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apoptosis_inhibitor_Bcl-2

Euk-Vir

Meleagrid_alphaherpesvirus_1

apoptosis_inhibitor_Bcl-2__NP_073382__Meleagrid_alphaherpesvirus_1__37108

Identity

Accession:
NP_073382 ↗
Protein ID:
apoptosis_inhibitor_Bcl-2
Kingdom:
euk

Quality

78.2 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Mardivirus› Meleagrid_alphaherpesvirus_1

TaxID: 37108

Cluster

View cluster (9 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 1-57_121-148
PDB
Domain cluster: representative
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2kbwA01 1.10.437.10 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like 0.83 71.0 5.78e-01 91.8% 98.0%
2kwhA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 29.0 3.47e-01 85.9% 76.8%
2d4uB00 1.20.120.30 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain 0.53 39.0 3.20e-01 77.6% 70.3%
2ic6A00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.52 30.0 3.31e-01 81.2% 69.0%
ECOD (8)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
51371 5000.3.1.0 ↗ alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death 0.78 71.0 5.70e-01 100.0% 97.5%
2168246 1176.1.1.1 ↗ alpha arrays › Nitrogenase vanadium-iron protein delta chain › Nitrogenase vanadium-iron protein delta chain › Nitrogenase vanadium-iron protein delta chain › AnfG_VnfG 0.68 51.0 4.59e-01 78.8% 72.6%
3056394 1176.1.1.1 ↗ alpha arrays › Nitrogenase vanadium-iron protein delta chain › Nitrogenase vanadium-iron protein delta chain › Nitrogenase vanadium-iron protein delta chain › AnfG_VnfG 0.65 48.0 4.35e-01 78.8% 68.9%
3314803 632.7.1.37 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › LETM1_RBD 0.60 34.0 2.99e-01 89.4% 38.3%
4200537 2008.1.1.0 ↗ a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like 0.59 48.0 2.97e-01 91.8% 39.3%
4029967 633.1.1.0 ↗ alpha bundles › Bromodomain-like › Bromodomain › Bromodomain 0.55 42.0 3.83e-01 100.0% 60.0%
3250375 192.1.1.0 ↗ alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain 0.52 32.0 3.41e-01 75.3% 69.3%
3583169 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.52 32.0 3.32e-01 74.1% 66.3%
D2 medium residues 58-120
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00452.25 best Bcl-2 33.6 6.50e-08 98.4% 59.0%
CATH (34)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1f16A00 1.10.437.10 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like 0.88 77.0 5.31e-01 100.0% 31.2%
4dciA00 6.10.140.1110 Special › Helix non-globular › Helix Hairpins › 0.80 59.0 4.40e-01 77.8% 36.7%
4fxdA06 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.79 67.0 4.96e-01 95.2% 85.6%
2ondA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.74 66.0 4.20e-01 100.0% 20.8%
4kb2A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.74 62.0 5.27e-01 96.8% 82.6%
5mlc900 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.74 64.0 5.43e-01 100.0% 84.1%
5lnkJ01 1.20.120.1200 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ 0.73 53.0 3.85e-01 76.2% 29.0%
1x46A00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.73 50.0 3.83e-01 73.0% 34.7%
2pmrA00 1.20.1270.90 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like 0.71 48.0 4.52e-01 76.2% 57.9%
3ay5A01 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.71 62.0 4.91e-01 100.0% 61.7%
2gtsA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.70 49.0 4.57e-01 76.2% 59.7%
4g3vA00 3.30.450.40 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › GAF domain 0.68 58.0 4.40e-01 98.4% 95.1%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.68 58.0 4.86e-01 100.0% 60.3%
7s0rB01 1.20.81.20 Mainly Alpha › Up-down Bundle › Receptor-associated Protein › 0.68 47.0 4.44e-01 73.0% 60.5%
3eslA01 1.20.58.2070 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 54.0 5.23e-01 100.0% 78.7%
1h7cA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 45.0 3.87e-01 87.3% 42.7%
3kkbA00 1.20.120.880 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase (KinB), sensor domain 0.66 55.0 4.57e-01 100.0% 55.6%
8fnyA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.65 56.0 3.90e-01 100.0% 29.1%
2gsvA00 6.10.140.40 Special › Helix non-globular › Helix Hairpins › 0.65 53.0 5.27e-01 93.7% 91.0%
4bpxD00 1.20.930.80 Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › 0.65 59.0 4.02e-01 100.0% 39.9%
1e1dA02 1.20.1270.20 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.64 45.0 4.13e-01 73.0% 69.0%
5jc3A02 1.20.1320.30 Mainly Alpha › Up-down Bundle › phosphoenolpyruvate carboxylase, domain 3 › 0.64 53.0 4.39e-01 98.4% 57.1%
1kt1A03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.64 55.0 4.13e-01 96.8% 39.2%
3edvB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 53.0 4.25e-01 100.0% 67.6%
3lbxB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 52.0 4.51e-01 100.0% 84.1%
1ldjA04 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.61 46.0 3.92e-01 100.0% 47.0%
3bjdA01 1.10.1240.20 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Lytic transglycosylase, superhelical linker domain 0.61 50.0 4.52e-01 88.9% 73.9%
3axjB02 1.20.58.200 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 0.61 53.0 4.83e-01 100.0% 82.4%
5dckA00 1.10.1200.30 Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Retrovirus capsid C-terminal domain 0.60 50.0 4.89e-01 95.2% 83.1%
3k3oA02 1.20.58.1360 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 49.0 4.48e-01 90.5% 82.1%
2lrmA00 1.10.890.30 Mainly Alpha › Orthogonal Bundle › 10k-s Protein, Hypothetical Protein A; Chain A › YmgD protein 0.59 41.0 3.80e-01 79.4% 56.0%
2n5fA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.58 47.0 3.87e-01 92.1% 75.6%
1wn0A00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.58 48.0 3.93e-01 100.0% 55.0%
1f2eA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.56 50.0 4.21e-01 100.0% 68.9%
ECOD (50)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3491658 5000.3.1.1 ↗ alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 0.85 76.0 5.51e-01 100.0% 37.6%
4312332 622.4.1.0 ↗ alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related 0.83 74.0 6.70e-01 98.4% 95.3%
3605793 604.9.1.0 ↗ alpha bundles › Spectrin repeat-like › Ribosomal protein S20 › Ribosomal protein S20 0.82 71.0 6.66e-01 100.0% 80.0%
3453777 604.5.1.37 ↗ alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › DUF679 0.77 68.0 5.61e-01 100.0% 67.0%
4031187 632.19.1.3 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A › DUF1542 0.75 54.0 5.07e-01 76.2% 65.3%
3448742 109.7.1.4 ↗ alpha superhelices › Repetitive alpha hairpins › Cytochrome c oxidase subunit E › Cytochrome c oxidase subunit E › SNAP 0.74 64.0 6.26e-01 100.0% 91.4%
3598195 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.73 59.0 4.51e-01 100.0% 39.3%
3269677 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.73 55.0 4.16e-01 87.3% 34.0%
3708380 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.73 64.0 4.05e-01 100.0% 19.4%
3778778 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.72 66.0 4.13e-01 100.0% 21.9%
3274306 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.72 61.0 5.09e-01 100.0% 53.6%
5012498 3843.1.1.28 ↗ alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › MbhD 0.72 53.0 5.27e-01 79.4% 75.4%
3885169 109.4.1.218 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SNAP 0.72 64.0 4.10e-01 100.0% 22.3%
3722903 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.71 56.0 3.82e-01 100.0% 23.5%
3618589 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.71 60.0 3.74e-01 100.0% 16.9%
5050399 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.71 63.0 4.05e-01 100.0% 21.4%
3511431 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.70 60.0 3.82e-01 100.0% 19.4%
3922322 109.4.1.192 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8 0.70 64.0 3.97e-01 100.0% 38.8%
4050574 192.17.1.11 ↗ alpha bundles › Long alpha-hairpin › Rabenosyn-5 Rab-binding domain-like › Rabenosyn-5 Rab-binding domain-like › UVR 0.70 56.0 5.27e-01 90.5% 72.0%
4024592 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.69 60.0 3.93e-01 100.0% 27.6%
3343865 109.4.1.43 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SAC3_GANP 0.69 60.0 4.10e-01 100.0% 27.7%
3687448 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.69 61.0 4.09e-01 100.0% 26.5%
3258417 109.4.1.192 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8 0.68 57.0 4.37e-01 100.0% 39.3%
3896763 101.1.1.66 ↗ alpha arrays › HTH › HTH › Three-helical HTH › Myb_DNA-bind_5 0.68 57.0 5.19e-01 95.2% 69.4%
None — 0.67 58.0 3.79e-01 100.0% 21.1%
4582542 192.11.1.1 ↗ alpha bundles › Long alpha-hairpin › C-terminal UvrC-binding domain of UvrB › C-terminal UvrC-binding domain of UvrB › UVR 0.67 57.0 5.75e-01 93.7% 95.2%
3427778 604.1.1.144 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › PF26575 0.67 57.0 5.29e-01 95.2% 96.2%
3333490 4207.1.1.86 ↗ alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › BPS1 0.67 46.0 4.05e-01 76.2% 47.4%
3487229 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.67 58.0 4.81e-01 100.0% 89.6%
3974601 601.3.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain 0.67 57.0 4.85e-01 100.0% 73.6%
3929377 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.67 58.0 5.30e-01 100.0% 84.7%
3290514 3579.1.1.6 ↗ extended segments › NADH-quinone oxidoreductase subunit J › NADH-quinone oxidoreductase subunit J › NADH-quinone oxidoreductase subunit J › MbhD+MbhE 0.66 50.0 3.61e-01 79.4% 30.3%
4385616 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.66 48.0 3.87e-01 76.2% 48.3%
3682803 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 58.0 4.06e-01 100.0% 29.5%
2559778 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 56.0 4.50e-01 100.0% 47.3%
3890976 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 51.0 3.75e-01 85.7% 31.2%
3796461 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.66 57.0 5.43e-01 100.0% 85.3%
3968183 3758.2.1.1 ↗ alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB 0.65 55.0 4.24e-01 100.0% 75.9%
3600361 3922.1.1.0 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.65 45.0 3.90e-01 76.2% 47.4%
3456370 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.65 47.0 3.50e-01 76.2% 40.0%
4574972 192.7.1.0 ↗ alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm 0.64 44.0 4.54e-01 76.2% 75.0%
3171295 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.64 55.0 3.16e-01 100.0% 14.1%
4357455 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.63 44.0 4.09e-01 84.1% 56.5%
3273217 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.62 51.0 4.63e-01 100.0% 81.1%
3996406 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.61 53.0 5.15e-01 100.0% 88.6%
4939058 3457.1.1.3 ↗ alpha bundles › GxGD membrane protease › GxGD membrane protease › GxGD membrane protease › Arc_PepC_II 0.61 50.0 3.44e-01 96.8% 92.4%
3398025 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.61 51.0 4.50e-01 100.0% 87.0%
5068379 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 52.0 4.41e-01 100.0% 58.1%
4980072 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 53.0 3.99e-01 100.0% 39.9%
3562136 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.56 46.0 3.65e-01 100.0% 60.6%