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RNA-dependent_RNA_polymerase

Euk-Vir

Murine_hepatitis_virus

RNA-dependent_RNA_polymerase__YP_009924352__Murine_hepatitis_virus__11138

Identity

Accession:
YP_009924352 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

90.7 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Betacoronavirus› Murine_hepatitis_virus

TaxID: 11138

Cluster

View cluster (23 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 1-122
PDB
Domain cluster: rep: nsp12__YP_008439222__Bat_coronavirus_CDPHE15_USA_2006__1384461__D18-119
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06478.20 best CoV_RPol_N 125.4 3.70e-36 89.3% 30.0%
D2 medium residues 322-392
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_740629__Infectious_bronchitis_virus__11120__D333-394
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06478.20 best CoV_RPol_N 57.0 2.50e-15 57.8% 11.7%
D3 medium residues 393-454
PDB
Domain cluster: representative
CATH (1)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5yw4A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 36.0 2.35e-01 74.2% 61.0%
D4 medium residues 455-480_683-734
PDB
Domain cluster: representative
CATH (18)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2nsaA00 1.10.3120.10 Mainly Alpha › Orthogonal Bundle › Trigger factor, domain 2 › Trigger factor, C-terminal domain 0.63 45.0 3.56e-01 75.6% 65.3%
1nafA02 1.20.58.160 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.61 42.0 4.10e-01 70.5% 69.4%
4ie5A02 1.20.58.1470 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FTO C-terminal domain 0.60 46.0 3.84e-01 82.1% 59.7%
5mmjo00 1.10.287.10 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding 0.60 42.0 4.28e-01 73.1% 77.3%
2xzmO02 1.10.287.10 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding 0.59 37.0 3.94e-01 79.5% 71.4%
1kt1A03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.58 40.0 3.20e-01 71.8% 47.5%
5h5mA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.57 41.0 3.45e-01 75.6% 60.0%
5c9eB01 1.20.1280.80 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.57 35.0 3.40e-01 76.9% 55.2%
1n1bB02 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.56 49.0 3.30e-01 97.4% 94.7%
2hsbA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.56 39.0 3.34e-01 73.1% 88.9%
2i9cA01 1.25.40.70 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) 0.56 44.0 3.88e-01 83.3% 71.2%
1d2mA03 6.10.140.240 Special › Helix non-globular › Helix Hairpins › 0.55 36.0 3.90e-01 79.5% 78.8%
1rqgA04 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.55 42.0 3.45e-01 84.6% 89.4%
6xz3A01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.54 41.0 3.59e-01 79.5% 78.6%
3nbxX03 1.20.58.1510 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 40.0 3.71e-01 78.2% 67.3%
1mijA00 1.10.10.500 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeo-prospero domain 0.54 42.0 3.56e-01 85.9% 82.0%
2d9dA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.51 36.0 3.52e-01 78.2% 66.3%
3h2zA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.51 40.0 3.21e-01 89.7% 77.3%
ECOD (19)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3397746 2498.1.1.3 ↗ mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M2 0.72 54.0 3.20e-01 79.5% 30.3%
3770675 5001.1.1.1 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.65 55.0 3.70e-01 92.3% 67.5%
4589812 3922.1.1.294 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › DUF2418 0.62 49.0 4.37e-01 84.6% 78.2%
3720004 604.3.1.0 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.61 42.0 4.08e-01 78.2% 64.7%
5001365 4271.1.1.0 ↗ alpha complex topology › PriB N-terminal domain-like › PriB N-terminal domain-like › PriB N-terminal domain-like 0.61 49.0 3.72e-01 89.7% 63.1%
4597947 140.1.1.0 ↗ alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 0.60 49.0 3.61e-01 91.0% 74.9%
None — 0.59 51.0 3.09e-01 96.2% 29.2%
5043291 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.58 45.0 4.51e-01 83.3% 87.5%
3319564 219.1.1.113 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › PF28979 0.58 47.0 3.79e-01 97.4% 44.4%
3189448 5050.1.1.9 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.58 45.0 3.36e-01 84.6% 78.4%
4099273 140.1.1.6 ↗ alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon_1,tRNA-synt_1g 0.56 49.0 3.54e-01 100.0% 63.8%
4005041 601.4.1.6 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › TorS_sensor_domain 0.54 45.0 3.79e-01 88.5% 84.0%
4331899 1180.1.1.1 ↗ alpha bundles › Flagellar biosynthetic protein FliP periplasmic domain › Flagellar biosynthetic protein FliP periplasmic domain › Flagellar biosynthetic protein FliP periplasmic domain › FliP 0.54 46.0 3.75e-01 97.4% 90.3%
4977386 601.13.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Flagellar export chaperone FliS › Flagellar export chaperone FliS 0.54 40.0 3.94e-01 79.5% 78.8%
5058934 2004.1.1.1221 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PF27431 0.53 41.0 2.76e-01 84.6% 59.4%
3510785 3345.1.1.1 ↗ alpha arrays › MRG domain › MRG domain › MRG domain › MRG 0.53 38.0 3.07e-01 75.6% 42.6%
4092649 5050.1.1.32 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Acatn 0.52 41.0 3.12e-01 88.5% 70.5%
3330532 109.4.1.31 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MA3 0.51 38.0 2.91e-01 80.8% 49.2%
5009698 5050.1.1.9 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 42.0 3.23e-01 93.6% 76.3%
D5 medium residues 481-581
PDB
Domain cluster: rep: putative_coronavirus_nsp9_-RdRp-__NP_839965__Porcine_epidemic_diarrhea_virus__28295__D437-453_491-565
D6 medium residues 582-617_735-832
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase__YP_009944302__Betacoronavirus_England_1__1263720__D461-490_606-620_725-816
D7 medium residues 618-682
PDB
Domain cluster: representative
CATH (28)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2r7rA05 1.10.357.80 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.66 57.0 4.22e-01 100.0% 40.9%
2be4A03 1.10.238.10 Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand 0.64 50.0 4.60e-01 100.0% 64.8%
1qrvA00 1.10.30.10 Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain 0.62 40.0 3.87e-01 83.1% 57.5%
3f2bA05 6.10.50.10 Special › Helix non-globular › Insulin-like, subunit E › 0.60 38.0 4.26e-01 93.8% 87.5%
3pjvD01 3.30.110.200 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › 0.60 33.0 3.15e-01 83.1% 42.3%
2ph7A01 1.10.3400.10 Mainly Alpha › Orthogonal Bundle › af_2093 domain like fold › af_2093 domain like 0.60 49.0 3.97e-01 92.3% 47.6%
7b9cA02 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.59 44.0 2.76e-01 93.8% 14.1%
2c4mA01 3.40.50.2000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; 0.58 42.0 2.56e-01 78.5% 43.8%
2hraA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.57 38.0 3.40e-01 92.3% 48.4%
1fxkB00 1.10.287.370 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.57 40.0 3.43e-01 75.4% 57.8%
4a17U01 1.10.287.310 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.56 38.0 3.61e-01 75.4% 59.7%
4hr6A00 6.10.250.2640 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.56 35.0 4.07e-01 72.3% 100.0%
4by6D02 1.25.40.800 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.56 43.0 3.00e-01 84.6% 24.4%
4mt1A07 3.30.70.1440 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain 0.55 46.0 4.02e-01 93.8% 82.4%
1rhcA00 3.20.20.30 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Luciferase-like domain 0.55 44.0 2.85e-01 89.2% 24.8%
2zdiB00 1.10.287.370 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.55 39.0 3.36e-01 75.4% 59.4%
3a6pA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.55 43.0 2.35e-01 86.2% 8.2%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.54 40.0 3.66e-01 89.2% 58.6%
3raoB00 3.20.20.30 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Luciferase-like domain 0.54 44.0 2.76e-01 90.8% 22.9%
2jhjA02 1.10.340.30 Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Hypothetical protein; domain 2 0.54 44.0 3.60e-01 89.2% 61.7%
4e1oA03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.53 39.0 3.40e-01 78.5% 83.7%
1xexB00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.52 34.0 2.65e-01 95.4% 26.7%
3aeiA00 1.10.287.370 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.52 42.0 3.72e-01 89.2% 68.1%
3m8eA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.52 39.0 3.36e-01 83.1% 51.5%
2pv0A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.52 41.0 2.90e-01 86.2% 46.1%
4a55A01 3.10.20.770 Alpha Beta › Roll › Ubiquitin-like (UB roll) › 0.51 42.0 2.79e-01 98.5% 20.3%
1q47A00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.51 39.0 2.44e-01 90.8% 87.4%
2hw5A02 1.10.12.10 Mainly Alpha › Orthogonal Bundle › Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 › Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 0.50 40.0 4.19e-01 92.3% 100.0%
ECOD (37)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3253944 5041.1.1.0 ↗ extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C 0.71 53.0 3.84e-01 78.5% 55.4%
3479114 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.69 59.0 3.43e-01 100.0% 10.7%
2636124 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.67 54.0 3.76e-01 100.0% 26.1%
4289835 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 52.0 3.69e-01 100.0% 28.6%
3258201 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 51.0 3.56e-01 100.0% 25.5%
4512738 3236.1.1.16 ↗ alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Asp-Al_Ex 0.63 49.0 3.09e-01 87.7% 72.5%
5072253 213.1.1.1 ↗ a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.63 40.0 3.30e-01 90.8% 33.6%
2337274 4993.1.1.2 ↗ extended segments › Glu-tRNAGln amidotransferase C subunit › Glu-tRNAGln amidotransferase C subunit › Glu-tRNAGln amidotransferase C subunit › AtzG-like 0.63 39.0 3.91e-01 89.2% 60.6%
3651060 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 47.0 3.39e-01 81.5% 31.6%
4003509 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.63 50.0 3.90e-01 100.0% 38.7%
5007248 5065.1.1.3 ↗ alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › BPD_transp_2 0.62 49.0 3.27e-01 93.8% 21.9%
3939572 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 47.0 3.33e-01 87.7% 27.1%
3863804 5.1.4.17 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › CPSF_A,MMS1_N 0.61 44.0 2.48e-01 95.4% 6.4%
4128920 304.114.1.0 ↗ a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain 0.60 44.0 4.11e-01 100.0% 61.2%
3911603 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.59 50.0 3.78e-01 100.0% 38.2%
5061659 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.59 47.0 4.50e-01 96.9% 77.3%
3405208 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.58 37.0 3.55e-01 86.2% 53.8%
3269516 102.1.1.41 ↗ alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like › EME1-MUS81_C 0.57 43.0 3.86e-01 83.1% 82.1%
3877444 5050.1.1.6 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP 0.57 47.0 3.19e-01 96.9% 41.1%
3188556 2002.1.1.16 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Bac_luciferase 0.56 46.0 2.83e-01 89.2% 21.9%
4244236 3681.1.1.0 ↗ a+b complex topology › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit 0.56 44.0 3.73e-01 87.7% 96.4%
3889291 5050.1.1.6 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP 0.55 46.0 3.20e-01 100.0% 51.0%
4149277 167.1.1.1 ↗ alpha arrays › Ribosomal protein S7 › Ribosomal protein S7 › Ribosomal protein S7 › Ribosomal_S7 0.54 45.0 3.48e-01 92.3% 73.1%
4303875 3018.1.1.0 ↗ a+b two layers › MesJ substrate recognition domain-like › MesJ substrate recognition domain-like › MesJ substrate recognition domain-like 0.54 45.0 4.06e-01 100.0% 67.8%
4589914 2002.1.1.16 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Bac_luciferase 0.54 43.0 2.76e-01 89.2% 24.7%
3882475 5050.1.1.6 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP 0.54 45.0 3.08e-01 100.0% 38.5%
3169173 3241.1.1.1 ↗ alpha arrays › Golgi phosphoprotein 3 › Golgi phosphoprotein 3 › Golgi phosphoprotein 3 › GPP34 0.53 43.0 2.93e-01 96.9% 68.1%
4112182 192.2.1.1 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2 0.53 43.0 3.52e-01 89.2% 54.2%
3169451 109.4.1.3193 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HAT, Suf, HAT_Syf1_CNRKL1_C, HAT_Syf1_CNRKL1_N, HAT_PRP39_N 0.53 38.0 2.24e-01 89.2% 7.9%
3591987 2003.1.5.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Met_10 0.53 45.0 2.89e-01 100.0% 53.9%
4415569 4055.1.1.1 ↗ a+b complex topology › a+b domain in virulence-associated V antigen › a+b domain in virulence-associated V antigen › a+b domain in virulence-associated V antigen › LcrV 0.53 40.0 3.18e-01 84.6% 37.9%
4181293 192.2.1.1 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2 0.53 43.0 3.59e-01 89.2% 58.2%
3482328 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.52 42.0 3.62e-01 89.2% 61.0%
4316271 3018.1.1.0 ↗ a+b two layers › MesJ substrate recognition domain-like › MesJ substrate recognition domain-like › MesJ substrate recognition domain-like 0.52 43.0 4.05e-01 100.0% 76.2%
3631552 102.1.2.1 ↗ alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › DNA-glycosylase › HhH-GPD 0.51 42.0 2.81e-01 89.2% 30.2%
3404813 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.51 39.0 3.77e-01 83.1% 74.7%
4586844 314.1.1.3 ↗ a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › tRNA-synt_2d 0.50 43.0 2.59e-01 98.5% 22.0%
D8 medium residues 833-920
PDB
Domain cluster: rep: NSP12__YP_009825029__Duck_coronavirus__300188__D836-945