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RNA_dependent_RNA_polymerase
Euk-VirHuman_rotavirus_B
RNA_dependent_RNA_polymerase__YP_008126843__Human_rotavirus_B__10942
Identity
- Accession:
- YP_008126843 ↗
- Protein ID:
- RNA_dependent_RNA_polymerase
- Kingdom:
- euk
Quality
61.4
mean pLDDT
Taxonomy
Orthornavirae›
Duplornaviricota›
Resentoviricetes›
Reovirales›
Sedoreoviridae›
Rotavirus›
Human_rotavirus_B
TaxID: 10942
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 3-92_762-881
D2
high
residues 95-305
D3
medium
residues 306-374
D4
medium
residues 375-430_521-532_583-598
Domain cluster:
representative
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1q90B00 | 1.20.810.10 | Mainly Alpha › Up-down Bundle › Cytochrome Bc1 Complex; Chain C › Cytochrome Bc1 Complex; Chain C | 0.58 | 40.0 | 3.01e-01 | 71.4% | 85.8% |
| 3lbxB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 41.0 | 3.79e-01 | 73.8% | 94.4% |
| 8igrI01 | 2.40.270.10 | Mainly Beta › Beta Barrel › Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6 › DNA-directed RNA polymerase, subunit 2, domain 6 | 0.53 | 38.0 | 2.94e-01 | 73.8% | 84.1% |
| 3bjdA01 | 1.10.1240.20 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Lytic transglycosylase, superhelical linker domain | 0.53 | 38.0 | 3.79e-01 | 75.0% | 76.1% |
| 1vctA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.50 | 37.0 | 3.39e-01 | 77.4% | 89.9% |
ECOD (10)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3719414 | 142.1.1.0 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors | 0.66 | 36.0 | 3.93e-01 | 77.4% | 64.3% |
| 3536832 | 109.4.1.87 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec6 | 0.63 | 46.0 | 2.94e-01 | 76.2% | 42.2% |
| 3191372 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.62 | 54.0 | 3.74e-01 | 98.8% | 67.3% |
| 3212587 | 188.1.1.0 ↗ | alpha arrays › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain | 0.60 | 41.0 | 3.13e-01 | 71.4% | 81.0% |
| 3799233 | 633.6.1.6 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACAD9-ACADV_C | 0.60 | 42.0 | 3.50e-01 | 72.6% | 68.3% |
| 4997717 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.59 | 41.0 | 2.88e-01 | 75.0% | 41.3% |
| 3207748 | 109.4.1.1256 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_3 | 0.57 | 51.0 | 3.32e-01 | 100.0% | 74.1% |
| 3223128 | 109.4.1.63 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TAP42 | 0.56 | 39.0 | 2.87e-01 | 73.8% | 45.8% |
| 3598836 | 604.7.1.0 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A | 0.55 | 39.0 | 3.48e-01 | 72.6% | 57.3% |
| 3741803 | 109.4.1.3069 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_1, ANAPC3, TPR_8, TPR_17, TPR_16 | 0.50 | 38.0 | 2.34e-01 | 81.0% | 13.3% |
D5
medium
residues 533-569_649-761
Domain cluster:
rep: KR816341.1__AKQ06880.1__X__00021__D162-195_238-325
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02123.22 best | RdRP_4 | 54.5 | 1.40e-14 | 89.3% | 16.8% |
D6
medium
residues 941-957_1079-1151
Domain cluster:
representative
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2r7rA07 | 3.30.230.140 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › | 0.65 | 55.0 | 5.12e-01 | 97.8% | 95.8% |
| 4rkcA02 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.59 | 41.0 | 2.97e-01 | 71.1% | 85.1% |
| 6ll8A02 | 3.10.310.20 | Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › DHHA2 domain | 0.57 | 38.0 | 3.51e-01 | 71.1% | 51.7% |
| 3s28A04 | 3.40.50.2000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; | 0.52 | 39.0 | 2.98e-01 | 80.0% | 77.5% |
| 1ax8A00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.52 | 45.0 | 4.07e-01 | 100.0% | 85.4% |
| 2kk4A00 | 3.10.20.840 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › | 0.52 | 31.0 | 3.12e-01 | 100.0% | 56.8% |
| 4lyaA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 45.0 | 3.23e-01 | 100.0% | 84.4% |
| 5bq3A02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.50 | 42.0 | 3.62e-01 | 96.7% | 88.4% |
D7
medium
residues 995-1078