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RNA-dependent_RNA_polymerase

Euk-Vir

Hubei_narna-like_virus_4

RNA-dependent_RNA_polymerase__YP_009337087__Hubei_narna-like_virus_4__1922958

Identity

Accession:
YP_009337087 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

50.0 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 8-195
PDB
D2 medium residues 221-246_309-374_416-480
PDB
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2r7rA05 1.10.357.80 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.68 60.0 5.84e-01 95.5% 94.9%
2f33A03 1.10.238.10 Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand 0.52 29.0 3.69e-01 70.1% 96.6%
3k59A02 3.30.70.2250 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › B family DNA polymerase, N domain, alpha/beta motif 0.51 18.0 2.52e-01 72.0% 61.2%
3x1oA00 1.20.120.1790 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.51 34.0 3.48e-01 77.1% 69.1%
ECOD (12)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
217141 304.48.1.15 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 0.79 74.0 5.54e-01 100.0% 64.7%
3960648 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.77 62.0 4.89e-01 83.4% 63.3%
3708776 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.76 55.0 4.22e-01 73.2% 64.6%
3589612 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.74 63.0 4.83e-01 89.2% 66.1%
4071235 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.73 61.0 4.18e-01 87.9% 41.8%
4516798 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.73 61.0 4.29e-01 87.9% 46.4%
3983816 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.72 58.0 4.90e-01 83.4% 65.6%
3792091 304.48.1.25 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 0.72 64.0 4.88e-01 94.3% 60.9%
3615272 304.48.1.25 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RRM_4 0.72 64.0 4.76e-01 95.5% 61.8%
3598902 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.71 62.0 4.66e-01 94.3% 61.3%
4932898 3281.1.1.1 alpha complex topology › Sodium/proton antiporter subunits-like › Sodium/proton antiporter subunits-like › NADH-quinone oxidoreductase subunit L (NuoL)-related › Proton_antipo_M 0.51 37.0 2.56e-01 75.8% 43.1%
5076633 3281.1.1.1 alpha complex topology › Sodium/proton antiporter subunits-like › Sodium/proton antiporter subunits-like › NADH-quinone oxidoreductase subunit L (NuoL)-related › Proton_antipo_M 0.50 36.0 2.55e-01 73.2% 97.1%
D3 medium residues 375-415_481-588
PDB
Domain cluster: representative
CATH (36)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1khvA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.74 56.0 5.97e-01 77.9% 100.0%
1gx5A03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.71 54.0 5.98e-01 78.5% 100.0%
1konA03 3.30.70.980 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YebC, transcriptional regulation domain 0.70 35.0 4.80e-01 73.8% 94.7%
1lfpA03 3.30.70.980 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › YebC, transcriptional regulation domain 0.69 35.0 4.82e-01 73.2% 98.6%
2ckwA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.66 47.0 5.34e-01 73.2% 100.0%
3onqA02 3.30.70.2730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.63 35.0 4.62e-01 71.1% 100.0%
2cyyA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.63 38.0 4.72e-01 83.9% 94.7%
3ce8A00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.63 38.0 4.77e-01 71.1% 100.0%
7npaA02 3.30.70.3340 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.61 31.0 4.02e-01 78.5% 84.7%
4dezA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.60 39.0 4.73e-01 80.5% 99.0%
4ushA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 37.0 4.33e-01 71.8% 88.3%
6c6uN00 3.30.70.940 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain 0.59 37.0 4.43e-01 76.5% 93.9%
2lxiA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.59 36.0 4.48e-01 73.2% 100.0%
1jqgA01 3.30.70.340 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Metallocarboxypeptidase-like 0.58 35.0 4.22e-01 73.8% 95.6%
3e8oB00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 38.0 4.58e-01 71.8% 99.0%
1kwmA01 3.30.70.340 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Metallocarboxypeptidase-like 0.57 33.0 4.10e-01 80.5% 94.3%
4ozjA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 37.0 4.34e-01 73.2% 94.2%
1ayeA01 3.30.70.340 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Metallocarboxypeptidase-like 0.56 35.0 4.14e-01 71.8% 92.9%
2bopA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.56 32.0 4.17e-01 73.8% 100.0%
2xhcA01 3.30.70.940 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain 0.56 35.0 4.28e-01 72.5% 98.9%
3smzA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.56 39.0 4.32e-01 97.3% 94.6%
1x4dA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.55 34.0 3.93e-01 71.8% 87.3%
4dn9B00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 35.0 4.23e-01 71.1% 97.9%
1iujA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.54 37.0 4.29e-01 71.8% 100.0%
3pm9A03 3.30.70.2190 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.54 41.0 4.47e-01 77.9% 96.7%
3kkfA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.54 37.0 4.26e-01 73.2% 99.0%
2hfvA01 3.30.70.790 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › UreE, C-terminal domain 0.53 29.0 3.83e-01 80.5% 100.0%
2exuA02 3.30.70.940 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain 0.53 33.0 4.03e-01 75.2% 100.0%
6lpnA03 3.30.70.2190 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 38.0 4.31e-01 75.8% 99.1%
5ixuA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 35.0 4.14e-01 71.8% 100.0%
6zxbA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.52 46.0 4.68e-01 96.6% 97.9%
3hx9B00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 34.0 4.04e-01 73.2% 100.0%
4labA00 3.30.2350.10 Alpha Beta › 2-Layer Sandwich › Pseudouridine synthase › Pseudouridine synthase 0.51 36.0 3.36e-01 71.1% 60.4%
5k9fA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.51 34.0 4.00e-01 73.8% 99.0%
3kizA02 3.90.650.10 Alpha Beta › Alpha-Beta Complex › Phosphoribosyl-aminoimidazole Synthetase; Chain A, domain 2 › PurM-like C-terminal domain 0.51 41.0 3.62e-01 86.6% 96.0%
4x0qA03 3.30.70.370 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.51 44.0 4.48e-01 100.0% 95.8%
ECOD (36)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4231349 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.71 35.0 4.93e-01 73.2% 100.0%
4070496 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.71 35.0 4.87e-01 74.5% 96.0%
4295716 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.70 35.0 4.86e-01 72.5% 100.0%
4093818 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.69 35.0 4.70e-01 73.8% 94.7%
4658950 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.69 36.0 4.89e-01 74.5% 100.0%
4156338 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.69 35.0 4.71e-01 73.2% 96.0%
4042122 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.68 34.0 4.69e-01 72.5% 100.0%
4502075 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.67 34.0 4.63e-01 73.2% 100.0%
4990288 304.7.1.0 a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors 0.66 31.0 4.42e-01 80.5% 98.5%
5026454 304.126.1.0 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C 0.66 31.0 4.44e-01 89.9% 100.0%
4594407 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.65 34.0 4.57e-01 79.2% 98.7%
4340559 304.154.1.0 a+b two layers › Alpha-beta plaits › Regulator of polyketide synthase expression N-terminal domain › Regulator of polyketide synthase expression N-terminal domain 0.64 45.0 4.95e-01 98.7% 88.3%
4037308 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.63 37.0 4.71e-01 77.9% 100.0%
5041412 304.57.1.0 a+b two layers › Alpha-beta plaits › Rpp14/Pop5-like › Rpp14/Pop5-like 0.63 34.0 4.40e-01 80.5% 91.8%
167276 304.5.1.8 a+b two layers › Alpha-beta plaits › GlnB-like › GlnB-like › DUF3240 0.63 38.0 4.74e-01 71.1% 98.9%
4980881 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.62 36.0 4.58e-01 71.8% 100.0%
3323407 304.126.1.2 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C › V-ATPase_C 0.61 37.0 4.33e-01 94.0% 84.8%
4971209 304.4.1.1 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › AsnC_trans_reg 0.60 39.0 4.70e-01 81.2% 97.0%
3922306 4323.1.1.2 alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › V-ATPase_C 0.60 37.0 2.97e-01 94.0% 31.4%
4050535 304.126.1.2 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C › V-ATPase_C 0.59 38.0 4.06e-01 90.6% 72.3%
4946218 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.59 38.0 4.43e-01 81.2% 90.5%
3939178 304.48.1.37 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_2 0.58 51.0 4.76e-01 94.6% 88.6%
3729138 304.8.1.2 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT 0.58 34.0 3.92e-01 72.5% 80.0%
4151399 304.8.1.5 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NIL 0.57 32.0 4.18e-01 79.2% 100.0%
3621957 304.60.1.2 a+b two layers › Alpha-beta plaits › Ribosomal protein L10-like › Ribosomal protein L10-like › Ribosomal_L10 0.54 38.0 3.47e-01 71.1% 57.8%
3825932 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.54 33.0 4.08e-01 73.8% 98.9%
3581912 304.60.1.0 a+b two layers › Alpha-beta plaits › Ribosomal protein L10-like › Ribosomal protein L10-like 0.54 38.0 3.51e-01 71.1% 60.5%
3926562 304.60.1.0 a+b two layers › Alpha-beta plaits › Ribosomal protein L10-like › Ribosomal protein L10-like 0.54 38.0 3.36e-01 71.1% 53.3%
3725060 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.54 35.0 3.72e-01 81.9% 74.6%
4064154 304.8.1.5 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NIL 0.52 34.0 4.09e-01 83.2% 100.0%
3470372 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.52 33.0 3.87e-01 76.5% 94.0%
5027026 304.111.1.1 a+b two layers › Alpha-beta plaits › PurM C-terminal domain-like › PurM C-terminal domain-like › AIRS_C 0.51 40.0 3.79e-01 83.2% 94.4%
5054343 304.111.1.1 a+b two layers › Alpha-beta plaits › PurM C-terminal domain-like › PurM C-terminal domain-like › AIRS_C 0.51 41.0 3.86e-01 85.9% 93.3%
4191627 304.111.1.1 a+b two layers › Alpha-beta plaits › PurM C-terminal domain-like › PurM C-terminal domain-like › AIRS_C 0.50 39.0 3.63e-01 81.9% 92.6%
3187204 304.111.1.1 a+b two layers › Alpha-beta plaits › PurM C-terminal domain-like › PurM C-terminal domain-like › AIRS_C 0.50 41.0 3.68e-01 86.6% 88.3%
4974695 304.111.1.0 a+b two layers › Alpha-beta plaits › PurM C-terminal domain-like › PurM C-terminal domain-like 0.50 39.0 3.81e-01 82.6% 93.5%
D4 medium residues 613-665
PDB