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Ribonucleoside-diphosphate_reductase

Euk-Vir

Pandoravirus_neocaledonia

Ribonucleoside-diphosphate_reductase__YP_009482455__Pandoravirus_neocaledonia__2107708

Identity

Accession:: YP_009482455 ↗
Protein ID:: Ribonucleoside-diphosphate_reductase
Kingdom:: euk

Quality

79.5 mean pLDDT

Cluster

View cluster (6 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 38-121

PDB

Domain cluster: rep: RR1__YP_010087146__Spodoptera_eridania_nucleopolyhedrovirus__2315721__D152-233

CATH (24)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2f07B00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.71	49.0	3.65e-01	70.2%	70.4%
2nwbA02	1.20.58.480	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.71	41.0	2.90e-01	100.0%	20.7%
1rp3A01	1.10.1740.10	Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif	0.71	50.0	5.00e-01	73.8%	82.4%
3nqxA02	1.10.390.10	Mainly Alpha › Orthogonal Bundle › Neutral Protease; domain 2 › Neutral Protease Domain 2	0.67	60.0	5.03e-01	100.0%	95.9%
3deeA01	1.10.150.690	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › DUF2063	0.67	56.0	5.58e-01	96.4%	91.9%
4nlbA02	1.10.150.80	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › HRDC domain	0.63	47.0	4.53e-01	91.7%	70.2%
2z4sA02	1.10.8.60	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 ›	0.62	40.0	4.21e-01	73.8%	75.0%
3llwD00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.62	48.0	3.36e-01	85.7%	45.0%
3bciA00	3.40.30.10	Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Glutaredoxin	0.61	51.0	4.10e-01	91.7%	65.5%
4rflA02	1.20.1090.10	Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain	0.60	53.0	4.07e-01	100.0%	72.9%
1j7nA01	3.40.390.10	Alpha Beta › 3-Layer(aba) Sandwich › Collagenase (Catalytic Domain) › Collagenase (Catalytic Domain)	0.59	44.0	3.25e-01	97.6%	30.2%
2mabA00	1.10.10.1350	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Spidroin domain, C-terminal domain	0.58	41.0	3.83e-01	73.8%	93.6%
2q14B01	1.10.3210.10	Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432	0.57	47.0	3.44e-01	89.3%	77.7%
2c41C01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.57	47.0	4.00e-01	94.0%	84.6%
4a25B01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.56	48.0	3.92e-01	95.2%	78.9%
1jr8A00	1.20.120.310	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › ERV/ALR sulfhydryl oxidase domain	0.54	46.0	4.30e-01	100.0%	78.1%
1sz2A02	3.40.367.20	Alpha Beta › 3-Layer(aba) Sandwich › Hexokinase; domain 1 ›	0.53	41.0	3.19e-01	85.7%	67.5%
4d2dA00	1.20.1250.20	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains	0.53	45.0	2.90e-01	100.0%	83.4%
1cjmA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.52	38.0	2.86e-01	78.6%	70.0%
1n1fA00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.52	46.0	3.80e-01	100.0%	64.1%
2ijqA00	1.10.3450.10	Mainly Alpha › Orthogonal Bundle › Hyaluronidase domain-like › TTHA0068-like	0.52	39.0	3.28e-01	83.3%	46.9%
2c42A06	3.40.50.970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains	0.51	39.0	2.59e-01	85.7%	18.2%
1agyA00	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.51	42.0	3.37e-01	97.6%	67.5%
1t9kA01	1.20.120.420	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1	0.51	42.0	3.62e-01	92.9%	70.0%

ECOD (34)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3607359	103.2.1.1 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › Ribonuc_red_lgN	0.97	85.0	6.04e-01	91.7%	36.6%
3519243	1074.1.1.0 ↗	alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases	0.94	84.0	6.04e-01	91.7%	38.5%
4485359	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.92	84.0	7.97e-01	100.0%	84.2%
3486229	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.92	88.0	8.59e-01	98.8%	94.4%
3784313	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.91	87.0	8.48e-01	100.0%	93.3%
2320584	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.89	85.0	8.04e-01	100.0%	89.7%
3594048	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.89	85.0	8.29e-01	100.0%	95.6%
4257906	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.88	83.0	8.15e-01	100.0%	94.4%
4312875	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.87	82.0	7.85e-01	100.0%	89.5%
1878968	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.83	78.0	7.29e-01	100.0%	84.0%
2791177	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.83	78.0	7.14e-01	100.0%	79.2%
4143596	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.82	71.0	6.97e-01	92.9%	95.6%
5043182	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.81	75.0	7.01e-01	98.8%	96.0%
4980139	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.81	75.0	7.07e-01	100.0%	95.0%
4961006	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.79	64.0	6.72e-01	94.0%	94.7%
4987957	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.78	63.0	6.69e-01	100.0%	97.3%
5010578	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.75	67.0	6.54e-01	100.0%	90.0%
3987696	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.74	41.0	3.26e-01	100.0%	27.9%
4306770	102.1.3.0 ↗	alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › PAP/OAS1 substrate-binding domain	0.71	61.0	5.27e-01	97.6%	75.6%
3610347	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.69	61.0	6.08e-01	96.4%	96.5%
5037154	4953.1.1.39 ↗	beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › LPG_synthase_TM	0.65	57.0	5.70e-01	96.4%	98.8%
3188177	5050.1.1.0 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter	0.63	51.0	3.70e-01	86.9%	82.2%
4163949	148.1.3.0 ↗	alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain	0.57	42.0	4.29e-01	77.4%	83.7%
3396058	3361.1.1.1 ↗	alpha bundles › C-terminal Pdr1-activating domain of J-protein Zuo1 › C-terminal Pdr1-activating domain of J-protein Zuo1 › C-terminal Pdr1-activating domain of J-protein Zuo1 › RAC_head	0.57	39.0	3.82e-01	70.2%	72.2%
3471904	601.1.1.57 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Talin_VBS2	0.56	45.0	3.98e-01	98.8%	61.7%
5001078	633.2.1.0 ↗	alpha bundles › Bromodomain-like › Carnobacteriocin B2 immunity protein › Carnobacteriocin B2 immunity protein	0.56	44.0	4.29e-01	86.9%	87.4%
3385104	148.1.3.0 ↗	alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain	0.55	42.0	4.36e-01	89.3%	87.5%
3731923	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.55	49.0	2.95e-01	96.4%	24.7%
3740087	633.15.1.1 ↗	alpha bundles › Bromodomain-like › alpha-ketoacid dehydrogenase kinase-N › alpha-ketoacid dehydrogenase kinase-N › BCDHK_Adom3	0.54	45.0	3.62e-01	90.5%	60.0%
3189146	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.53	44.0	3.96e-01	92.9%	89.2%
3802180	148.1.3.205 ↗	alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › AAA_lid_At3g28540	0.53	37.0	3.69e-01	71.4%	82.4%
4945865	633.12.1.0 ↗	alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like	0.52	44.0	4.39e-01	98.8%	97.8%
3893564	109.4.1.536 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Mei4	0.51	44.0	3.18e-01	94.0%	59.2%
3587205	633.2.1.1 ↗	alpha bundles › Bromodomain-like › Carnobacteriocin B2 immunity protein › Carnobacteriocin B2 immunity protein › EntA_Immun	0.51	42.0	4.14e-01	100.0%	88.9%

D2 medium residues 122-251

PDB

Domain cluster: rep: NC_007021.1__YP_238596.1__TwortORF045__00062__D44-158

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00317.27 best	Ribonuc_red_lgN	65.0	7.40e-18	60.0%	96.1%

D3 medium residues 263-351_784-825

PDB

Domain cluster: rep: IMGVR_UViG_3300028089_000252-3300028089-Ga0255299_10029802__D277-388_452-478

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02867.21 best	Ribonuc_red_lgC	65.4	5.60e-18	49.6%	11.8%
PF02867.21	Ribonuc_red_lgC	48.9	5.60e-13	37.4%	8.4%

CATH (31)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2wghA00	3.20.70.20	Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain ›	0.95	77.0	4.66e-01	100.0%	16.8%
1xjkA00	3.20.70.20	Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain ›	0.94	68.0	4.18e-01	100.0%	15.5%
1r1rA02	3.20.70.20	Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain ›	0.91	73.0	4.66e-01	100.0%	21.1%
3b0pA01	3.20.20.70	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I	0.69	45.0	3.72e-01	100.0%	37.5%
3hn7A03	3.90.190.20	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain	0.65	42.0	4.08e-01	100.0%	57.8%
1hv9A01	3.90.550.10	Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A	0.64	37.0	3.09e-01	87.0%	33.0%
2ggoA01	3.90.550.10	Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A	0.63	36.0	3.10e-01	85.5%	35.2%
1z90B01	3.90.550.10	Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A	0.63	43.0	3.10e-01	88.5%	26.3%
2rdmA00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.63	36.0	3.72e-01	100.0%	58.1%
1pjqA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.62	31.0	3.35e-01	98.5%	53.6%
5f2kB02	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.62	43.0	3.70e-01	100.0%	43.9%
3ogzA01	3.90.550.10	Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A	0.61	41.0	2.85e-01	90.1%	20.3%
4tv5A00	3.20.20.60	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Phosphoenolpyruvate-binding domains	0.61	44.0	3.52e-01	100.0%	39.2%
1e8cB03	3.90.190.20	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain	0.61	40.0	3.89e-01	99.2%	60.6%
2mzbA00	3.90.550.10	Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A	0.60	36.0	3.11e-01	88.5%	38.8%
3loqA02	3.40.50.620	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs	0.60	34.0	3.43e-01	99.2%	55.0%
2jjmA01	3.40.50.2000	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B;	0.59	39.0	3.48e-01	100.0%	47.2%
4ecmA00	3.90.550.10	Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A	0.58	37.0	2.98e-01	87.0%	33.9%
4a8jA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.58	40.0	3.19e-01	100.0%	33.9%
2w9xA02	3.40.50.1110	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase	0.58	50.0	4.15e-01	100.0%	54.2%
3qleA00	3.40.50.1000	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like	0.56	34.0	3.06e-01	88.5%	42.3%
1xo1A02	3.40.50.1010	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 5'-nuclease	0.56	34.0	3.23e-01	86.3%	49.7%
1edzA02	3.40.50.10860	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Leucine Dehydrogenase, chain A, domain 1	0.56	27.0	2.77e-01	94.7%	45.0%
3kcnB00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.55	39.0	3.85e-01	100.0%	69.3%
3cg4A00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.55	38.0	3.96e-01	100.0%	75.4%
3e48A01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.54	43.0	3.83e-01	98.5%	59.6%
6y1xB01	3.20.20.70	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I	0.54	41.0	3.28e-01	93.1%	42.4%
3cfyA00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.54	38.0	3.84e-01	100.0%	73.1%
3cu5B00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.53	38.0	3.85e-01	100.0%	74.4%
8c0zE01	3.50.50.60	Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain	0.52	36.0	3.70e-01	100.0%	73.3%
3cw9A01	3.40.50.980	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.51	31.0	2.81e-01	89.3%	44.8%

ECOD (50)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3823652	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.95	77.0	4.80e-01	100.0%	19.1%
4015532	2500.1.1.0 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel	0.95	77.0	4.78e-01	100.0%	18.8%
4298539	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.95	76.0	4.78e-01	100.0%	20.0%
996122	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.93	75.0	4.67e-01	100.0%	18.6%
3500621	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.93	74.0	4.70e-01	100.0%	20.6%
4145444	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.92	73.0	4.66e-01	100.0%	20.4%
3942765	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.92	73.0	4.65e-01	100.0%	20.2%
3963206	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.92	73.0	4.63e-01	100.0%	19.9%
5063882	1074.1.1.6 ↗	alpha arrays › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Alpha helical domain of ribonucleotide reductases › Ribonuc_red_lgC	0.92	70.0	4.88e-01	100.0%	28.7%
3590466	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.92	73.0	4.62e-01	100.0%	19.6%
3972491	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.92	70.0	4.40e-01	100.0%	17.9%
4993733	2500.1.1.0 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel	0.92	70.0	4.43e-01	100.0%	18.7%
4067125	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.91	73.0	4.66e-01	100.0%	21.0%
4937370	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.91	70.0	4.33e-01	100.0%	17.0%
3958480	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.91	73.0	5.01e-01	100.0%	28.9%
4994375	2500.1.1.0 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel	0.91	70.0	4.49e-01	100.0%	20.6%
4934525	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.91	70.0	4.39e-01	100.0%	18.9%
4985374	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.91	70.0	4.35e-01	100.0%	17.9%
4990406	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.83	70.0	4.38e-01	100.0%	19.3%
4963031	2500.1.1.2 ↗	a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ribonuc_red_lgC	0.75	72.0	4.48e-01	100.0%	24.6%
5040858	2007.1.3.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg	0.70	40.0	4.12e-01	97.7%	57.6%
5077482	300.1.1.8 ↗	a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease › PLDc_2	0.68	43.0	3.88e-01	100.0%	46.9%
5042576	300.1.1.8 ↗	a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease › PLDc_2	0.67	42.0	4.04e-01	100.0%	54.0%
4169701	7512.1.1.3 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glycos_transf_1	0.65	37.0	3.20e-01	86.3%	34.8%
3268663	2003.1.5.82 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_31	0.64	40.0	3.45e-01	100.0%	38.6%
4987485	7516.1.1.1 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › NTP_transferase	0.63	39.0	3.18e-01	87.8%	34.0%
4564199	7512.1.1.3 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glycos_transf_1	0.62	35.0	2.82e-01	77.9%	30.2%
5016344	7516.1.1.24 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › NTP_transf_3	0.62	38.0	3.33e-01	85.5%	40.5%
5018378	2007.15.1.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › N-deoxyribosyltransferase › N-deoxyribosyltransferase	0.61	36.0	3.78e-01	98.5%	63.5%
3961342	7516.1.1.1 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › NTP_transferase	0.60	40.0	3.42e-01	87.8%	42.9%
4933886	7512.1.1.3 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glycos_transf_1	0.60	34.0	3.04e-01	87.0%	37.8%
3599422	7512.1.1.0 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase	0.60	36.0	3.14e-01	89.3%	37.6%
3206238	2004.1.1.1 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA	0.60	41.0	3.40e-01	87.8%	39.1%
3301279	7516.1.1.1 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › NTP_transferase	0.59	41.0	3.02e-01	89.3%	29.2%
2795467	7516.1.1.0 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases	0.58	38.0	2.90e-01	87.0%	28.7%
3289626	300.1.1.1 ↗	a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease › PLDc	0.58	42.0	3.59e-01	100.0%	46.7%
4373157	7516.1.1.24 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › NTP_transf_3	0.58	38.0	2.99e-01	87.8%	31.9%
3285824	2005.1.1.13 ↗	a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CTP_transf_like	0.57	34.0	2.96e-01	87.0%	38.0%
5050810	7575.1.1.0 ↗	a/b three-layered sandwiches › Caspase-like › Caspase-like › Caspase-like	0.56	43.0	3.51e-01	98.5%	45.1%
4365581	2007.1.3.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg	0.56	39.0	3.75e-01	100.0%	62.7%
2168236	7516.1.1.0 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases	0.55	34.0	3.10e-01	87.8%	45.7%
5073822	7512.1.1.2 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Phosphorylase	0.55	33.0	3.17e-01	85.5%	50.7%
3187540	2006.1.4.0 ↗	a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like	0.55	42.0	3.49e-01	100.0%	46.8%
3936273	7516.1.1.7 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › UDPGP	0.54	44.0	2.99e-01	91.6%	24.6%
4945466	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.54	41.0	3.54e-01	100.0%	49.3%
4094395	2007.1.3.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg	0.54	38.0	3.79e-01	100.0%	69.3%
5055317	2006.1.4.0 ↗	a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like	0.52	41.0	3.96e-01	93.1%	74.0%
3335826	2004.1.1.1 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA	0.51	33.0	3.01e-01	100.0%	47.2%
3592890	7516.1.1.0 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases	0.51	39.0	2.94e-01	87.0%	32.4%
4946006	2002.1.1.106 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › GDPD	0.51	41.0	3.36e-01	100.0%	47.9%

D4 medium residues 369-451_506-569_649-737_750-783

PDB

Domain cluster: representative

CATH (6)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2imzA00	2.170.16.10	Mainly Beta › Beta Complex › Endonuclease - Pi-scei; Chain A, domain 1 › Hedgehog/Intein (Hint) domain	0.83	38.0	5.36e-01	98.1%	85.2%
4e2tB00	2.170.16.10	Mainly Beta › Beta Complex › Endonuclease - Pi-scei; Chain A, domain 1 › Hedgehog/Intein (Hint) domain	0.81	39.0	4.98e-01	98.5%	75.1%
1am2A00	2.170.16.10	Mainly Beta › Beta Complex › Endonuclease - Pi-scei; Chain A, domain 1 › Hedgehog/Intein (Hint) domain	0.75	42.0	5.18e-01	98.5%	82.9%
2lcjA00	2.170.16.10	Mainly Beta › Beta Complex › Endonuclease - Pi-scei; Chain A, domain 1 › Hedgehog/Intein (Hint) domain	0.73	40.0	4.90e-01	98.9%	78.9%
5o9iA00	2.170.16.10	Mainly Beta › Beta Complex › Endonuclease - Pi-scei; Chain A, domain 1 › Hedgehog/Intein (Hint) domain	0.73	39.0	4.98e-01	98.5%	84.2%
1dfaA01	2.170.16.10	Mainly Beta › Beta Complex › Endonuclease - Pi-scei; Chain A, domain 1 › Hedgehog/Intein (Hint) domain	0.56	37.0	4.33e-01	98.5%	90.1%

ECOD (13)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4941327	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.88	41.0	5.74e-01	95.2%	85.5%
5052154	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.84	39.0	5.08e-01	98.9%	75.2%
4934481	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.83	41.0	5.61e-01	98.5%	88.5%
4274856	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.82	44.0	5.66e-01	98.1%	86.7%
4983616	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.80	40.0	5.14e-01	98.9%	78.8%
5032319	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.79	39.0	5.27e-01	98.5%	86.0%
5035476	69.1.1.4 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint › Intein_splicing	0.79	41.0	5.40e-01	98.5%	86.3%
4975503	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.76	40.0	4.98e-01	98.9%	78.9%
4180552	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.71	39.0	5.01e-01	98.9%	87.9%
5029854	69.1.1.4 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint › Intein_splicing	0.62	41.0	4.65e-01	99.6%	84.8%
4996523	69.1.1.0 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint	0.60	39.0	4.59e-01	98.5%	88.5%
4084747	242.1.1.7 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3	0.55	52.0	4.91e-01	98.5%	90.6%
4629526	69.1.1.4 ↗	beta complex topology › Hedgehog/intein › Hedgehog/intein › Hint › Intein_splicing	0.53	51.0	4.83e-01	98.9%	90.3%

D5 medium residues 570-648

PDB

Domain cluster: representative

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3fbiD00	1.10.10.1340	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Mediator of RNA polymerase II, submodule Med31 (Soh1)	0.51	34.0	3.22e-01	89.9%	56.4%
1z57A02	1.10.510.10	Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1	0.51	41.0	3.04e-01	93.7%	75.7%

D6 medium residues 826-932

PDB

Domain cluster: rep: IMGVR_UViG_3300007266_000133-3300007266-Ga0101450_1063125__D8-101

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02867.21 best	Ribonuc_red_lgC	119.9	1.80e-34	100.0%	20.4%

D7 medium residues 1173-1240

PDB

Domain cluster: rep: IMGVR_UViG_3300006567_000026-3300006567-Ga0099958_11086953__D213-268

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02867.21 best	Ribonuc_red_lgC	35.0	9.70e-09	100.0%	12.0%