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RNA_dependent_RNA_polymerase

Euk-Vir

Newbury_agent_1

RNA_dependent_RNA_polymerase__YP_529897__Newbury_agent_1__331642

Identity

Accession:
YP_529897 ↗
Protein ID:
RNA_dependent_RNA_polymerase
Kingdom:
euk

Quality

93.5 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 58-79_192-241_281-399
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00680.26 best RdRP_1 80.6 1.40e-22 62.8% 25.1%
PF00680.26 RdRP_1 27.3 2.10e-06 36.1% 10.9%
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1khvA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.93 62.0 7.68e-01 77.5% 100.0%
3h5xA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.92 56.0 7.27e-01 74.3% 100.0%
2ckwA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.92 55.0 7.25e-01 73.8% 100.0%
5jxsA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.89 65.0 7.50e-01 86.4% 99.3%
1gx5A03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.84 53.0 6.66e-01 78.0% 100.0%
1jwwA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.72 32.0 4.85e-01 70.7% 100.0%
4hkqA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.70 47.0 5.32e-01 100.0% 89.6%
3hvwA00 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.58 40.0 4.37e-01 78.5% 84.9%
3a1yG01 3.30.70.1730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein L10, N-terminal RNA-binding domain 0.55 37.0 4.32e-01 78.5% 94.8%
4lniA02 3.30.590.10 Alpha Beta › 2-Layer Sandwich › Creatine Kinase; Chain A, domain 2 › Glutamine synthetase/guanido kinase, catalytic domain 0.55 40.0 3.28e-01 72.8% 56.4%
4x0qA03 3.30.70.370 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.54 38.0 4.29e-01 83.2% 95.8%
4wcwA01 3.30.460.10 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 0.51 30.0 3.72e-01 82.2% 96.4%
3q23A02 3.30.70.2440 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.51 35.0 3.92e-01 75.9% 89.9%
ECOD (34)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5364 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.95 80.0 6.06e-01 85.9% 80.3%
1875037 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.91 75.0 5.76e-01 84.8% 81.3%
5367 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.87 73.0 5.65e-01 86.9% 83.1%
None 0.86 73.0 5.68e-01 86.9% 82.0%
1173784 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.86 73.0 5.67e-01 87.4% 82.4%
1697857 304.48.1.30 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › CPV_RdRP_pol_dom 0.70 58.0 4.71e-01 86.4% 95.1%
3983816 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.67 56.0 5.05e-01 86.9% 75.6%
3945039 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.67 59.0 4.85e-01 93.7% 95.5%
3336938 304.48.1.43 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Mitovir_RNA_pol 0.67 63.0 5.68e-01 100.0% 89.2%
3260077 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.66 58.0 4.59e-01 94.8% 87.4%
3589612 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 51.0 4.18e-01 80.1% 93.9%
3630469 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.65 57.0 4.71e-01 92.1% 79.4%
3173834 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 54.0 4.14e-01 86.4% 80.7%
4296494 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 56.0 4.73e-01 90.6% 78.0%
3451410 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 60.0 4.48e-01 100.0% 76.4%
4332626 3532.1.1.0 alpha arrays › RNA-binding domain of telomerase › RNA-binding domain of telomerase › RNA-binding domain of telomerase 0.65 56.0 3.91e-01 91.6% 47.1%
3258201 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 47.0 4.44e-01 75.9% 83.0%
3258406 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 59.0 4.18e-01 99.0% 69.7%
3939572 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.64 55.0 5.17e-01 91.1% 96.9%
4497954 304.48.1.73 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1, RVT_N 0.63 51.0 4.33e-01 84.3% 92.6%
4188583 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 56.0 4.34e-01 94.8% 81.2%
3068775 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 53.0 5.23e-01 90.6% 83.3%
4380832 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 55.0 4.35e-01 94.8% 85.6%
4963354 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.62 30.0 4.19e-01 72.8% 92.6%
4434853 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 49.0 4.57e-01 84.3% 67.1%
4424453 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 56.0 4.02e-01 99.5% 73.5%
3984781 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.59 43.0 4.63e-01 75.9% 88.7%
4029996 304.102.1.3 a+b two layers › Alpha-beta plaits › Pseudouridine synthase › Pseudouridine synthase › PseudoU_synth_1 0.54 38.0 3.16e-01 71.2% 84.4%
4173640 304.55.1.27 a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Origin of replication-binding domains › Phage_GPA 0.53 43.0 3.85e-01 85.9% 60.4%
3938275 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.53 49.0 4.44e-01 100.0% 90.2%
3463534 101.1.10.57 alpha arrays › HTH › HTH › Cyclin-like › AAA_34 0.52 26.0 3.47e-01 80.6% 89.0%
3949523 316.1.1.5 a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › RsfS 0.51 30.0 3.71e-01 82.2% 93.3%
5039503 304.126.1.0 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C 0.50 38.0 3.56e-01 78.5% 77.5%
4542315 304.1.1.1 a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C 0.50 30.0 3.40e-01 89.0% 75.8%
D2 medium residues 80-147_172-191
PDB
Domain cluster: representative
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3hgkE00 1.20.1280.110 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.56 34.0 3.58e-01 85.2% 67.5%
3t0yA01 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.52 34.0 3.89e-01 83.0% 90.9%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1875037 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.88 83.0 5.24e-01 100.0% 28.3%
3990885 164.1.1.0 alpha bundles › Chorismate mutase II › Chorismate mutase II › Chorismate mutase II 0.56 32.0 3.25e-01 71.6% 55.6%
5037901 7579.1.1.0 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases 0.50 36.0 2.64e-01 83.0% 23.8%
D3 medium residues 400-480
PDB
CATH (24)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2ckwA04 1.20.960.20 Mainly Alpha › Up-down Bundle › Mitochondrial Import Receptor Subunit Tom20; Chain A › 0.91 83.0 7.41e-01 100.0% 72.9%
1khvA05 1.20.960.20 Mainly Alpha › Up-down Bundle › Mitochondrial Import Receptor Subunit Tom20; Chain A › 0.87 77.0 7.23e-01 100.0% 79.4%
3nkyA03 1.20.960.20 Mainly Alpha › Up-down Bundle › Mitochondrial Import Receptor Subunit Tom20; Chain A › 0.81 54.0 5.67e-01 98.8% 76.7%
1ra6A03 1.20.960.20 Mainly Alpha › Up-down Bundle › Mitochondrial Import Receptor Subunit Tom20; Chain A › 0.79 58.0 5.68e-01 100.0% 72.4%
1ugoA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.67 54.0 5.07e-01 86.4% 77.8%
2xgjA03 1.10.3380.30 Mainly Alpha › Orthogonal Bundle › Sec63 N-terminal domain-like fold › 0.66 53.0 3.92e-01 87.7% 74.4%
2d2sA01 1.20.58.1210 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain 0.65 54.0 4.80e-01 90.1% 75.9%
5nl6B01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 51.0 4.48e-01 86.4% 81.8%
2gsvA00 6.10.140.40 Special › Helix non-globular › Helix Hairpins › 0.64 49.0 5.31e-01 82.7% 97.0%
4jgwA01 1.20.870.10 Mainly Alpha › Up-down Bundle › Son of sevenless (SoS) protein; Chain S, domain 1 › Son of sevenless (SoS) protein Chain: S domain 1 0.63 55.0 4.46e-01 98.8% 52.6%
4dmvA01 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 47.0 4.69e-01 86.4% 77.6%
2ifuD00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.62 55.0 3.85e-01 100.0% 38.9%
3bt5A00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.61 48.0 3.97e-01 86.4% 90.7%
3x17A02 1.50.10.10 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › 0.61 53.0 3.38e-01 100.0% 75.3%
1he8A03 1.25.40.70 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) 0.58 48.0 4.34e-01 100.0% 66.7%
1juqC00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.57 49.0 4.09e-01 100.0% 80.5%
4akgA11 1.20.920.20 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › 0.56 44.0 3.05e-01 85.2% 66.7%
2lseA00 1.20.120.1360 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.53 46.0 4.31e-01 97.5% 79.2%
6fhpD00 1.10.390.10 Mainly Alpha › Orthogonal Bundle › Neutral Protease; domain 2 › Neutral Protease Domain 2 0.53 36.0 3.93e-01 85.2% 90.3%
1te5A00 3.60.20.10 Alpha Beta › 4-Layer Sandwich › Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 › Aminohydrolase, N-terminal nucleophile (Ntn) domain 0.53 47.0 3.34e-01 100.0% 51.4%
3pntB00 1.25.40.520 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.53 45.0 3.75e-01 100.0% 65.0%
2ntxA02 1.20.58.1310 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › PRONE domain, subdomain 2 0.52 45.0 4.19e-01 97.5% 84.5%
7arcP01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 45.0 3.16e-01 98.8% 54.2%
2pusA04 6.10.140.300 Special › Helix non-globular › Helix Hairpins › 0.51 44.0 4.09e-01 100.0% 91.7%
ECOD (19)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
158313 4967.1.1.2 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RdRP_1 0.88 78.0 6.59e-01 100.0% 60.6%
3779 4967.1.1.2 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RdRP_1 0.87 77.0 6.96e-01 100.0% 72.0%
4949691 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.68 57.0 4.46e-01 96.3% 43.5%
3730068 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.67 54.0 4.42e-01 85.2% 67.1%
3692615 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 57.0 4.33e-01 96.3% 73.3%
5016155 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 53.0 4.84e-01 96.3% 65.5%
3227787 109.4.1.1361 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_CAND1 0.66 58.0 4.24e-01 97.5% 57.2%
3177237 106.1.1.0 alpha arrays › Globin-like › Globin-like › Globin-like 0.64 52.0 4.21e-01 85.2% 86.2%
4029717 109.4.1.303 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › STAG 0.63 54.0 3.31e-01 96.3% 21.9%
3325473 109.4.1.189 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_2 0.63 53.0 4.25e-01 97.5% 46.9%
3515234 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.63 55.0 4.62e-01 100.0% 60.7%
4030521 604.12.1.2 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › Vta1 0.62 46.0 4.72e-01 88.9% 85.3%
3414187 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.61 54.0 3.39e-01 97.5% 29.8%
3569307 109.4.1.46 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › IBN_N 0.61 52.0 3.32e-01 96.3% 23.9%
1870497 3271.1.1.1 alpha arrays › CdiA C-terminal nuclease domain › CdiA C-terminal nuclease domain › CdiA C-terminal nuclease domain › Ntox28 0.61 48.0 4.55e-01 87.7% 87.1%
3259837 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.60 51.0 3.28e-01 98.8% 19.1%
3220643 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.59 47.0 3.90e-01 86.4% 63.6%
4018805 109.4.1.356 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.58 49.0 3.05e-01 95.1% 16.6%
3230224 708.1.1.0 beta complex topology › ETN0001 domain-like › ETN0001 domain-like › NAC/WRKY/GCM/WOPR domain 0.58 51.0 4.06e-01 98.8% 86.9%