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RNA-directed_RNA_polymerase

Euk-Vir

Enterovirus_C

RNA-directed_RNA_polymerase__NP_740478__Enterovirus_C__138950

Identity

Accession:
NP_740478 ↗
Protein ID:
RNA-directed_RNA_polymerase
Kingdom:
euk

Quality

94.9 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Picornavirales› Picornaviridae› Enterovirus› Enterovirus_C

TaxID: 138950

Cluster

View cluster (450 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 2-59
PDB
Domain cluster: representative
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
None — 0.97 92.0 5.40e-01 100.0% 15.8%
2541763 304.48.1.8 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.82 71.0 4.27e-01 100.0% 14.7%
D2 high residues 373-459
PDB
Domain cluster: rep: putative_3D_RNA-dependent_RNA_polymerase__YP_009553719__tremovirus_B1__2058161__D405-481
D3 medium residues 64-83_193-204_238-293
PDB
Domain cluster: rep: 3D__YP_002956129__Cosavirus_D__2003650__D183-203_245-295
CATH (8)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2r7rA05 1.10.357.80 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.72 65.0 5.14e-01 100.0% 96.0%
4rg6A02 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.54 37.0 3.91e-01 81.8% 80.5%
3ic9A02 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.53 30.0 3.28e-01 93.2% 67.1%
2qzcA00 1.20.910.10 Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like 0.52 41.0 3.12e-01 85.2% 81.8%
2wpvE00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.52 41.0 2.89e-01 85.2% 54.3%
2zy9A03 1.10.357.20 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › SLC41 divalent cation transporters, integral membrane domain 0.51 38.0 3.02e-01 77.3% 73.0%
5cm2Z00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.51 36.0 2.87e-01 73.9% 82.1%
3k11A00 1.50.10.10 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › 0.50 39.0 2.63e-01 89.8% 28.5%
ECOD (21)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3781350 5041.1.1.20 ↗ extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › PF26669 0.63 32.0 2.90e-01 90.9% 35.8%
3912893 5001.1.1.1 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.57 39.0 2.64e-01 71.6% 76.7%
3803690 109.4.1.1275 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_1, PPR_2, PPR_3, PPR_long, TPR_24 0.57 41.0 2.67e-01 85.2% 17.6%
3682008 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 39.0 3.51e-01 78.4% 51.6%
3680466 109.4.1.883 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 0.56 38.0 3.31e-01 81.8% 45.9%
3328696 109.4.1.1257 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_1, PPR_2 0.56 41.0 3.68e-01 87.5% 55.2%
3432599 109.4.1.883 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 0.55 39.0 2.53e-01 85.2% 16.6%
3300366 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.55 42.0 3.44e-01 79.5% 61.9%
3348499 109.4.1.883 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 0.54 42.0 4.04e-01 81.8% 81.0%
3811350 109.4.1.1277 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_1, PPR_2, TPR_24 0.54 40.0 3.41e-01 87.5% 48.6%
3332656 109.4.1.420 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR 0.53 40.0 3.22e-01 80.7% 64.6%
3458101 109.4.1.1254 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, E_motif 0.53 40.0 2.62e-01 80.7% 33.5%
3678680 109.4.1.420 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR 0.52 40.0 3.23e-01 81.8% 55.3%
3309609 109.4.1.1258 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_1, PPR_2 0.52 38.0 3.28e-01 84.1% 47.9%
3455535 109.4.1.420 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR 0.52 40.0 3.16e-01 79.5% 54.3%
3337844 109.4.1.420 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR 0.52 39.0 2.86e-01 79.5% 39.1%
3826428 109.4.1.420 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR 0.52 39.0 3.37e-01 79.5% 68.9%
3650242 109.4.1.883 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 0.52 39.0 3.00e-01 80.7% 44.5%
3613338 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.51 42.0 2.27e-01 89.8% 6.6%
3338684 109.4.1.1293 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_1 0.51 38.0 3.53e-01 79.5% 81.7%
3415024 5001.1.1.1 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.50 35.0 2.49e-01 73.9% 78.1%
D4 medium residues 84-192
PDB
Domain cluster: rep: 3D__YP_009179377__sicinivirus_A1__2773315__D75-149_180-201
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 43.0 3.80e-11 95.4% 22.2%
D5 medium residues 205-237_294-372
PDB
Domain cluster: rep: RNA_dependent_RNA_polymerase__YP_529897__Newbury_agent_1__331642__D58-79_192-241_281-399
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 36.9 2.70e-09 68.8% 16.7%
PF02123.22 RdRP_4 22.1 9.10e-05 68.8% 14.4%