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apoptosis_regulator_BHRF1
Euk-VirHuman_gammaherpesvirus_4
apoptosis_regulator_BHRF1__YP_401646__Human_gammaherpesvirus_4__10376
Identity
- Accession:
- YP_401646 ↗
- Protein ID:
- apoptosis_regulator_BHRF1
- Kingdom:
- euk
Quality
75.2
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Lymphocryptovirus›
human_gammaherpesvirus_4
TaxID: 10376
Cluster
View cluster (9 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 43-189
Domain cluster:
rep: anti-apoptotic_factor__YP_009407967__Eptesipox_virus__1329402__D6-165
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00452.25 best | Bcl-2 | 42.0 | 1.60e-10 | 68.0% | 95.0% |
CATH (14)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2kbwA01 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.80 | 61.0 | 6.01e-01 | 78.2% | 81.0% |
| 1f16A00 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.77 | 68.0 | 6.21e-01 | 99.3% | 72.9% |
| 3qbrX00 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.76 | 57.0 | 5.59e-01 | 78.9% | 78.9% |
| 1ohuA00 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.74 | 59.0 | 5.65e-01 | 83.7% | 73.3% |
| 1uddA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.67 | 59.0 | 5.15e-01 | 93.9% | 98.6% |
| 1q59A00 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.67 | 55.0 | 5.20e-01 | 86.4% | 86.6% |
| 2rkkA01 | 1.25.40.270 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Vacuolar protein sorting-associated protein vta1 | 0.67 | 47.0 | 4.61e-01 | 71.4% | 98.7% |
| 6vqqA01 | 1.20.1080.10 | Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein. | 0.66 | 46.0 | 3.73e-01 | 70.7% | 88.1% |
| 1lq7A00 | 1.20.1270.70 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Designed single chain three-helix bundle | 0.63 | 30.0 | 4.28e-01 | 89.1% | 100.0% |
| 2kmfA01 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.53 | 34.0 | 4.04e-01 | 82.3% | 94.1% |
| 3mzvA00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.52 | 38.0 | 3.01e-01 | 76.2% | 95.8% |
| 3lxzB02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.51 | 36.0 | 3.76e-01 | 75.5% | 78.3% |
| 5dz2A00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.50 | 40.0 | 3.21e-01 | 86.4% | 92.2% |
| 1b5lA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.50 | 38.0 | 3.80e-01 | 78.9% | 83.6% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2464246 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.82 | 63.0 | 6.29e-01 | 78.9% | 79.7% |
| 4053747 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.80 | 72.0 | 6.79e-01 | 95.9% | 84.6% |
| 4605105 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.78 | 68.0 | 6.29e-01 | 91.8% | 81.7% |
| 3919852 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.77 | 68.0 | 6.36e-01 | 95.9% | 76.7% |
| 3313 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.77 | 68.0 | 6.21e-01 | 99.3% | 72.9% |
| 3231057 | 5000.3.1.2 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2,BH4 | 0.76 | 61.0 | 5.74e-01 | 83.7% | 74.3% |
| 3554813 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.76 | 68.0 | 6.37e-01 | 95.9% | 83.4% |
| 3474099 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.74 | 61.0 | 5.80e-01 | 87.1% | 75.3% |
| 3316 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.67 | 55.0 | 5.20e-01 | 86.4% | 86.6% |
| 3275160 | 3352.1.1.6 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › Glyco_transf_22 | 0.58 | 44.0 | 3.43e-01 | 78.9% | 54.5% |
| 3291547 | 601.1.1.84 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › DUF350 | 0.58 | 39.0 | 3.93e-01 | 98.6% | 67.6% |
| 3770066 | 3291.1.1.169 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › KIF21A_4th | 0.57 | 28.0 | 2.51e-01 | 73.5% | 33.8% |
| 3637886 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 38.0 | 3.59e-01 | 70.7% | 55.0% |
| 5018433 | 1075.1.2.41 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › TctA | 0.56 | 39.0 | 3.39e-01 | 72.1% | 90.8% |
| 3593287 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.54 | 38.0 | 4.09e-01 | 92.5% | 81.5% |
| 3420207 | 3755.4.1.17 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Rx_N | 0.54 | 36.0 | 3.87e-01 | 94.6% | 76.9% |
| 3179160 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.53 | 38.0 | 3.38e-01 | 73.5% | 93.7% |
| 3766742 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.52 | 36.0 | 4.04e-01 | 89.8% | 89.6% |
| 5051018 | 1075.1.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain | 0.51 | 46.0 | 3.68e-01 | 100.0% | 72.8% |
| 4118685 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 37.0 | 3.30e-01 | 73.5% | 86.8% |
| 4505591 | 5050.1.1.25 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › TLC | 0.51 | 38.0 | 3.20e-01 | 75.5% | 85.7% |
| 3212831 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.51 | 40.0 | 3.67e-01 | 81.6% | 78.9% |
| 3243203 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.50 | 40.0 | 3.55e-01 | 82.3% | 74.7% |