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UL22

Euk-Vir

Anatid_alphaherpesvirus_1

UL22__YP_003084400__Anatid_alphaherpesvirus_1__104388

Identity

Accession:: YP_003084400 ↗
Protein ID:: UL22
Kingdom:: euk

Quality

73.4 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Mardivirus› anatid_alphaherpesvirus_1

TaxID: 104388

Cluster

View cluster (30 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 40-137

PDB

D2 high residues 647-783

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF17488.8 best	Herpes_glycoH_C	68.4	7.70e-19	99.3%	91.5%

CATH (6)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3m1cA04	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.93	84.0	8.58e-01	97.8%	97.0%
2xqyA03	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.92	83.0	8.49e-01	97.8%	96.2%
7b7nH01	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.85	76.0	7.87e-01	95.6%	100.0%
4g65B02	3.30.70.1450	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Regulator of K+ conductance, C-terminal domain	0.56	27.0	3.14e-01	96.4%	63.0%
2jveA00	2.10.60.10	Mainly Beta › Ribbon › CD59 › CD59	0.55	27.0	3.44e-01	94.9%	83.1%
1nr4C00	2.40.50.40	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) ›	0.51	24.0	3.08e-01	100.0%	81.8%

ECOD (6)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1309233	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.92	83.0	8.09e-01	97.8%	86.5%
119479	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.92	84.0	8.22e-01	99.3%	88.4%
1936537	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.82	78.0	7.54e-01	100.0%	91.3%
2095502	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.80	75.0	7.38e-01	100.0%	93.1%
4830885	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.78	57.0	6.54e-01	77.4%	100.0%
3271952	284.1.1.1 ↗	a+b two layers › FKBP-like › FKBP-like › FKBP-like › FKBP_C	0.50	40.0	3.78e-01	85.4%	89.4%

D3 medium residues 206-322

PDB

Domain cluster: rep: envelope_glycoprotein_H__YP_010087581__Cervid_alphaherpesvirus_3__2115790__D207-328

D4 medium residues 524-646

PDB

Domain cluster: rep: envelope_glycoprotein_H__NP_045337__Bovine_alphaherpesvirus_1__10320__D538-631

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02489.22 best	Herpes_glycop_H	32.5	5.30e-08	78.0%	10.6%

CATH (4)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1wjtA00	1.20.930.10	Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0.54	35.0	3.75e-01	97.6%	77.7%
3ajwA00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.51	30.0	2.99e-01	89.4%	53.7%
1sqmA04	1.25.40.320	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain	0.51	31.0	2.94e-01	99.2%	48.3%
3bqkA02	1.20.1310.20	Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Duffy-antigen binding domain	0.50	43.0	4.02e-01	95.1%	100.0%

ECOD (13)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1554358	3146.1.1.1 ↗	a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H	0.82	75.0	4.71e-01	100.0%	20.4%
2095476	3146.1.1.1 ↗	a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H	0.81	61.0	3.88e-01	91.1%	17.0%
3838292	1079.1.1.5 ↗	alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › DsbD_2	0.60	42.0	3.55e-01	73.2%	83.3%
3353564	1075.1.1.4 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane_3	0.56	44.0	3.93e-01	85.4%	72.4%
4957293	1079.1.1.14 ↗	alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › MarC	0.56	40.0	3.41e-01	74.8%	81.3%
4974664	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.55	31.0	3.14e-01	100.0%	55.0%
3656227	633.7.1.0 ↗	alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like	0.54	31.0	3.11e-01	100.0%	52.3%
4561800	5059.1.1.1 ↗	alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA	0.54	37.0	3.67e-01	70.7%	88.5%
3979252	601.46.1.1 ↗	alpha bundles › Four-helical up-and-down bundle › Regulatory CZB domain of diguanylate cyclase YdeH › Regulatory CZB domain of diguanylate cyclase YdeH › CZB	0.53	32.0	3.42e-01	77.2%	66.4%
5047166	5050.1.1.10 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_2	0.53	38.0	3.11e-01	74.8%	97.4%
4946784	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.53	38.0	3.17e-01	73.2%	75.2%
5034157	1015.1.1.2 ↗	alpha complex topology › Insulin-induced gene (Insig) homologs › Insulin-induced gene (Insig) homologs › Insulin-induced gene (Insig) homologs › Caroten_synth	0.53	42.0	3.62e-01	87.0%	78.5%
3781826	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.50	42.0	3.39e-01	89.4%	91.3%

D5 medium residues 793-831

PDB

Domain cluster: representative