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U30
Euk-VirHuman_betaherpesvirus_6A
U30__NP_042923__Human_betaherpesvirus_6A__32603
Identity
- Accession:
- NP_042923 ↗
- Protein ID:
- U30
- Kingdom:
- euk
Quality
70.7
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Roseolovirus›
Human_betaherpesvirus_6A
TaxID: 32603
Cluster
View cluster (39 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 792-1033
Domain cluster:
rep: tegument_protein_UL37__NP_612690__Panine_betaherpesvirus_2__188763__D711-904
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04523.19 best | Herpes_U30 | 199.8 | 9.70e-59 | 100.0% | 27.5% |
CATH (18)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1t72A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.76 | 39.0 | 5.43e-01 | 83.9% | 100.0% |
| 1fewA00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.73 | 49.0 | 5.61e-01 | 83.1% | 93.1% |
| 6gy8A01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.70 | 57.0 | 5.12e-01 | 85.5% | 89.2% |
| 2rd0B00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.69 | 39.0 | 5.05e-01 | 76.0% | 95.0% |
| 6h2dS01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.69 | 52.0 | 5.43e-01 | 77.3% | 91.5% |
| 6grjB01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.67 | 55.0 | 5.06e-01 | 85.5% | 91.7% |
| 4dciA00 | 6.10.140.1110 | Special › Helix non-globular › Helix Hairpins › | 0.63 | 34.0 | 4.39e-01 | 78.1% | 87.8% |
| 5j1hA01 | 1.20.58.1060 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 41.0 | 4.66e-01 | 80.2% | 85.7% |
| 4k1pE00 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.62 | 52.0 | 4.70e-01 | 87.2% | 88.0% |
| 2v0xA01 | 1.10.287.3160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 37.0 | 4.42e-01 | 76.4% | 86.3% |
| 3rkoG00 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.60 | 25.0 | 3.90e-01 | 88.8% | 94.0% |
| 4iloA00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.57 | 41.0 | 4.24e-01 | 76.0% | 75.4% |
| 1a36A04 | 1.10.132.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.57 | 29.0 | 3.41e-01 | 71.5% | 67.4% |
| 1nfvA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.53 | 36.0 | 4.21e-01 | 83.1% | 97.6% |
| 5y06A01 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.52 | 39.0 | 4.05e-01 | 76.9% | 97.8% |
| 1bgfA00 | 1.10.532.10 | Mainly Alpha › Orthogonal Bundle › Transcription Factor, Stat-4 › STAT transcription factor, N-terminal domain | 0.52 | 21.0 | 2.98e-01 | 74.4% | 75.0% |
| 1s3qG00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.51 | 34.0 | 4.06e-01 | 89.7% | 98.2% |
| 4xpwA00 | 1.20.120.50 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like | 0.51 | 25.0 | 3.25e-01 | 76.9% | 81.7% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3369676 | 603.2.1.13 ↗ | alpha bundles › STAT-like › STAT › STAT › NET2A_C | 0.79 | 57.0 | 6.56e-01 | 72.7% | 100.0% |
| 3696407 | 4121.1.1.7 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › PF26616 | 0.70 | 51.0 | 5.18e-01 | 80.2% | 75.7% |
| 3756246 | 5086.1.1.117 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › WWC1 | 0.69 | 35.0 | 4.22e-01 | 71.1% | 71.2% |
| 3779488 | 3755.4.1.69 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PF28341 | 0.67 | 53.0 | 5.85e-01 | 82.6% | 99.0% |
| 5064482 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.67 | 39.0 | 4.71e-01 | 76.9% | 83.6% |
| 4999293 | 603.2.1.0 ↗ | alpha bundles › STAT-like › STAT › STAT | 0.67 | 53.0 | 4.78e-01 | 81.4% | 79.7% |
| 3798265 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.67 | 46.0 | 5.04e-01 | 85.1% | 84.6% |
| 3724523 | 4121.1.1.7 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › PF26616 | 0.66 | 49.0 | 4.26e-01 | 81.4% | 51.1% |
| 5042955 | 2004.1.1.87 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N | 0.66 | 39.0 | 2.88e-01 | 76.9% | 23.9% |
| 3187178 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.65 | 36.0 | 4.02e-01 | 77.3% | 65.6% |
| 4214119 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.65 | 39.0 | 3.70e-01 | 77.3% | 50.9% |
| 3935140 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.64 | 40.0 | 4.68e-01 | 76.9% | 83.9% |
| 3471820 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.64 | 50.0 | 5.14e-01 | 80.2% | 88.7% |
| 4976067 | 1203.1.2.0 ↗ | alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 | 0.63 | 40.0 | 3.78e-01 | 94.2% | 52.1% |
| 4775818 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.61 | 37.0 | 4.19e-01 | 76.0% | 75.8% |
| 3696922 | 3291.1.1.1 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Snf7 | 0.57 | 35.0 | 4.35e-01 | 78.1% | 97.3% |
| 3239816 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.55 | 41.0 | 4.52e-01 | 76.4% | 98.5% |
| 5031890 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.55 | 38.0 | 3.86e-01 | 70.7% | 94.7% |
| 3611163 | 2004.1.1.480 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_21, AAA_29 | 0.54 | 42.0 | 3.37e-01 | 78.1% | 92.1% |
| 5079778 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.52 | 39.0 | 3.14e-01 | 75.2% | 80.2% |
| 5060376 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.52 | 37.0 | 4.12e-01 | 74.0% | 90.5% |
| 3268736 | 2004.1.1.433 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_23 | 0.51 | 38.0 | 3.00e-01 | 76.4% | 94.5% |
| 4117257 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.51 | 39.0 | 3.61e-01 | 93.8% | 63.0% |
| 4001188 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.51 | 43.0 | 3.48e-01 | 88.0% | 58.9% |
| 4676629 | 3755.3.1.290 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › PPI_helical | 0.50 | 38.0 | 3.90e-01 | 76.9% | 95.2% |
D2
medium
residues 136-246
Domain cluster:
rep: tegument_protein_UL37__YP_004940219__Saimiriine_betaherpesvirus_4__1535247__D1-106
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04523.19 best | Herpes_U30 | 85.3 | 3.90e-24 | 82.9% | 9.7% |
CATH (15)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3eslA02 | 1.25.40.930 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.66 | 47.0 | 4.61e-01 | 83.8% | 68.9% |
| 4ksaA02 | 1.20.140.90 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Malonyl-CoA decarboxylase, oligemerization domain | 0.63 | 52.0 | 4.90e-01 | 89.2% | 96.4% |
| 5mdtA00 | 1.25.40.90 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.60 | 48.0 | 4.38e-01 | 87.4% | 81.6% |
| 3n2oA03 | 1.20.58.930 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 40.0 | 4.24e-01 | 70.3% | 91.7% |
| 7ru9C01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.58 | 47.0 | 3.60e-01 | 88.3% | 39.7% |
| 7fhyB01 | 1.50.10.100 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Chondroitin AC/alginate lyase | 0.57 | 50.0 | 3.71e-01 | 97.3% | 43.0% |
| 3t33A00 | 1.50.10.10 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.57 | 48.0 | 3.34e-01 | 95.5% | 96.3% |
| 2i2xB01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.56 | 44.0 | 4.62e-01 | 91.9% | 92.0% |
| 2v7kA01 | 1.20.58.1320 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.56 | 39.0 | 3.87e-01 | 72.1% | 69.6% |
| 1nzeA00 | 1.20.120.290 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle | 0.55 | 36.0 | 3.66e-01 | 94.6% | 66.1% |
| 2c2lA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.54 | 39.0 | 3.70e-01 | 87.4% | 62.4% |
| 4fjqA02 | 1.50.10.130 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Terpene synthase, N-terminal domain | 0.54 | 40.0 | 3.64e-01 | 80.2% | 61.1% |
| 2c42A03 | 3.40.920.10 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate-ferredoxin Oxidoreductase; domain 3 › Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 0.53 | 41.0 | 3.36e-01 | 83.8% | 86.3% |
| 4i17A00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.52 | 44.0 | 3.53e-01 | 92.8% | 53.1% |
| 3myvA01 | 1.25.40.390 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.51 | 43.0 | 3.48e-01 | 97.3% | 81.9% |
ECOD (14)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3253853 | 109.4.1.1665 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF30377 | 0.65 | 54.0 | 3.85e-01 | 90.1% | 45.2% |
| 3849249 | 109.25.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A | 0.62 | 54.0 | 4.63e-01 | 97.3% | 76.1% |
| 3992191 | 109.4.1.134 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SPIN90_LRD | 0.61 | 45.0 | 4.73e-01 | 93.7% | 88.0% |
| 3996811 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.60 | 46.0 | 4.05e-01 | 89.2% | 55.2% |
| 3765227 | 109.3.1.92 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › ZSWIM4-8_C | 0.57 | 48.0 | 3.70e-01 | 97.3% | 43.2% |
| 3259081 | 1065.1.1.1 ↗ | alpha bundles › SPX domain › SPX domain › SPX domain › SPX | 0.56 | 41.0 | 3.43e-01 | 76.6% | 80.5% |
| 3583862 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.56 | 42.0 | 4.00e-01 | 81.1% | 74.1% |
| 3936985 | 604.3.1.0 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain | 0.55 | 41.0 | 3.74e-01 | 80.2% | 76.8% |
| 3735378 | 109.3.1.233 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › DUF7104 | 0.55 | 43.0 | 3.46e-01 | 89.2% | 42.2% |
| 3480118 | 109.4.1.276 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › EDC4_C | 0.54 | 46.0 | 4.14e-01 | 95.5% | 66.5% |
| 3173511 | 109.4.1.179 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Nro1 | 0.54 | 45.0 | 4.09e-01 | 93.7% | 82.6% |
| 3321593 | 109.4.1.1308 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_1, PPR_2, PPR_3, TPR_24 | 0.52 | 42.0 | 3.67e-01 | 86.5% | 63.9% |
| 3547608 | 1134.1.1.16 ↗ | alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain › ERK-JNK_inhib | 0.52 | 43.0 | 4.06e-01 | 95.5% | 97.9% |
| 3337529 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.52 | 41.0 | 3.63e-01 | 91.0% | 58.2% |
D3
medium
residues 356-475
Domain cluster:
rep: tegument_protein_UL37__YP_004940219__Saimiriine_betaherpesvirus_4__1535247__D207-302
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04523.19 best | Herpes_U30 | 113.7 | 1.10e-32 | 100.0% | 14.0% |
CATH (4)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 8eb0A01 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.59 | 29.0 | 3.31e-01 | 86.7% | 61.6% |
| 3cuqC01 | 1.10.10.570 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › """Winged helix"" DNA-binding domain. Chain C. Domain 1" | 0.54 | 30.0 | 3.33e-01 | 90.8% | 66.3% |
| 4ewcA03 | 1.20.120.1660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.51 | 31.0 | 3.72e-01 | 76.7% | 96.0% |
| 6gpxB00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.51 | 37.0 | 2.90e-01 | 75.0% | 84.8% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1283715 | 3852.1.1.1 ↗ | alpha superhelices › UL37 N-terminal half › UL37 N-terminal half › UL37 N-terminal half › Herpes_UL37_1 | 0.79 | 71.0 | 4.59e-01 | 94.2% | 23.9% |
| 4023423 | 5057.1.1.0 ↗ | alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore | 0.54 | 44.0 | 3.85e-01 | 86.7% | 91.7% |
D4
medium
residues 670-790
Domain cluster:
rep: tegument_protein_UL37__YP_009253934__Macaca_nemestrina_herpesvirus_7__1846169__D552-645
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04523.19 best | Herpes_U30 | 94.9 | 4.90e-27 | 100.0% | 12.5% |