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RNA-dependent_RNA_polymerase

Euk-Vir

Penicillium_chrysogenum_virus

RNA-dependent_RNA_polymerase__YP_392482__Penicillium_chrysogenum_virus__158372

Identity

Accession:
YP_392482 ↗
Protein ID:
RNA-dependent_RNA_polymerase
Kingdom:
euk

Quality

77.0 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 326-456_828-856
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02123.22 best RdRP_4 35.6 7.80e-09 80.6% 23.9%
D2 medium residues 71-235
PDB
D4 medium residues 512-635_671-730
PDB
D5 medium residues 636-670_731-826
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02123.22 best RdRP_4 99.4 3.40e-28 74.1% 19.6%
D6 medium residues 857-930_969-1001
PDB
Domain cluster: representative
D7 medium residues 931-968_1014-1060
PDB
Domain cluster: representative
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3dv9A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.55 34.0 3.64e-01 85.9% 72.9%
1gq2A02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.53 39.0 2.68e-01 78.8% 78.0%
4s3mB02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.53 46.0 4.30e-01 96.5% 100.0%
D8 medium residues 1002-1013_1061-1117
PDB
Domain cluster: representative
CATH (35)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4m70B00 1.10.246.200 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › WPP domain 0.77 58.0 5.28e-01 79.7% 92.3%
5ci5B02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.76 54.0 3.81e-01 75.4% 76.0%
2xd3A02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.73 52.0 3.70e-01 73.9% 76.3%
3if8B02 1.20.58.730 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 51.0 4.56e-01 73.9% 69.0%
3uorB02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.73 57.0 4.02e-01 84.1% 75.2%
1j5sA01 3.20.20.140 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases 0.72 53.0 3.33e-01 78.3% 96.7%
3qufA02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.71 50.0 3.44e-01 73.9% 78.6%
4ovjA02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.71 52.0 3.65e-01 78.3% 77.7%
4jd9G00 1.10.238.20 Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain 0.70 55.0 4.50e-01 82.6% 62.5%
1eu8A02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.70 52.0 3.68e-01 79.7% 76.0%
4rjzA02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.67 52.0 3.76e-01 84.1% 74.5%
1rp3G02 1.20.140.160 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › PhyR, sigma-like (SL) domain 0.66 49.0 3.88e-01 79.7% 66.9%
4e69A00 3.40.1190.20 Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase 0.66 52.0 3.43e-01 88.4% 82.6%
2ougA00 3.30.70.940 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain 0.65 48.0 3.80e-01 79.7% 66.0%
4ex8A00 3.40.1790.10 Alpha Beta › 3-Layer(aba) Sandwich › Indigoidine synthase fold › Indigoidine synthase domain 0.64 48.0 3.18e-01 82.6% 49.8%
3hx3A01 1.10.8.20 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › N-terminal domain of phosphatidylinositol transfer protein sec14p 0.63 44.0 4.49e-01 73.9% 88.1%
1txuA01 1.10.246.120 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › 0.62 55.0 4.95e-01 98.6% 88.3%
3u61D03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.61 46.0 4.28e-01 82.6% 63.7%
4hiaA00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.61 52.0 3.89e-01 95.7% 59.7%
3c18A02 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.61 46.0 3.88e-01 81.2% 66.1%
6xzqA01 3.40.91.90 Alpha Beta › 3-Layer(aba) Sandwich › Restriction Endonuclease › Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain 0.61 47.0 3.58e-01 82.6% 91.4%
1rykA00 1.10.1470.10 Mainly Alpha › Orthogonal Bundle › Protein Yjbj; Chain: A; › YjbJ 0.60 42.0 4.28e-01 91.3% 75.4%
2go7A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.59 44.0 4.52e-01 95.7% 82.1%
2i53A02 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.59 44.0 3.86e-01 82.6% 58.6%
2pmrA00 1.20.1270.90 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like 0.58 43.0 4.21e-01 78.3% 90.8%
2mh3A00 4.10.280.10 Few Secondary Structures › Irregular › MYOD Basic-Helix-Loop-Helix Domain, subunit B › Helix-loop-helix DNA-binding domain 0.58 37.0 3.73e-01 76.8% 64.3%
3vayA02 1.20.120.1600 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.58 50.0 4.64e-01 95.7% 85.1%
2oo2A00 1.20.1270.90 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like 0.58 44.0 4.26e-01 81.2% 82.9%
3t46A00 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.57 41.0 4.03e-01 76.8% 77.3%
4didB01 1.20.58.450 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Cell division control protein 42 homolog 0.56 45.0 3.90e-01 91.3% 69.3%
2yi9A05 1.20.1270.270 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › VP1, C-terminal extension domain 0.56 41.0 3.99e-01 79.7% 71.4%
4ap9A02 1.10.150.210 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Phosphoserine phosphatase; domain 2 0.55 35.0 3.77e-01 81.2% 75.0%
8e9gK01 1.10.287.3510 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.54 41.0 3.80e-01 84.1% 76.9%
2el7A02 1.10.240.10 Mainly Alpha › Orthogonal Bundle › Tyrosyl-Transfer RNA Synthetase › Tyrosyl-Transfer RNA Synthetase 0.53 40.0 3.60e-01 82.6% 58.5%
6zhiB02 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.51 38.0 3.65e-01 82.6% 79.5%
ECOD (22)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5010827 7523.1.1.28 a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › SBP_bac_8 0.79 63.0 3.82e-01 84.1% 60.0%
4972100 7523.1.1.0 a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II 0.74 56.0 3.76e-01 79.7% 73.5%
5069340 4163.1.1.1 alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like › Sld5 0.74 43.0 3.51e-01 97.1% 33.3%
4940746 3457.1.1.1 alpha bundles › GxGD membrane protease › GxGD membrane protease › GxGD membrane protease › Peptidase_A24 0.73 52.0 3.76e-01 73.9% 40.0%
4039740 3317.1.1.2 alpha arrays › KorB C-terminal domain-like › KorB C-terminal domain › KorB C-terminal domain › HTH_ParB 0.73 47.0 4.85e-01 78.3% 70.8%
3065995 148.1.3.0 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.71 54.0 3.92e-01 82.6% 54.1%
3961339 191.1.1.0 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain 0.71 52.0 4.16e-01 78.3% 91.9%
321266 2002.1.1.98 a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › UxaC 0.71 55.0 3.31e-01 84.1% 97.5%
5005181 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.69 53.0 3.95e-01 82.6% 90.3%
3963102 191.1.1.0 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain 0.68 51.0 4.06e-01 79.7% 87.9%
3968663 191.1.1.0 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain 0.65 47.0 4.01e-01 76.8% 85.2%
4942062 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.64 46.0 4.34e-01 76.8% 87.1%
5027497 632.6.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit 0.63 48.0 4.56e-01 81.2% 97.5%
4946474 3317.1.1.0 alpha arrays › KorB C-terminal domain-like › KorB C-terminal domain › KorB C-terminal domain 0.61 41.0 4.25e-01 75.4% 73.8%
4949146 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.61 46.0 4.32e-01 79.7% 92.8%
5044025 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.60 44.0 4.17e-01 78.3% 89.4%
4088578 101.35.1.0 alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX 0.60 48.0 4.97e-01 95.7% 96.9%
4942424 632.11.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like › DUF357 0.58 43.0 4.22e-01 81.2% 86.7%
3520403 633.6.1.6 alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACAD9-ACADV_C 0.57 42.0 3.66e-01 78.3% 82.9%
3435434 632.1.1.13 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › Rx_N 0.57 43.0 3.72e-01 79.7% 83.8%
3810451 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.52 39.0 3.65e-01 81.2% 84.4%
5070372 164.1.1.0 alpha bundles › Chorismate mutase II › Chorismate mutase II › Chorismate mutase II 0.51 42.0 3.90e-01 95.7% 78.9%