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bifunctional_dihydrofolate_reductase-thymidylate_synthase
Euk-VirAcanthamoeba_polyphaga_mimivirus
bifunctional_dihydrofolate_reductase-thymidylate_synthase__YP_003987009__Acanthamoeba_polyphaga_mimivirus__212035
Identity
- Accession:
- YP_003987009 ↗
- Protein ID:
- bifunctional_dihydrofolate_reductase-thymidylate_synthase
- Kingdom:
- euk
Quality
80.4
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Imitervirales›
Mimiviridae›
Mimivirus›
Acanthamoeba_polyphaga_mimivirus
TaxID: 212035
Cluster
View cluster (13 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 4-195
Domain cluster:
rep: dihydrofolate_reductase__YP_009119754__Pandoravirus_inopinatum__1605721__D21-210
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 69.7 | 3.30e-19 | 91.1% | 79.2% |
CATH (65)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.93 | 73.0 | 8.10e-01 | 100.0% | 98.1% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.91 | 72.0 | 8.03e-01 | 100.0% | 98.7% |
| 1vdrA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.91 | 72.0 | 7.92e-01 | 100.0% | 98.7% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 79.0 | 8.23e-01 | 100.0% | 97.7% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 73.0 | 7.98e-01 | 100.0% | 98.8% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 74.0 | 7.95e-01 | 100.0% | 97.0% |
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 79.0 | 8.09e-01 | 100.0% | 94.1% |
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.87 | 80.0 | 8.14e-01 | 100.0% | 97.3% |
| 1cz3B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 70.0 | 7.49e-01 | 100.0% | 95.8% |
| 3vcoA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 76.0 | 7.86e-01 | 100.0% | 97.3% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.84 | 82.0 | 7.95e-01 | 100.0% | 96.1% |
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 79.0 | 7.56e-01 | 100.0% | 94.0% |
| 1aoeA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.81 | 76.0 | 7.63e-01 | 100.0% | 96.9% |
| 2xw7A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 67.0 | 7.06e-01 | 100.0% | 96.0% |
| 3jtwA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.78 | 67.0 | 7.04e-01 | 100.0% | 97.7% |
| 2h2qB01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.78 | 73.0 | 7.04e-01 | 100.0% | 88.2% |
| 3kgyA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 70.0 | 6.69e-01 | 100.0% | 95.4% |
| 2p4gA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 70.0 | 6.33e-01 | 100.0% | 90.7% |
| 2b3zA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.71 | 68.0 | 6.38e-01 | 100.0% | 93.8% |
| 3zpgA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.71 | 68.0 | 6.48e-01 | 100.0% | 93.5% |
| 2aznA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.71 | 68.0 | 6.43e-01 | 100.0% | 96.8% |
| 2g6vA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.69 | 66.0 | 6.22e-01 | 100.0% | 93.7% |
| 4xt6A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.68 | 65.0 | 6.00e-01 | 100.0% | 88.2% |
| 4ha7B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.67 | 60.0 | 5.85e-01 | 100.0% | 87.3% |
| 2vdwG00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.63 | 53.0 | 4.77e-01 | 92.2% | 96.7% |
| 2h6eA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.62 | 44.0 | 5.02e-01 | 89.1% | 97.2% |
| 3gvpA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.61 | 44.0 | 4.84e-01 | 89.1% | 89.3% |
| 5je6A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 51.0 | 4.84e-01 | 89.6% | 97.9% |
| 8k5lA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 50.0 | 4.98e-01 | 89.1% | 100.0% |
| 3l8dA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 49.0 | 4.83e-01 | 89.1% | 98.5% |
| 3busB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 50.0 | 4.66e-01 | 92.2% | 99.6% |
| 3p12A01 | 3.40.1650.10 | Alpha Beta › 3-Layer(aba) Sandwich › RbsD-like fold › RbsD-like domain | 0.59 | 32.0 | 3.97e-01 | 79.2% | 83.1% |
| 3pukA01 | 3.40.50.2060 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Sec1/Munc18 (SM) protein, domain 1 | 0.58 | 37.0 | 4.41e-01 | 85.9% | 93.8% |
| 3sm3A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 46.0 | 4.53e-01 | 85.4% | 98.6% |
| 1hnnA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 50.0 | 4.55e-01 | 94.3% | 98.5% |
| 3dluA00 | 3.30.56.30 | Alpha Beta › 2-Layer Sandwich › Phenylalanyl-tRNA Synthetase; Chain B, domain 1 › Signal recognition particle, SRP19-like subunit | 0.58 | 23.0 | 3.22e-01 | 100.0% | 72.6% |
| 4lwoE01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 40.0 | 4.37e-01 | 71.4% | 95.6% |
| 3ofkA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 50.0 | 4.90e-01 | 94.3% | 94.1% |
| 3gnlA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 44.0 | 4.74e-01 | 89.6% | 95.2% |
| 3c6kB03 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 46.0 | 4.71e-01 | 86.5% | 97.9% |
| 2efjA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 48.0 | 4.66e-01 | 91.1% | 99.5% |
| 1vm0A00 | 3.30.110.20 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain | 0.56 | 25.0 | 3.53e-01 | 78.6% | 84.9% |
| 3lpmA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 46.0 | 4.50e-01 | 92.2% | 78.6% |
| 2h00B00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 48.0 | 4.67e-01 | 91.7% | 87.1% |
| 1xdzA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 47.0 | 4.44e-01 | 91.7% | 76.1% |
| 4z2yA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 47.0 | 4.56e-01 | 91.1% | 94.0% |
| 2i62A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 49.0 | 4.47e-01 | 95.3% | 99.2% |
| 6gnaA02 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.56 | 30.0 | 3.82e-01 | 78.1% | 90.7% |
| 3douA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 46.0 | 4.84e-01 | 90.6% | 97.7% |
| 2yx1A03 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 44.0 | 4.60e-01 | 91.1% | 91.1% |
| 3h2bB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 47.0 | 4.69e-01 | 92.2% | 95.4% |
| 2xheA01 | 3.40.50.2060 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Sec1/Munc18 (SM) protein, domain 1 | 0.55 | 36.0 | 4.24e-01 | 88.0% | 96.9% |
| 3e7pA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 47.0 | 4.31e-01 | 92.2% | 94.5% |
| 3g88A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 46.0 | 4.32e-01 | 91.1% | 73.2% |
| 1qzzA03 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 44.0 | 4.69e-01 | 92.7% | 98.8% |
| 4dgsA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.54 | 41.0 | 4.51e-01 | 85.4% | 97.4% |
| 2a35A00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.54 | 41.0 | 3.98e-01 | 77.6% | 96.6% |
| 3e23A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 47.0 | 4.65e-01 | 93.8% | 94.9% |
| 4qttB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 45.0 | 4.71e-01 | 92.7% | 100.0% |
| 1ej0A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 45.0 | 4.66e-01 | 91.1% | 99.4% |
| 1dxyA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.53 | 43.0 | 4.33e-01 | 86.5% | 100.0% |
| 7b7tA02 | 3.40.50.2030 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.52 | 37.0 | 4.04e-01 | 100.0% | 87.4% |
| 5d6nA00 | 3.40.50.12780 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › ANL, N-terminal domain | 0.52 | 45.0 | 3.37e-01 | 92.2% | 76.0% |
| 4lpsA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 48.0 | 4.64e-01 | 100.0% | 88.8% |
| 1sc6A02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.52 | 42.0 | 4.46e-01 | 88.0% | 95.4% |
ECOD (76)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4624802 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.93 | 76.0 | 8.24e-01 | 100.0% | 98.2% |
| 4965070 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 76.0 | 7.96e-01 | 100.0% | 92.0% |
| 4276639 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 74.0 | 7.92e-01 | 100.0% | 93.5% |
| 4652224 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 75.0 | 8.13e-01 | 100.0% | 97.6% |
| 3963884 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 73.0 | 8.03e-01 | 99.5% | 98.1% |
| 3360231 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 82.0 | 7.71e-01 | 100.0% | 80.5% |
| 2503171 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 79.0 | 8.17e-01 | 100.0% | 96.1% |
| 137968 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 74.0 | 7.95e-01 | 100.0% | 97.0% |
| 185430 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 79.0 | 8.10e-01 | 100.0% | 94.6% |
| 4392683 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 73.0 | 7.87e-01 | 100.0% | 97.6% |
| 4667474 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 80.0 | 8.34e-01 | 100.0% | 99.4% |
| 3900511 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 80.0 | 8.17e-01 | 100.0% | 97.3% |
| 4402042 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 80.0 | 8.21e-01 | 100.0% | 97.8% |
| 2831687 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 70.0 | 7.35e-01 | 100.0% | 90.8% |
| 4123104 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 71.0 | 7.64e-01 | 100.0% | 97.6% |
| 4315799 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 75.0 | 7.89e-01 | 100.0% | 98.3% |
| 3913441 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 80.0 | 8.05e-01 | 100.0% | 96.3% |
| 3232633 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 79.0 | 8.10e-01 | 100.0% | 98.4% |
| 4021830 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.85 | 82.0 | 7.72e-01 | 100.0% | 97.8% |
| 10268 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 82.0 | 7.98e-01 | 100.0% | 96.1% |
| 4392834 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 82.0 | 7.61e-01 | 100.0% | 96.1% |
| 3611921 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.84 | 81.0 | 7.57e-01 | 100.0% | 91.3% |
| 3738384 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.84 | 81.0 | 7.43e-01 | 100.0% | 89.2% |
| 3593841 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.84 | 81.0 | 7.68e-01 | 100.0% | 92.3% |
| 5030442 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.83 | 71.0 | 7.52e-01 | 100.0% | 98.8% |
| 3974710 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.83 | 71.0 | 7.44e-01 | 100.0% | 96.6% |
| 5029141 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.83 | 70.0 | 7.30e-01 | 100.0% | 94.9% |
| 4115051 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 80.0 | 7.27e-01 | 100.0% | 95.0% |
| 4228699 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 78.0 | 7.69e-01 | 99.5% | 99.5% |
| 3590464 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 68.0 | 7.15e-01 | 100.0% | 97.7% |
| 5058063 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 68.0 | 7.13e-01 | 100.0% | 97.1% |
| 3056343 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 75.0 | 7.26e-01 | 100.0% | 92.5% |
| 136641 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 67.0 | 7.04e-01 | 100.0% | 97.7% |
| 3581890 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.78 | 74.0 | 7.39e-01 | 100.0% | 96.4% |
| 3277763 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 66.0 | 6.80e-01 | 100.0% | 97.8% |
| 5073892 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 67.0 | 6.79e-01 | 100.0% | 96.8% |
| 3278932 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 67.0 | 6.81e-01 | 100.0% | 97.9% |
| 163852 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 70.0 | 6.33e-01 | 100.0% | 90.7% |
| 3279668 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 66.0 | 6.74e-01 | 100.0% | 98.4% |
| 3282327 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 69.0 | 6.87e-01 | 100.0% | 97.9% |
| 5063695 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 66.0 | 6.67e-01 | 100.0% | 96.8% |
| 4033392 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 69.0 | 6.67e-01 | 100.0% | 97.1% |
| 4577003 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 68.0 | 6.56e-01 | 100.0% | 96.7% |
| 4663296 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 68.0 | 6.49e-01 | 100.0% | 96.8% |
| 5001085 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.71 | 68.0 | 6.28e-01 | 100.0% | 90.6% |
| 235716 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.71 | 68.0 | 6.60e-01 | 100.0% | 98.1% |
| 3740375 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.71 | 67.0 | 6.69e-01 | 100.0% | 100.0% |
| 5050939 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.71 | 67.0 | 6.23e-01 | 100.0% | 94.9% |
| 3278543 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.70 | 65.0 | 6.56e-01 | 100.0% | 97.9% |
| 4949256 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.67 | 64.0 | 6.10e-01 | 100.0% | 97.7% |
| 4980571 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.67 | 64.0 | 6.06e-01 | 100.0% | 98.2% |
| 5082494 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.67 | 63.0 | 6.03e-01 | 100.0% | 96.8% |
| 4309221 | 7514.1.1.0 ↗ | a/b three-layered sandwiches › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.66 | 37.0 | 4.86e-01 | 83.9% | 99.0% |
| 3962559 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.60 | 46.0 | 5.07e-01 | 91.1% | 100.0% |
| 4019786 | 2003.1.5.151 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23, Methyltransf_25 | 0.60 | 51.0 | 4.51e-01 | 93.2% | 93.8% |
| 4023089 | 2003.1.5.79 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 | 0.58 | 50.0 | 4.27e-01 | 93.8% | 85.5% |
| 3960615 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.57 | 47.0 | 4.77e-01 | 87.5% | 98.9% |
| 4372405 | 2003.1.5.25 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GidB | 0.57 | 48.0 | 4.53e-01 | 91.1% | 77.0% |
| 5053279 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.57 | 48.0 | 4.84e-01 | 90.6% | 98.4% |
| 9383 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.57 | 48.0 | 4.30e-01 | 92.7% | 92.9% |
| 3315603 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.57 | 48.0 | 4.76e-01 | 92.2% | 88.8% |
| 4437131 | 2003.1.5.25 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GidB | 0.56 | 48.0 | 4.70e-01 | 92.2% | 85.2% |
| 4257947 | 2003.1.5.79 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 | 0.56 | 49.0 | 4.77e-01 | 95.3% | 97.7% |
| 3734216 | 323.1.1.3 ↗ | a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding | 0.56 | 38.0 | 3.87e-01 | 84.9% | 68.9% |
| 3207687 | 2003.1.1.37 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C | 0.55 | 45.0 | 4.51e-01 | 86.5% | 98.0% |
| 3279992 | 323.1.1.3 ↗ | a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding | 0.55 | 35.0 | 3.69e-01 | 84.9% | 68.0% |
| None | — | 0.54 | 47.0 | 4.57e-01 | 92.7% | 90.0% | |
| 4989916 | 2003.1.1.37 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C | 0.54 | 44.0 | 4.49e-01 | 85.9% | 98.4% |
| 4451549 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.54 | 46.0 | 4.52e-01 | 92.7% | 90.4% |
| 5078688 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.53 | 46.0 | 4.49e-01 | 92.7% | 91.4% |
| 3626497 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.53 | 46.0 | 4.18e-01 | 95.3% | 95.2% |
| 4931802 | 2003.1.5.81 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 | 0.53 | 45.0 | 4.52e-01 | 92.2% | 92.3% |
| 4037133 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.53 | 46.0 | 4.52e-01 | 92.7% | 93.1% |
| 4075097 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.53 | 46.0 | 4.60e-01 | 92.7% | 96.4% |
| 4533168 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.52 | 44.0 | 4.37e-01 | 92.7% | 92.2% |
| 3595479 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.51 | 43.0 | 4.32e-01 | 89.1% | 94.2% |
D2
medium
residues 270-319_413-563
Domain cluster:
rep: Filtrate_w_scaffold_1_prodigal-single.1__X__X__00126__D2-227
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 154.5 | 4.40e-45 | 76.6% | 53.2% |
| PF00303.25 | Thymidylat_synt | 31.7 | 1.30e-07 | 24.4% | 18.5% |
CATH (7)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1bo7A00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.91 | 89.0 | 7.33e-01 | 100.0% | 100.0% |
| 1bkpA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.87 | 85.0 | 7.42e-01 | 100.0% | 100.0% |
| 3egyX00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.87 | 84.0 | 7.83e-01 | 98.0% | 99.1% |
| 1tisA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.86 | 82.0 | 7.13e-01 | 99.5% | 100.0% |
| 3v8hC00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.80 | 72.0 | 6.16e-01 | 92.0% | 100.0% |
| 1b5eA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.66 | 61.0 | 5.72e-01 | 97.5% | 96.7% |
| 1ft9A02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 23.0 | 3.48e-01 | 78.1% | 100.0% |
ECOD (36)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3944795 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.94 | 91.0 | 7.25e-01 | 99.0% | 99.4% |
| 3203076 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.94 | 92.0 | 7.52e-01 | 100.0% | 99.1% |
| 2540892 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.93 | 91.0 | 7.41e-01 | 100.0% | 87.2% |
| 4664958 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 0.92 | 90.0 | 7.96e-01 | 99.0% | 100.0% |
| 4228846 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.92 | 89.0 | 7.33e-01 | 99.0% | 100.0% |
| 4151800 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.92 | 90.0 | 7.54e-01 | 99.5% | 100.0% |
| 3479792 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 0.92 | 89.0 | 7.44e-01 | 99.0% | 91.9% |
| 4225236 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.91 | 89.0 | 7.68e-01 | 100.0% | 100.0% |
| 5059575 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.91 | 87.0 | 7.47e-01 | 98.5% | 100.0% |
| 4599962 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 0.91 | 88.0 | 7.69e-01 | 100.0% | 99.6% |
| 4108234 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.91 | 88.0 | 7.24e-01 | 99.0% | 99.7% |
| 4086625 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 88.0 | 7.57e-01 | 99.5% | 99.6% |
| 3164619 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 87.0 | 7.52e-01 | 99.0% | 100.0% |
| 4937005 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 87.0 | 7.03e-01 | 99.0% | 100.0% |
| 1900468 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.89 | 87.0 | 7.59e-01 | 100.0% | 99.6% |
| 3824671 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.88 | 80.0 | 6.95e-01 | 93.0% | 92.1% |
| 3955287 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 0.85 | 67.0 | 6.28e-01 | 80.1% | 95.3% |
| 4582423 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.85 | 66.0 | 6.42e-01 | 79.6% | 99.1% |
| 5015648 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.85 | 64.0 | 6.43e-01 | 77.6% | 99.5% |
| 5046158 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.84 | 64.0 | 6.42e-01 | 76.6% | 99.0% |
| 4949404 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.84 | 65.0 | 6.20e-01 | 79.1% | 92.2% |
| 4998171 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.84 | 66.0 | 6.26e-01 | 80.1% | 91.3% |
| 4938917 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.84 | 65.0 | 5.98e-01 | 79.1% | 89.8% |
| 5031349 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.84 | 64.0 | 6.30e-01 | 78.6% | 98.6% |
| 5022688 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.84 | 64.0 | 6.48e-01 | 78.1% | 99.5% |
| 4954631 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.83 | 65.0 | 6.14e-01 | 79.1% | 99.6% |
| 4932636 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.83 | 65.0 | 6.34e-01 | 79.6% | 98.1% |
| 5050802 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.83 | 65.0 | 5.68e-01 | 80.6% | 98.2% |
| 5065331 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.82 | 64.0 | 6.23e-01 | 80.6% | 95.0% |
| 2028021 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.82 | 76.0 | 6.36e-01 | 96.5% | 96.8% |
| 5001950 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.81 | 65.0 | 5.93e-01 | 81.1% | 90.4% |
| 4985883 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.81 | 64.0 | 6.32e-01 | 80.6% | 95.2% |
| 5005700 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.79 | 61.0 | 6.60e-01 | 79.6% | 98.3% |
| 5068964 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.76 | 70.0 | 6.05e-01 | 95.0% | 92.0% |
| 1900473 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.66 | 61.0 | 5.65e-01 | 97.0% | 94.7% |
| 4976145 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.64 | 62.0 | 5.93e-01 | 100.0% | 94.7% |
D3
medium
residues 320-412
Domain cluster:
rep: thymidylate_synthase__YP_006347622__European_catfish_virus__84739__D66-177
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 72.6 | 4.10e-20 | 100.0% | 27.2% |