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RNA-dependent_RNA_polymerase

Euk-Vir

Shahe_narna-like_virus_7

RNA-dependent_RNA_polymerase__YP_009336622__Shahe_narna-like_virus_7__1923435

Identity

Accession:
YP_009336622 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

82.8 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 356-424
PDB
Domain cluster: representative
CATH (10)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2pmrA00 1.20.1270.90 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like 0.64 38.0 3.77e-01 84.1% 53.9%
6uqyB01 3.40.50.1110 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase 0.59 52.0 3.52e-01 100.0% 46.0%
2w43A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.58 42.0 4.54e-01 76.8% 100.0%
1t72A02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.58 47.0 4.23e-01 89.9% 87.8%
3r84A00 1.10.287.3490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.58 43.0 4.10e-01 78.3% 69.1%
7c1iA01 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.57 43.0 3.77e-01 79.7% 86.0%
2hujA00 1.20.120.440 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like 0.56 42.0 3.47e-01 79.7% 94.4%
3u61D03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.53 43.0 4.00e-01 94.2% 72.5%
4od4A02 1.20.120.1780 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › UbiA prenyltransferase 0.53 45.0 3.84e-01 98.6% 79.0%
4dylA02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.52 40.0 3.60e-01 87.0% 60.6%
ECOD (21)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5069176 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.72 43.0 4.30e-01 79.7% 58.6%
4982047 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.72 42.0 4.27e-01 79.7% 58.6%
5016654 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.72 41.0 4.28e-01 82.6% 61.5%
4981750 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.71 42.0 4.03e-01 79.7% 51.2%
5061329 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.71 42.0 4.01e-01 79.7% 51.2%
5060801 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.71 42.0 4.23e-01 84.1% 58.6%
5060146 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.70 41.0 4.30e-01 79.7% 63.1%
5060848 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.69 39.0 4.20e-01 81.2% 65.0%
4219218 192.7.1.2 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.69 43.0 3.70e-01 91.3% 39.1%
5062154 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.68 36.0 3.73e-01 78.3% 55.4%
5070668 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.66 36.0 3.50e-01 78.3% 48.0%
5060982 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.65 39.0 3.82e-01 82.6% 54.7%
4982050 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.64 39.0 3.93e-01 84.1% 60.0%
1288932 4970.1.1.0 alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I 0.62 40.0 3.92e-01 81.2% 60.5%
5079025 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.62 37.0 3.76e-01 72.5% 58.6%
3167132 192.3.1.0 alpha bundles › Long alpha-hairpin › Fe,Mn superoxide dismutase (SOD), N-terminal domain › Fe,Mn superoxide dismutase (SOD), N-terminal domain 0.61 38.0 3.39e-01 92.8% 44.2%
3742692 3134.1.1.1 a+b two layers › N-terminal domain of DC-UbP › N-terminal domain of DC-UbP › N-terminal domain of DC-UbP › UBD 0.58 43.0 3.82e-01 78.3% 94.0%
5009946 5068.1.1.1 alpha bundles › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › Cytochrom_B_C 0.56 39.0 3.46e-01 84.1% 50.0%
4408647 192.7.1.2 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.56 42.0 3.64e-01 79.7% 54.3%
5062160 632.23.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Helical linker domain in nicking endonuclease N.BspD6I › Helical linker domain in nicking endonuclease N.BspD6I 0.54 41.0 4.11e-01 79.7% 80.0%
3201044 7087.1.1.1 alpha bundles › Emopamil binding protein (EBP) transmembrane domain › Emopamil binding protein (EBP) transmembrane domain › Emopamil binding protein (EBP) transmembrane domain › EBP 0.53 48.0 3.65e-01 100.0% 52.5%
D2 high residues 455-555
PDB
Domain cluster: representative
CATH (36)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1wleA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.71 48.0 4.67e-01 74.3% 62.3%
1wp7A00 1.10.287.770 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like 0.69 44.0 5.26e-01 77.2% 100.0%
3a98A02 1.20.1270.350 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Dedicator of cytokinesis N-terminal subdomain 0.69 53.0 5.69e-01 100.0% 95.4%
5dn6J00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.69 46.0 5.19e-01 74.3% 93.2%
4im0A04 1.20.1270.420 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.68 62.0 4.63e-01 98.0% 78.2%
3r2kA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.68 49.0 4.20e-01 81.2% 48.7%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.68 49.0 4.71e-01 84.2% 65.0%
3a8pA02 6.10.140.680 Special › Helix non-globular › Helix Hairpins › 0.68 46.0 4.43e-01 75.2% 61.4%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.68 46.0 4.89e-01 82.2% 79.3%
4xvxA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.68 63.0 5.47e-01 100.0% 76.9%
3axjB02 1.20.58.200 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 0.67 44.0 4.77e-01 77.2% 78.8%
2vkzA02 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.67 44.0 3.28e-01 86.1% 26.0%
2uv8A07 6.10.140.1410 Special › Helix non-globular › Helix Hairpins › 0.67 44.0 4.77e-01 86.1% 80.0%
2oexA02 1.20.140.50 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › alix/aip1 like domains 0.66 60.0 4.76e-01 98.0% 81.7%
1r0dA00 1.20.1410.10 Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain 0.66 59.0 4.80e-01 100.0% 59.6%
6ynwH01 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.66 44.0 5.07e-01 83.2% 94.6%
4i0xG00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.65 43.0 4.99e-01 78.2% 98.5%
1siqA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.65 58.0 5.03e-01 100.0% 78.1%
2uuiA00 1.20.120.550 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain 0.64 54.0 4.70e-01 97.0% 60.0%
3vbbE01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.64 46.0 4.34e-01 74.3% 84.0%
2xubA05 6.10.140.1450 Special › Helix non-globular › Helix Hairpins › 0.64 46.0 4.69e-01 74.3% 91.7%
8ek4A01 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.64 48.0 4.34e-01 83.2% 59.4%
2gd5A00 6.10.140.1230 Special › Helix non-globular › Helix Hairpins › 0.63 54.0 4.77e-01 91.1% 74.6%
1fewA00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.63 45.0 3.74e-01 74.3% 44.5%
2lw1A00 1.10.287.380 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain 0.63 42.0 4.54e-01 74.3% 81.2%
2p4vA01 1.10.287.180 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain 0.62 42.0 4.69e-01 79.2% 90.8%
2gl2B00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.61 44.0 4.30e-01 75.2% 69.7%
3tbiB02 6.10.140.1670 Special › Helix non-globular › Helix Hairpins › 0.60 48.0 4.82e-01 84.2% 90.0%
1wteB01 1.10.3250.10 Mainly Alpha › Orthogonal Bundle › type ii restriction endonuclease, domain 1 › type ii restriction endonuclease, domain 1 0.59 41.0 3.62e-01 93.1% 49.0%
4cqiA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 43.0 4.27e-01 79.2% 75.7%
1zzpA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.57 44.0 4.36e-01 98.0% 77.1%
1x8zB00 1.20.140.40 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein 0.57 52.0 4.56e-01 100.0% 68.7%
4p9fA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.52 37.0 3.26e-01 73.3% 61.8%
1h3lB00 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.52 34.0 3.76e-01 97.0% 85.9%
3f7cA00 1.20.1590.10 Mainly Alpha › Up-down Bundle › YP_001051499.1 fold like › YP_001051499.1 domain like 0.52 45.0 3.69e-01 100.0% 70.9%
4od4A01 1.10.357.140 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › UbiA prenyltransferase 0.50 42.0 3.60e-01 89.1% 80.1%
ECOD (26)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4939228 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.75 49.0 5.70e-01 78.2% 95.7%
3174647 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.72 48.0 5.67e-01 75.2% 100.0%
3740547 5086.1.1.87 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › ING 0.70 49.0 4.77e-01 75.2% 65.5%
3737505 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.70 48.0 5.42e-01 75.2% 94.7%
4629029 3285.1.1.1 alpha duplicates or obligate multimers › Alix V domain › Alix V domain › Alix V domain › ALIX_LYPXL_bnd 0.70 64.0 5.08e-01 98.0% 74.7%
4638470 101.1.2.311 alpha arrays › HTH › HTH › winged helix domain › RNA12 0.69 48.0 3.98e-01 71.3% 43.5%
4024277 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.69 47.0 5.33e-01 75.2% 94.7%
3287601 150.5.1.1 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › WXG100 0.68 47.0 4.91e-01 75.2% 75.5%
3544521 904.1.1.1 few secondary structure elements › B-box zinc-binding domain-like › B-box zinc-binding domain › B-box zinc-binding domain › zf-B_box 0.68 55.0 4.90e-01 98.0% 60.7%
3402026 2004.1.1.199 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23,SbcC_Walker_B 0.68 47.0 2.96e-01 74.3% 14.4%
3584217 632.7.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain 0.67 55.0 5.26e-01 100.0% 76.5%
3832264 2004.1.1.184 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11 0.66 50.0 3.14e-01 78.2% 20.6%
3977955 601.4.1.1 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › TarH 0.66 47.0 4.13e-01 89.1% 51.0%
3609516 4177.1.1.0 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.65 59.0 4.89e-01 99.0% 83.4%
3389783 5030.1.1.0 extended segments › Photosystem II reaction center protein L, PsbL › Photosystem II reaction center protein L, PsbL › Photosystem II reaction center protein L, PsbL 0.65 45.0 4.49e-01 74.3% 69.5%
3814372 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.63 56.0 5.53e-01 98.0% 97.1%
5067588 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.62 54.0 4.95e-01 96.0% 74.1%
4192155 601.1.1.43 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Serendipity_A 0.62 49.0 4.67e-01 98.0% 71.7%
4029819 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.62 46.0 3.80e-01 77.2% 79.3%
3728035 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.62 55.0 5.18e-01 99.0% 84.0%
5007109 601.3.1.1 alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt 0.62 43.0 3.98e-01 99.0% 56.2%
5082191 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.61 42.0 4.29e-01 97.0% 72.0%
4984270 4.1.1.481 beta barrels › SH3 › SH3 › SH3 › MS_channel_1st_1 0.59 42.0 4.29e-01 92.1% 75.0%
3096680 602.1.1.1 alpha arrays › L-aspartase middle domain-like › L-aspartase middle domain-like › L-aspartase middle domain-like › Lyase_1 0.59 52.0 4.73e-01 99.0% 92.1%
5052771 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.58 46.0 4.46e-01 92.1% 74.8%
3962505 601.33.1.1 alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › CHAD 0.54 47.0 3.55e-01 96.0% 45.2%
D3 medium residues 27-63_142-189_221-262
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF05919.17 best Mitovir_RNA_pol 42.4 6.90e-11 64.6% 10.5%
CATH (1)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2r7rA05 1.10.357.80 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.66 60.0 5.39e-01 99.2% 97.2%
ECOD (4)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3945039 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.74 55.0 3.99e-01 76.4% 59.4%
5078830 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 48.0 3.74e-01 70.9% 53.2%
5002351 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.67 50.0 3.56e-01 77.2% 53.1%
4434853 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 48.0 3.81e-01 76.4% 62.5%
D4 medium residues 75-141
PDB
Domain cluster: representative
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1ysqA00 3.30.450.40 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › GAF domain 0.58 49.0 3.71e-01 100.0% 64.1%
4uobA02 1.10.340.30 Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Hypothetical protein; domain 2 0.53 43.0 3.55e-01 91.0% 97.6%
2uyyA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.51 43.0 3.64e-01 100.0% 78.0%
D5 medium residues 190-220_263-353
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF05919.17 best Mitovir_RNA_pol 119.6 2.70e-34 75.4% 18.1%