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RNA_dependent_RNA_polymerase
Euk-VirCypovirus_14
RNA_dependent_RNA_polymerase__NP_149135__Cypovirus_14__205908
Identity
- Accession:
- NP_149135 ↗
- Protein ID:
- RNA_dependent_RNA_polymerase
- Kingdom:
- euk
Quality
81.0
mean pLDDT
Cluster
View cluster (29 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 42-85_146-366
Domain cluster:
rep: RNA-dependent_RNA_polymerase__YP_009158917__Lutzomyia_reovirus_1__1670669__D23-269_297-353_757-788
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22209.2 best | CPV_RdRP_N | 249.6 | 4.40e-74 | 78.9% | 74.6% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697856 | 4963.1.1.3 ↗ | alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › CPV_RdRP_N | 0.96 | 91.0 | 8.14e-01 | 96.6% | 92.2% |
| 4905 | 4963.1.1.2 ↗ | alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › RdRP_5 | 0.79 | 73.0 | 6.39e-01 | 96.2% | 91.0% |
| 4937968 | 3352.1.1.1 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3 | 0.52 | 37.0 | 3.09e-01 | 70.6% | 86.5% |
D2
medium
residues 86-145
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22209.2 best | CPV_RdRP_N | 60.9 | 1.90e-16 | 100.0% | 23.8% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697856 | 4963.1.1.3 ↗ | alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › CPV_RdRP_N | 0.88 | 82.0 | 4.93e-01 | 100.0% | 17.4% |
| 3497607 | 2011.1.1.0 ↗ | a/b three-layered sandwiches › Phosphorylase/hydrolase-like › Zn-dependent exopeptidases › Zn-dependent exopeptidases | 0.55 | 47.0 | 2.92e-01 | 96.7% | 100.0% |
D3
medium
residues 467-499_511-526_567-652
Domain cluster:
representative
Pfam (2)
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1mukA02 | 3.90.1850.10 | Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3 | 0.83 | 78.0 | 5.12e-01 | 100.0% | 36.9% |
| 2r7rA05 | 1.10.357.80 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › | 0.61 | 55.0 | 5.01e-01 | 97.8% | 76.1% |
| 1vq0A02 | 3.90.1280.10 | Alpha Beta › Alpha-Beta Complex › CBS domain Like › HSP33 redox switch-like | 0.53 | 18.0 | 2.77e-01 | 74.8% | 71.9% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697857 | 304.48.1.30 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › CPV_RdRP_pol_dom | 0.89 | 85.0 | 6.06e-01 | 100.0% | 54.8% |
| 3883010 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.54 | 49.0 | 3.77e-01 | 100.0% | 59.7% |
| 3877925 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.54 | 48.0 | 3.50e-01 | 100.0% | 52.7% |
D4
medium
residues 527-566_653-744
Domain cluster:
rep: KR816341.1__AKQ06880.1__X__00021__D162-195_238-325
D5
medium
residues 923-1017
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22213.2 best | CPV_RdRP_C | 112.3 | 4.20e-32 | 100.0% | 27.4% |
CATH (11)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4zvaA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.59 | 44.0 | 3.83e-01 | 80.0% | 73.2% |
| 1x42A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.58 | 33.0 | 3.57e-01 | 73.7% | 63.9% |
| 1nv8B01 | 1.10.8.10 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain | 0.57 | 29.0 | 3.29e-01 | 98.9% | 62.0% |
| 2yqzA02 | 1.10.8.900 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.54 | 31.0 | 3.68e-01 | 100.0% | 80.9% |
| 2y39A00 | 1.20.120.1490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.54 | 37.0 | 3.62e-01 | 71.6% | 98.2% |
| 1dkqA02 | 3.40.50.1240 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate mutase-like | 0.53 | 38.0 | 3.51e-01 | 74.7% | 100.0% |
| 1gcvA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.53 | 39.0 | 3.49e-01 | 77.9% | 80.7% |
| 6tqfA01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.53 | 42.0 | 2.83e-01 | 85.3% | 76.5% |
| 2z6vA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.53 | 43.0 | 2.98e-01 | 94.7% | 70.4% |
| 3mhsB00 | 1.10.246.140 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › ENY2/SUS1 | 0.51 | 37.0 | 3.82e-01 | 77.9% | 97.8% |
| 3umcD02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.51 | 31.0 | 3.37e-01 | 74.7% | 73.1% |
ECOD (9)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1697853 | 4962.1.1.2 ↗ | alpha complex topology › C-terminal additional helical subdomain in reovirus polymerase lambda3 › C-terminal additional helical subdomain in reovirus polymerase lambda3 › C-terminal additional helical subdomain in reovirus polymerase lambda3 › RdRP_5 | 0.66 | 56.0 | 3.78e-01 | 100.0% | 24.5% |
| 4965656 | 4336.1.1.1 ↗ | alpha duplicates or obligate multimers › YheA/YmcA-like › YheA/YmcA-like › YheA/YmcA-like › Com_YlbF | 0.58 | 36.0 | 3.42e-01 | 88.4% | 50.4% |
| 2538989 | 4336.1.1.1 ↗ | alpha duplicates or obligate multimers › YheA/YmcA-like › YheA/YmcA-like › YheA/YmcA-like › Com_YlbF | 0.58 | 40.0 | 3.77e-01 | 70.5% | 79.1% |
| 3784855 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.56 | 39.0 | 2.94e-01 | 72.6% | 86.4% |
| 3839699 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.54 | 41.0 | 3.26e-01 | 81.1% | 98.5% |
| 4033700 | 4336.1.1.1 ↗ | alpha duplicates or obligate multimers › YheA/YmcA-like › YheA/YmcA-like › YheA/YmcA-like › Com_YlbF | 0.52 | 36.0 | 3.61e-01 | 71.6% | 84.0% |
| 4098259 | 110.1.1.13 ↗ | alpha arrays › DEATH domain › DEATH domain › DEATH domain › DUF3603 | 0.52 | 36.0 | 3.59e-01 | 71.6% | 90.8% |
| 3398929 | 5041.1.1.32 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › TMEM141 | 0.50 | 30.0 | 3.12e-01 | 100.0% | 62.2% |
| 5055491 | 610.3.1.1 ↗ | alpha arrays › ERP29 C domain-like › GatB/GatE C-terminal domain › GatB/GatE C-terminal domain › GatB_Yqey | 0.50 | 30.0 | 2.58e-01 | 70.5% | 35.0% |
D6
medium
residues 1076-1158