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RNA-dependent_RNA_polymerase
Euk-VirHubei_lepidoptera_virus_3
RNA-dependent_RNA_polymerase__YP_009330258__Hubei_lepidoptera_virus_3__1922905
Identity
- Accession:
- YP_009330258 ↗
- Protein ID:
- RNA-dependent_RNA_polymerase
- Kingdom:
- euk
Quality
85.6
mean pLDDT
Cluster
View cluster (29 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 348-631
Domain cluster:
rep: hypothetical_protein_2__YP_009336713__Beihai_toti-like_virus_4__1922734__D167-187_213-323_360-427
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22212.2 best | CPV_RdRP_pol_dom | 318.6 | 6.00e-95 | 100.0% | 77.2% |
CATH (4)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1mukA02 | 3.90.1850.10 | Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3 | 0.82 | 79.0 | 6.31e-01 | 100.0% | 58.4% |
| 2r7rA05 | 1.10.357.80 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › | 0.75 | 45.0 | 5.67e-01 | 98.2% | 94.9% |
| 2kjwA00 | 3.30.70.60 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B | 0.51 | 17.0 | 2.85e-01 | 75.7% | 81.2% |
| 3jvvA01 | 3.30.450.90 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › | 0.51 | 15.0 | 2.43e-01 | 82.7% | 63.0% |
ECOD (34)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697857 | 304.48.1.30 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › CPV_RdRP_pol_dom | 0.89 | 80.0 | 7.35e-01 | 100.0% | 75.7% |
| 5368 | 304.48.1.23 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_5 | 0.82 | 79.0 | 6.91e-01 | 100.0% | 75.3% |
| 223786 | 304.48.1.16 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_4 | 0.77 | 63.0 | 6.04e-01 | 98.9% | 74.3% |
| 3983816 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.74 | 43.0 | 4.63e-01 | 70.8% | 65.2% |
| 5018583 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.70 | 49.0 | 4.77e-01 | 87.3% | 63.8% |
| 3173834 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.70 | 50.0 | 4.38e-01 | 86.3% | 49.8% |
| 3945039 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.70 | 50.0 | 4.75e-01 | 87.3% | 61.8% |
| 4461237 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.70 | 50.0 | 4.02e-01 | 87.3% | 39.4% |
| 4516798 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.69 | 50.0 | 4.20e-01 | 87.3% | 44.8% |
| 4497954 | 304.48.1.73 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1, RVT_N | 0.69 | 50.0 | 4.91e-01 | 87.0% | 67.4% |
| 3589612 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.69 | 51.0 | 4.86e-01 | 87.0% | 64.5% |
| 3272030 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.68 | 57.0 | 5.06e-01 | 100.0% | 62.3% |
| 4004424 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.68 | 50.0 | 4.57e-01 | 87.0% | 56.8% |
| 3258406 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.68 | 57.0 | 4.48e-01 | 100.0% | 43.9% |
| 3938749 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.67 | 57.0 | 5.15e-01 | 100.0% | 67.3% |
| 3676014 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.67 | 53.0 | 4.15e-01 | 100.0% | 40.5% |
| 5078830 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.66 | 47.0 | 4.91e-01 | 81.0% | 76.6% |
| 5002351 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.66 | 49.0 | 4.43e-01 | 87.0% | 56.3% |
| 3645993 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.66 | 53.0 | 4.74e-01 | 100.0% | 60.8% |
| 4138932 | 304.48.1.72 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_N | 0.65 | 46.0 | 4.59e-01 | 86.6% | 68.0% |
| 1695458 | 304.48.1.7 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flu_PB1 | 0.65 | 61.0 | 5.11e-01 | 100.0% | 75.4% |
| 4424453 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.64 | 53.0 | 4.21e-01 | 100.0% | 44.0% |
| 3615272 | 304.48.1.25 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 | 0.64 | 52.0 | 4.64e-01 | 90.1% | 61.0% |
| 1411401 | 304.48.1.7 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flu_PB1 | 0.64 | 61.0 | 5.01e-01 | 100.0% | 75.4% |
| 3792091 | 304.48.1.25 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 | 0.64 | 47.0 | 4.39e-01 | 90.5% | 60.9% |
| 3598902 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.64 | 51.0 | 4.60e-01 | 89.4% | 61.3% |
| 3267570 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.63 | 45.0 | 4.21e-01 | 100.0% | 59.1% |
| 3209439 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.62 | 52.0 | 4.99e-01 | 100.0% | 76.6% |
| 4262041 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.61 | 37.0 | 3.88e-01 | 84.9% | 65.1% |
| 4236458 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.59 | 45.0 | 4.30e-01 | 86.6% | 68.4% |
| 3097450 | 304.48.1.12 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mononeg_RNA_pol | 0.59 | 55.0 | 4.91e-01 | 100.0% | 80.0% |
| 4068028 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.57 | 41.0 | 4.16e-01 | 82.4% | 72.1% |
| 3174620 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.53 | 39.0 | 3.82e-01 | 75.4% | 68.7% |
| 4991918 | 632.18.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › hypothetical protein PA2901 › hypothetical protein PA2901 | 0.50 | 19.0 | 2.99e-01 | 95.1% | 87.6% |
D2
high
residues 1003-1069_1126-1200
Domain cluster:
representative
Pfam (2)
ECOD (1)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697859 | 4962.1.1.4 ↗ | alpha complex topology › C-terminal additional helical subdomain in reovirus polymerase lambda3 › C-terminal additional helical subdomain in reovirus polymerase lambda3 › C-terminal additional helical subdomain in reovirus polymerase lambda3 › CPV_RdRP_C | 0.82 | 78.0 | 5.58e-01 | 99.3% | 55.7% |
D3
medium
residues 45-228
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22209.2 best | CPV_RdRP_N | 234.2 | 2.30e-69 | 94.0% | 69.0% |
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2r7rA02 | 1.20.120.1390 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.69 | 54.0 | 5.83e-01 | 97.8% | 96.1% |
ECOD (7)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697856 | 4963.1.1.3 ↗ | alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › CPV_RdRP_N | 0.90 | 88.0 | 6.86e-01 | 100.0% | 56.7% |
| 4905 | 4963.1.1.2 ↗ | alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › RdRP_5 | 0.82 | 78.0 | 6.01e-01 | 100.0% | 57.8% |
| 5018197 | 3487.1.1.1 ↗ | a+b three layers › Integron cassette protein VCH_CASS3 › Integron cassette protein VCH_CASS3 › Integron cassette protein VCH_CASS3 › M1E1E6-like | 0.58 | 32.0 | 3.96e-01 | 98.9% | 84.3% |
| 3324571 | 611.7.1.8 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › RPW8 | 0.53 | 34.0 | 3.62e-01 | 76.6% | 70.9% |
| 3314358 | 1021.1.1.2 ↗ | a+b two layers › C-terminal domain in RNA helicases › C-terminal domain in RNA helicases › C-terminal domain in RNA helicases › RNA_hel_CTD | 0.52 | 23.0 | 3.24e-01 | 89.7% | 85.9% |
| 5051294 | 601.41.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › C-terminal domain in uncharacterized DUF3829-like protein › C-terminal domain in uncharacterized DUF3829-like protein | 0.51 | 28.0 | 3.28e-01 | 98.4% | 76.8% |
| 4956867 | 7064.1.1.0 ↗ | alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 | 0.51 | 29.0 | 3.28e-01 | 89.7% | 72.9% |
D4
medium
residues 229-347
Domain cluster:
rep: RNA-dependent_RNA_polymerase_P3a__YP_003934919__Raspberry_latent_virus__907191__D248-343
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22209.2 best | CPV_RdRP_N | 99.5 | 3.00e-28 | 64.7% | 30.6% |
D5
medium
residues 632-717
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22212.2 best | CPV_RdRP_pol_dom | 70.6 | 1.40e-19 | 82.6% | 19.5% |
CATH (27)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2r7rA04 | 3.30.70.2480 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.74 | 68.0 | 5.49e-01 | 100.0% | 54.8% |
| 3va7A05 | 3.30.1360.40 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.73 | 46.0 | 4.40e-01 | 72.1% | 55.0% |
| 4kyzA00 | 3.30.70.600 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 | 0.72 | 54.0 | 4.35e-01 | 83.7% | 41.3% |
| 3cjeA00 | 3.30.300.20 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain | 0.71 | 51.0 | 4.24e-01 | 75.6% | 58.0% |
| 1ghhA00 | 3.30.910.10 | Alpha Beta › 2-Layer Sandwich › Protein Binding, DinI Protein; Chain A › DinI-like | 0.71 | 49.0 | 5.02e-01 | 72.1% | 75.3% |
| 4alzA03 | 3.30.70.1770 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.70 | 49.0 | 5.54e-01 | 77.9% | 100.0% |
| 2yqrA01 | 3.30.1370.10 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 | 0.69 | 48.0 | 4.56e-01 | 73.3% | 75.7% |
| 2kl8A00 | 3.30.70.600 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 | 0.68 | 51.0 | 5.17e-01 | 82.6% | 81.2% |
| 2kjwA00 | 3.30.70.60 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B | 0.68 | 52.0 | 5.02e-01 | 82.6% | 76.0% |
| 1mg7A01 | 3.30.70.1000 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Switch protein XOL-1, GHMP-like | 0.68 | 53.0 | 4.26e-01 | 86.0% | 42.3% |
| 2c5wB00 | 3.40.710.10 | Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily | 0.65 | 45.0 | 2.93e-01 | 72.1% | 86.5% |
| 2qpqA01 | 3.40.190.150 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Bordetella uptake gene, domain 1 | 0.64 | 57.0 | 4.57e-01 | 100.0% | 87.2% |
| 2zueA01 | 3.30.1360.70 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Arginyl tRNA synthetase N-terminal domain | 0.63 | 49.0 | 4.53e-01 | 86.0% | 72.2% |
| 2e1bA02 | 3.30.980.10 | Alpha Beta › 2-Layer Sandwich › Threonyl-tRNA Synthetase; Chain A, domain 2 › Threonyl-trna Synthetase; Chain A, domain 2 | 0.63 | 50.0 | 4.42e-01 | 88.4% | 93.8% |
| 3p96A02 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.61 | 47.0 | 4.82e-01 | 94.2% | 88.1% |
| 1v4pC01 | 3.30.980.10 | Alpha Beta › 2-Layer Sandwich › Threonyl-tRNA Synthetase; Chain A, domain 2 › Threonyl-trna Synthetase; Chain A, domain 2 | 0.59 | 47.0 | 4.45e-01 | 88.4% | 90.7% |
| 2i6tA02 | 3.90.110.10 | Alpha Beta › Alpha-Beta Complex › L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 › Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal | 0.59 | 47.0 | 3.96e-01 | 89.5% | 91.4% |
| 3zl8A02 | 3.40.1190.10 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain | 0.55 | 40.0 | 2.98e-01 | 76.7% | 45.6% |
| 2xzmG00 | 1.10.455.10 | Mainly Alpha › Orthogonal Bundle › Ribosomal Protein S7 › Ribosomal protein S7/S5 | 0.54 | 34.0 | 2.69e-01 | 73.3% | 29.2% |
| 2x9oA00 | 3.40.1500.20 | Alpha Beta › 3-Layer(aba) Sandwich › oxygen-dependent coproporphyrinogen oxidase › | 0.54 | 46.0 | 3.43e-01 | 97.7% | 100.0% |
| 1sb7A02 | 3.30.2340.10 | Alpha Beta › 2-Layer Sandwich › Pseudouridine synthase › TruD, insertion domain | 0.52 | 43.0 | 3.77e-01 | 91.9% | 75.0% |
| 5tprA02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.52 | 45.0 | 3.42e-01 | 97.7% | 84.3% |
| 3q9vA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.52 | 45.0 | 4.35e-01 | 97.7% | 94.9% |
| 3lwsF02 | 3.90.1150.10 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 | 0.52 | 38.0 | 3.64e-01 | 88.4% | 66.3% |
| 1jg8A02 | 3.90.1150.10 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 | 0.51 | 36.0 | 3.56e-01 | 87.2% | 67.7% |
| 3wnzA02 | 3.30.1490.20 | Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › ATP-grasp fold, A domain | 0.50 | 37.0 | 3.64e-01 | 80.2% | 72.8% |
| 4cclA02 | 3.40.366.30 | Alpha Beta › 3-Layer(aba) Sandwich › Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 › 50S ribosomal protein L16 arginine hydroxylase; Chain A, Domain 2 | 0.50 | 36.0 | 2.94e-01 | 76.7% | 56.0% |
ECOD (28)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4999908 | 3501.1.1.0 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 | 0.82 | 52.0 | 5.88e-01 | 73.3% | 84.6% |
| 5012782 | 3501.1.1.2 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › DUF2067 | 0.82 | 52.0 | 5.96e-01 | 73.3% | 86.2% |
| 4990535 | 305.2.1.2 ↗ | a+b two layers › DCoH-like › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › DUF2067 | 0.80 | 50.0 | 5.64e-01 | 72.1% | 83.1% |
| 4976823 | 305.2.1.0 ↗ | a+b two layers › DCoH-like › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) | 0.78 | 51.0 | 5.50e-01 | 72.1% | 77.3% |
| 4943420 | 3501.1.1.2 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › DUF2067 | 0.78 | 51.0 | 5.55e-01 | 73.3% | 81.4% |
| 3287406 | 306.6.1.1 ↗ | a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like › CT_C_D | 0.76 | 48.0 | 5.01e-01 | 73.3% | 68.8% |
| 5051224 | 304.128.1.0 ↗ | a+b two layers › Alpha-beta plaits › ferredoxin-like domain in periplasmic region of MacB › ferredoxin-like domain in periplasmic region of MacB | 0.74 | 49.0 | 5.37e-01 | 82.6% | 84.3% |
| 5070538 | 3501.1.1.1 ↗ | a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 › Pcc1 | 0.73 | 48.0 | 5.19e-01 | 73.3% | 81.4% |
| 3935908 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.73 | 66.0 | 5.78e-01 | 100.0% | 68.0% |
| 4928456 | 306.6.1.0 ↗ | a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like | 0.72 | 46.0 | 5.17e-01 | 70.9% | 86.2% |
| 1034330 | 324.1.1.1 ↗ | a+b two layers › OsmC-like › OsmC-like › OsmC-like › OsmC | 0.71 | 51.0 | 4.25e-01 | 75.6% | 58.0% |
| 4938397 | 304.117.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC | 0.70 | 49.0 | 5.21e-01 | 95.3% | 84.0% |
| 5012054 | 310.3.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related | 0.70 | 52.0 | 5.66e-01 | 95.3% | 95.7% |
| 3800293 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.70 | 54.0 | 5.29e-01 | 83.7% | 82.8% |
| 3596282 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.70 | 52.0 | 5.04e-01 | 79.1% | 85.3% |
| 3967558 | 306.6.1.1 ↗ | a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like › CT_C_D | 0.69 | 46.0 | 4.69e-01 | 73.3% | 69.4% |
| 3282344 | 304.20.1.0 ↗ | a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0.69 | 54.0 | 5.17e-01 | 86.0% | 80.0% |
| 3971382 | 3261.1.1.4 ↗ | a+b two layers › amino-terminal domain of OmpATb › amino-terminal domain of OmpATb › amino-terminal domain of OmpATb › Yop-YscD_ppl_3rd | 0.68 | 49.0 | 5.38e-01 | 79.1% | 100.0% |
| 3616172 | 304.162.1.2 ↗ | a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › FLAD1_M | 0.68 | 52.0 | 5.36e-01 | 90.7% | 87.5% |
| 3963906 | 304.55.2.0 ↗ | a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like | 0.67 | 46.0 | 4.52e-01 | 74.4% | 65.3% |
| 3624104 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.65 | 49.0 | 5.22e-01 | 82.6% | 94.5% |
| 5050596 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.64 | 49.0 | 5.27e-01 | 100.0% | 100.0% |
| 3879987 | 601.48.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › vWA2 C-terminal domain › vWA2 C-terminal domain | 0.60 | 34.0 | 3.89e-01 | 77.9% | 73.8% |
| 3190457 | 7573.1.1.1 ↗ | a/b three-layered sandwiches › PRTase-like › PRTase-like › PRTase-like › Pribosyltran | 0.54 | 41.0 | 3.18e-01 | 82.6% | 68.3% |
| 3760685 | 109.4.1.335 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SEN1_N | 0.52 | 36.0 | 2.20e-01 | 70.9% | 18.9% |
| 4059011 | 2008.1.1.48 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › RE_NgoBV | 0.51 | 44.0 | 3.60e-01 | 98.8% | 62.9% |
| 2526356 | 2008.1.1.48 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › RE_NgoBV | 0.50 | 44.0 | 3.25e-01 | 100.0% | 69.5% |
| 3928653 | 247.1.1.0 ↗ | a+b four layers › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase | 0.50 | 43.0 | 3.45e-01 | 100.0% | 46.7% |
D6
medium
residues 718-842
Domain cluster:
representative
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1mukA02 | 3.90.1850.10 | Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3 | 0.78 | 55.0 | 3.53e-01 | 100.0% | 17.5% |
| 1dfaA03 | 3.10.28.10 | Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases | 0.58 | 33.0 | 3.77e-01 | 78.4% | 73.7% |
| 7dl8C01 | 3.30.110.20 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain | 0.55 | 31.0 | 3.56e-01 | 78.4% | 76.4% |
| 2ca9A02 | 3.30.70.1150 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT-like. Chain A, domain 2 | 0.54 | 29.0 | 3.38e-01 | 73.6% | 73.0% |
| 4ft4A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.52 | 37.0 | 2.73e-01 | 73.6% | 58.0% |
ECOD (17)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697858 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.91 | 83.0 | 7.78e-01 | 100.0% | 80.8% |
| 3300663 | 304.12.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 | 0.60 | 30.0 | 3.91e-01 | 70.4% | 85.7% |
| 5030783 | 242.1.1.3 ↗ | a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › Hom_end | 0.59 | 33.0 | 3.72e-01 | 79.2% | 70.5% |
| 3740284 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.58 | 32.0 | 3.74e-01 | 76.0% | 76.5% |
| 4962586 | 304.8.1.8 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_4 | 0.58 | 31.0 | 3.70e-01 | 77.6% | 77.1% |
| 4464568 | 242.1.1.7 ↗ | a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 | 0.57 | 34.0 | 3.77e-01 | 82.4% | 74.0% |
| 3253272 | 2003.1.5.54 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_10 | 0.56 | 42.0 | 3.21e-01 | 80.0% | 66.7% |
| 4941329 | 242.1.1.7 ↗ | a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 | 0.55 | 34.0 | 3.75e-01 | 80.0% | 76.0% |
| 4179054 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.55 | 32.0 | 3.15e-01 | 84.0% | 51.4% |
| 3703249 | 306.3.1.1 ↗ | a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 | 0.54 | 31.0 | 3.16e-01 | 79.2% | 55.5% |
| 3846578 | 225.1.1.16 ↗ | a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › DUF4554 | 0.54 | 37.0 | 3.42e-01 | 80.0% | 54.4% |
| 3785963 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.54 | 42.0 | 3.44e-01 | 82.4% | 64.6% |
| 3781188 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.53 | 30.0 | 3.45e-01 | 84.8% | 75.6% |
| 4202370 | 304.8.1.5 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NIL | 0.52 | 30.0 | 3.27e-01 | 77.6% | 68.0% |
| 4993810 | 242.1.1.7 ↗ | a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 | 0.52 | 37.0 | 3.82e-01 | 82.4% | 77.5% |
| 4998393 | 242.1.1.0 ↗ | a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases | 0.51 | 33.0 | 3.48e-01 | 80.8% | 71.8% |
| 5029542 | 242.1.1.7 ↗ | a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 | 0.50 | 31.0 | 3.37e-01 | 80.8% | 73.3% |
D7
medium
residues 843-917
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22213.2 best | CPV_RdRP_C | 74.9 | 1.00e-20 | 82.7% | 18.7% |
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3i9v101 | 6.10.250.1450 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.52 | 31.0 | 3.33e-01 | 72.0% | 70.0% |
D8
medium
residues 918-1002_1086-1104
Domain cluster:
rep: RNA_dependent_RNA_polymerase__NP_149135__Cypovirus_14__205908__D923-1017
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22213.2 best | CPV_RdRP_C | 102.3 | 4.60e-29 | 81.7% | 24.8% |
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3layF00 | 1.20.120.1490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.62 | 30.0 | 3.44e-01 | 93.3% | 61.5% |
| 4oydB00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.55 | 26.0 | 2.58e-01 | 91.3% | 39.3% |
| 2oauA01 | 1.10.287.1260 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.53 | 36.0 | 3.68e-01 | 70.2% | 98.0% |
ECOD (6)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697859 | 4962.1.1.4 ↗ | alpha complex topology › C-terminal additional helical subdomain in reovirus polymerase lambda3 › C-terminal additional helical subdomain in reovirus polymerase lambda3 › C-terminal additional helical subdomain in reovirus polymerase lambda3 › CPV_RdRP_C | 0.65 | 57.0 | 3.83e-01 | 93.3% | 49.6% |
| 3561510 | 601.4.1.63 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › TRC8_N | 0.64 | 31.0 | 2.99e-01 | 90.4% | 40.0% |
| 4932808 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.56 | 31.0 | 3.07e-01 | 90.4% | 48.7% |
| 3723690 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.56 | 34.0 | 3.24e-01 | 100.0% | 52.0% |
| 3973441 | 606.1.1.0 ↗ | alpha complex topology › Nop N-terminal domain › Nop N-terminal domain › Nop N-terminal domain | 0.52 | 33.0 | 3.49e-01 | 90.4% | 72.2% |
| 3712286 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.50 | 30.0 | 2.30e-01 | 78.8% | 25.8% |