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RNA-dependent_RNA_polymerase

Euk-Vir

Sclerotinia_sclerotiorum_megabirnavirus_1

RNA-dependent_RNA_polymerase__YP_009143529__Sclerotinia_sclerotiorum_megabirnavirus_1__1661257

Identity

Accession:
YP_009143529 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

61.5 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 5-19_38-172
PDB
D2 medium residues 246-306
PDB
D3 medium residues 429-509_584-639
PDB
Domain cluster: representative
ECOD (4)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4943123 604.12.1.134 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › AAA 0.59 30.0 3.80e-01 90.5% 80.0%
4651060 633.22.1.0 alpha bundles › Bromodomain-like › Vitamin K epoxide reductase (VKOR) › Vitamin K epoxide reductase (VKOR) 0.55 35.0 3.27e-01 83.9% 52.1%
3450026 633.4.1.1 alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.52 29.0 2.73e-01 100.0% 44.8%
4282150 3896.1.1.3 alpha duplicates or obligate multimers › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase › CobS 0.50 43.0 3.56e-01 95.6% 74.9%
D4 medium residues 510-583_640-668
PDB
Domain cluster: representative
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2r7rA05 1.10.357.80 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.55 50.0 4.13e-01 98.1% 71.6%
4oo1I01 2.40.50.880 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.50 22.0 2.53e-01 96.1% 50.7%
ECOD (5)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1697857 304.48.1.30 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › CPV_RdRP_pol_dom 0.70 63.0 4.36e-01 100.0% 51.0%
2841957 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.70 62.0 4.42e-01 100.0% 67.1%
3960648 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.68 62.0 4.40e-01 100.0% 51.8%
3465998 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 58.0 4.21e-01 100.0% 53.1%
2033701 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.57 50.0 3.92e-01 100.0% 57.7%
D5 medium residues 669-755
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02123.22 best RdRP_4 23.5 3.50e-05 100.0% 16.6%
CATH (32)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4pwuC00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.77 54.0 5.68e-01 93.1% 80.8%
1konA03 3.30.70.980 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YebC, transcriptional regulation domain 0.68 45.0 4.80e-01 94.3% 78.7%
3mahA02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.67 45.0 4.91e-01 78.2% 87.0%
6e4nA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.66 44.0 4.78e-01 74.7% 84.5%
2mzwA01 3.30.70.870 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Elongation Factor G (Translational Gtpase), domain 3 0.64 43.0 4.60e-01 75.9% 78.9%
3ungC03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.63 49.0 4.29e-01 100.0% 55.6%
3h7hB00 3.30.70.940 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain 0.62 48.0 4.76e-01 97.7% 78.9%
2o5aA01 3.30.460.10 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 0.61 54.0 5.11e-01 98.9% 98.0%
2djwA01 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.60 41.0 4.38e-01 79.3% 83.8%
4lowA00 3.30.1360.20 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Transcriptional coactivator/pterin dehydratase 0.60 41.0 4.19e-01 71.3% 73.8%
5wt3A01 3.30.70.2580 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 36.0 4.02e-01 86.2% 80.0%
3ruyA01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.59 41.0 3.48e-01 87.4% 43.4%
3to8A02 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.59 46.0 4.53e-01 92.0% 78.1%
3rqtA01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.59 40.0 2.93e-01 70.1% 39.3%
1ybtB00 3.30.70.1230 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain 0.58 52.0 4.16e-01 100.0% 75.0%
2jhjA02 1.10.340.30 Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Hypothetical protein; domain 2 0.56 46.0 4.15e-01 98.9% 65.0%
5esyA01 3.30.540.10 Alpha Beta › 2-Layer Sandwich › Fructose-1,6-Bisphosphatase; Chain A, domain 1 › Fructose-1,6-Bisphosphatase, subunit A, domain 1 0.56 47.0 3.52e-01 92.0% 52.8%
4o7iA01 3.30.540.10 Alpha Beta › 2-Layer Sandwich › Fructose-1,6-Bisphosphatase; Chain A, domain 1 › Fructose-1,6-Bisphosphatase, subunit A, domain 1 0.55 44.0 3.56e-01 89.7% 53.8%
1vefA01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.55 39.0 3.36e-01 85.1% 44.1%
2fnaA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.54 41.0 3.20e-01 81.6% 85.2%
2i8eA01 3.30.70.240 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.53 37.0 3.92e-01 80.5% 86.5%
1go4A00 3.30.900.10 Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain 0.53 44.0 3.46e-01 94.3% 80.6%
7l9pK01 3.30.900.10 Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain 0.53 31.0 2.83e-01 70.1% 42.0%
3lwsF02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.52 38.0 3.63e-01 87.4% 66.3%
1yfmA02 1.20.200.10 Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) 0.52 42.0 3.03e-01 89.7% 79.2%
1gkxA01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.52 41.0 3.48e-01 88.5% 94.7%
1inpA02 3.30.540.10 Alpha Beta › 2-Layer Sandwich › Fructose-1,6-Bisphosphatase; Chain A, domain 1 › Fructose-1,6-Bisphosphatase, subunit A, domain 1 0.51 39.0 3.07e-01 81.6% 70.1%
4cclA02 3.40.366.30 Alpha Beta › 3-Layer(aba) Sandwich › Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 › 50S ribosomal protein L16 arginine hydroxylase; Chain A, Domain 2 0.51 36.0 2.91e-01 73.6% 66.7%
6qlyA02 1.20.80.10 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › 0.51 31.0 3.07e-01 78.2% 55.7%
3a32A01 3.30.930.10 Alpha Beta › 2-Layer Sandwich › BirA Bifunctional Protein; domain 2 › Bira Bifunctional Protein; Domain 2 0.51 42.0 2.85e-01 90.8% 87.7%
6rh8A02 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.51 40.0 3.39e-01 88.5% 69.6%
3d36B01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.50 40.0 3.33e-01 88.5% 87.5%
ECOD (49)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3964348 304.28.1.3 a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD-TM1 0.75 52.0 5.51e-01 82.8% 82.7%
5063278 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.74 49.0 5.55e-01 92.0% 90.8%
3164240 3012.1.1.0 a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain 0.73 52.0 5.68e-01 83.9% 92.9%
5079022 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.72 56.0 5.19e-01 83.9% 77.3%
4997766 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.71 56.0 5.25e-01 83.9% 81.9%
5040890 304.3.1.1 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain › HMA 0.71 47.0 5.42e-01 82.8% 98.3%
3658421 304.28.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain 0.70 48.0 5.09e-01 80.5% 81.3%
4952886 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.70 55.0 5.03e-01 94.3% 63.5%
5023739 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.70 54.0 5.14e-01 83.9% 82.9%
4957408 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.70 54.0 5.15e-01 83.9% 82.9%
4419939 3012.1.1.0 a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain 0.70 51.0 5.25e-01 85.1% 83.7%
4947994 1036.1.1.0 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain 0.69 55.0 5.17e-01 85.1% 82.9%
3926633 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.69 55.0 4.37e-01 100.0% 41.6%
5070744 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.69 53.0 4.80e-01 82.8% 66.7%
3927940 304.36.1.2 a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › RVT_1 0.69 60.0 5.71e-01 100.0% 90.5%
4950395 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.69 54.0 5.00e-01 83.9% 78.2%
5044372 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.68 53.0 4.93e-01 83.9% 79.1%
5040415 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.68 53.0 5.00e-01 83.9% 82.9%
4930178 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.68 53.0 4.90e-01 83.9% 78.2%
5027911 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.68 53.0 5.10e-01 85.1% 87.0%
5082425 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.67 52.0 5.04e-01 94.3% 73.0%
5050432 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.67 53.0 4.94e-01 86.2% 80.0%
4935680 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.67 52.0 4.84e-01 83.9% 79.1%
3939861 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.67 57.0 5.14e-01 96.6% 69.2%
3935796 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.67 56.0 4.54e-01 100.0% 48.2%
5050596 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.66 50.0 5.51e-01 95.4% 100.0%
3927365 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.66 55.0 4.04e-01 100.0% 33.1%
5025078 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.66 51.0 4.86e-01 83.9% 80.0%
6830 316.1.1.5 a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › RsfS 0.65 53.0 5.00e-01 89.7% 93.5%
4963940 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.63 41.0 4.49e-01 71.3% 82.9%
4937870 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.63 49.0 4.78e-01 83.9% 86.3%
3968428 304.36.1.1 a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › DUF520 0.63 50.0 4.96e-01 86.2% 92.2%
4975149 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.63 49.0 4.72e-01 85.1% 87.0%
5016606 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.62 42.0 3.60e-01 77.0% 43.6%
3919669 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.61 48.0 4.48e-01 98.9% 67.3%
4649093 304.48.1.4 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Guanylate_cyc 0.61 56.0 4.28e-01 100.0% 78.9%
5048091 2005.1.1.7 a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › tRNA-synt_1d 0.60 48.0 3.07e-01 86.2% 20.9%
3515653 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.59 44.0 4.49e-01 80.5% 84.7%
4559752 242.1.1.6 a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_WhiA 0.58 39.0 3.90e-01 73.6% 66.7%
4675939 242.1.1.6 a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_WhiA 0.55 39.0 3.62e-01 74.7% 56.5%
4271274 225.1.1.28 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › PF29744 0.53 43.0 3.55e-01 88.5% 69.4%
4244236 3681.1.1.0 a+b complex topology › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit 0.53 36.0 3.37e-01 70.1% 75.5%
4324625 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.53 41.0 3.48e-01 86.2% 91.6%
6565 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.53 36.0 3.27e-01 70.1% 53.7%
4018916 149.1.1.1 alpha arrays › Cytochrome P450 › Cytochrome P450 › Cytochrome P450 › p450 0.52 43.0 2.74e-01 93.1% 76.4%
3172255 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.51 41.0 3.21e-01 88.5% 65.5%
3704440 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.51 40.0 3.44e-01 88.5% 66.0%
3671286 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.50 40.0 3.23e-01 88.5% 93.3%
3970801 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.50 40.0 3.27e-01 88.5% 88.8%
D6 medium residues 847-920
PDB
D7 medium residues 1026-1117
PDB