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RNA-dependent_RNA_polymerase

Euk-Vir

Hubei_narna-like_virus_25

RNA-dependent_RNA_polymerase__YP_009336494__Hubei_narna-like_virus_25__1922956

Identity

Accession:
YP_009336494 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

85.2 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 7-118
PDB
CATH (15)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
6ks6a01 1.10.560.10 Mainly Alpha › Orthogonal Bundle › GROEL; domain 1 › GroEL-like equatorial domain 0.66 59.0 4.44e-01 100.0% 87.0%
2a2fX02 1.20.58.670 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Dsl1p vesicle tethering complex, Tip20p subunit, domain D 0.58 40.0 3.85e-01 83.0% 61.2%
2xmoA02 1.10.246.180 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › 0.57 36.0 4.03e-01 96.4% 83.7%
2j0jA02 1.20.80.10 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › 0.53 34.0 3.37e-01 81.2% 58.2%
7p2yd01 1.10.520.20 Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › N-terminal domain of the delta subunit of the F1F0-ATP synthase 0.53 43.0 4.49e-01 92.0% 100.0%
4lqkA00 1.10.437.20 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › dsDNA poxvirus 0.53 34.0 3.31e-01 92.9% 55.3%
4mo1A00 1.10.274.110 Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › 0.53 47.0 4.33e-01 100.0% 90.3%
1xioA00 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.52 44.0 3.59e-01 93.8% 77.4%
3dewA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 39.0 3.68e-01 80.4% 64.3%
2xq0A03 1.10.390.10 Mainly Alpha › Orthogonal Bundle › Neutral Protease; domain 2 › Neutral Protease Domain 2 0.52 40.0 3.60e-01 82.1% 95.5%
4qqwA01 1.10.3210.30 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › 0.52 46.0 3.61e-01 100.0% 75.2%
3h20A04 1.10.1240.50 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › 0.51 26.0 2.85e-01 80.4% 57.3%
4logB00 1.10.565.10 Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor 0.51 44.0 3.59e-01 99.1% 90.5%
2zueA03 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.51 40.0 3.99e-01 85.7% 79.8%
2nrjA01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.50 43.0 3.14e-01 100.0% 32.4%
ECOD (15)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5002810 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.75 38.0 4.06e-01 80.4% 55.0%
3600444 7064.1.1.0 alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 0.72 65.0 6.00e-01 100.0% 96.6%
3219385 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.63 47.0 3.43e-01 100.0% 28.3%
3516004 2004.1.1.30 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.61 47.0 3.45e-01 100.0% 29.8%
3743981 5081.1.1.2 alpha bundles › Rhomboid-like › Rhomboid-like › Rhomboid-like › DER1 0.61 48.0 4.03e-01 83.9% 82.1%
4075663 563.1.1.1 alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP 0.60 41.0 4.37e-01 100.0% 79.0%
5010019 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.60 39.0 3.39e-01 83.0% 42.3%
3738477 109.1.1.11 alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › Arc1p_N_like 0.54 36.0 3.64e-01 98.2% 65.2%
4386395 563.1.1.1 alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP 0.54 41.0 4.34e-01 82.1% 100.0%
5054990 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.53 41.0 3.85e-01 85.7% 65.9%
4026650 5081.1.1.2 alpha bundles › Rhomboid-like › Rhomboid-like › Rhomboid-like › DER1 0.53 48.0 3.93e-01 100.0% 98.5%
3760145 106.1.1.8 alpha arrays › Globin-like › Globin-like › Globin-like › HisK-N-like 0.52 42.0 3.89e-01 100.0% 66.0%
3220023 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.51 45.0 4.16e-01 100.0% 81.3%
3742209 6140.1.1.0 alpha superhelices › Cdc45-Binding Domain in Sld3/Treslin › Cdc45-Binding Domain in Sld3/Treslin › Cdc45-Binding Domain in Sld3/Treslin 0.51 38.0 3.04e-01 78.6% 66.8%
4406227 186.1.1.1 alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N › Phage_int_SAM_1 0.51 44.0 4.31e-01 99.1% 87.2%
D2 high residues 539-699
PDB
Domain cluster: representative
CATH (23)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3a98A02 1.20.1270.350 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Dedicator of cytokinesis N-terminal subdomain 0.67 37.0 4.86e-01 77.6% 100.0%
2qytA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.67 26.0 3.30e-01 95.0% 56.4%
4hehA01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.66 21.0 2.95e-01 79.5% 55.4%
4btfA01 1.20.930.20 Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Adaptor protein Cbl, N-terminal domain 0.65 34.0 4.15e-01 71.4% 78.0%
3d6jA02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.63 28.0 4.21e-01 90.1% 100.0%
3behB01 1.20.120.540 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels 0.61 33.0 3.82e-01 75.8% 70.9%
2pejA00 1.10.1200.210 Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Chaperonin-like RbcX 0.61 35.0 4.18e-01 93.8% 83.5%
4oe8C00 1.10.8.1170 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.60 32.0 4.15e-01 73.9% 93.1%
1h7cA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 33.0 3.96e-01 97.5% 81.6%
4hr1A00 1.20.1270.410 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.58 42.0 4.83e-01 87.0% 100.0%
2cmrA00 1.20.58.1860 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 31.0 2.90e-01 93.2% 42.2%
3edvB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 33.0 3.61e-01 99.4% 66.9%
1eo0A00 1.20.930.10 Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 0.57 25.0 3.32e-01 70.2% 77.9%
3owaB04 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.56 41.0 4.16e-01 87.0% 77.1%
3vkgA12 1.10.287.2610 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.55 36.0 3.28e-01 100.0% 49.3%
1n1bB02 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.55 41.0 3.34e-01 77.0% 84.7%
3o6xA02 1.20.120.1560 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.54 42.0 4.34e-01 81.4% 88.5%
4e40A00 1.20.1260.80 Mainly Alpha › Up-down Bundle › Ferritin › 0.51 37.0 3.25e-01 74.5% 82.4%
7lb8B01 1.10.3470.10 Mainly Alpha › Orthogonal Bundle › ABC transporter involved in vitamin B12 uptake, BtuC › ABC transporter involved in vitamin B12 uptake, BtuC 0.51 40.0 3.20e-01 82.0% 99.1%
4mh6A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.51 34.0 3.44e-01 99.4% 66.7%
1jm6B02 1.20.140.20 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain 0.51 36.0 3.67e-01 85.1% 74.5%
2pkeA02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.51 26.0 3.56e-01 80.7% 100.0%
1qu7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.50 33.0 2.97e-01 99.4% 47.1%
ECOD (33)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5036915 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.68 33.0 2.73e-01 100.0% 27.4%
3498465 604.6.1.0 alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.67 28.0 3.16e-01 100.0% 49.6%
3896730 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.66 29.0 3.23e-01 100.0% 49.6%
3659174 138.1.1.0 alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain 0.63 31.0 3.81e-01 73.9% 74.0%
3425962 603.1.1.116 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF27980 0.61 25.0 3.27e-01 97.5% 65.9%
3245526 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.60 25.0 3.06e-01 99.4% 57.1%
4473674 148.1.3.0 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.59 39.0 4.60e-01 73.9% 97.3%
4431851 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.59 34.0 3.78e-01 93.8% 70.0%
3385717 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.57 35.0 3.44e-01 100.0% 56.5%
3875112 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.56 34.0 2.67e-01 100.0% 28.2%
5001019 4177.1.1.0 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.56 40.0 4.00e-01 73.9% 85.9%
3313420 611.9.1.4 alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.56 36.0 3.86e-01 70.8% 74.3%
3550685 4177.1.1.38 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › Tektin 0.56 41.0 4.00e-01 74.5% 84.6%
4016578 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.56 29.0 3.47e-01 95.0% 74.3%
4515899 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.56 33.0 3.30e-01 100.0% 55.3%
3944731 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.55 35.0 3.47e-01 95.0% 60.6%
4955452 5069.1.1.0 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.54 27.0 2.90e-01 72.0% 51.9%
4014383 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.54 33.0 3.51e-01 74.5% 66.4%
3935029 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.54 31.0 3.51e-01 95.7% 72.0%
3398025 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.53 24.0 3.06e-01 92.5% 69.0%
3816971 3755.3.1.285 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › NET2A 0.53 35.0 3.51e-01 100.0% 63.5%
4998688 192.2.1.89 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › DUF7121 0.53 36.0 3.14e-01 100.0% 45.7%
3918382 2004.1.1.433 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_23 0.52 41.0 2.85e-01 83.2% 82.5%
3672790 611.9.1.4 alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.52 39.0 4.16e-01 77.6% 91.7%
4516566 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.52 35.0 3.34e-01 100.0% 57.9%
3586765 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.52 37.0 4.19e-01 83.9% 99.2%
4026916 3871.1.1.1 alpha duplicates or obligate multimers › PHIST › PHIST › PHIST › PRESAN 0.52 37.0 3.90e-01 74.5% 82.1%
4276314 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.52 34.0 3.10e-01 100.0% 48.6%
5010298 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.52 36.0 3.59e-01 85.1% 68.3%
5043292 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.51 34.0 3.18e-01 100.0% 54.9%
4995769 102.1.2.10 alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › DNA-glycosylase › Q_salvage 0.51 35.0 2.91e-01 86.3% 37.0%
3193529 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.51 35.0 2.69e-01 100.0% 32.3%
3675423 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.50 34.0 3.47e-01 100.0% 68.8%
D3 medium residues 119-132_154-280_327-355
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF05919.17 best Mitovir_RNA_pol 58.2 1.10e-15 72.4% 23.9%
D4 medium residues 133-153_281-326_356-446
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF05919.17 best Mitovir_RNA_pol 108.3 7.20e-31 59.5% 17.9%
PF05919.17 Mitovir_RNA_pol 33.8 2.80e-08 31.6% 9.0%
CATH (9)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4hkqA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.72 58.0 6.12e-01 100.0% 93.1%
3h5xA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.72 51.0 5.92e-01 81.0% 100.0%
1khvA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.70 54.0 5.92e-01 79.7% 100.0%
5jxsA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.68 56.0 5.91e-01 86.7% 97.9%
2r7rA04 3.30.70.2480 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.63 47.0 4.78e-01 84.8% 79.0%
3pjxA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.59 45.0 4.36e-01 81.0% 80.1%
3tvkA00 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.58 46.0 4.55e-01 86.7% 76.7%
3mmlF01 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.53 26.0 3.46e-01 78.5% 89.9%
4q6rA02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.51 28.0 3.08e-01 89.9% 61.8%
ECOD (60)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3810170 304.48.1.43 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mitovir_RNA_pol 0.94 81.0 7.64e-01 88.0% 100.0%
3306901 304.48.1.43 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mitovir_RNA_pol 0.94 76.0 7.48e-01 82.9% 93.9%
3336938 304.48.1.43 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mitovir_RNA_pol 0.92 89.0 7.39e-01 100.0% 91.2%
3983816 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.83 68.0 5.72e-01 85.4% 74.8%
1789314 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.82 70.0 5.12e-01 89.9% 75.1%
3945039 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.82 72.0 5.47e-01 91.8% 95.5%
3451410 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.81 76.0 5.31e-01 100.0% 76.4%
4188583 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.81 74.0 5.28e-01 95.6% 82.4%
None 0.81 76.0 4.94e-01 100.0% 55.3%
3173834 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.81 66.0 4.77e-01 85.4% 80.7%
3068775 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.80 67.0 6.10e-01 87.3% 82.8%
3679386 4967.1.1.0 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.80 69.0 5.20e-01 90.5% 57.4%
3015534 304.48.1.12 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mononeg_RNA_pol 0.80 68.0 4.93e-01 89.2% 99.3%
3939861 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.78 58.0 6.55e-01 83.5% 100.0%
3353681 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.77 59.0 5.64e-01 79.1% 93.3%
4019374 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.77 70.0 5.11e-01 97.5% 94.6%
4434853 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.76 61.0 5.23e-01 82.9% 65.8%
3947863 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.76 63.0 5.27e-01 86.7% 70.6%
3968281 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 63.0 5.43e-01 88.0% 72.8%
3209439 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.72 61.0 4.78e-01 89.9% 96.2%
3935796 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.71 58.0 5.72e-01 85.4% 83.5%
5054705 304.7.1.0 a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors 0.71 34.0 4.68e-01 71.5% 90.0%
3934202 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 56.0 5.85e-01 82.9% 100.0%
3643305 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 55.0 5.88e-01 80.4% 100.0%
3708776 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.69 64.0 5.03e-01 100.0% 99.7%
3615476 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.67 60.0 4.68e-01 94.9% 92.3%
3708065 304.11.1.0 a+b two layers › Alpha-beta plaits › Probable ACP-binding domain of malonyl-CoA ACP transacylase › Probable ACP-binding domain of malonyl-CoA ACP transacylase 0.66 32.0 4.53e-01 74.1% 98.6%
3315278 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.66 43.0 4.77e-01 74.1% 82.4%
1893002 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 61.0 5.14e-01 100.0% 94.9%
3933460 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 61.0 5.08e-01 100.0% 89.4%
3931851 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 60.0 5.01e-01 98.7% 89.1%
3937813 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 61.0 5.00e-01 100.0% 85.9%
3927736 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 61.0 5.20e-01 100.0% 88.7%
3937440 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 60.0 4.98e-01 100.0% 90.2%
3271795 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 60.0 4.88e-01 100.0% 82.8%
3938275 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 60.0 5.05e-01 100.0% 92.5%
3510717 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 59.0 4.97e-01 100.0% 89.2%
3781210 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 59.0 4.96e-01 99.4% 90.6%
3933633 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 59.0 4.95e-01 100.0% 90.0%
3939219 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 58.0 4.87e-01 99.4% 87.2%
3927691 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 58.0 4.95e-01 99.4% 91.6%
3930235 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 59.0 4.87e-01 100.0% 86.8%
3785231 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 58.0 4.67e-01 100.0% 78.0%
4096485 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 57.0 4.83e-01 98.7% 90.4%
3934891 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 58.0 4.97e-01 98.7% 95.8%
3932482 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 58.0 4.99e-01 100.0% 94.7%
3934979 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 58.0 4.50e-01 100.0% 70.3%
3923429 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 58.0 5.34e-01 98.7% 96.4%
3252343 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 57.0 4.82e-01 99.4% 88.8%
4618808 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 57.0 4.75e-01 100.0% 87.4%
3927796 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 57.0 4.74e-01 99.4% 86.8%
3926167 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 57.0 4.79e-01 100.0% 89.6%
3926633 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 58.0 5.46e-01 100.0% 98.4%
3678489 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 56.0 5.21e-01 100.0% 91.0%
3257066 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 57.0 4.88e-01 100.0% 77.9%
3927365 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 57.0 4.84e-01 100.0% 75.5%
3926536 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.59 55.0 4.63e-01 100.0% 86.5%
3529282 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.56 52.0 4.61e-01 99.4% 92.3%
4246496 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.55 51.0 4.45e-01 99.4% 94.2%
2718745 306.3.1.2 a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › Img2 0.50 28.0 3.60e-01 79.7% 100.0%
D5 medium residues 447-538
PDB
Domain cluster: representative
CATH (18)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1txuA01 1.10.246.120 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › 0.67 48.0 4.77e-01 73.9% 79.8%
2rldA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.65 45.0 4.17e-01 71.7% 61.4%
2c42A03 3.40.920.10 Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate-ferredoxin Oxidoreductase; domain 3 › Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 0.61 47.0 3.56e-01 80.4% 94.8%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.57 40.0 3.76e-01 75.0% 91.5%
4d8mA01 1.20.190.10 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain 0.54 42.0 3.21e-01 83.7% 57.9%
6vudA01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.54 38.0 3.63e-01 73.9% 90.8%
2aj4B03 1.20.1440.340 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.53 46.0 3.83e-01 96.7% 67.3%
3llkA02 1.20.120.310 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › ERV/ALR sulfhydryl oxidase domain 0.53 37.0 3.21e-01 78.3% 46.2%
2aamC00 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.53 45.0 3.31e-01 100.0% 61.5%
2qfcA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.53 44.0 3.17e-01 93.5% 32.4%
4mrsA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.53 41.0 2.91e-01 88.0% 89.2%
2keyA00 1.10.150.130 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain 0.52 39.0 3.71e-01 100.0% 67.0%
7ae2A01 1.20.120.580 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › bsu32300-like 0.52 43.0 3.83e-01 92.4% 83.2%
2wzkA02 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.51 40.0 3.68e-01 87.0% 92.1%
1miwA03 1.20.58.560 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.51 41.0 4.07e-01 88.0% 89.0%
8hbfB01 3.90.1520.10 Alpha Beta › Alpha-Beta Complex › H-NOX domain › H-NOX domain 0.51 43.0 3.49e-01 94.6% 93.9%
3hdtA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 39.0 3.24e-01 82.6% 68.5%
5figA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.51 35.0 3.44e-01 77.2% 66.0%
ECOD (18)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1711454 633.24.1.2 alpha bundles › Bromodomain-like › RABEX-5 helical domain › RABEX-5 helical domain › DUF5601 0.69 47.0 4.80e-01 70.7% 80.0%
3965046 604.12.1.76 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › IspA 0.68 45.0 5.02e-01 75.0% 88.6%
4988365 180.1.1.1 alpha bundles › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › PAP2 0.64 43.0 3.96e-01 73.9% 52.5%
4231435 604.9.1.1 alpha bundles › Spectrin repeat-like › Ribosomal protein S20 › Ribosomal protein S20 › Ribosomal_S20p 0.64 42.0 4.34e-01 71.7% 71.8%
4963078 3843.1.1.0 alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K 0.64 45.0 4.52e-01 81.5% 71.6%
3963163 601.1.2.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.61 44.0 3.69e-01 75.0% 62.6%
4960839 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.60 44.0 4.31e-01 77.2% 80.0%
3277630 633.21.1.0 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 0.60 42.0 3.69e-01 73.9% 53.2%
3675163 3881.1.1.1 alpha bundles › CNOT9 binding domain CN9BD (DUF3819) › CNOT9 binding domain CN9BD (DUF3819) › CNOT9 binding domain CN9BD (DUF3819) › DUF3819 0.59 44.0 3.47e-01 80.4% 79.5%
3230196 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 52.0 4.76e-01 97.8% 85.0%
3618897 7516.1.1.51 a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glyco_transf_21 0.57 47.0 3.12e-01 89.1% 87.1%
3716106 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.55 48.0 2.76e-01 100.0% 24.7%
4057629 3869.1.1.1 alpha arrays › Mitochondrial 54S ribosomal protein L2 › Mitochondrial 54S ribosomal protein L2 › Mitochondrial 54S ribosomal protein L2 › Ribosomal_L27_C 0.54 48.0 3.68e-01 96.7% 44.8%
3846352 109.2.1.4 alpha superhelices › Repetitive alpha hairpins › alpha/alpha toroid › alpha/alpha toroid › Cobalamin_bind 0.53 46.0 3.22e-01 97.8% 59.0%
5056432 607.1.1.0 alpha arrays › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 0.52 46.0 4.16e-01 97.8% 90.4%
4082099 7516.1.1.2 a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 0.51 43.0 2.94e-01 91.3% 44.4%
5028214 3457.1.1.1 alpha bundles › GxGD membrane protease › GxGD membrane protease › GxGD membrane protease › Peptidase_A24 0.50 34.0 2.78e-01 76.1% 32.5%
3236498 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.50 42.0 3.46e-01 97.8% 73.7%