 | 101.1.2.20 ↗ | alpha arrays › HTH › HTH › winged helix domain › Arg_repressor | 0.57 | 33.0 | 3.83e-01 | 77.2% | 80.0% |
| 3807816 | 101.1.2.245 ↗ | alpha arrays › HTH › HTH › winged helix domain › PORR | 0.56 | 37.0 | 2.87e-01 | 81.5% | 29.0% |
| 4625844 | 101.1.2.20 ↗ | alpha arrays › HTH › HTH › winged helix domain › Arg_repressor | 0.55 | 33.0 | 3.65e-01 | 80.4% | 75.7% |
| 4999836 | 140.1.1.7 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_2 | 0.54 | 37.0 | 3.18e-01 | 80.4% | 44.1% |
| 4096180 | 101.1.2.20 ↗ | alpha arrays › HTH › HTH › winged helix domain › Arg_repressor | 0.54 | 33.0 | 3.88e-01 | 79.3% | 95.0% |
| 5014575 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.54 | 39.0 | 3.73e-01 | 80.4% | 64.5% |
| None | — | 0.53 | 37.0 | 2.94e-01 | 80.4% | 36.1% | |
| 4420336 | 192.11.1.0 ↗ | alpha bundles › Long alpha-hairpin › C-terminal UvrC-binding domain of UvrB › C-terminal UvrC-binding domain of UvrB | 0.52 | 37.0 | 2.93e-01 | 84.8% | 33.5% |
| 4576714 | 140.1.1.7 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_2 | 0.51 | 37.0 | 3.24e-01 | 85.9% | 49.0% |
| 4628534 | 140.1.1.7 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_2 | 0.51 | 37.0 | 3.16e-01 | 85.9% | 45.6% |
| 4943885 | 873.1.1.1 ↗ | a+b complex topology › H-NOX domain › H-NOX domain › H-NOX domain › V4R | 0.51 | 39.0 | 3.49e-01 | 85.9% | 87.9% |
| 5083874 | 140.1.1.14 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › tRNA-synt_1e | 0.50 | 37.0 | 3.32e-01 | 85.9% | 52.9% |
| 3937930 | 206.1.1.10 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Choline_kinase | 0.50 | 40.0 | 2.66e-01 | 87.0% | 56.3% |