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RNA-dependent_RNA_polymerase

Euk-Vir

Beihai_narna-like_virus_22

RNA-dependent_RNA_polymerase__YP_009333139__Beihai_narna-like_virus_22__1922450

Identity

Accession:
YP_009333139 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

82.8 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 870-1003
PDB
D2 medium residues 24-118
PDB
Domain cluster: representative
CATH (8)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
6lo8F01 1.10.287.810 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Mitochondrial import inner membrane translocase subunit tim13 like domains 0.59 28.0 3.18e-01 98.9% 59.4%
4nsmA00 6.10.250.2770 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.58 28.0 3.17e-01 96.8% 59.2%
3ljcA02 1.20.58.1480 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 48.0 4.38e-01 95.8% 68.3%
2wujA00 6.10.250.660 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.54 28.0 3.59e-01 95.8% 94.0%
1a3qA01 2.60.40.340 Mainly Beta › Sandwich › Immunoglobulin-like › Rel homology domain (RHD), DNA-binding domain 0.53 38.0 3.12e-01 75.8% 50.8%
3rrkA02 1.20.1460.20 Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › 0.52 37.0 3.23e-01 80.0% 45.8%
4bzaA01 3.10.20.310 Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac 0.50 30.0 3.45e-01 80.0% 82.4%
4gyvE00 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.50 38.0 3.02e-01 83.2% 98.6%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3539619 7015.1.1.1 alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › DHHC 0.56 42.0 3.63e-01 80.0% 60.0%
D3 medium residues 119-207
PDB
Domain cluster: representative
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.68 40.0 3.81e-01 84.3% 51.0%
3lnnB03 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.65 36.0 4.15e-01 80.9% 73.1%
1v5dA01 1.50.10.10 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › 0.61 44.0 2.97e-01 76.4% 100.0%
4iloA00 1.10.287.1490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.61 42.0 3.08e-01 71.9% 100.0%
1e91A00 1.20.1160.11 Mainly Alpha › Up-down Bundle › Paired amphipathic helix 2 (pah2 repeat) › Paired amphipathic helix 0.60 43.0 4.41e-01 74.2% 95.3%
2l10A00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.59 50.0 4.22e-01 95.5% 84.8%
4e6nA02 6.10.140.1010 Special › Helix non-globular › Helix Hairpins › 0.59 35.0 4.00e-01 80.9% 78.8%
5cofA00 1.20.120.450 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain 0.56 43.0 3.47e-01 82.0% 68.6%
4qgpB00 1.10.287.1080 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like 0.54 40.0 3.82e-01 97.8% 66.4%
4rngC00 1.20.1280.290 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.53 35.0 3.63e-01 95.5% 73.5%
3er9B01 1.20.1270.320 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Poxvirus poly(A) polymerase, N domain 0.52 30.0 2.90e-01 84.3% 46.2%
1v8bA01 3.40.50.1480 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Adenosylhomocysteinase-like 0.51 41.0 2.90e-01 91.0% 28.3%
3axjB01 1.20.58.190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 0.50 37.0 3.14e-01 94.4% 45.2%
ECOD (20)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3516873 159.1.1.3 alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › Hypothetical protein AF_0060 › DUF1599 0.66 45.0 4.69e-01 98.9% 77.5%
3219672 601.1.2.79 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › TMEM126_like 0.64 49.0 3.83e-01 80.9% 81.5%
4168740 563.1.1.1 alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP 0.63 54.0 4.25e-01 93.3% 49.4%
4353495 563.1.1.1 alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP 0.62 54.0 4.29e-01 97.8% 54.7%
3359325 4207.1.2.0 alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › MED7 hinge region 0.62 36.0 3.18e-01 77.5% 40.8%
3494376 109.46.1.1 alpha superhelices › Repetitive alpha hairpins › Helical domain in TOPLESS related protein 2 (TPR2) › Helical domain in TOPLESS related protein 2 (TPR2) › CTLH 0.60 43.0 3.90e-01 75.3% 66.4%
3210541 611.7.1.9 alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › SesA 0.60 34.0 2.81e-01 80.9% 30.0%
3036200 108.2.1.0 alpha arrays › EF-hand › Insect pheromone/odorant-binding proteins › Insect pheromone/odorant-binding proteins 0.59 41.0 3.66e-01 71.9% 89.0%
3167154 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 39.0 2.92e-01 98.9% 26.2%
5019788 5050.1.1.86 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › LysE 0.56 49.0 3.74e-01 96.6% 88.8%
3734442 192.8.1.35 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › DUF6594 0.54 33.0 2.91e-01 78.7% 41.5%
4976290 192.1.1.0 alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain 0.53 37.0 3.88e-01 82.0% 80.0%
3973681 5051.1.1.0 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like 0.53 45.0 2.91e-01 100.0% 72.7%
3387205 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.53 35.0 3.57e-01 79.8% 68.9%
3280270 633.6.1.1 alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1 0.52 42.0 3.60e-01 96.6% 55.0%
3619314 633.6.1.1 alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1 0.52 40.0 3.88e-01 95.5% 74.0%
3971351 4121.1.1.0 a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like 0.51 37.0 2.80e-01 76.4% 60.9%
3201716 622.1.1.7 alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain › DUF7607 0.51 43.0 4.02e-01 100.0% 74.5%
3186154 622.1.1.7 alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain › DUF7607 0.50 42.0 3.96e-01 100.0% 74.5%
3753969 622.4.1.0 alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related 0.50 41.0 4.02e-01 92.1% 80.0%
D4 medium residues 232-258_420-476
PDB
Domain cluster: representative
CATH (20)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4m9aA01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.59 49.0 4.47e-01 94.0% 94.1%
2yvkA01 1.20.120.420 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 0.59 45.0 3.72e-01 81.0% 58.1%
1rx0C01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.59 49.0 4.39e-01 94.0% 86.2%
2ix5A01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.58 49.0 4.26e-01 95.2% 83.6%
3solA00 1.20.58.1630 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Chaperone lipoprotein PulS/OutS 0.58 33.0 3.28e-01 92.9% 50.5%
8fbnB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.58 47.0 3.48e-01 89.3% 37.8%
2az0B00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.57 34.0 3.65e-01 95.2% 69.0%
5lnkJ01 1.20.120.1200 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ 0.57 43.0 3.40e-01 83.3% 39.6%
2vsgA02 1.10.470.10 Mainly Alpha › Orthogonal Bundle › Variant Surface Glycoprotein, subunit A; domain 2 › Variant Surface Glycoprotein, subunit A, domain 2 0.55 37.0 3.05e-01 100.0% 36.9%
2d2sA01 1.20.58.1210 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain 0.55 40.0 3.63e-01 77.4% 77.6%
1ls1A01 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.54 40.0 3.94e-01 78.6% 76.4%
1aoyA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.53 27.0 2.86e-01 71.4% 51.3%
7oq4Z01 1.20.120.950 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein DUF5062 0.53 40.0 3.85e-01 81.0% 72.4%
4dmvA01 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 38.0 3.80e-01 76.2% 82.4%
3cqcB01 1.20.58.1380 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.52 41.0 4.06e-01 84.5% 91.1%
4it4A02 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.52 39.0 3.89e-01 81.0% 95.6%
4dqlA03 3.40.50.80 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module 0.51 42.0 3.40e-01 92.9% 46.6%
1wgwA00 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.51 38.0 3.66e-01 81.0% 72.7%
3b9qA01 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.51 36.0 3.56e-01 79.8% 69.7%
2zj2A03 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.50 35.0 3.54e-01 73.8% 95.2%
ECOD (16)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3428914 650.1.1.1 alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.67 35.0 4.14e-01 94.0% 74.5%
3713038 650.1.1.1 alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.62 40.0 4.17e-01 85.7% 70.0%
3930451 386.1.1.10 few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › MAT1 0.61 35.0 4.04e-01 100.0% 78.3%
4431515 304.41.1.1 a+b two layers › Alpha-beta plaits › Glutamyl tRNA-reductase catalytic, N-terminal domain › Glutamyl tRNA-reductase catalytic, N-terminal domain › GlutR_N 0.58 43.0 3.61e-01 81.0% 87.7%
55142 604.3.1.1 alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG 0.58 40.0 4.06e-01 72.6% 89.5%
3610239 650.1.1.1 alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.57 38.0 4.05e-01 86.9% 78.7%
3388805 109.4.1.274 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Usp38-like_N 0.57 46.0 3.26e-01 90.5% 30.9%
3595910 622.4.1.0 alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related 0.55 34.0 3.50e-01 96.4% 63.7%
5053401 601.33.1.0 alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain 0.54 40.0 4.31e-01 77.4% 97.1%
3835982 181.1.1.1 alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins › SRP54_N 0.53 37.0 3.59e-01 81.0% 65.3%
4800170 2006.1.1.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like 0.52 36.0 3.34e-01 95.2% 57.1%
5032076 650.1.1.1 alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.52 37.0 3.57e-01 89.3% 66.3%
3470998 3718.1.1.2 alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › NAD4L 0.51 37.0 3.90e-01 86.9% 85.3%
3480589 650.1.1.0 alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.51 35.0 3.69e-01 70.2% 84.0%
4109 181.1.1.1 alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins › SRP54_N 0.51 38.0 3.66e-01 81.0% 72.7%
4929471 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.50 42.0 3.20e-01 90.5% 91.6%
D5 medium residues 259-367
PDB
Domain cluster: representative
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1mhxA00 3.10.20.10 Alpha Beta › Roll › Ubiquitin-like (UB roll) › 0.55 24.0 3.04e-01 89.9% 66.2%
2v1xA03 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 31.0 3.18e-01 77.1% 56.4%
5dymA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.52 28.0 2.96e-01 77.1% 55.2%
4ivkA00 3.40.710.10 Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily 0.52 45.0 3.13e-01 100.0% 78.5%
ECOD (16)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4928190 101.1.2.26 alpha arrays › HTH › HTH › winged helix domain › HxlR 0.62 29.0 3.28e-01 78.0% 54.8%
4029392 375.1.1.179 few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › TFIIE_alpha 0.61 31.0 2.59e-01 77.1% 27.0%
3802871 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.59 26.0 2.71e-01 91.7% 39.0%
3792091 304.48.1.25 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 0.59 48.0 3.38e-01 100.0% 27.5%
3598902 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.58 47.0 3.25e-01 100.0% 25.3%
3589192 101.1.1.68 alpha arrays › HTH › HTH › Three-helical HTH › HTH_38 0.57 30.0 3.39e-01 76.1% 66.3%
3920672 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.57 25.0 2.77e-01 91.7% 45.6%
3684015 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.56 25.0 2.61e-01 91.7% 41.0%
3921728 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.56 25.0 2.51e-01 91.7% 35.7%
3236563 3567.1.1.0 a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer 0.56 25.0 2.39e-01 90.8% 32.8%
5075144 101.1.9.16 alpha arrays › HTH › HTH › Putative DNA-binding domain › HTH_17 0.55 27.0 3.20e-01 77.1% 66.7%
4926994 101.1.2.150 alpha arrays › HTH › HTH › winged helix domain › HTH_45 0.54 24.0 2.47e-01 89.9% 38.5%
3349668 208.1.1.5 beta duplicates or obligate multimers › Single-stranded left-handed beta-helix › Trimeric LpxA-like enzymes › Trimeric LpxA-like enzymes › UDPGP 0.53 27.0 2.34e-01 77.1% 28.9%
4996402 242.1.1.0 a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.51 31.0 3.35e-01 97.2% 70.5%
3993677 823.1.1.0 a+b two layers › Head-to-tail joining protein W, gpW › Head-to-tail joining protein W, gpW › Head-to-tail joining protein W, gpW 0.50 26.0 3.16e-01 100.0% 75.7%
3466238 206.1.1.14 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › ABC1 0.50 44.0 2.98e-01 100.0% 83.1%
D6 medium residues 368-419_477-584
PDB
D7 medium residues 585-709
PDB
Domain cluster: representative
CATH (1)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3zgzA04 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.59 45.0 4.00e-01 89.6% 56.5%
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
None 0.62 45.0 3.99e-01 77.6% 51.7%
3287020 3997.1.1.1 alpha arrays › Helical insertion domain in magnesium chelatase catalytic subunit › Helical insertion domain in magnesium chelatase catalytic subunit › Helical insertion domain in magnesium chelatase catalytic subunit › CobN-Mg_chel 0.50 39.0 3.27e-01 91.2% 49.5%
D8 medium residues 756-838
PDB
Domain cluster: representative