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VP2
Euk-VirRotavirus_I
VP2__YP_009130675__Rotavirus_I__1637496
Identity
- Accession:
- YP_009130675 ↗
- Protein ID:
- VP2
- Kingdom:
- euk
Quality
53.2
mean pLDDT
Taxonomy
Orthornavirae›
Duplornaviricota›
Resentoviricetes›
Reovirales›
Sedoreoviridae›
Rotavirus›
Rotavirus_I
TaxID: 1637496
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 3-76
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF25649.1 best | Rotavirus_VP2 | 103.2 | 1.30e-29 | 100.0% | 7.7% |
CATH (40)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7ru9C01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.77 | 65.0 | 4.39e-01 | 100.0% | 25.8% |
| 2nr4A02 | 1.20.58.290 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hypothetical membrane protein ta0354_69_121. | 0.75 | 49.0 | 5.42e-01 | 73.0% | 86.2% |
| 3cbuA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.74 | 66.0 | 5.44e-01 | 100.0% | 70.1% |
| 2b1eA01 | 1.20.58.1150 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 58.0 | 5.55e-01 | 85.1% | 76.7% |
| 2xl4A00 | 1.20.120.1420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › LntA helical domain | 0.73 | 58.0 | 4.65e-01 | 86.5% | 60.5% |
| 3uo2B02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.73 | 55.0 | 5.32e-01 | 82.4% | 86.9% |
| 1s35A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.72 | 56.0 | 5.11e-01 | 85.1% | 89.1% |
| 2e9xA01 | 1.20.58.1030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.72 | 59.0 | 4.92e-01 | 89.2% | 86.7% |
| 1t72A02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.71 | 55.0 | 5.07e-01 | 85.1% | 87.8% |
| 1j5wA02 | 1.20.58.180 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2 | 0.70 | 54.0 | 5.39e-01 | 85.1% | 84.4% |
| 2cwoA01 | 1.20.58.1200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › RNA silencing suppressor P21, N-terminal domain | 0.69 | 52.0 | 5.22e-01 | 79.7% | 95.9% |
| 2odmA00 | 1.10.287.750 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like | 0.69 | 54.0 | 5.29e-01 | 83.8% | 84.8% |
| 3eabE00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.69 | 54.0 | 5.17e-01 | 85.1% | 91.9% |
| 1hu3A00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.69 | 60.0 | 4.43e-01 | 100.0% | 37.3% |
| 2wl8C00 | 1.20.120.900 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pex19, mPTS binding domain | 0.68 | 48.0 | 4.22e-01 | 100.0% | 50.5% |
| 1q0gA00 | 1.20.120.400 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nickel-containing superoxide dismutase | 0.68 | 50.0 | 4.35e-01 | 79.7% | 72.6% |
| 4ap2B01 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.68 | 58.0 | 4.78e-01 | 95.9% | 79.9% |
| 4wqoD00 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.67 | 57.0 | 4.69e-01 | 95.9% | 75.9% |
| 3nfqB02 | 1.20.930.10 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.67 | 57.0 | 5.06e-01 | 100.0% | 65.7% |
| 3mq1A01 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 49.0 | 4.56e-01 | 77.0% | 88.0% |
| 2d2sA02 | 1.20.58.1220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, C-terminal helical domain | 0.67 | 57.0 | 5.26e-01 | 100.0% | 87.1% |
| 2yb5F01 | 1.20.1280.250 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.67 | 48.0 | 4.66e-01 | 78.4% | 69.8% |
| 4i1eA03 | 1.25.10.30 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › IP3 receptor type 1 binding core, RIH domain | 0.64 | 55.0 | 4.59e-01 | 100.0% | 82.0% |
| 1fpoC02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.64 | 49.0 | 4.65e-01 | 85.1% | 87.9% |
| 2mx8A01 | 1.10.274.70 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, N-terminal domain | 0.64 | 46.0 | 4.10e-01 | 78.4% | 97.3% |
| 4ecgA00 | 1.20.1420.20 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › M75 peptidase, HXXE motif | 0.64 | 54.0 | 3.56e-01 | 100.0% | 66.3% |
| 7shlA02 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.64 | 54.0 | 4.65e-01 | 97.3% | 86.9% |
| 4a17U01 | 1.10.287.310 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.63 | 48.0 | 4.78e-01 | 82.4% | 81.8% |
| 4y6cA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.63 | 52.0 | 3.88e-01 | 98.6% | 33.5% |
| 1y6xA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.63 | 44.0 | 4.21e-01 | 73.0% | 63.2% |
| 4dvyP01 | 1.10.357.130 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › | 0.62 | 53.0 | 3.99e-01 | 98.6% | 79.7% |
| 7qocA01 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.62 | 52.0 | 3.96e-01 | 97.3% | 86.1% |
| 4mhlA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.60 | 48.0 | 3.70e-01 | 85.1% | 62.7% |
| 3evyA00 | 1.20.58.910 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 48.0 | 4.65e-01 | 89.2% | 90.4% |
| 5an3A01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.60 | 53.0 | 4.43e-01 | 100.0% | 60.5% |
| 6i2mB02 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.58 | 47.0 | 4.14e-01 | 94.6% | 79.5% |
| 2gkmA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.58 | 41.0 | 3.54e-01 | 77.0% | 81.1% |
| 1bgfA00 | 1.10.532.10 | Mainly Alpha › Orthogonal Bundle › Transcription Factor, Stat-4 › STAT transcription factor, N-terminal domain | 0.56 | 42.0 | 3.66e-01 | 82.4% | 58.1% |
| 3aq5A00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.51 | 41.0 | 3.59e-01 | 90.5% | 80.3% |
| 1g8qA00 | 1.10.1450.10 | Mainly Alpha › Orthogonal Bundle › Cd81 Antigen, Extracellular Domain; Chain: A › Tetraspanin | 0.51 | 40.0 | 3.84e-01 | 98.6% | 74.4% |
ECOD (35)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3578688 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.81 | 72.0 | 4.90e-01 | 100.0% | 33.5% |
| 3703139 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.78 | 69.0 | 4.73e-01 | 100.0% | 34.6% |
| 3596608 | 1134.1.1.0 ↗ | alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain | 0.77 | 61.0 | 5.81e-01 | 85.1% | 74.1% |
| 3168273 | 1134.1.1.0 ↗ | alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain | 0.77 | 61.0 | 6.40e-01 | 85.1% | 96.9% |
| 3505450 | 109.4.1.276 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › EDC4_C | 0.76 | 68.0 | 5.57e-01 | 100.0% | 61.5% |
| 3600074 | 603.2.1.0 ↗ | alpha bundles › STAT-like › STAT › STAT | 0.76 | 68.0 | 5.50e-01 | 100.0% | 72.1% |
| 3765900 | 109.4.1.470 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › INTS2 | 0.76 | 69.0 | 5.76e-01 | 100.0% | 64.8% |
| 3618830 | 622.1.1.1 ↗ | alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain › HSCB_C | 0.74 | 57.0 | 5.51e-01 | 83.8% | 87.1% |
| 3848246 | 109.12.1.4 ↗ | alpha superhelices › Repetitive alpha hairpins › C-terminal domain of Ku80 › C-terminal domain of Ku80 › ZSWIM4-8_C | 0.74 | 63.0 | 5.46e-01 | 95.9% | 85.2% |
| 3172105 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.74 | 65.0 | 5.72e-01 | 100.0% | 77.3% |
| 3626530 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.73 | 54.0 | 5.04e-01 | 79.7% | 85.3% |
| 3601623 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.73 | 60.0 | 5.61e-01 | 89.2% | 90.0% |
| 3402442 | 174.1.1.45 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › MENTAL | 0.73 | 57.0 | 4.39e-01 | 85.1% | 44.7% |
| 3232756 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.73 | 63.0 | 6.05e-01 | 97.3% | 94.1% |
| 3488551 | 109.4.1.844 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ZSWIM4-8_C | 0.73 | 63.0 | 4.64e-01 | 97.3% | 57.9% |
| 4199922 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.72 | 63.0 | 5.29e-01 | 100.0% | 88.5% |
| 4036522 | 604.9.1.1 ↗ | alpha bundles › Spectrin repeat-like › Ribosomal protein S20 › Ribosomal protein S20 › Ribosomal_S20p | 0.71 | 52.0 | 4.97e-01 | 79.7% | 73.3% |
| 4015785 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.70 | 61.0 | 3.74e-01 | 100.0% | 17.5% |
| 3726917 | 109.4.1.356 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans | 0.69 | 59.0 | 3.66e-01 | 100.0% | 19.8% |
| 4010033 | 7558.1.1.1 ↗ | a/b three-layered sandwiches › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Acyltransferase | 0.67 | 57.0 | 3.77e-01 | 94.6% | 49.7% |
| 3169192 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.66 | 59.0 | 3.72e-01 | 100.0% | 20.0% |
| 3933605 | 3651.1.1.0 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain | 0.65 | 56.0 | 4.59e-01 | 100.0% | 54.5% |
| 3789554 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.64 | 50.0 | 4.69e-01 | 83.8% | 87.8% |
| 4511318 | 2498.1.1.26 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M56 | 0.64 | 50.0 | 3.46e-01 | 85.1% | 63.2% |
| 3852805 | 109.4.1.95 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_2 | 0.63 | 51.0 | 4.22e-01 | 98.6% | 48.3% |
| 3958142 | 6102.1.1.0 ↗ | alpha arrays › N-terminal domain of segregation and condensation protein A, ScpA › N-terminal domain of segregation and condensation protein A, ScpA › N-terminal domain of segregation and condensation protein A, ScpA | 0.62 | 48.0 | 3.79e-01 | 85.1% | 40.0% |
| 3923684 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.60 | 52.0 | 4.00e-01 | 100.0% | 92.4% |
| 3261803 | 633.24.1.0 ↗ | alpha bundles › Bromodomain-like › RABEX-5 helical domain › RABEX-5 helical domain | 0.60 | 43.0 | 4.20e-01 | 78.4% | 80.0% |
| 4223433 | 6102.1.1.1 ↗ | alpha arrays › N-terminal domain of segregation and condensation protein A, ScpA › N-terminal domain of segregation and condensation protein A, ScpA › N-terminal domain of segregation and condensation protein A, ScpA › SMC_ScpA | 0.59 | 47.0 | 3.66e-01 | 86.5% | 41.9% |
| 5001327 | 601.28.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like | 0.59 | 43.0 | 4.10e-01 | 85.1% | 65.6% |
| 4940427 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.58 | 45.0 | 4.50e-01 | 86.5% | 92.0% |
| 2808456 | 3651.1.1.1 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B | 0.58 | 50.0 | 4.48e-01 | 97.3% | 71.3% |
| 3313378 | 109.40.1.7 ↗ | alpha superhelices › Repetitive alpha hairpins › DNA polymerase alpha-binding protein Ctf4 C-terminal domain › DNA polymerase alpha-binding protein Ctf4 C-terminal domain › FA_desaturase | 0.58 | 50.0 | 4.77e-01 | 100.0% | 87.8% |
| 3625454 | 3651.1.1.1 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B | 0.57 | 48.0 | 4.27e-01 | 93.2% | 69.1% |
| 5078788 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.54 | 47.0 | 4.46e-01 | 98.6% | 98.9% |
D2
high
residues 793-930
D3
medium
residues 212-268_294-352_770-792
D4
medium
residues 369-419_665-769
D5
medium
residues 452-647