←Back to structures
capsid_protein
Euk-VirBearded_dragon_parvovirus
capsid_protein__YP_009154713__Bearded_dragon_parvovirus__1670662
Identity
- Accession:
- YP_009154713 ↗
- Protein ID:
- capsid_protein
- Kingdom:
- euk
Quality
69.0
mean pLDDT
Taxonomy
Shotokuvirae›
Cossaviricota›
Quintoviricetes›
Piccovirales›
Parvoviridae›
Dependoparvovirus›
Bearded_dragon_parvovirus
TaxID: 1670662
Cluster
View cluster (92 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 36-124
Domain cluster:
rep: capsid_protein_VP1__YP_009508795__Bat_bocavirus_XM30__2259811__D8-95
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF08398.16 best | Phospholip_A2_4 | 103.5 | 8.50e-30 | 89.9% | 100.0% |
D2
high
residues 216-413_623-674
Domain cluster:
rep: VP2__YP_009508801__Miniopterus_schreibersii_bat_bocavirus__1911554__D51-253_470-529
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00740.24 best | VP1_2 | 235.0 | 2.20e-69 | 79.2% | 41.1% |
| PF00740.24 | VP1_2 | 32.9 | 3.80e-08 | 22.0% | 8.0% |
CATH (47)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2g8gA00 | 2.170.30.10 | Mainly Beta › Beta Complex › Empty Capsid Viral Protein 2 › Parvovirus coat protein VP1/VP2 | 0.96 | 94.0 | 7.03e-01 | 100.0% | 88.5% |
| 1c8dA00 | 2.170.30.10 | Mainly Beta › Beta Complex › Empty Capsid Viral Protein 2 › Parvovirus coat protein VP1/VP2 | 0.93 | 90.0 | 6.69e-01 | 100.0% | 90.0% |
| 4qc8A00 | 2.170.30.10 | Mainly Beta › Beta Complex › Empty Capsid Viral Protein 2 › Parvovirus coat protein VP1/VP2 | 0.92 | 90.0 | 6.87e-01 | 100.0% | 88.0% |
| 1s58A00 | 2.170.30.10 | Mainly Beta › Beta Complex › Empty Capsid Viral Protein 2 › Parvovirus coat protein VP1/VP2 | 0.91 | 89.0 | 6.71e-01 | 100.0% | 87.4% |
| 6b9tF02 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.79 | 28.0 | 4.35e-01 | 97.2% | 76.1% |
| 3es4A00 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.79 | 28.0 | 4.16e-01 | 98.4% | 70.7% |
| 2bnmA02 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.79 | 30.0 | 4.37e-01 | 97.2% | 74.2% |
| 1cauA00 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.73 | 30.0 | 3.55e-01 | 99.2% | 54.1% |
| 4lejA01 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.72 | 30.0 | 3.59e-01 | 99.2% | 55.1% |
| 1zvfB01 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.70 | 27.0 | 3.33e-01 | 99.2% | 53.7% |
| 2f4pA00 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.68 | 27.0 | 3.65e-01 | 99.6% | 66.4% |
| 2ws9201 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.68 | 47.0 | 5.27e-01 | 97.6% | 89.2% |
| 5u55A02 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.66 | 28.0 | 3.86e-01 | 98.4% | 76.2% |
| 4yarA02 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.66 | 26.0 | 3.59e-01 | 98.4% | 69.1% |
| 4qpiB00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.65 | 43.0 | 4.63e-01 | 98.8% | 76.5% |
| 5mqcB00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.65 | 44.0 | 4.62e-01 | 99.2% | 73.6% |
| 5yl1A01 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.64 | 46.0 | 5.31e-01 | 97.2% | 100.0% |
| 1stmA00 | 2.60.120.220 | Mainly Beta › Sandwich › Jelly Rolls › Satellite virus coat domain | 0.64 | 36.0 | 4.75e-01 | 97.6% | 97.9% |
| 7chkB01 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.64 | 35.0 | 4.71e-01 | 94.4% | 100.0% |
| 3es1A02 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.63 | 28.0 | 3.89e-01 | 98.4% | 82.5% |
| 1b35A00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.62 | 50.0 | 4.94e-01 | 99.2% | 79.2% |
| 3am2A02 | 2.60.120.1050 | Mainly Beta › Sandwich › Jelly Rolls › | 0.62 | 29.0 | 4.01e-01 | 98.4% | 88.9% |
| 2ztnA01 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.62 | 44.0 | 5.03e-01 | 98.0% | 95.3% |
| 5wxuA02 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.62 | 27.0 | 3.28e-01 | 99.2% | 59.9% |
| 1fmd100 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.62 | 35.0 | 4.01e-01 | 98.8% | 72.7% |
| 6jhsA00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.61 | 43.0 | 4.31e-01 | 99.2% | 68.8% |
| 5jzgA00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.61 | 41.0 | 4.30e-01 | 98.8% | 74.3% |
| 3jb4C00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.60 | 41.0 | 4.24e-01 | 98.8% | 72.2% |
| 6tfjA01 | 2.60.120.260 | Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like | 0.60 | 26.0 | 3.67e-01 | 91.2% | 84.3% |
| 2q30A01 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.59 | 23.0 | 3.78e-01 | 100.0% | 98.9% |
| 3cjiB00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.57 | 43.0 | 4.41e-01 | 99.6% | 79.8% |
| 2w9xB01 | 2.60.120.260 | Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like | 0.57 | 25.0 | 3.83e-01 | 94.8% | 100.0% |
| 1fmd200 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.57 | 43.0 | 4.65e-01 | 100.0% | 89.4% |
| 6eiwA01 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.57 | 43.0 | 4.84e-01 | 98.4% | 100.0% |
| 4indA01 | 2.60.120.1320 | Mainly Beta › Sandwich › Jelly Rolls › | 0.56 | 30.0 | 3.94e-01 | 94.0% | 89.7% |
| 2ws9100 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.56 | 43.0 | 4.33e-01 | 98.8% | 79.3% |
| 2qcsB02 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.55 | 24.0 | 3.30e-01 | 94.0% | 77.6% |
| 2f1eA00 | 2.60.40.1470 | Mainly Beta › Sandwich › Immunoglobulin-like › ApaG domain | 0.55 | 25.0 | 3.51e-01 | 98.4% | 87.1% |
| 1uijB01 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.54 | 27.0 | 3.24e-01 | 99.6% | 69.1% |
| 4qkbA00 | 2.60.120.590 | Mainly Beta › Sandwich › Jelly Rolls › Alpha-ketoglutarate-dependent dioxygenase AlkB-like | 0.54 | 28.0 | 3.25e-01 | 97.6% | 67.2% |
| 2yc2A00 | 2.60.120.260 | Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like | 0.53 | 29.0 | 3.87e-01 | 95.2% | 100.0% |
| 3cjiA00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.52 | 44.0 | 4.40e-01 | 99.2% | 85.7% |
| 1tvgA00 | 2.60.120.260 | Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like | 0.52 | 29.0 | 3.84e-01 | 93.6% | 99.3% |
| 3thpA02 | 2.60.120.1520 | Mainly Beta › Sandwich › Jelly Rolls › | 0.52 | 30.0 | 3.75e-01 | 99.2% | 92.1% |
| 6l9iA01 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.51 | 25.0 | 2.86e-01 | 99.6% | 60.0% |
| 2dt4A00 | 3.30.1330.80 | Alpha Beta › 2-Layer Sandwich › 60s Ribosomal Protein L30; Chain: A; › Hypothetical protein, similar to alpha- acetolactate decarboxylase; domain 2 | 0.51 | 26.0 | 3.36e-01 | 97.2% | 83.2% |
| 5j98B00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.51 | 45.0 | 4.45e-01 | 100.0% | 89.2% |
ECOD (47)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2644354 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.97 | 95.0 | 7.08e-01 | 100.0% | 89.0% |
| 3107916 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.94 | 74.0 | 6.86e-01 | 79.2% | 69.7% |
| 2990572 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.94 | 92.0 | 6.81e-01 | 100.0% | 88.8% |
| 4884619 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.93 | 91.0 | 6.69e-01 | 100.0% | 88.7% |
| 2707659 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.92 | 90.0 | 6.79e-01 | 100.0% | 85.0% |
| 2142463 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.92 | 90.0 | 6.69e-01 | 100.0% | 89.4% |
| 2990501 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.92 | 72.0 | 6.06e-01 | 79.2% | 64.3% |
| 3107798 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.92 | 90.0 | 6.68e-01 | 100.0% | 88.3% |
| 3108999 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.92 | 71.0 | 7.24e-01 | 79.2% | 90.7% |
| 1195 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.91 | 89.0 | 6.71e-01 | 100.0% | 87.4% |
| 4880563 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.91 | 64.0 | 7.46e-01 | 71.2% | 99.5% |
| 3063115 | 10.2.1.9 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_coat | 0.84 | 62.0 | 7.05e-01 | 76.4% | 94.9% |
| 1034414 | 10.2.1.16 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Parvo_NS1 | 0.78 | 73.0 | 6.06e-01 | 97.6% | 82.3% |
| 1197 | 10.2.1.28 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Denso_VP4 | 0.75 | 70.0 | 5.80e-01 | 98.0% | 86.7% |
| 3106452 | 10.2.1.28 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Denso_VP4 | 0.75 | 70.0 | 5.81e-01 | 98.0% | 86.7% |
| 1112407 | 10.2.1.28 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Denso_VP4 | 0.73 | 68.0 | 5.80e-01 | 97.6% | 87.1% |
| 3187888 | 10.12.1.3 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › Cupin_1 | 0.73 | 29.0 | 3.70e-01 | 98.0% | 60.8% |
| 5033161 | 10.1.2.0 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) | 0.69 | 37.0 | 5.04e-01 | 95.6% | 100.0% |
| 3473996 | 10.2.1.0 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) | 0.68 | 64.0 | 6.11e-01 | 98.0% | 93.2% |
| 178766 | 10.2.1.53 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › IHHNV_capsid | 0.68 | 64.0 | 5.94e-01 | 98.0% | 84.9% |
| 5047632 | 10.1.2.183 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) › PPC | 0.65 | 29.0 | 4.20e-01 | 92.8% | 91.8% |
| 4871782 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.64 | 23.0 | 4.01e-01 | 76.4% | 100.0% |
| 5033861 | 10.1.2.183 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) › PPC | 0.64 | 31.0 | 4.18e-01 | 93.2% | 86.9% |
| 5039565 | 10.1.2.0 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) | 0.63 | 34.0 | 4.64e-01 | 96.0% | 100.0% |
| None | — | 0.63 | 25.0 | 3.24e-01 | 93.6% | 61.3% | |
| 146645 | 10.32.1.16 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › Clenterotox | 0.62 | 29.0 | 3.99e-01 | 98.4% | 87.4% |
| 4877367 | 10.2.1.1 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Rhv | 0.62 | 35.0 | 4.04e-01 | 98.8% | 73.4% |
| None | — | 0.62 | 25.0 | 3.23e-01 | 94.0% | 62.0% | |
| 3231820 | 5001.1.1.52 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › SID-1_RNA_chan | 0.61 | 33.0 | 4.39e-01 | 98.0% | 93.6% |
| 3628503 | 10.32.1.3 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › Calpain_III | 0.61 | 36.0 | 4.49e-01 | 98.0% | 92.9% |
| 3691986 | 10.32.1.246 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › PalB_C | 0.61 | 36.0 | 4.42e-01 | 97.6% | 91.0% |
| 3404051 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.60 | 38.0 | 4.69e-01 | 98.0% | 100.0% |
| 3889464 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.59 | 36.0 | 4.54e-01 | 96.8% | 100.0% |
| 3646939 | 10.32.1.212 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › GUB_WAK_bind | 0.58 | 34.0 | 3.88e-01 | 99.2% | 74.4% |
| 5082643 | 10.1.2.0 ↗ | beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) | 0.58 | 36.0 | 4.42e-01 | 96.8% | 98.1% |
| 3318466 | 10.2.1.0 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) | 0.57 | 26.0 | 3.04e-01 | 100.0% | 56.8% |
| 2321067 | 10.12.1.13 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › Pirin | 0.56 | 27.0 | 3.41e-01 | 99.6% | 73.5% |
| 3320430 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.56 | 27.0 | 3.58e-01 | 99.6% | 83.8% |
| 3601703 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.55 | 36.0 | 4.28e-01 | 94.4% | 94.3% |
| 3243464 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.55 | 31.0 | 4.09e-01 | 97.2% | 98.6% |
| 2982737 | 10.2.1.0 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) | 0.54 | 44.0 | 4.24e-01 | 98.8% | 74.8% |
| 3937351 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.54 | 32.0 | 3.91e-01 | 91.6% | 89.7% |
| 3075118 | 10.2.1.1 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Rhv | 0.53 | 49.0 | 4.84e-01 | 100.0% | 93.5% |
| 3519988 | 10.32.1.0 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like | 0.53 | 25.0 | 3.59e-01 | 98.0% | 96.4% |
| 3311207 | 10.32.1.212 ↗ | beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like › GUB_WAK_bind | 0.52 | 25.0 | 2.73e-01 | 100.0% | 51.6% |
| 3801842 | 10.2.1.92 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › WAK, GUB_WAK_bind | 0.51 | 32.0 | 3.52e-01 | 99.6% | 75.1% |
| 4466937 | 11.1.1.248 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › bMG6 | 0.51 | 24.0 | 3.21e-01 | 98.0% | 82.3% |
D3
medium
residues 416-478
Domain cluster:
rep: capsid_protein__YP_077178__Adeno-associated_virus_-_7__202812__D428-485
D4
medium
residues 501-564_604-622