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U14
Euk-VirHuman_betaherpesvirus_6A
U14__NP_042906__Human_betaherpesvirus_6A__32603
Identity
- Accession:
- NP_042906 ↗
- Protein ID:
- U14
- Kingdom:
- euk
Quality
57.6
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Roseolovirus›
Human_betaherpesvirus_6A
TaxID: 32603
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 32-99
Domain cluster:
rep: tegument_protein_UL25__YP_004940051__Aotine_betaherpesvirus_1__50290__D159-246
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04637.17 best | Herpes_pp85 | 95.5 | 3.60e-27 | 100.0% | 12.6% |
CATH (12)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5mlc900 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.63 | 49.0 | 4.27e-01 | 85.3% | 89.7% |
| 1m62A00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.61 | 47.0 | 4.40e-01 | 85.3% | 80.5% |
| 1s35A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 43.0 | 3.87e-01 | 85.3% | 91.1% |
| 3p9vA00 | 3.30.530.20 | Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain | 0.57 | 49.0 | 3.82e-01 | 100.0% | 70.3% |
| 1bxiA00 | 1.10.1200.20 | Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Colicin E immunity protein | 0.57 | 37.0 | 3.49e-01 | 70.6% | 54.2% |
| 4mloA03 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.56 | 45.0 | 4.75e-01 | 88.2% | 98.4% |
| 2lrmA00 | 1.10.890.30 | Mainly Alpha › Orthogonal Bundle › 10k-s Protein, Hypothetical Protein A; Chain A › YmgD protein | 0.55 | 39.0 | 3.68e-01 | 75.0% | 71.4% |
| 3gwlA00 | 1.20.120.310 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › ERV/ALR sulfhydryl oxidase domain | 0.53 | 41.0 | 3.67e-01 | 89.7% | 60.4% |
| 1u8bA02 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.51 | 38.0 | 3.99e-01 | 92.6% | 93.4% |
| 4dyqA01 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.51 | 39.0 | 3.49e-01 | 85.3% | 56.3% |
| 2q0oC00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.51 | 36.0 | 3.32e-01 | 77.9% | 58.1% |
| 2ktaA01 | 6.10.140.530 | Special › Helix non-globular › Helix Hairpins › | 0.50 | 37.0 | 3.95e-01 | 79.4% | 100.0% |
ECOD (13)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1828346 | 1063.1.1.1 ↗ | alpha complex topology › Tegument protein U14 › Tegument protein U14 › Tegument protein U14 › Herpes_pp85 | 0.99 | 96.0 | 5.56e-01 | 100.0% | 15.2% |
| 3964804 | 192.29.1.271 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Sipho_Gp157 | 0.64 | 37.0 | 3.22e-01 | 95.6% | 39.0% |
| 3281872 | 532.1.1.0 ↗ | alpha arrays › Type III secretion system domain-like › Antibiotic binding domain of TipA-like multidrug resistance regulators › Antibiotic binding domain of TipA-like multidrug resistance regulators | 0.61 | 47.0 | 4.00e-01 | 85.3% | 85.0% |
| 3220288 | 509.1.1.14 ↗ | alpha bundles › PAH2 domain › PAH2 domain › PAH2 domain › ANIS5_cation-bd | 0.58 | 42.0 | 4.28e-01 | 83.8% | 81.5% |
| 3233668 | 108.1.1.156 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand › ANIS5_cation-bd | 0.58 | 41.0 | 4.29e-01 | 80.9% | 85.0% |
| 3946093 | 101.1.1.58 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › HTH_18 | 0.55 | 40.0 | 4.31e-01 | 77.9% | 98.2% |
| 2624828 | 529.1.1.1 ↗ | few secondary structure elements › Anaphylotoxins (complement system) › Anaphylotoxins (complement system) › Anaphylotoxins (complement system) › ANATO | 0.55 | 44.0 | 4.26e-01 | 100.0% | 81.8% |
| 3614578 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.53 | 41.0 | 3.83e-01 | 89.7% | 65.9% |
| 3639674 | 7579.1.1.44 ↗ | a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_6 | 0.53 | 45.0 | 2.97e-01 | 100.0% | 39.4% |
| 4838669 | 529.1.1.1 ↗ | few secondary structure elements › Anaphylotoxins (complement system) › Anaphylotoxins (complement system) › Anaphylotoxins (complement system) › ANATO | 0.53 | 44.0 | 4.42e-01 | 98.5% | 94.4% |
| 3789307 | 101.1.1.2 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › HTH_AraC | 0.53 | 39.0 | 3.95e-01 | 91.2% | 81.4% |
| 4973490 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.52 | 45.0 | 4.47e-01 | 100.0% | 97.1% |
| 3736330 | 2003.1.2.6 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › FMO-like,NAD_binding_8 | 0.52 | 43.0 | 2.61e-01 | 100.0% | 78.9% |
D2
high
residues 102-256
Domain cluster:
rep: tegument_protein_UL25__YP_004940051__Aotine_betaherpesvirus_1__50290__D247-382
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04637.17 best | Herpes_pp85 | 263.9 | 3.40e-78 | 100.0% | 29.0% |
D3
medium
residues 261-325
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04637.17 best | Herpes_pp85 | 86.6 | 1.80e-24 | 100.0% | 12.0% |
CATH (27)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1u5pA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.87 | 59.0 | 4.93e-01 | 70.8% | 51.9% |
| 2gtsA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.84 | 57.0 | 5.36e-01 | 70.8% | 72.7% |
| 4hr1A00 | 1.20.1270.410 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.82 | 73.0 | 5.98e-01 | 100.0% | 77.1% |
| 4fxdA04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.80 | 60.0 | 4.42e-01 | 78.5% | 54.2% |
| 6r1nA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.80 | 65.0 | 5.50e-01 | 87.7% | 98.1% |
| 3icxA01 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.79 | 54.0 | 5.14e-01 | 70.8% | 100.0% |
| 2ewfA02 | 1.20.1270.310 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.78 | 69.0 | 6.43e-01 | 100.0% | 81.5% |
| 1wa8A00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.77 | 53.0 | 4.64e-01 | 72.3% | 69.7% |
| 1uruA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.76 | 65.0 | 4.63e-01 | 100.0% | 80.9% |
| 5af7B03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.75 | 66.0 | 5.09e-01 | 100.0% | 61.5% |
| 2qkwA00 | 1.20.1270.140 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto | 0.73 | 65.0 | 5.63e-01 | 100.0% | 86.1% |
| 1zkeA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.70 | 47.0 | 4.45e-01 | 70.8% | 84.0% |
| 2j0wA02 | 1.20.120.1320 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartokinase, catalytic domain | 0.68 | 58.0 | 5.28e-01 | 100.0% | 87.1% |
| 4wzxA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.67 | 46.0 | 4.41e-01 | 72.3% | 62.7% |
| 2rpaA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.66 | 45.0 | 4.34e-01 | 72.3% | 61.0% |
| 3bxjA02 | 1.10.506.20 | Mainly Alpha › Orthogonal Bundle › GTPase Activation - p120GAP; domain 1 › | 0.66 | 57.0 | 5.03e-01 | 100.0% | 69.4% |
| 1i6zA00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.65 | 44.0 | 3.51e-01 | 70.8% | 34.8% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.65 | 55.0 | 4.69e-01 | 95.4% | 69.4% |
| 2mpkA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.60 | 41.0 | 4.01e-01 | 72.3% | 78.4% |
| 4mk6A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.59 | 49.0 | 3.64e-01 | 96.9% | 52.1% |
| 1kblA05 | 1.20.80.30 | Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › | 0.59 | 50.0 | 4.60e-01 | 100.0% | 83.1% |
| 3h2zA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.56 | 46.0 | 3.52e-01 | 98.5% | 71.6% |
| 2wzvA01 | 3.40.109.10 | Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › NADH Oxidase | 0.54 | 41.0 | 2.92e-01 | 83.1% | 67.0% |
| 1qguB04 | 1.20.89.10 | Mainly Alpha › Up-down Bundle › Nitrogenase Molybdenum-iron Protein, subunit B; domain 4 › Nitrogenase Molybdenum-iron Protein, subunit B, domain 4 | 0.54 | 38.0 | 3.56e-01 | 78.5% | 59.0% |
| 4nphA02 | 1.20.1270.330 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.54 | 44.0 | 4.25e-01 | 93.8% | 100.0% |
| 4fcgA00 | 3.80.10.10 | Alpha Beta › Alpha-Beta Horseshoe › Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) › Ribonuclease Inhibitor | 0.51 | 43.0 | 2.89e-01 | 100.0% | 38.9% |
| 6pmiF01 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.50 | 45.0 | 4.20e-01 | 100.0% | 86.3% |
ECOD (29)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1828346 | 1063.1.1.1 ↗ | alpha complex topology › Tegument protein U14 › Tegument protein U14 › Tegument protein U14 › Herpes_pp85 | 0.96 | 92.0 | 5.35e-01 | 100.0% | 14.5% |
| 4927172 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.86 | 78.0 | 6.70e-01 | 100.0% | 68.0% |
| 5006608 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.85 | 78.0 | 7.23e-01 | 100.0% | 90.0% |
| 3223278 | 605.4.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein | 0.85 | 77.0 | 6.52e-01 | 100.0% | 72.4% |
| 5031855 | 632.15.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) | 0.81 | 71.0 | 6.66e-01 | 100.0% | 90.0% |
| 3822258 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.80 | 71.0 | 5.53e-01 | 100.0% | 60.7% |
| 3502455 | 4177.1.1.2 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR | 0.79 | 70.0 | 4.86e-01 | 100.0% | 76.6% |
| 3417096 | 3939.1.1.0 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain | 0.79 | 54.0 | 4.49e-01 | 70.8% | 45.5% |
| 3585716 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.78 | 69.0 | 5.59e-01 | 100.0% | 68.8% |
| 4979981 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.78 | 63.0 | 5.24e-01 | 87.7% | 92.7% |
| 4570960 | 605.1.1.137 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › RRP36 | 0.77 | 52.0 | 3.91e-01 | 70.8% | 33.1% |
| 3988791 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.77 | 55.0 | 5.43e-01 | 75.4% | 75.7% |
| 4972787 | 601.18.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 | 0.77 | 70.0 | 6.10e-01 | 100.0% | 74.7% |
| 3406218 | 604.7.1.0 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A | 0.76 | 51.0 | 4.31e-01 | 70.8% | 43.6% |
| 5076876 | 604.12.1.1 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT | 0.73 | 49.0 | 4.63e-01 | 70.8% | 62.5% |
| 3480265 | 604.12.1.1 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT | 0.72 | 49.0 | 4.60e-01 | 70.8% | 62.5% |
| 2770964 | 5073.1.3.0 ↗ | alpha bundles › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain-related › Potassium-transporting ATPase subunit KdpB transmembrane domain | 0.71 | 55.0 | 4.50e-01 | 83.1% | 47.5% |
| 4930292 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.71 | 48.0 | 4.72e-01 | 70.8% | 72.9% |
| 5003155 | 223.1.1.25 ↗ | a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 | 0.71 | 49.0 | 3.52e-01 | 72.3% | 25.4% |
| 5015362 | 5076.2.1.3 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › DUF4013 | 0.71 | 49.0 | 3.19e-01 | 72.3% | 16.8% |
| None | — | 0.69 | 47.0 | 3.06e-01 | 72.3% | 19.5% | |
| 3999274 | 5086.1.1.102 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PTHB1_hp | 0.68 | 46.0 | 3.97e-01 | 70.8% | 46.7% |
| 2337262 | 1189.1.1.1 ↗ | alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › Trypan_glycop | 0.68 | 47.0 | 4.15e-01 | 72.3% | 51.5% |
| 3879426 | 604.12.1.1 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT | 0.66 | 45.0 | 4.18e-01 | 70.8% | 57.8% |
| 5042109 | 3860.1.1.0 ↗ | alpha bundles › Myosin VI lever arm › Myosin VI lever arm › Myosin VI lever arm | 0.64 | 37.0 | 3.64e-01 | 100.0% | 49.3% |
| 3573038 | 4207.1.1.99 ↗ | alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › PF28139 | 0.58 | 41.0 | 3.75e-01 | 75.4% | 57.8% |
| 3171901 | 181.1.1.1 ↗ | alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins › SRP54_N | 0.56 | 45.0 | 4.04e-01 | 92.3% | 68.4% |
| 3267491 | 604.12.1.1 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT | 0.54 | 49.0 | 4.81e-01 | 100.0% | 95.7% |
| 3402139 | 604.12.1.1 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT | 0.52 | 47.0 | 4.28e-01 | 100.0% | 78.8% |
D4
medium
residues 326-351_380-414_429-461