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apoptosis_inhibitor
Euk-VirMurmansk_poxvirus
apoptosis_inhibitor__YP_009408216__Murmansk_poxvirus__2025359
Identity
- Accession:
- YP_009408216 ↗
- Protein ID:
- apoptosis_inhibitor
- Kingdom:
- euk
Quality
77.2
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Pokkesviricetes›
Chitovirales›
Poxviridae›
Centapoxvirus›
Murmansk_poxvirus
TaxID: 2025359
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-55
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF11099.14 best | M11L | 30.2 | 7.20e-07 | 83.6% | 25.6% |
CATH (19)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2js5A00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.74 | 50.0 | 4.62e-01 | 70.9% | 56.3% |
| 1lujB01 | 1.10.10.490 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Beta-catenin-interacting ICAT | 0.71 | 57.0 | 5.78e-01 | 87.3% | 92.5% |
| 2gsqA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.71 | 57.0 | 4.58e-01 | 89.1% | 77.8% |
| 2kmuA00 | 1.10.10.1460 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.66 | 53.0 | 5.33e-01 | 92.7% | 100.0% |
| 2kw6A00 | 6.10.140.1300 | Special › Helix non-globular › Helix Hairpins › | 0.65 | 41.0 | 3.91e-01 | 72.7% | 53.8% |
| 7paxA01 | 3.40.1180.10 | Alpha Beta › 3-Layer(aba) Sandwich › Undecaprenyl pyrophosphate synthetase › Decaprenyl diphosphate synthase-like | 0.65 | 47.0 | 3.02e-01 | 78.2% | 19.6% |
| 4izzB02 | 1.10.10.1680 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › HetR, N-terminal DNA-binding domain | 0.62 | 51.0 | 4.77e-01 | 90.9% | 82.4% |
| 2pusA04 | 6.10.140.300 | Special › Helix non-globular › Helix Hairpins › | 0.62 | 52.0 | 4.28e-01 | 100.0% | 82.4% |
| 2yf4F00 | 1.10.3420.10 | Mainly Alpha › Orthogonal Bundle › putative ntp pyrophosphohydrolase like fold › putative ntp pyrophosphohydrolase like domain | 0.61 | 43.0 | 3.12e-01 | 74.5% | 39.2% |
| 1x4tA01 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.61 | 41.0 | 4.05e-01 | 78.2% | 65.5% |
| 6srbA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.61 | 47.0 | 3.76e-01 | 83.6% | 58.7% |
| 3tklB01 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 43.0 | 4.14e-01 | 89.1% | 66.1% |
| 1lvfB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 47.0 | 3.87e-01 | 87.3% | 94.2% |
| 2jx4A01 | 6.10.140.460 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 41.0 | 4.31e-01 | 72.7% | 83.3% |
| 4ielA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.59 | 43.0 | 3.53e-01 | 83.6% | 68.1% |
| 2clbA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.57 | 50.0 | 3.65e-01 | 100.0% | 91.8% |
| 2cazD00 | 6.10.140.820 | Special › Helix non-globular › Helix Hairpins › | 0.57 | 39.0 | 3.79e-01 | 70.9% | 85.0% |
| 3k92A01 | 1.10.8.1210 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.56 | 49.0 | 4.78e-01 | 98.2% | 91.7% |
| 3rq9A00 | 1.10.287.2500 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.55 | 43.0 | 3.78e-01 | 83.6% | 96.2% |
ECOD (18)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3909017 | 192.5.1.1 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1 | 0.69 | 38.0 | 3.23e-01 | 74.5% | 31.1% |
| 3260684 | 377.1.1.0 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like | 0.67 | 43.0 | 4.34e-01 | 72.7% | 65.5% |
| 4828003 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.66 | 47.0 | 3.71e-01 | 76.4% | 83.5% |
| 5083776 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.64 | 50.0 | 4.14e-01 | 83.6% | 89.5% |
| 3659915 | 192.7.1.45 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Na_sulph_symp | 0.64 | 49.0 | 4.43e-01 | 83.6% | 93.3% |
| 3559937 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.63 | 48.0 | 4.03e-01 | 87.3% | 92.4% |
| 3189269 | 3184.1.1.1 ↗ | alpha bundles › mRNA 3'-end-processing protein Rna15p hinge domain › mRNA 3'-end-processing protein Rna15p hinge domain › mRNA 3'-end-processing protein Rna15p hinge domain › CSTF2_hinge | 0.63 | 42.0 | 3.75e-01 | 70.9% | 61.4% |
| 3709920 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.61 | 52.0 | 3.39e-01 | 100.0% | 69.4% |
| 3555578 | 633.22.1.15 ↗ | alpha bundles › Bromodomain-like › Vitamin K epoxide reductase (VKOR) › Vitamin K epoxide reductase (VKOR) › OST3_OST6 | 0.60 | 43.0 | 3.42e-01 | 76.4% | 50.9% |
| 3302089 | 6074.1.1.0 ↗ | extended segments › Transmembrane helix of E1 envelope glycoprotein › Transmembrane helix of E1 envelope glycoprotein › Transmembrane helix of E1 envelope glycoprotein | 0.59 | 41.0 | 3.92e-01 | 72.7% | 63.1% |
| 5077223 | 206.1.3.23 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › RNA_ligase | 0.59 | 49.0 | 3.02e-01 | 98.2% | 26.4% |
| 3600071 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.58 | 45.0 | 4.30e-01 | 87.3% | 92.3% |
| 4138504 | 310.2.1.1 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › RRF | 0.57 | 48.0 | 3.38e-01 | 98.2% | 97.8% |
| 4194508 | 101.1.8.1 ↗ | alpha arrays › HTH › HTH › DNA breaking-rejoining enzymes › Phage_integrase | 0.55 | 43.0 | 4.39e-01 | 94.5% | 98.2% |
| 3565062 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.54 | 44.0 | 3.38e-01 | 94.5% | 95.7% |
| 3591320 | 5043.1.1.2 ↗ | extended segments › Sensor proteins transmembrane domains › Htr2 transmembrane domain-like › Htr2 transmembrane domain-like › SPC12 | 0.53 | 43.0 | 3.93e-01 | 85.5% | 67.1% |
| 4646549 | 650.1.1.1 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ | 0.53 | 41.0 | 3.47e-01 | 83.6% | 71.6% |
| 2663455 | 192.7.1.0 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm | 0.51 | 39.0 | 3.62e-01 | 92.7% | 64.7% |
D2
medium
residues 56-164
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF11099.14 best | M11L | 40.0 | 7.20e-10 | 98.2% | 57.5% |
CATH (13)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2ondA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.70 | 54.0 | 3.87e-01 | 81.7% | 61.4% |
| 1f16A00 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.69 | 62.0 | 5.15e-01 | 100.0% | 60.4% |
| 3zheC01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.63 | 49.0 | 4.18e-01 | 82.6% | 84.2% |
| 5cwkA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.62 | 47.0 | 4.11e-01 | 80.7% | 75.0% |
| 4g1tA02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.61 | 35.0 | 4.45e-01 | 84.4% | 100.0% |
| 2xgsB01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.61 | 36.0 | 4.25e-01 | 88.1% | 86.3% |
| 4uqxA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.60 | 36.0 | 3.96e-01 | 73.4% | 73.0% |
| 2ebfX02 | 1.20.140.180 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.59 | 45.0 | 4.15e-01 | 80.7% | 82.5% |
| 3tm8B00 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.55 | 44.0 | 3.25e-01 | 88.1% | 84.0% |
| 1wvtA00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.54 | 39.0 | 3.55e-01 | 74.3% | 100.0% |
| 5an3A01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.54 | 43.0 | 4.14e-01 | 87.2% | 81.4% |
| 4ip8A00 | 1.10.132.110 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Serum amyloid A protein | 0.52 | 42.0 | 4.33e-01 | 90.8% | 91.4% |
| 3kkbA00 | 1.20.120.880 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase (KinB), sensor domain | 0.51 | 42.0 | 4.07e-01 | 91.7% | 77.8% |
ECOD (13)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1514726 | 5000.3.1.6 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › M11L | 0.86 | 62.0 | 5.51e-01 | 74.3% | 55.4% |
| 3624258 | 109.4.1.1808 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd3, PF30235 | 0.67 | 52.0 | 3.04e-01 | 84.4% | 22.8% |
| 3598764 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.66 | 45.0 | 3.58e-01 | 72.5% | 35.3% |
| 3972011 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.65 | 39.0 | 3.38e-01 | 84.4% | 38.2% |
| 3611674 | 109.4.1.1276 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › FAT, HEAT_ATR | 0.65 | 45.0 | 3.69e-01 | 72.5% | 39.5% |
| 3721280 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.64 | 44.0 | 3.75e-01 | 70.6% | 43.4% |
| 3706362 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.64 | 49.0 | 3.57e-01 | 81.7% | 40.7% |
| 4357450 | 109.4.1.1329 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › NatB_MDM20, PF31234 | 0.60 | 51.0 | 3.13e-01 | 93.6% | 35.6% |
| 3679810 | 109.4.1.590 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › NopRA1 | 0.60 | 42.0 | 4.42e-01 | 72.5% | 86.3% |
| 3213627 | 626.1.1.1 ↗ | alpha complex topology › Formin homology 2 domain (FH2 domain) › Formin homology 2 domain (FH2 domain) › Formin homology 2 domain (FH2 domain) › FH2 | 0.59 | 48.0 | 3.34e-01 | 89.0% | 91.2% |
| 3949956 | 3352.1.1.0 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain | 0.59 | 50.0 | 3.44e-01 | 95.4% | 53.4% |
| 3599624 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 45.0 | 2.86e-01 | 86.2% | 44.1% |
| 3815482 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.52 | 40.0 | 2.76e-01 | 81.7% | 46.9% |