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RNA_dependent_RNA_polymerase

Euk-Vir

Rosellinia_necatrix_quadrivirus_1

RNA_dependent_RNA_polymerase__YP_005097975__Rosellinia_necatrix_quadrivirus_1__1000373

Identity

Accession:
YP_005097975 ↗
Protein ID:
RNA_dependent_RNA_polymerase
Kingdom:
euk

Quality

59.7 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 448-543
PDB
D2 medium residues 332-373_385-397
PDB
D3 medium residues 398-435_564-627
PDB
Domain cluster: representative
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1jkwA01 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.56 39.0 3.35e-01 73.5% 78.4%
1g8qA00 1.10.1450.10 Mainly Alpha › Orthogonal Bundle › Cd81 Antigen, Extracellular Domain; Chain: A › Tetraspanin 0.53 34.0 3.57e-01 97.1% 72.2%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3996308 3352.1.1.0 alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain 0.58 46.0 3.38e-01 87.3% 99.0%
3294222 2003.1.5.31 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GRAS 0.53 45.0 3.10e-01 99.0% 87.2%
1934768 191.1.1.32 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_30 0.52 40.0 3.74e-01 84.3% 91.1%
D4 medium residues 689-723_811-975
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02123.22 best RdRP_4 50.2 2.80e-13 95.0% 31.6%
D5 medium residues 976-1028
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02123.22 best RdRP_4 22.9 5.30e-05 98.1% 11.0%
CATH (53)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4pwuC00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.75 64.0 5.71e-01 98.1% 70.5%
1in0A01 3.30.70.860 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.74 64.0 5.94e-01 100.0% 78.6%
2dt9A01 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.72 57.0 5.22e-01 94.3% 66.2%
2w01B00 3.30.70.1230 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain 0.71 61.0 4.17e-01 100.0% 55.8%
1zhvA00 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.71 59.0 4.51e-01 100.0% 38.8%
3fryA01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.69 55.0 5.25e-01 100.0% 76.6%
1lxnA00 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.69 60.0 4.94e-01 100.0% 59.2%
4qbuA03 3.30.70.250 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Malonyl-CoA ACP transacylase, ACP-binding 0.69 58.0 5.48e-01 98.1% 84.8%
6le1A01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.68 56.0 5.19e-01 92.5% 82.4%
2y3mA02 3.30.1370.130 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.68 53.0 5.24e-01 92.5% 82.1%
2iboA00 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.66 56.0 4.82e-01 98.1% 61.8%
1s7hA01 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.66 57.0 5.02e-01 100.0% 70.0%
1lxjA00 3.30.70.930 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.66 56.0 4.59e-01 100.0% 55.3%
2qsrA01 3.90.1150.50 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Transcription-repair-coupling factor, D7 domain 0.65 53.0 3.84e-01 92.5% 32.3%
4erdA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.65 53.0 4.39e-01 100.0% 58.3%
2l48A00 3.30.70.2030 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.64 55.0 4.79e-01 100.0% 67.1%
3ezjA02 3.30.1370.120 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.63 50.0 4.72e-01 92.5% 75.0%
7q5yB01 3.30.460.80 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › NADH:ubiquinone oxidoreductase Nqo5 subunit 0.63 51.0 4.11e-01 98.1% 44.2%
2f1fA02 3.30.70.1150 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT-like. Chain A, domain 2 0.63 52.0 4.69e-01 100.0% 66.7%
2kgsA01 3.40.1520.20 Alpha Beta › 3-Layer(aba) Sandwich › hypothetical protein tt1634 › 0.63 54.0 4.30e-01 98.1% 99.1%
4obuA01 3.90.1150.170 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › 0.62 49.0 3.32e-01 92.5% 25.6%
1utaA00 3.30.70.1070 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Sporulation related repeat 0.62 50.0 4.59e-01 100.0% 72.7%
3l44A01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.60 50.0 3.59e-01 100.0% 35.5%
2jhjA02 1.10.340.30 Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Hypothetical protein; domain 2 0.60 47.0 3.74e-01 90.6% 85.8%
6liuC02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.59 45.0 3.76e-01 94.3% 50.0%
5xyiK00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.59 41.0 3.53e-01 75.5% 63.3%
7xinA03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.59 44.0 3.70e-01 90.6% 50.5%
4ie5A02 1.20.58.1470 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FTO C-terminal domain 0.59 45.0 3.47e-01 86.8% 61.9%
1fxrA00 3.30.70.20 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 47.0 4.45e-01 98.1% 76.6%
4r5qA00 3.90.320.10 Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A › 0.58 42.0 2.88e-01 81.1% 56.3%
2cgqA00 1.10.1200.10 Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › ACP-like 0.57 48.0 4.39e-01 100.0% 75.7%
6uf3A00 3.40.630.190 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › LCP protein 0.56 42.0 2.74e-01 96.2% 17.7%
1tbxB00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.55 43.0 3.66e-01 86.8% 65.6%
6uvuA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.55 40.0 3.37e-01 84.9% 53.8%
2pg4A00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.55 40.0 3.53e-01 84.9% 72.5%
3tx8A02 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.54 42.0 3.56e-01 100.0% 72.8%
4kdyB01 3.40.30.10 Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Glutaredoxin 0.54 40.0 3.56e-01 81.1% 87.5%
1pjqA02 3.30.160.110 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Sirohaem synthase, central domain 0.53 33.0 3.81e-01 84.9% 91.7%
6nifA01 3.30.900.10 Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain 0.53 45.0 3.14e-01 100.0% 86.3%
2wpvE00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.53 40.0 2.54e-01 92.5% 15.7%
3cuoD00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.53 41.0 3.56e-01 92.5% 64.9%
3e9lA02 1.20.80.40 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › Prp8 RNase H domain, fingers region 0.53 43.0 3.66e-01 96.2% 75.8%
3nftA00 1.20.1710.10 Mainly Alpha › Up-down Bundle › IpaD-like › IpaD-like 0.52 43.0 2.75e-01 92.5% 37.8%
2x49A02 3.40.5.40 Alpha Beta › 3-Layer(aba) Sandwich › Ribosomal Protein L9; domain 1 › FHIPEP family, domain 2 0.52 36.0 3.74e-01 96.2% 87.5%
2dy1A01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.52 42.0 2.72e-01 96.2% 44.0%
4l9yD00 3.20.20.60 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Phosphoenolpyruvate-binding domains 0.52 46.0 2.92e-01 100.0% 45.7%
6spbZ00 3.30.1390.20 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein L30; Chain: A, › Ribosomal protein L30/L7 0.51 39.0 3.85e-01 98.1% 82.5%
1u6gC00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.51 44.0 2.36e-01 100.0% 8.3%
2qmaA02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.51 42.0 3.22e-01 92.5% 39.2%
7l9pK01 3.30.900.10 Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain 0.51 39.0 3.12e-01 90.6% 45.4%
4iggB06 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.50 44.0 2.94e-01 100.0% 45.1%
5owcA00 1.20.90.10 Mainly Alpha › Up-down Bundle › Phospholipase A2 › Phospholipase A2 domain 0.50 40.0 3.19e-01 94.3% 74.6%
4uyiA00 3.30.710.10 Alpha Beta › 2-Layer Sandwich › Potassium Channel Kv1.1; Chain A › Potassium Channel Kv1.1; Chain A 0.50 41.0 3.26e-01 100.0% 59.8%
ECOD (45)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4392601 304.36.1.1 a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › DUF520 0.75 65.0 5.88e-01 100.0% 75.3%
3670391 4121.1.1.2 a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › MRS2-like 0.75 57.0 3.55e-01 92.5% 14.5%
4636695 304.36.1.1 a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › DUF520 0.75 65.0 6.04e-01 100.0% 80.9%
4598960 304.36.1.0 a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like 0.74 64.0 5.93e-01 100.0% 81.4%
4302225 304.1.1.1 a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C 0.73 62.0 4.93e-01 100.0% 50.4%
4309637 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.73 61.0 5.32e-01 100.0% 60.7%
4543273 304.36.1.1 a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › DUF520 0.73 62.0 5.91e-01 100.0% 89.2%
4090279 304.36.1.1 a+b two layers › Alpha-beta plaits › YajQ-like › YajQ-like › DUF520 0.72 62.0 5.41e-01 100.0% 64.7%
5044181 304.117.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC 0.72 60.0 5.47e-01 98.1% 76.0%
5063713 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.72 59.0 5.73e-01 98.1% 85.0%
3278082 304.120.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.71 60.0 5.84e-01 98.1% 86.7%
3972409 327.16.1.3 a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system › Secretin_N 0.71 56.0 5.40e-01 92.5% 78.3%
3324543 4121.1.1.2 a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › MRS2-like 0.70 56.0 3.53e-01 92.5% 17.1%
3581763 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.70 59.0 5.50e-01 100.0% 77.1%
3283204 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.70 58.0 5.48e-01 98.1% 80.0%
3408055 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.69 57.0 4.94e-01 98.1% 60.0%
3230011 6106.1.1.0 extended segments › Photosystem II protein Y, psbY › Photosystem II protein Y, psbY › Photosystem II protein Y, psbY 0.68 52.0 4.55e-01 90.6% 54.1%
5023231 304.120.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.68 58.0 5.04e-01 100.0% 88.2%
3539399 304.8.1.10 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_7 0.68 54.0 4.47e-01 100.0% 47.6%
3738318 327.11.2.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.67 54.0 4.82e-01 92.5% 76.2%
3524888 304.8.1.10 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_7 0.66 52.0 4.84e-01 96.2% 68.6%
4487980 327.11.2.60 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_SLS1_2 0.66 53.0 5.11e-01 90.6% 81.7%
4559752 242.1.1.6 a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_WhiA 0.66 52.0 4.39e-01 86.8% 55.6%
5042968 304.120.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.64 52.0 5.01e-01 98.1% 81.5%
4028494 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.64 52.0 4.38e-01 100.0% 59.0%
3603400 304.120.1.6 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.64 52.0 4.80e-01 100.0% 70.7%
3734074 327.11.2.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.62 48.0 4.51e-01 94.3% 70.0%
3179971 327.11.2.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.61 48.0 4.37e-01 94.3% 76.2%
3575665 2004.1.1.17 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Myosin_head 0.59 45.0 2.62e-01 86.8% 8.9%
4335143 327.11.2.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.59 46.0 3.99e-01 94.3% 60.0%
4565985 5051.1.1.3 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › SSF 0.58 47.0 2.77e-01 92.5% 55.7%
3669948 109.4.1.1495 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF26522 0.57 45.0 2.53e-01 86.8% 18.3%
4968322 304.126.1.0 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C 0.56 44.0 4.45e-01 96.2% 92.7%
4061257 109.4.1.1255 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N, Cnd1 0.55 41.0 2.31e-01 100.0% 6.1%
3598913 267.1.1.0 a+b complex topology › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain 0.54 43.0 2.98e-01 100.0% 45.8%
3943761 3227.1.1.1 alpha complex topology › phosphorylation-coupled saccharide transporter ChbC › phosphorylation-coupled saccharide transporter ChbC › phosphorylation-coupled saccharide transporter ChbC › PTS_EIIC 0.54 41.0 2.51e-01 90.6% 38.6%
5014663 2004.1.1.85 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ArsA_ATPase 0.54 41.0 2.59e-01 86.8% 53.6%
4663703 267.1.1.3 a+b complex topology › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Cation_ATPase 0.54 42.0 3.02e-01 100.0% 41.9%
5043449 267.1.1.3 a+b complex topology › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Cation_ATPase 0.53 42.0 3.01e-01 100.0% 41.0%
4018916 149.1.1.1 alpha arrays › Cytochrome P450 › Cytochrome P450 › Cytochrome P450 › p450 0.53 42.0 2.50e-01 94.3% 71.9%
3225058 101.1.2.566 alpha arrays › HTH › HTH › winged helix domain › CDT1, CDT1_C 0.53 40.0 2.55e-01 84.9% 23.7%
4025406 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.52 38.0 2.49e-01 81.1% 51.7%
3991594 601.42.1.0 alpha bundles › Four-helical up-and-down bundle › Helical bundle in ROQ domain › Helical bundle in ROQ domain 0.52 39.0 2.84e-01 84.9% 85.9%
3920157 109.4.1.2709 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TIP120, HEAT_GCN1 0.50 43.0 2.41e-01 100.0% 13.0%
3227786 109.4.1.548 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TIP120 0.50 43.0 2.37e-01 100.0% 12.0%
D6 medium residues 1152-1250
PDB