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SRR1747030_scaffold_3_prodigal-single.1__X__X__00188
Bact-VirSRR1747030_scaffold_3_prodigal-single.1__X__X__00188
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-172
Domain cluster:
rep: dihydrofolate_reductase__YP_009119754__Pandoravirus_inopinatum__1605721__D21-210
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 145.6 | 1.50e-42 | 100.0% | 99.4% |
CATH (72)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.91 | 80.0 | 8.34e-01 | 100.0% | 98.1% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 80.0 | 8.34e-01 | 100.0% | 98.7% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 81.0 | 8.27e-01 | 100.0% | 97.0% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.88 | 78.0 | 8.10e-01 | 100.0% | 98.7% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 84.0 | 8.32e-01 | 100.0% | 97.7% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 78.0 | 8.02e-01 | 100.0% | 98.8% |
| 1vdrA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 76.0 | 7.91e-01 | 100.0% | 98.7% |
| 4eckA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 82.0 | 8.09e-01 | 100.0% | 98.3% |
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 82.0 | 7.44e-01 | 100.0% | 94.0% |
| 1cz3B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 76.0 | 7.68e-01 | 100.0% | 95.8% |
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 81.0 | 7.79e-01 | 100.0% | 94.1% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 80.0 | 7.39e-01 | 100.0% | 96.1% |
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 80.0 | 7.71e-01 | 100.0% | 97.3% |
| 1juvA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 78.0 | 7.42e-01 | 99.4% | 99.5% |
| 2p4gA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.81 | 77.0 | 6.67e-01 | 100.0% | 90.7% |
| 1aoeA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.81 | 78.0 | 7.45e-01 | 100.0% | 96.9% |
| 2hxvA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 76.0 | 7.19e-01 | 100.0% | 98.5% |
| 2aznA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 75.0 | 6.85e-01 | 100.0% | 96.8% |
| 2b3zA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 75.0 | 6.72e-01 | 100.0% | 93.8% |
| 3zpgA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.78 | 75.0 | 6.81e-01 | 100.0% | 93.5% |
| 3kgyA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.78 | 74.0 | 6.73e-01 | 100.0% | 95.4% |
| 3vcoA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.78 | 74.0 | 7.23e-01 | 100.0% | 97.3% |
| 3jtwA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 73.0 | 7.31e-01 | 100.0% | 97.7% |
| 2g6vA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 73.0 | 6.62e-01 | 100.0% | 93.7% |
| 3ky8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 73.0 | 7.29e-01 | 100.0% | 99.4% |
| 4xt6A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 73.0 | 6.41e-01 | 100.0% | 88.2% |
| 2xw7A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 71.0 | 7.07e-01 | 100.0% | 96.0% |
| 2gd9A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.70 | 64.0 | 6.54e-01 | 98.8% | 98.8% |
| 2qq5A00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.61 | 47.0 | 4.23e-01 | 80.7% | 95.0% |
| 1v84A00 | 3.90.550.10 | Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A | 0.61 | 44.0 | 3.89e-01 | 74.3% | 89.0% |
| 3l8dA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 50.0 | 4.77e-01 | 90.1% | 98.5% |
| 4mtlA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 51.0 | 4.81e-01 | 91.8% | 83.2% |
| 3edmD00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.60 | 46.0 | 4.31e-01 | 80.7% | 96.7% |
| 3cvoA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 51.0 | 4.87e-01 | 90.6% | 88.7% |
| 3ntvA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 50.0 | 4.70e-01 | 91.2% | 86.2% |
| 1rjgA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 51.0 | 4.26e-01 | 91.8% | 75.9% |
| 3ggdA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 50.0 | 4.50e-01 | 91.8% | 87.7% |
| 4ymhD00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 50.0 | 4.54e-01 | 91.8% | 81.2% |
| 4j1qA00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.59 | 51.0 | 3.87e-01 | 94.2% | 94.2% |
| 1mldA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.58 | 44.0 | 4.73e-01 | 77.8% | 97.9% |
| 4zemA02 | 3.40.50.10470 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Translation initiation factor eif-2b; domain 2 | 0.58 | 44.0 | 4.50e-01 | 79.5% | 100.0% |
| 3g7uA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 44.0 | 4.35e-01 | 79.5% | 98.9% |
| 3fzgA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 49.0 | 4.72e-01 | 91.8% | 87.2% |
| 2qmwA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.58 | 33.0 | 4.16e-01 | 100.0% | 100.0% |
| 1xdzA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 49.0 | 4.40e-01 | 91.2% | 69.7% |
| 3tztA00 | 3.90.550.10 | Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A | 0.57 | 43.0 | 3.86e-01 | 77.2% | 84.5% |
| 4necC01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 48.0 | 4.48e-01 | 91.8% | 90.4% |
| 3abiA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.57 | 42.0 | 4.21e-01 | 75.4% | 93.0% |
| 3iv6A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 48.0 | 4.69e-01 | 91.8% | 88.0% |
| 1vm0A00 | 3.30.110.20 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain | 0.57 | 28.0 | 3.75e-01 | 99.4% | 87.1% |
| 5t5dA00 | 3.40.35.10 | Alpha Beta › 3-Layer(aba) Sandwich › Fructose Permease › Phosphotransferase system, sorbose subfamily IIB component | 0.56 | 45.0 | 4.74e-01 | 97.7% | 96.0% |
| 4qdjA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 48.0 | 4.50e-01 | 91.2% | 81.7% |
| 5cm2Z00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 46.0 | 4.50e-01 | 87.7% | 96.7% |
| 7uqyB01 | 3.90.550.10 | Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A | 0.55 | 40.0 | 3.75e-01 | 74.3% | 91.6% |
| 3futA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 47.0 | 4.51e-01 | 91.8% | 88.4% |
| 2dr3A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.55 | 49.0 | 4.44e-01 | 96.5% | 88.8% |
| 1omzB00 | 3.90.550.10 | Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A | 0.55 | 41.0 | 3.64e-01 | 77.2% | 94.5% |
| 3dtnA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 47.0 | 4.62e-01 | 92.4% | 88.8% |
| 3hn2B01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.55 | 40.0 | 4.04e-01 | 76.0% | 100.0% |
| 3ngxA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.54 | 38.0 | 4.37e-01 | 94.7% | 98.4% |
| 3iekA02 | 3.40.50.10890 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.54 | 44.0 | 4.36e-01 | 87.7% | 96.7% |
| 3n5lA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.54 | 32.0 | 3.47e-01 | 100.0% | 69.9% |
| 7dl8C01 | 3.30.110.20 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain | 0.53 | 24.0 | 3.27e-01 | 95.9% | 79.8% |
| 3plnA03 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.53 | 40.0 | 4.23e-01 | 79.5% | 98.7% |
| 1v4vA02 | 3.40.50.2000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; | 0.53 | 40.0 | 4.19e-01 | 79.5% | 94.3% |
| 3rhzA02 | 3.40.50.2000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; | 0.52 | 40.0 | 4.19e-01 | 80.1% | 86.6% |
| 4ydsA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 45.0 | 4.16e-01 | 95.3% | 90.7% |
| 3d3uA01 | 3.40.1080.10 | Alpha Beta › 3-Layer(aba) Sandwich › Glutaconate Coenzyme A-transferase › Glutaconate Coenzyme A-transferase | 0.52 | 42.0 | 4.29e-01 | 86.0% | 93.3% |
| 2d1cA01 | 3.40.718.10 | Alpha Beta › 3-Layer(aba) Sandwich › Isopropylmalate Dehydrogenase › Isopropylmalate Dehydrogenase | 0.51 | 45.0 | 3.54e-01 | 97.1% | 65.9% |
| 5tz8A01 | 3.90.550.10 | Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A | 0.51 | 37.0 | 3.39e-01 | 74.3% | 84.5% |
| 7k3zG01 | 3.50.7.10 | Alpha Beta › 3-Layer(bba) Sandwich › GroEL › GroEL | 0.51 | 33.0 | 3.07e-01 | 100.0% | 50.2% |
| 1d4oA00 | 3.40.50.1220 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › TPP-binding domain | 0.51 | 42.0 | 4.18e-01 | 98.2% | 85.3% |
ECOD (80)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4276639 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 84.0 | 8.43e-01 | 100.0% | 93.5% |
| 4563316 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 79.0 | 8.04e-01 | 100.0% | 92.1% |
| 3963884 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 81.0 | 8.38e-01 | 99.4% | 98.1% |
| 4295510 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 80.0 | 8.27e-01 | 100.0% | 97.5% |
| 137968 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 81.0 | 8.27e-01 | 100.0% | 97.0% |
| 4279950 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 81.0 | 8.29e-01 | 100.0% | 97.6% |
| 2847460 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 75.0 | 7.89e-01 | 100.0% | 95.5% |
| 169540 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 79.0 | 8.10e-01 | 100.0% | 95.2% |
| 4652224 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 80.0 | 8.26e-01 | 100.0% | 97.6% |
| 4624802 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 80.0 | 8.22e-01 | 100.0% | 98.2% |
| 2831687 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 79.0 | 7.87e-01 | 100.0% | 90.8% |
| 2580403 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 68.0 | 6.77e-01 | 87.1% | 77.1% |
| 3611921 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 84.0 | 7.45e-01 | 100.0% | 91.3% |
| 3593841 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.87 | 84.0 | 7.59e-01 | 100.0% | 92.3% |
| 3263045 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 83.0 | 7.80e-01 | 100.0% | 94.0% |
| 2503171 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 84.0 | 8.26e-01 | 100.0% | 96.1% |
| 4115051 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 83.0 | 7.25e-01 | 100.0% | 95.0% |
| 3360231 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 83.0 | 7.49e-01 | 100.0% | 80.5% |
| 4965070 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 78.0 | 7.77e-01 | 100.0% | 92.0% |
| 4392683 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 78.0 | 7.98e-01 | 100.0% | 97.6% |
| 3697700 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 82.0 | 6.57e-01 | 100.0% | 97.3% |
| 136031 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.84 | 82.0 | 7.43e-01 | 100.0% | 98.1% |
| 4123104 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.84 | 76.0 | 7.81e-01 | 100.0% | 97.6% |
| 4315799 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.83 | 80.0 | 7.98e-01 | 100.0% | 98.3% |
| 4228699 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.83 | 80.0 | 7.53e-01 | 99.4% | 99.5% |
| 185430 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.83 | 81.0 | 7.81e-01 | 100.0% | 94.6% |
| 4183099 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.83 | 79.0 | 7.74e-01 | 100.0% | 93.3% |
| 4402042 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 80.0 | 7.72e-01 | 100.0% | 97.8% |
| 3913441 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 79.0 | 7.61e-01 | 100.0% | 96.3% |
| 10266 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 78.0 | 7.42e-01 | 99.4% | 99.5% |
| 5029141 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 74.0 | 7.38e-01 | 100.0% | 94.9% |
| 10273 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 76.0 | 7.19e-01 | 100.0% | 98.5% |
| 2389059 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 75.0 | 6.63e-01 | 100.0% | 91.2% |
| 3284365 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 76.0 | 7.23e-01 | 100.0% | 97.4% |
| 3282759 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 75.0 | 7.36e-01 | 100.0% | 97.8% |
| 5058063 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 74.0 | 7.42e-01 | 100.0% | 97.1% |
| 5030442 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 74.0 | 7.46e-01 | 100.0% | 98.8% |
| 3953555 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 75.0 | 7.20e-01 | 100.0% | 96.8% |
| 235716 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 74.0 | 6.90e-01 | 100.0% | 98.1% |
| 3289265 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 74.0 | 7.32e-01 | 100.0% | 98.9% |
| 3289701 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 74.0 | 6.79e-01 | 100.0% | 97.7% |
| 5073892 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 74.0 | 7.11e-01 | 100.0% | 96.8% |
| 136641 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 73.0 | 7.31e-01 | 100.0% | 97.7% |
| 137569 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 73.0 | 7.23e-01 | 100.0% | 97.7% |
| 3385448 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.77 | 67.0 | 6.93e-01 | 100.0% | 96.9% |
| 3277763 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 72.0 | 7.05e-01 | 100.0% | 97.8% |
| 3278543 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 72.0 | 6.94e-01 | 100.0% | 97.9% |
| 3839944 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 70.0 | 6.88e-01 | 100.0% | 92.7% |
| 3430689 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.74 | 69.0 | 6.51e-01 | 100.0% | 98.0% |
| 1841334 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.73 | 60.0 | 6.46e-01 | 100.0% | 97.3% |
| 160146 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.71 | 66.0 | 6.52e-01 | 100.0% | 94.4% |
| 3435230 | 7512.1.1.0 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase | 0.63 | 48.0 | 4.16e-01 | 78.4% | 88.5% |
| 4998886 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.61 | 52.0 | 4.75e-01 | 91.8% | 97.4% |
| 4972068 | 2003.1.1.386 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Sacchrp_dh_C | 0.61 | 47.0 | 3.58e-01 | 78.9% | 91.9% |
| 3286078 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.60 | 50.0 | 4.46e-01 | 90.6% | 99.6% |
| 3485233 | 2003.1.5.73 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16 | 0.60 | 51.0 | 4.44e-01 | 91.8% | 71.2% |
| 1312123 | 2003.1.5.73 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16 | 0.60 | 51.0 | 4.81e-01 | 91.2% | 81.8% |
| 5071530 | 2003.1.5.14 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_3 | 0.59 | 50.0 | 4.94e-01 | 91.2% | 89.6% |
| 4585549 | 2003.1.1.39 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Sacchrp_dh_NADP | 0.59 | 44.0 | 4.18e-01 | 77.2% | 88.0% |
| 4996390 | 2003.1.5.14 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_3 | 0.59 | 50.0 | 4.93e-01 | 91.2% | 91.6% |
| 3678575 | 304.8.1.45 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant | 0.58 | 20.0 | 3.52e-01 | 99.4% | 96.4% |
| 5059452 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.58 | 49.0 | 4.76e-01 | 91.8% | 96.9% |
| 3382243 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.58 | 20.0 | 3.52e-01 | 99.4% | 98.1% |
| 5030244 | 2003.1.5.60 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FmrO | 0.58 | 49.0 | 4.94e-01 | 90.6% | 96.5% |
| 1504881 | 2003.1.5.60 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FmrO | 0.58 | 49.0 | 4.72e-01 | 91.8% | 87.2% |
| 3285198 | 2003.1.5.81 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 | 0.57 | 48.0 | 4.57e-01 | 91.2% | 85.6% |
| 4941791 | 2003.1.5.82 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_31 | 0.57 | 49.0 | 4.67e-01 | 91.2% | 90.9% |
| 4499454 | 2003.1.5.155 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › RrnaAD, Methyltransf_25 | 0.56 | 48.0 | 4.66e-01 | 91.8% | 97.4% |
| 4207588 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.56 | 45.0 | 4.48e-01 | 85.4% | 88.6% |
| 4946040 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.56 | 44.0 | 3.58e-01 | 99.4% | 43.3% |
| 3719711 | 7512.1.1.0 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase | 0.55 | 43.0 | 4.53e-01 | 80.1% | 98.7% |
| 5071911 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.55 | 47.0 | 4.29e-01 | 91.8% | 79.6% |
| 4024901 | 328.3.1.0 ↗ | a+b two layers › IF3-like › Translation initiation factor IF3, C-terminal domain › Translation initiation factor IF3, C-terminal domain | 0.53 | 27.0 | 3.68e-01 | 100.0% | 96.5% |
| 5057918 | 7516.1.1.2 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 | 0.53 | 38.0 | 3.15e-01 | 74.3% | 59.1% |
| 4560183 | 7512.1.1.32 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_trans_1_4 | 0.52 | 41.0 | 3.92e-01 | 81.3% | 83.1% |
| 1563527 | 3979.1.1.4 ↗ | a+b four layers › Mre11 nuclease C-terminal domain › Mre11 nuclease C-terminal domain › Mre11 nuclease C-terminal domain › Mre11_2nd | 0.52 | 22.0 | 3.22e-01 | 80.7% | 98.4% |
| 4124049 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.51 | 42.0 | 3.95e-01 | 89.5% | 81.8% |
| 4100440 | 3979.1.1.4 ↗ | a+b four layers › Mre11 nuclease C-terminal domain › Mre11 nuclease C-terminal domain › Mre11 nuclease C-terminal domain › Mre11_2nd | 0.51 | 21.0 | 3.18e-01 | 79.5% | 100.0% |
| 3290757 | 2004.1.1.422 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › MMR_HSR1, RsgA_GTPase | 0.50 | 40.0 | 3.70e-01 | 98.2% | 64.0% |
| 4989786 | 2004.1.1.146 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase | 0.50 | 44.0 | 4.25e-01 | 95.9% | 93.8% |
D2
high
residues 201-330
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF11753.14 best | DUF3310 | 45.4 | 1.00e-11 | 43.1% | 93.3% |
CATH (43)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2bvlA01 | 1.20.58.1190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.80 | 46.0 | 5.54e-01 | 87.7% | 84.9% |
| 4dmvA01 | 1.20.58.1190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.80 | 45.0 | 5.46e-01 | 86.9% | 84.7% |
| 2b0hA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.74 | 48.0 | 4.87e-01 | 86.9% | 66.4% |
| 1dtoA01 | 1.10.287.30 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 | 0.74 | 45.0 | 5.06e-01 | 85.4% | 77.5% |
| 4it4A02 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.72 | 43.0 | 5.08e-01 | 86.9% | 84.6% |
| 1xzpA02 | 1.20.120.430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 | 0.72 | 50.0 | 4.58e-01 | 71.5% | 83.1% |
| 7q37A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.71 | 49.0 | 4.14e-01 | 70.0% | 85.5% |
| 1m56C02 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.71 | 52.0 | 4.39e-01 | 86.9% | 49.5% |
| 1cgnA00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.71 | 48.0 | 4.96e-01 | 86.2% | 72.6% |
| 6a3kA00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.71 | 49.0 | 4.96e-01 | 86.2% | 71.3% |
| 3gehA02 | 1.20.120.430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 | 0.70 | 49.0 | 4.50e-01 | 71.5% | 85.0% |
| 4k0dA00 | 1.20.120.1730 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.70 | 44.0 | 4.32e-01 | 86.9% | 58.0% |
| 3geeA02 | 1.20.120.430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 | 0.69 | 48.0 | 4.36e-01 | 70.8% | 82.7% |
| 1st6A04 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.69 | 45.0 | 4.79e-01 | 86.9% | 74.4% |
| 2l6hA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.68 | 44.0 | 4.21e-01 | 86.2% | 55.2% |
| 3ieeA02 | 1.20.58.820 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Uncharacterised protein PF12889, C-terminal DUF3829 | 0.68 | 43.0 | 4.78e-01 | 86.9% | 79.6% |
| 2yksA02 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.68 | 42.0 | 4.46e-01 | 89.2% | 68.4% |
| 3t6gB00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.67 | 47.0 | 4.70e-01 | 71.5% | 95.5% |
| 6xz3A01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.67 | 44.0 | 4.66e-01 | 86.2% | 74.4% |
| 2yevA03 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.67 | 47.0 | 4.12e-01 | 71.5% | 74.5% |
| 6adqG01 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.67 | 49.0 | 4.37e-01 | 86.9% | 55.6% |
| 1h6gA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.65 | 43.0 | 4.46e-01 | 87.7% | 71.4% |
| 1wn0A00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.65 | 49.0 | 4.92e-01 | 76.9% | 84.0% |
| 7cfmR01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.65 | 45.0 | 3.63e-01 | 71.5% | 89.7% |
| 1jmwA00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.63 | 45.0 | 4.36e-01 | 86.9% | 65.1% |
| 4abnA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.62 | 42.0 | 3.24e-01 | 97.7% | 31.9% |
| 2ynqB00 | 1.25.40.680 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Type VII secretion system EssB, C-terminal-like domain | 0.60 | 36.0 | 3.41e-01 | 100.0% | 50.3% |
| 1qkrB00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.59 | 51.0 | 4.56e-01 | 99.2% | 66.7% |
| 5b2nA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.58 | 47.0 | 3.74e-01 | 86.9% | 92.0% |
| 1yw0A00 | 1.20.58.480 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.56 | 43.0 | 3.49e-01 | 80.0% | 82.7% |
| 2oexA01 | 1.20.120.560 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › alix/aip1 in complex with the ypdl late domain | 0.56 | 39.0 | 3.75e-01 | 71.5% | 64.3% |
| 3akjA02 | 1.10.1070.20 | Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 › | 0.56 | 39.0 | 3.44e-01 | 72.3% | 77.6% |
| 1zvuA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.56 | 39.0 | 3.80e-01 | 71.5% | 67.9% |
| 3m71A00 | 1.50.10.150 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Voltage-dependent anion channel | 0.54 | 41.0 | 3.13e-01 | 79.2% | 74.0% |
| 2l5aA00 | 1.10.20.10 | Mainly Alpha › Orthogonal Bundle › Histone, subunit A › Histone, subunit A | 0.54 | 44.0 | 3.78e-01 | 91.5% | 96.9% |
| 6dcjA02 | 1.25.40.650 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.53 | 37.0 | 4.10e-01 | 80.8% | 89.4% |
| 1v9mA03 | 1.20.1690.10 | Mainly Alpha › Up-down Bundle › V-type ATP synthase subunit C fold › V-type ATP synthase subunit C domain | 0.53 | 36.0 | 4.11e-01 | 70.0% | 94.8% |
| 3f4mA00 | 1.20.1440.160 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like | 0.52 | 35.0 | 3.36e-01 | 87.7% | 57.8% |
| 1br2A03 | 1.20.120.720 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Myosin VI head, motor domain, U50 subdomain | 0.52 | 35.0 | 4.08e-01 | 70.0% | 97.9% |
| 1kvkA02 | 3.30.70.890 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain | 0.51 | 34.0 | 3.34e-01 | 86.2% | 59.5% |
| 3qc1A01 | 1.25.40.540 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAP42-like family | 0.51 | 44.0 | 4.18e-01 | 100.0% | 80.1% |
| 3rkgA02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.51 | 46.0 | 4.28e-01 | 100.0% | 87.8% |
| 4f0uA00 | 1.10.490.20 | Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins | 0.50 | 41.0 | 3.83e-01 | 87.7% | 77.5% |
ECOD (37)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3613901 | 5082.1.1.1 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux | 0.76 | 70.0 | 6.00e-01 | 100.0% | 95.5% |
| 3595370 | 5082.1.1.0 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like | 0.74 | 68.0 | 5.73e-01 | 100.0% | 95.3% |
| 3179058 | 5082.1.1.1 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux | 0.73 | 66.0 | 5.65e-01 | 100.0% | 94.1% |
| 2549628 | 5001.1.1.6 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Bac_rhodopsin | 0.72 | 50.0 | 4.23e-01 | 70.8% | 82.5% |
| 4592499 | 601.25.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › TrmE connector domain › TrmE connector domain › MnmE_helical | 0.70 | 49.0 | 4.48e-01 | 71.5% | 84.8% |
| 3235191 | 5001.1.1.41 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srw | 0.69 | 48.0 | 3.49e-01 | 70.0% | 78.8% |
| 4944283 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.68 | 48.0 | 4.74e-01 | 72.3% | 95.7% |
| 150274 | 601.16.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › Focal_AT | 0.68 | 44.0 | 4.38e-01 | 86.2% | 61.2% |
| 3535566 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.67 | 47.0 | 4.78e-01 | 87.7% | 74.4% |
| 5008363 | 5069.1.1.26 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › NrfD | 0.66 | 47.0 | 3.81e-01 | 86.2% | 41.7% |
| 3721451 | 5069.1.1.7 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_B561 | 0.64 | 45.0 | 4.08e-01 | 72.3% | 78.2% |
| 3187372 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.63 | 42.0 | 3.78e-01 | 86.2% | 48.9% |
| 5073911 | 5039.1.1.0 ↗ | alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like | 0.63 | 44.0 | 4.49e-01 | 85.4% | 72.3% |
| 4376272 | 601.2.1.4 ↗ | alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes › Cytochrom_C_2 | 0.63 | 48.0 | 4.68e-01 | 89.2% | 73.4% |
| 3237197 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.62 | 42.0 | 4.44e-01 | 70.0% | 100.0% |
| 3235128 | 601.18.1.6 ↗ | alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › Got1 | 0.62 | 43.0 | 4.40e-01 | 70.8% | 88.8% |
| 3224746 | 601.1.2.1 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Vinculin | 0.62 | 42.0 | 4.34e-01 | 70.0% | 100.0% |
| 3969620 | 5069.1.2.2 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Respiratory nitrate reductase 1 gamma chain › DUF3483 | 0.61 | 49.0 | 4.21e-01 | 96.2% | 55.9% |
| 3668980 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.61 | 50.0 | 4.99e-01 | 91.5% | 83.7% |
| 3492595 | 192.29.1.11 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › FerA | 0.60 | 43.0 | 4.38e-01 | 72.3% | 96.8% |
| 3224634 | 5001.1.1.41 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srw | 0.60 | 42.0 | 3.04e-01 | 72.3% | 68.9% |
| 4930491 | 5069.1.1.15 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_C_asm | 0.59 | 41.0 | 3.69e-01 | 86.2% | 51.7% |
| 4034204 | 5069.1.1.5 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cyt_bd_oxida_II | 0.59 | 41.0 | 3.73e-01 | 86.2% | 53.1% |
| 3626002 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.58 | 46.0 | 4.28e-01 | 99.2% | 66.5% |
| 3176312 | 601.1.3.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 | 0.56 | 46.0 | 3.96e-01 | 86.2% | 73.5% |
| 4069363 | 633.13.1.1 ↗ | alpha bundles › Bromodomain-like › DsbB-like › DsbB-like › DsbB | 0.56 | 49.0 | 4.58e-01 | 93.1% | 83.1% |
| 4634185 | 601.25.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › TrmE connector domain › TrmE connector domain › MnmE_helical | 0.56 | 47.0 | 4.43e-01 | 89.2% | 87.1% |
| 4026826 | 3651.1.1.0 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain | 0.55 | 41.0 | 4.11e-01 | 98.5% | 76.9% |
| 5054201 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.54 | 38.0 | 4.09e-01 | 72.3% | 100.0% |
| 3264566 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.54 | 46.0 | 3.90e-01 | 90.8% | 75.7% |
| 3238853 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.54 | 44.0 | 3.61e-01 | 86.9% | 82.6% |
| 5040882 | 5069.1.1.15 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_C_asm | 0.53 | 50.0 | 3.67e-01 | 100.0% | 71.6% |
| 3530843 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.52 | 41.0 | 4.17e-01 | 95.4% | 84.8% |
| 3332244 | 1075.5.1.5 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Rft-1 | 0.52 | 41.0 | 3.22e-01 | 86.9% | 55.3% |
| 3437020 | 601.30.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Helical bundle domain in hypothetical protein PH1320 › Helical bundle domain in hypothetical protein PH1320 › NOG1_N | 0.51 | 40.0 | 3.78e-01 | 87.7% | 69.7% |
| 5028782 | 5073.1.2.0 ↗ | alpha bundles › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain-related › Copper efflux ATPase transmembrane domain | 0.50 | 42.0 | 3.66e-01 | 100.0% | 58.5% |
| 4176577 | 601.1.2.3 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › GCIP_C | 0.50 | 42.0 | 4.25e-01 | 99.2% | 90.0% |