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Rev
Euk-VirHuman_immunodeficiency_virus_1
Rev__NP_057854__Human_immunodeficiency_virus_1__11676
Identity
- Accession:
- NP_057854 ↗
- Protein ID:
- Rev
- Kingdom:
- euk
Quality
69.7
mean pLDDT
Taxonomy
Pararnavirae›
Artverviricota›
Revtraviricetes›
Ortervirales›
Retroviridae›
Lentivirus›
Human_immunodeficiency_virus_1
TaxID: 11676
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 9-64
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00424.24 best | REV | 102.0 | 2.10e-29 | 100.0% | 59.6% |
CATH (54)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3lphC00 | 6.10.140.630 | Special › Helix non-globular › Helix Hairpins › | 0.97 | 92.0 | 9.09e-01 | 100.0% | 98.3% |
| 3fppA03 | 6.10.140.1990 | Special › Helix non-globular › Helix Hairpins › | 0.83 | 73.0 | 6.30e-01 | 98.2% | 100.0% |
| 3l1nA01 | 6.10.140.790 | Special › Helix non-globular › Helix Hairpins › | 0.81 | 64.0 | 6.68e-01 | 85.7% | 100.0% |
| 1jvmB00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.81 | 55.0 | 4.47e-01 | 71.4% | 43.0% |
| 4h63H01 | 1.20.58.1710 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.80 | 72.0 | 6.59e-01 | 100.0% | 83.3% |
| 1fs0G02 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.80 | 71.0 | 6.07e-01 | 100.0% | 89.9% |
| 1m5iA00 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.79 | 71.0 | 5.71e-01 | 100.0% | 58.1% |
| 3g80A00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.79 | 69.0 | 6.32e-01 | 98.2% | 83.6% |
| 4l0rB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.79 | 71.0 | 6.47e-01 | 100.0% | 91.8% |
| 1ij5A01 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.79 | 66.0 | 5.98e-01 | 92.9% | 89.5% |
| 1c17M00 | 1.20.120.220 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › ATP synthase, F0 complex, subunit A | 0.78 | 68.0 | 5.10e-01 | 100.0% | 98.6% |
| 6vq6G02 | 1.20.1460.10 | Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 | 0.78 | 70.0 | 4.82e-01 | 100.0% | 90.8% |
| 4i0xG00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.77 | 67.0 | 6.25e-01 | 96.4% | 86.8% |
| 3r84B00 | 6.10.280.160 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator of RNA polymerase II transcription subunit 22 | 0.77 | 67.0 | 5.96e-01 | 98.2% | 87.5% |
| 2ia1A01 | 3.30.500.20 | Alpha Beta › 2-Layer Sandwich › Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 › BH3703-like domains | 0.76 | 65.0 | 5.08e-01 | 96.4% | 78.2% |
| 2xokP00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.76 | 66.0 | 6.10e-01 | 100.0% | 82.4% |
| 4w4kA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.75 | 65.0 | 5.79e-01 | 100.0% | 81.7% |
| 2q0oC00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.75 | 66.0 | 5.76e-01 | 100.0% | 67.4% |
| 2r9iA00 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.74 | 63.0 | 5.89e-01 | 96.4% | 81.7% |
| 3layF00 | 1.20.120.1490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.74 | 66.0 | 5.91e-01 | 100.0% | 76.9% |
| 1pd3A00 | 1.10.287.230 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.74 | 64.0 | 6.50e-01 | 96.4% | 100.0% |
| 1z0jB00 | 4.10.860.20 | Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › Rabenosyn, Rab binding domain | 0.73 | 57.0 | 5.97e-01 | 87.5% | 94.1% |
| 2b1eA01 | 1.20.58.1150 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.73 | 60.0 | 5.21e-01 | 91.1% | 62.8% |
| 1wa8A00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.72 | 62.0 | 5.21e-01 | 100.0% | 60.6% |
| 1b3qA01 | 1.10.287.560 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Histidine kinase CheA-like, homodimeric domain | 0.72 | 62.0 | 6.07e-01 | 96.4% | 88.7% |
| 2ieqA00 | 1.20.5.300 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.71 | 60.0 | 5.24e-01 | 98.2% | 96.6% |
| 2bdeA03 | 1.20.58.1160 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.71 | 60.0 | 5.50e-01 | 100.0% | 89.6% |
| 5jazA03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.71 | 53.0 | 4.53e-01 | 82.1% | 49.5% |
| 1cf7B00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.71 | 49.0 | 4.32e-01 | 73.2% | 75.6% |
| 3hr0B01 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.71 | 61.0 | 5.49e-01 | 98.2% | 75.9% |
| 3mq1A01 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.71 | 60.0 | 5.20e-01 | 100.0% | 62.0% |
| 3sjqC00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.70 | 60.0 | 5.38e-01 | 96.4% | 72.5% |
| 3b2eF00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.70 | 61.0 | 5.93e-01 | 98.2% | 91.9% |
| 2wzkA01 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.70 | 59.0 | 4.65e-01 | 100.0% | 48.8% |
| 4dciA00 | 6.10.140.1110 | Special › Helix non-globular › Helix Hairpins › | 0.70 | 61.0 | 4.53e-01 | 100.0% | 40.8% |
| 4abmD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.70 | 61.0 | 5.55e-01 | 100.0% | 75.3% |
| 2gv9A05 | 1.10.287.690 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain | 0.69 | 58.0 | 5.74e-01 | 98.2% | 89.8% |
| 4egwA02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.69 | 59.0 | 4.68e-01 | 98.2% | 60.5% |
| 1nu7D02 | 1.20.120.760 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Staphylcoagulase, helix bundle, domain 2 | 0.69 | 61.0 | 4.66e-01 | 100.0% | 68.8% |
| 3rpmA02 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.69 | 57.0 | 5.03e-01 | 94.6% | 63.5% |
| 7smtA02 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.68 | 55.0 | 3.97e-01 | 92.9% | 100.0% |
| 2e5yA02 | 1.20.5.440 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › ATP synthase delta/epsilon subunit, C-terminal domain | 0.68 | 50.0 | 5.37e-01 | 85.7% | 97.8% |
| 4fvmA06 | 1.10.287.690 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain | 0.67 | 52.0 | 5.50e-01 | 89.3% | 100.0% |
| 3h6pC00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.67 | 55.0 | 5.55e-01 | 92.9% | 98.2% |
| 2qgqA01 | 3.80.30.20 | Alpha Beta › Alpha-Beta Horseshoe › pyruvate-formate lyase- activating enzyme › tm_1862 like domain | 0.66 | 59.0 | 3.93e-01 | 100.0% | 52.8% |
| 2rkhA02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.64 | 55.0 | 5.04e-01 | 100.0% | 73.7% |
| 2qkdA04 | 2.60.120.1040 | Mainly Beta › Sandwich › Jelly Rolls › ZPR1, A/B domain | 0.63 | 49.0 | 3.85e-01 | 87.5% | 61.4% |
| 4i1eA03 | 1.25.10.30 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › IP3 receptor type 1 binding core, RIH domain | 0.63 | 52.0 | 3.94e-01 | 92.9% | 51.1% |
| 2gtaA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.63 | 51.0 | 4.40e-01 | 96.4% | 58.8% |
| 4bzaA01 | 3.10.20.310 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac | 0.62 | 44.0 | 4.15e-01 | 76.8% | 61.8% |
| 1p49A02 | 1.10.287.550 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.60 | 49.0 | 4.89e-01 | 100.0% | 94.9% |
| 1vq8V00 | 1.10.287.310 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.58 | 46.0 | 4.45e-01 | 91.1% | 81.5% |
| 5mj6A04 | 1.25.50.20 | Mainly Alpha › Alpha Horseshoe › Zincin-like fold › | 0.57 | 45.0 | 2.85e-01 | 91.1% | 26.0% |
| 4at7B02 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.56 | 49.0 | 3.40e-01 | 100.0% | 57.1% |
ECOD (37)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 407167 | 3824.1.1.1 ↗ | alpha bundles › HIV Rev › HIV Rev › HIV Rev › REV | 0.93 | 87.0 | 8.36e-01 | 100.0% | 95.2% |
| 3614494 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.82 | 76.0 | 4.75e-01 | 100.0% | 21.5% |
| 3710592 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.82 | 68.0 | 5.69e-01 | 91.1% | 100.0% |
| 5044572 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.79 | 70.0 | 5.68e-01 | 100.0% | 61.0% |
| 3507551 | 192.5.1.0 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat | 0.79 | 65.0 | 5.45e-01 | 91.1% | 82.1% |
| 3971109 | 5086.1.1.85 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_AAEA_pHBA | 0.78 | 70.0 | 6.33e-01 | 100.0% | 98.7% |
| 3399338 | 605.1.1.24 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › ACP53EA | 0.77 | 63.0 | 5.10e-01 | 87.5% | 100.0% |
| 3680918 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.77 | 64.0 | 6.14e-01 | 94.6% | 98.5% |
| 4243374 | 1075.1.2.12 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › EMP70 | 0.77 | 69.0 | 4.76e-01 | 100.0% | 40.0% |
| 4021482 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.76 | 67.0 | 3.98e-01 | 100.0% | 14.5% |
| 3784740 | 3712.1.1.1 ↗ | a+b complex topology › Mediator of RNA polymerase II transcription subunit 11 › Mediator of RNA polymerase II transcription subunit 11 › Mediator of RNA polymerase II transcription subunit 11 › Med11 | 0.76 | 66.0 | 6.00e-01 | 96.4% | 84.0% |
| 3581368 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.76 | 67.0 | 4.90e-01 | 100.0% | 63.3% |
| 3951222 | 3939.1.1.0 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain | 0.75 | 61.0 | 5.69e-01 | 89.3% | 87.1% |
| 1106555 | 3812.1.1.1 ↗ | alpha bundles › Type III secretion protein YscE › Type III secretion protein YscE › Type III secretion protein YscE › T3SS_needle_E | 0.75 | 64.0 | 6.06e-01 | 94.6% | 83.3% |
| 3990854 | 192.7.1.0 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm | 0.75 | 63.0 | 5.41e-01 | 94.6% | 94.4% |
| 3448091 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.74 | 65.0 | 5.15e-01 | 98.2% | 72.8% |
| 3646439 | 192.8.1.263 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › DUF7615 | 0.74 | 66.0 | 5.72e-01 | 100.0% | 69.4% |
| 3448294 | 3826.1.1.33 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › eIF-4B | 0.73 | 63.0 | 5.48e-01 | 96.4% | 64.7% |
| 3204772 | 192.1.1.31 ↗ | alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain › Cep57_MT_bd | 0.73 | 65.0 | 5.38e-01 | 100.0% | 59.0% |
| 3261777 | 4177.1.1.8 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3 | 0.72 | 66.0 | 4.32e-01 | 100.0% | 68.4% |
| 3566072 | 386.1.1.0 ↗ | few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers | 0.72 | 61.0 | 5.76e-01 | 100.0% | 78.6% |
| 3754265 | 603.1.1.187 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DNA_repr_REX1B | 0.72 | 61.0 | 5.33e-01 | 100.0% | 62.2% |
| 4838801 | 3710.1.1.1 ↗ | alpha bundles › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › CHD5 | 0.72 | 62.0 | 5.97e-01 | 98.2% | 86.2% |
| 3989824 | 192.1.1.0 ↗ | alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain | 0.71 | 58.0 | 6.05e-01 | 92.9% | 100.0% |
| 3904130 | 1203.1.2.1 ↗ | alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › ASD2 | 0.71 | 62.0 | 4.89e-01 | 100.0% | 49.2% |
| 3703494 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.71 | 62.0 | 5.02e-01 | 100.0% | 52.7% |
| 5001323 | 4333.1.1.2 ↗ | a+b complex topology › DNA methylase specificity domain › DNA methylase specificity domain › DNA methylase specificity domain › TaqI_C | 0.70 | 62.0 | 3.88e-01 | 100.0% | 19.0% |
| 4128596 | 3710.1.1.1 ↗ | alpha bundles › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › CHD5 | 0.69 | 61.0 | 5.87e-01 | 100.0% | 95.4% |
| 4027007 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.69 | 60.0 | 4.41e-01 | 100.0% | 37.4% |
| 3178563 | 605.3.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Nonstructural protein ns2, Nep, M1-binding domain › Nonstructural protein ns2, Nep, M1-binding domain | 0.69 | 55.0 | 5.81e-01 | 92.9% | 100.0% |
| 5035759 | 605.1.1.306 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › PF30649 | 0.69 | 57.0 | 5.52e-01 | 98.2% | 95.4% |
| 3598977 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.67 | 57.0 | 5.06e-01 | 100.0% | 94.1% |
| 3219629 | 109.4.1.2417 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Importin_rep_6, TPR_IPO5 | 0.66 | 55.0 | 3.27e-01 | 100.0% | 12.3% |
| 4876531 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.66 | 55.0 | 3.93e-01 | 100.0% | 30.2% |
| 3593272 | 375.1.9.0 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Zinc-nucleated domain of serine integrase | 0.65 | 50.0 | 3.92e-01 | 100.0% | 37.0% |
| 3648687 | 604.12.1.89 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › CDP-OH_P_transf | 0.63 | 52.0 | 4.53e-01 | 98.2% | 62.1% |
| 3479160 | 192.10.1.0 ↗ | alpha bundles › Long alpha-hairpin › DnaK suppressor protein DksA, alpha-hairpin domain › DnaK suppressor protein DksA, alpha-hairpin domain | 0.63 | 51.0 | 4.05e-01 | 100.0% | 44.4% |