RNA-directed_RNA_polymerase

Euk-Vir

Rhinovirus_A

RNA-directed_RNA_polymerase__NP_740401__Rhinovirus_A__147711

Identity

94.4 mean pLDDT

Orthornavirae› Pisuviricota› Pisoniviricetes› Picornavirales› Picornaviridae› Enterovirus› Rhinovirus_A

TaxID: 147711

View cluster (450 members)

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high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 371-458

PDB

Domain cluster: rep: putative_3D_RNA-dependent_RNA_polymerase__YP_009553719__tremovirus_B1__2058161__D405-481

D2 medium residues 1-23_237-289

PDB

Domain cluster: rep: 3D__NP_740536__Enterovirus_A__138948__D1-16_240-289

D3 medium residues 39-64_104-181

PDB

Domain cluster: rep: hypothetical_protein_2__YP_009337735__Wenling_sobemo-like_virus_2__1923541__D4-91_185-200

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00680.26 best	RdRP_1	51.5	1.00e-13	100.0%	20.0%

ECOD (6)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
None	—		0.98	96.0	6.23e-01	100.0%	39.1%
1173784	304.48.1.8 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1	0.97	94.0	6.13e-01	100.0%	38.8%
5367	304.48.1.8 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1	0.89	84.0	5.52e-01	100.0%	40.2%
2541763	304.48.1.8 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1	0.88	84.0	5.49e-01	100.0%	38.9%
3422064	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.60	53.0	3.60e-01	99.0%	35.9%
3241316	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.57	49.0	3.50e-01	97.1%	40.9%

D4 medium residues 65-103_182-204

PDB

Domain cluster: representative

CATH (1)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4q45A03	1.10.150.20	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › 5' to 3' exonuclease, C-terminal subdomain	0.56	32.0	3.33e-01	85.5%	60.0%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3718287	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.55	34.0	2.51e-01	79.0%	21.1%

D5 medium residues 205-236_290-369

PDB

Domain cluster: rep: RNA_dependent_RNA_polymerase__YP_529897__Newbury_agent_1__331642__D58-79_192-241_281-399

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00680.26 best	RdRP_1	38.7	7.70e-10	73.2%	18.2%
PF02123.22	RdRP_4	24.9	1.40e-05	70.5%	14.0%