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conserved_DNA_polymerase_delta_catalytic_subunit

Euk-Vir

Melbournevirus

conserved_DNA_polymerase_delta_catalytic_subunit__YP_009094792__Melbournevirus__1560514

Identity

Accession:: YP_009094792 ↗
Protein ID:: conserved_DNA_polymerase_delta_catalytic_subunit
Kingdom:: euk

Quality

74.6 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Marseilleviridae› Marseillevirus› Marseillevirus_sp._'Melbournevirus'

TaxID: 1560514

Cluster

View cluster (158 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 20-206

PDB

Domain cluster: rep: DNA_polymerase__YP_010084862__Shrimp_hemocyte_iridescent_virus__2039780__D2-200

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03104.26 best	DNA_pol_B_exo1	23.0	6.50e-05	29.4%	21.1%

CATH (44)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3k59A01	2.40.50.590	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › DNA polymerase B, N domain, beta-barrel	0.83	34.0	5.17e-01	100.0%	87.1%
1d5aA01	3.30.342.10	Alpha Beta › 2-Layer Sandwich › DNA Polymerase; Chain A, domain 1 › DNA Polymerase, chain B, domain 1	0.83	57.0	6.35e-01	81.3%	86.1%
4b08A01	2.40.50.730	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) ›	0.80	32.0	5.09e-01	100.0%	91.4%
3iayA01	2.40.50.730	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) ›	0.75	34.0	4.79e-01	100.0%	84.7%
1whwA01	3.30.70.330	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain	0.71	35.0	4.88e-01	93.0%	94.7%
1h2vZ00	3.30.70.330	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain	0.70	32.0	4.61e-01	70.6%	89.2%
1xjvA01	2.40.50.140	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins	0.70	32.0	3.71e-01	100.0%	57.7%
4egvA02	2.40.50.840	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) ›	0.70	27.0	4.34e-01	100.0%	92.0%
1y7pB01	3.30.70.260	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain	0.68	31.0	4.56e-01	70.6%	100.0%
3ce8A00	3.30.70.120	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.67	33.0	4.49e-01	91.4%	95.5%
2j5aA00	3.30.70.60	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B	0.66	37.0	4.77e-01	93.0%	96.2%
6ro0F00	2.40.50.110	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) ›	0.66	32.0	4.32e-01	100.0%	87.8%
3ahpA00	3.30.70.120	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.66	34.0	4.47e-01	84.5%	88.7%
1cqmA00	3.30.70.60	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B	0.66	36.0	4.75e-01	92.5%	100.0%
2ypyA00	3.30.70.390	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Epstein Barr virus nuclear antigen-1, DNA-binding domain	0.66	35.0	4.13e-01	90.9%	72.4%
4y6iA00	3.30.70.120	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.65	34.0	4.44e-01	83.4%	90.3%
1vmbA00	3.30.70.60	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B	0.64	38.0	4.80e-01	89.3%	100.0%
4e98C00	3.30.70.120	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.64	33.0	4.30e-01	82.9%	88.6%
1o51A00	3.30.70.120	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.63	32.0	4.42e-01	87.7%	100.0%
2yq1C00	3.30.70.390	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Epstein Barr virus nuclear antigen-1, DNA-binding domain	0.63	34.0	4.02e-01	90.4%	74.0%
2rilA00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.63	33.0	4.51e-01	75.4%	100.0%
4ozjA00	3.30.70.120	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.62	34.0	4.47e-01	90.9%	97.1%
1tr0A00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.61	35.0	4.54e-01	70.1%	100.0%
3m05B01	3.30.70.120	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.60	31.0	4.27e-01	90.4%	100.0%
7o4xA01	3.30.70.120	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.59	31.0	4.19e-01	82.4%	96.0%
2qycA00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.59	34.0	4.33e-01	88.2%	100.0%
2nyiA02	3.30.70.260	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain	0.59	30.0	4.14e-01	70.6%	100.0%
4i6yA02	3.30.70.420	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain	0.59	35.0	4.43e-01	76.5%	100.0%
2ftrA00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.59	33.0	4.33e-01	74.9%	100.0%
2fb0A00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.58	31.0	4.10e-01	72.2%	100.0%
7k98B01	2.40.50.140	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins	0.58	30.0	3.76e-01	100.0%	81.6%
2od6C00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.57	34.0	4.27e-01	92.0%	100.0%
3bn7A00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.57	32.0	4.20e-01	71.1%	100.0%
1rjjA00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.57	33.0	4.12e-01	94.7%	95.5%
3fmbA01	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.56	31.0	4.07e-01	72.7%	100.0%
1lq9A00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.54	33.0	4.10e-01	91.4%	100.0%
1r6yA00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.54	31.0	3.99e-01	72.2%	100.0%
3i6eA01	3.30.390.10	Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain	0.54	28.0	3.78e-01	98.9%	93.2%
3uiuA01	3.30.200.20	Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1	0.53	25.0	3.37e-01	76.5%	84.5%
1ekrA00	3.30.70.640	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Molybdopterin cofactor biosynthesis C (MoaC) domain	0.53	37.0	4.12e-01	73.8%	92.3%
2jzlA00	2.30.60.10	Mainly Beta › Roll › HIV-inactivating Protein, Cyanovirin-n › Cyanovirin-N	0.52	31.0	3.86e-01	97.9%	96.4%
3x1lB03	2.60.40.4350	Mainly Beta › Sandwich › Immunoglobulin-like ›	0.52	30.0	3.80e-01	72.2%	97.1%
3go9A02	3.30.830.10	Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like	0.51	36.0	3.49e-01	72.7%	88.9%
1q2lA01	3.30.830.10	Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like	0.50	39.0	3.57e-01	81.3%	82.3%

ECOD (61)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3788812	304.114.1.6 ↗	a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain › DNA_pol_B_exo1	0.88	79.0	7.12e-01	100.0%	71.7%
4988803	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.88	67.0	5.05e-01	95.2%	36.7%
4997715	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.88	73.0	7.67e-01	100.0%	94.1%
4500300	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.85	68.0	5.21e-01	97.9%	39.7%
5023017	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.85	69.0	6.56e-01	98.9%	72.6%
4504110	2484.1.1.197 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2	0.85	70.0	5.24e-01	100.0%	38.3%
4942684	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.85	72.0	7.57e-01	100.0%	96.5%
4944520	304.8.1.0 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like	0.85	72.0	6.66e-01	98.9%	71.7%
4299557	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.84	70.0	6.95e-01	98.4%	82.6%
4972474	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.84	72.0	4.70e-01	100.0%	24.3%
5005284	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.84	40.0	5.75e-01	99.5%	92.6%
5025207	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.84	38.0	5.74e-01	100.0%	96.5%
4977731	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.84	63.0	5.06e-01	99.5%	43.0%
3192875	304.114.1.0 ↗	a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain	0.83	77.0	5.52e-01	100.0%	37.5%
5055355	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.82	38.0	5.49e-01	100.0%	92.2%
4949765	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.82	59.0	6.30e-01	97.9%	83.6%
3800859	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.80	75.0	7.38e-01	98.4%	99.0%
3794217	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.80	75.0	5.26e-01	98.4%	42.1%
5019480	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.78	73.0	4.71e-01	100.0%	25.0%
5012082	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.78	37.0	5.25e-01	100.0%	91.6%
4982118	304.4.1.0 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel	0.73	39.0	4.85e-01	90.4%	83.5%
3738561	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.72	40.0	5.47e-01	99.5%	100.0%
4022366	2484.1.1.161 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.71	51.0	3.40e-01	72.7%	36.5%
4141632	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.70	37.0	5.06e-01	90.4%	100.0%
4342306	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.69	37.0	4.96e-01	92.5%	97.0%
5076410	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.69	60.0	4.68e-01	90.4%	61.4%
4976869	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.69	37.0	4.76e-01	100.0%	87.0%
4411078	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.69	37.0	5.01e-01	92.0%	100.0%
4438032	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.68	36.0	4.92e-01	71.7%	100.0%
4523594	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.68	38.0	4.63e-01	80.7%	83.3%
4301978	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.68	37.0	4.79e-01	91.4%	93.3%
4350044	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.68	37.0	4.91e-01	75.4%	99.0%
4296360	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.68	36.0	4.85e-01	90.4%	100.0%
4982659	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.67	59.0	4.65e-01	90.9%	64.3%
3520250	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.67	37.0	4.90e-01	91.4%	100.0%
4213698	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.67	37.0	4.76e-01	93.6%	92.7%
4349987	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.67	35.0	4.79e-01	71.7%	100.0%
4081765	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.66	34.0	4.73e-01	71.7%	100.0%
4226954	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.66	35.0	4.72e-01	90.4%	100.0%
4353875	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.65	39.0	4.69e-01	80.7%	88.0%
3468300	304.9.1.0 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD	0.65	39.0	4.90e-01	82.9%	96.5%
3486979	304.9.1.0 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD	0.65	35.0	4.39e-01	75.4%	84.3%
4230468	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.64	37.0	4.43e-01	90.9%	83.9%
4628567	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.64	36.0	4.40e-01	74.3%	86.1%
3179745	304.4.1.0 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel	0.64	38.0	4.81e-01	93.6%	99.1%
4554484	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.64	37.0	4.17e-01	92.5%	72.4%
3826486	304.9.1.114 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1, RRM_2	0.63	37.0	4.02e-01	73.8%	68.4%
3730752	304.4.1.0 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel	0.63	37.0	4.69e-01	72.2%	100.0%
4510101	304.12.1.1 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6	0.63	35.0	4.27e-01	80.2%	83.3%
3731574	304.4.1.0 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel	0.63	36.0	4.59e-01	71.1%	98.1%
5081878	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.63	55.0	4.30e-01	90.9%	61.4%
3220212	304.12.1.11 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › DUF7637	0.63	36.0	4.56e-01	70.1%	95.5%
3564603	304.9.1.0 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD	0.62	33.0	4.48e-01	74.3%	100.0%
5069333	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.62	54.0	4.17e-01	90.9%	59.5%
4322730	304.4.1.14 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › Dabb	0.59	36.0	4.51e-01	90.4%	100.0%
3733394	304.4.1.0 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel	0.58	34.0	4.17e-01	89.3%	92.1%
4683054	309.1.1.16 ↗	a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › LuxS/MPP-like metallohydrolase › Peptidase_M16, Peptidase_M16_C, M16C_assoc, PreP_C	0.58	43.0	2.74e-01	75.9%	84.8%
4011808	304.12.1.0 ↗	a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6	0.57	32.0	3.84e-01	70.6%	82.5%
1144136	304.4.1.0 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel	0.57	38.0	4.31e-01	75.4%	89.9%
3495445	304.9.1.1 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1	0.52	39.0	3.06e-01	76.5%	72.7%
4047925	304.4.1.4 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › ABM	0.51	32.0	3.92e-01	77.5%	100.0%

D2 medium residues 214-346

PDB

Domain cluster: rep: DNA_polymerase_catalytic_subunit__YP_401712__Human_gammaherpesvirus_4__10376__D288-457

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03104.26 best	DNA_pol_B_exo1	75.9	4.60e-21	97.7%	49.6%

CATH (9)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3iayA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.91	86.0	7.12e-01	100.0%	61.0%
2gv9A03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.90	83.0	6.81e-01	96.2%	64.3%
1q8iA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.87	70.0	6.13e-01	97.7%	59.5%
1noyB02	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.83	77.0	6.22e-01	96.2%	64.6%
1s5jA02	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.82	71.0	6.12e-01	97.0%	61.9%
4fvmA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.78	73.0	5.90e-01	98.5%	70.9%
1d5aA02	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.77	73.0	6.05e-01	100.0%	98.6%
4qclA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.76	73.0	5.59e-01	100.0%	99.6%
4ep4A00	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.57	42.0	3.93e-01	92.5%	60.8%

ECOD (92)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4022366	2484.1.1.161 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.92	86.0	5.30e-01	100.0%	20.3%
None	—		0.92	87.0	5.34e-01	100.0%	20.5%
3710418	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.92	88.0	6.07e-01	100.0%	35.2%
3558197	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.91	85.0	6.69e-01	98.5%	52.2%
3368695	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.91	86.0	5.91e-01	100.0%	33.3%
3628202	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.91	87.0	5.31e-01	100.0%	19.7%
None	—		0.91	86.0	5.30e-01	100.0%	20.3%
None	—		0.91	87.0	6.08e-01	100.0%	36.2%
5029084	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.91	76.0	6.20e-01	100.0%	51.1%
4981192	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.91	69.0	5.39e-01	98.5%	40.8%
4799493	2.1.1.25 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1	0.90	78.0	8.19e-01	91.7%	98.3%
4891100	2484.1.1.161 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.89	84.0	6.46e-01	98.5%	54.9%
1822623	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.88	85.0	6.43e-01	100.0%	90.9%
3206356	304.114.1.0 ↗	a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain	0.87	82.0	5.64e-01	99.2%	37.5%
4029124	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.86	77.0	5.98e-01	94.0%	50.4%
5023018	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.86	81.0	6.80e-01	100.0%	62.9%
4972474	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.85	82.0	5.01e-01	100.0%	33.9%
3192875	304.114.1.0 ↗	a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain	0.85	78.0	5.13e-01	96.2%	29.0%
3784398	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.84	79.0	6.23e-01	99.2%	57.6%
3825992	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.84	80.0	6.31e-01	100.0%	56.8%
4997716	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.84	72.0	5.87e-01	98.5%	52.9%
3168836	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.84	79.0	6.17e-01	99.2%	57.6%
3797773	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.83	78.0	5.84e-01	98.5%	84.7%
3404726	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.83	78.0	5.81e-01	98.5%	50.8%
3798596	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.83	78.0	6.34e-01	98.5%	57.8%
5005285	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.82	79.0	6.32e-01	100.0%	99.1%
4888481	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.82	61.0	4.73e-01	76.7%	39.5%
3496492	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.82	75.0	5.61e-01	95.5%	52.1%
None	—		0.82	79.0	4.64e-01	100.0%	27.4%
None	—		0.82	78.0	4.64e-01	99.2%	28.5%
4649118	2484.1.1.197 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2	0.81	79.0	5.36e-01	100.0%	58.2%
3802227	2484.1.1.197 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2	0.81	79.0	4.61e-01	100.0%	26.9%
3584771	2484.1.1.197 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2	0.81	79.0	5.81e-01	100.0%	78.0%
3605750	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.81	79.0	4.58e-01	100.0%	25.3%
3619240	304.48.1.59 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_exo1, DNA_pol_B_exo2	0.81	78.0	4.68e-01	100.0%	30.1%
3266685	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.81	78.0	4.43e-01	100.0%	19.7%
11143	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.81	77.0	5.35e-01	99.2%	40.3%
4953654	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.81	77.0	5.52e-01	100.0%	65.0%
3471270	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.81	72.0	5.30e-01	94.0%	40.0%
4504110	2484.1.1.197 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2	0.81	77.0	5.23e-01	100.0%	52.3%
4944521	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.80	72.0	6.01e-01	98.5%	59.0%
5067181	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.80	76.0	5.17e-01	100.0%	54.2%
5056578	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.80	76.0	5.66e-01	100.0%	74.6%
4942685	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.79	76.0	4.95e-01	100.0%	46.2%
3089543	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.79	74.0	6.18e-01	98.5%	69.2%
3683241	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.79	75.0	5.48e-01	100.0%	49.7%
4932453	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.79	75.0	5.47e-01	100.0%	82.5%
3692564	2.1.1.25 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1	0.79	75.0	5.12e-01	100.0%	62.7%
4934764	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	75.0	5.26e-01	100.0%	62.2%
4988803	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	75.0	5.14e-01	100.0%	90.9%
3193111	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	74.0	5.19e-01	100.0%	68.4%
5027090	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	75.0	5.91e-01	100.0%	91.8%
3214818	304.114.1.0 ↗	a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain	0.78	72.0	5.08e-01	97.7%	35.7%
4282509	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.78	75.0	4.73e-01	100.0%	38.1%
3597964	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.78	74.0	5.50e-01	100.0%	85.2%
4452101	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	75.0	6.12e-01	100.0%	97.7%
3167764	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	74.0	5.50e-01	100.0%	85.2%
3466667	2484.1.1.161 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.78	74.0	4.59e-01	100.0%	62.6%
4002044	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	74.0	5.31e-01	100.0%	75.6%
4323378	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.77	74.0	5.53e-01	100.0%	88.6%
3702504	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.77	74.0	5.51e-01	100.0%	88.1%
3492151	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.77	74.0	5.33e-01	100.0%	85.8%
4983222	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.77	73.0	5.16e-01	100.0%	63.3%
3705562	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.77	72.0	4.50e-01	100.0%	36.9%
5054032	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.76	73.0	5.11e-01	100.0%	36.8%
5076614	2484.1.1.328 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B	0.76	73.0	4.53e-01	100.0%	36.7%
3256261	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.76	73.0	5.67e-01	99.2%	94.1%
5035328	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.76	73.0	5.87e-01	100.0%	91.9%
4932479	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.76	73.0	5.38e-01	100.0%	71.8%
4939488	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.76	73.0	5.46e-01	100.0%	72.8%
1790898	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.76	72.0	5.55e-01	100.0%	89.7%
4874454	2.1.1.25 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1	0.76	72.0	5.58e-01	100.0%	91.7%
4218318	2484.1.1.295 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, RNase_H_2	0.76	72.0	5.26e-01	100.0%	71.6%
4024811	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.76	72.0	5.47e-01	100.0%	93.2%
4972218	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.75	71.0	4.67e-01	100.0%	46.2%
5048995	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.75	68.0	4.75e-01	100.0%	33.6%
4963375	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.75	64.0	5.19e-01	93.2%	50.6%
4929239	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.74	71.0	5.13e-01	100.0%	74.5%
4990754	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.73	70.0	5.71e-01	100.0%	93.3%
5043498	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.73	70.0	4.82e-01	100.0%	54.1%
5063605	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.73	70.0	4.96e-01	100.0%	59.4%
5076410	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.73	70.0	4.87e-01	100.0%	56.8%
4966854	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.73	70.0	4.90e-01	100.0%	88.3%
4982659	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.73	70.0	4.93e-01	100.0%	58.6%
4492006	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.72	70.0	5.33e-01	100.0%	74.4%
5068716	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.72	69.0	5.00e-01	100.0%	66.9%
5036329	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.71	68.0	5.47e-01	100.0%	87.2%
5073666	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.70	67.0	4.78e-01	100.0%	66.6%
3683989	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.69	66.0	5.55e-01	100.0%	100.0%
3444879	2484.1.1.67 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3	0.57	44.0	4.27e-01	93.2%	71.3%
5024580	7515.1.1.6 ↗	a/b three-layered sandwiches › Alkaline phosphatase-like › Alkaline phosphatase-like › Alkaline phosphatase-like › Phosphodiest	0.51	45.0	3.43e-01	94.7%	81.6%
2822318	7510.1.1.2 ↗	a/b three-layered sandwiches › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like › PTA_PTB	0.51	42.0	4.26e-01	99.2%	89.3%

D3 medium residues 347-400_470-485

PDB

Domain cluster: rep: DNA_polymerase_catalytic_subunit__YP_009342373__Spheniscid_alphaherpesvirus_1__2560777__D504-588

CATH (8)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3iayA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.85	80.0	5.46e-01	100.0%	38.5%
2gv9A03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.85	72.0	4.95e-01	91.4%	36.7%
4qclA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.85	73.0	4.79e-01	92.9%	42.4%
1noyB02	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.79	66.0	4.57e-01	91.4%	35.0%
4fvmA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.79	67.0	4.57e-01	92.9%	53.4%
6vddD01	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.73	62.0	4.47e-01	91.4%	65.9%
1af7A01	1.10.155.10	Mainly Alpha › Orthogonal Bundle › Chemotaxis Receptor Methyltransferase Cher; domain 1 › Chemotaxis receptor methyltransferase CheR, N-terminal domain	0.53	34.0	3.28e-01	81.4%	56.2%
1o07A00	3.40.710.10	Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily	0.50	40.0	2.72e-01	97.1%	51.3%

ECOD (51)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3628202	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.93	87.0	4.91e-01	100.0%	13.2%
3710418	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.93	87.0	5.28e-01	100.0%	23.5%
4022366	2484.1.1.161 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.92	86.0	4.87e-01	100.0%	13.9%
None	—		0.92	86.0	4.84e-01	100.0%	13.8%
3368695	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.92	86.0	5.19e-01	100.0%	22.6%
None	—		0.91	85.0	5.22e-01	100.0%	24.1%
None	—		0.91	85.0	4.82e-01	100.0%	13.9%
5005285	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.91	81.0	5.40e-01	94.3%	34.9%
3558197	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.90	84.0	5.58e-01	100.0%	36.3%
4981192	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.90	78.0	5.15e-01	92.9%	31.4%
4972474	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.89	79.0	4.46e-01	94.3%	12.3%
5035328	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.89	79.0	5.28e-01	94.3%	36.6%
5025208	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.88	76.0	5.13e-01	91.4%	33.9%
4958553	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.88	79.0	5.40e-01	95.7%	36.8%
5069333	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.88	76.0	4.62e-01	91.4%	20.8%
5054032	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.88	78.0	4.75e-01	94.3%	23.0%
5081878	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.88	76.0	4.70e-01	92.9%	21.9%
3932596	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.87	73.0	4.94e-01	90.0%	34.5%
4323378	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.87	74.0	4.77e-01	91.4%	29.0%
4953654	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.87	76.0	4.75e-01	94.3%	24.4%
5017082	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.87	76.0	4.69e-01	94.3%	22.8%
4879892	2.1.1.25 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1	0.86	72.0	4.99e-01	90.0%	36.9%
3466667	2484.1.1.161 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.86	76.0	4.29e-01	94.3%	13.2%
3705562	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.86	74.0	4.20e-01	92.9%	13.1%
3797773	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.86	72.0	4.62e-01	90.0%	27.8%
4452101	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.86	75.0	5.14e-01	94.3%	37.3%
3683241	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.85	76.0	4.79e-01	95.7%	27.2%
5023018	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.85	72.0	5.03e-01	91.4%	37.6%
3496492	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.85	71.0	4.58e-01	90.0%	38.3%
1822623	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.85	72.0	4.71e-01	91.4%	29.6%
3995965	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.85	72.0	5.19e-01	91.4%	47.0%
4874454	2.1.1.25 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1	0.84	72.0	4.71e-01	91.4%	42.6%
3520437	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.84	72.0	5.17e-01	92.9%	42.1%
3794217	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.84	71.0	4.14e-01	91.4%	15.7%
3606428	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.84	73.0	4.95e-01	94.3%	38.3%
1790898	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.83	71.0	4.63e-01	91.4%	41.7%
3214818	304.114.1.0 ↗	a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain	0.83	70.0	4.32e-01	91.4%	22.1%
3192875	304.114.1.0 ↗	a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain	0.83	70.0	4.17e-01	91.4%	17.2%
4002044	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.83	70.0	4.41e-01	91.4%	24.1%
3404726	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.83	72.0	4.64e-01	94.3%	27.8%
3684974	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.83	74.0	4.21e-01	97.1%	13.2%
3825992	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.82	74.0	4.91e-01	97.1%	34.8%
3206356	304.114.1.0 ↗	a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain	0.82	73.0	4.47e-01	97.1%	21.8%
4023334	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.82	73.0	4.77e-01	97.1%	31.1%
3168836	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.81	73.0	4.85e-01	97.1%	34.5%
4939488	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.81	70.0	4.53e-01	92.9%	27.6%
2958185	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.81	68.0	4.49e-01	92.9%	43.1%
3784398	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.80	71.0	4.76e-01	97.1%	34.1%
11143	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.77	66.0	4.12e-01	94.3%	22.7%
4029124	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.74	61.0	4.06e-01	90.0%	42.8%
4037893	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.51	38.0	2.80e-01	81.4%	73.5%

D4 medium residues 401-469

PDB

Domain cluster: representative

CATH (43)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3dzaA01	1.20.120.1940	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YfdX protein domain	0.70	59.0	5.01e-01	95.7%	82.9%
4heoA00	1.10.8.10	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain	0.69	48.0	5.22e-01	72.5%	94.5%
2d9jA02	1.10.167.10	Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2	0.68	59.0	5.71e-01	100.0%	98.7%
4kjmA02	1.20.5.420	Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C	0.68	48.0	5.29e-01	73.9%	96.4%
1vhnA02	1.10.1200.80	Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Putative flavin oxidoreducatase; domain 2	0.67	57.0	5.71e-01	100.0%	100.0%
1xvhB00	1.20.120.1850	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Ebh helix bundles repeating unit (S and A modules)	0.67	48.0	3.99e-01	75.4%	47.5%
2qsbA00	1.20.1440.50	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Ta0600-like	0.66	47.0	4.47e-01	76.8%	72.9%
2oocB00	1.20.120.160	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain	0.66	57.0	5.06e-01	100.0%	68.6%
1k32A03	3.30.750.44	Alpha Beta › 2-Layer Sandwich › Transcription Regulator spoIIAA ›	0.66	46.0	4.58e-01	73.9%	88.9%
1r4gA00	1.10.8.10	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain	0.65	47.0	5.23e-01	78.3%	100.0%
4eqyA02	1.20.1180.10	Mainly Alpha › Up-down Bundle › Udp N-acetylglucosamine O-acyltransferase; Domain 2 › Udp N-acetylglucosamine O-acyltransferase, C-terminal domain	0.65	48.0	4.81e-01	84.1%	80.0%
3u8vA00	1.20.120.660	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain	0.64	55.0	5.21e-01	98.6%	95.2%
2m6uA00	1.20.81.20	Mainly Alpha › Up-down Bundle › Receptor-associated Protein ›	0.64	46.0	4.36e-01	75.4%	93.9%
3d8lA00	1.10.8.940	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Uncharacterised protein, phage p2 ORF12	0.64	44.0	4.03e-01	71.0%	73.6%
4l8iB00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.64	45.0	3.91e-01	75.4%	84.8%
3iqtA01	1.20.120.160	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain	0.64	54.0	4.66e-01	98.6%	87.7%
1oksA00	1.10.8.10	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain	0.63	44.0	4.84e-01	84.1%	94.3%
3k1hA00	3.30.1120.180	Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain › Flagellar FLiS export co-chaperone, HP1076	0.63	54.0	4.64e-01	100.0%	73.9%
2cwoA01	1.20.58.1200	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › RNA silencing suppressor P21, N-terminal domain	0.61	40.0	3.98e-01	100.0%	63.5%
1wtyA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.61	53.0	4.53e-01	100.0%	95.7%
3nrhA00	1.20.120.1550	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Protein of unknown function DUF5063	0.61	54.0	4.13e-01	100.0%	72.2%
4c0qB00	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.60	49.0	2.85e-01	92.8%	9.6%
4zvaA00	1.10.490.10	Mainly Alpha › Orthogonal Bundle › Globin-like › Globins	0.60	45.0	3.56e-01	81.2%	82.6%
3d0wA00	1.10.760.20	Mainly Alpha › Orthogonal Bundle › Cytochrome Bc1 Complex; Chain D, domain 2 › Protein of unknown function DUF3243	0.60	54.0	5.02e-01	100.0%	80.2%
2lpnA00	1.10.225.10	Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like	0.60	50.0	4.44e-01	97.1%	72.4%
2p0tA01	1.10.60.30	Mainly Alpha › Orthogonal Bundle › Diphtheria Toxin Repressor; domain 2 › PSPTO4464-like domains	0.59	43.0	4.23e-01	91.3%	71.1%
4pfyA03	3.10.105.10	Alpha Beta › Roll › Dipeptide-binding Protein; domain 3 › Dipeptide-binding Protein; Domain 3	0.59	50.0	3.49e-01	97.1%	87.1%
1zu4A01	1.20.120.140	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain	0.59	47.0	4.46e-01	91.3%	75.9%
5mdtA00	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.59	41.0	3.28e-01	82.6%	34.2%
3s0aA00	1.10.238.20	Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain	0.59	49.0	4.19e-01	95.7%	100.0%
1sz9C00	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.58	42.0	3.45e-01	79.7%	42.9%
2uubT00	1.20.58.110	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Ribosomal protein S20	0.58	42.0	3.78e-01	78.3%	63.6%
4dvyP03	1.20.120.1270	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CagA exotoxin domain III	0.56	46.0	3.69e-01	100.0%	73.2%
3crjC00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.56	47.0	3.61e-01	100.0%	59.8%
3qqaA02	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.55	43.0	3.46e-01	85.5%	66.7%
4lvpA00	1.10.418.70	Mainly Alpha › Orthogonal Bundle › Actin-binding Protein, T-fimbrin; domain 1 › Intraflagellar transport protein 81, N-terminal domain	0.54	47.0	3.90e-01	97.1%	78.2%
2r4gA02	1.10.10.1970	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › TERT catalytic subunit-like	0.54	37.0	3.87e-01	75.4%	78.1%
3o39A00	1.20.120.1490	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.54	36.0	3.35e-01	71.0%	91.7%
3tjmA02	1.10.1470.20	Mainly Alpha › Orthogonal Bundle › Protein Yjbj; Chain: A; › Fatty acid synthase; domain 2	0.53	39.0	3.66e-01	82.6%	61.1%
1vkeB00	1.20.1290.10	Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like	0.53	41.0	3.63e-01	84.1%	96.0%
2l6jA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.53	40.0	3.54e-01	85.5%	71.2%
3deeA01	1.10.150.690	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › DUF2063	0.53	38.0	3.65e-01	79.7%	67.4%
3e4bA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.51	38.0	2.45e-01	85.5%	21.5%

ECOD (33)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3963859	2002.1.1.56 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Dus	0.82	74.0	4.67e-01	100.0%	21.6%
4494528	632.2.1.40 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains › DUF515	0.76	54.0	5.95e-01	73.9%	100.0%
5044958	632.22.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats	0.75	53.0	5.00e-01	72.5%	85.0%
3237526	371.1.1.0 ↗	few secondary structure elements › Phospholipase A2, PLA2 › Phospholipase A2, PLA2 › Phospholipase A2, PLA2	0.75	55.0	5.20e-01	79.7%	71.8%
5074457	1030.1.1.0 ↗	alpha duplicates or obligate multimers › Crispr-associated protein Csm2 › Crispr-associated protein Csm2 › Crispr-associated protein Csm2	0.75	63.0	5.48e-01	100.0%	61.9%
4031266	632.2.1.1 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains › GA	0.75	53.0	5.89e-01	73.9%	98.1%
4678110	632.2.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains	0.72	51.0	4.91e-01	75.4%	67.5%
4779202	632.3.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Phosphoprotein XD domain › Phosphoprotein XD domain	0.70	49.0	5.51e-01	72.5%	100.0%
4973584	604.3.1.51 ↗	alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › 8xMP	0.69	48.0	4.51e-01	73.9%	85.2%
4252460	2002.1.1.56 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Dus	0.69	59.0	3.86e-01	100.0%	21.5%
4825592	109.3.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat	0.68	47.0	3.57e-01	73.9%	58.1%
3544765	109.4.1.601 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PLU-1	0.67	48.0	4.27e-01	75.4%	53.0%
1155488	632.2.1.1 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains › GA	0.66	48.0	5.04e-01	75.4%	90.3%
4094836	310.2.1.1 ↗	a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › RRF	0.66	49.0	3.66e-01	79.7%	92.2%
4238416	603.1.1.125 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PLU-1	0.65	47.0	4.16e-01	75.4%	85.0%
4955536	4121.1.1.1 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA	0.65	46.0	3.26e-01	75.4%	53.2%
3534690	4030.1.1.2 ↗	alpha bundles › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › F-actin_cap_A	0.65	42.0	4.54e-01	88.4%	81.8%
3508214	310.2.1.0 ↗	a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF	0.63	46.0	3.80e-01	79.7%	72.3%
4664739	5060.1.1.1 ↗	alpha bundles › V-type ATP synthase subunit C › V-type ATP synthase subunit C › V-type ATP synthase subunit C › vATP-synt_AC39	0.62	54.0	4.55e-01	98.6%	78.3%
4106746	3932.1.1.0 ↗	alpha bundles › CRISPR/Cas system-associated protein Csm6 6H domain › CRISPR/Cas system-associated protein Csm6 6H domain › CRISPR/Cas system-associated protein Csm6 6H domain	0.59	49.0	4.75e-01	94.2%	96.2%
3353941	1134.1.1.7 ↗	alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain › ALA1	0.59	42.0	4.32e-01	78.3%	83.1%
4554674	138.1.1.0 ↗	alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain	0.58	47.0	4.09e-01	92.8%	63.7%
3505959	632.2.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains	0.58	44.0	4.46e-01	82.6%	88.6%
3533060	110.1.1.0 ↗	alpha arrays › DEATH domain › DEATH domain › DEATH domain	0.58	50.0	4.25e-01	97.1%	61.7%
3728782	7579.1.1.6 ↗	a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_1	0.58	52.0	3.33e-01	98.6%	39.7%
4992050	5069.1.3.0 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits	0.58	48.0	4.01e-01	89.9%	91.3%
3705127	509.1.1.0 ↗	alpha bundles › PAH2 domain › PAH2 domain › PAH2 domain	0.57	42.0	3.84e-01	79.7%	72.6%
3961309	191.1.1.48 ↗	alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_46	0.57	51.0	4.17e-01	98.6%	88.8%
4626172	7579.1.1.92 ↗	a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_1, Abhydrolase_6	0.55	48.0	3.25e-01	100.0%	25.8%
3383984	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.53	46.0	3.25e-01	100.0%	76.5%
4024888	108.1.1.0 ↗	alpha arrays › EF-hand › EF-hand-related › EF-hand	0.52	39.0	3.97e-01	82.6%	100.0%
4543	109.4.1.70 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CID	0.52	38.0	3.09e-01	81.2%	40.3%
5005176	604.15.1.0 ↗	alpha bundles › Spectrin repeat-like › Efb C-domain-like › Efb C-domain-like	0.50	34.0	3.52e-01	72.5%	93.8%

D5 medium residues 567-749

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00136.27 best	DNA_pol_B	78.1	8.90e-22	99.5%	29.8%

CATH (38)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3m7gA02	1.10.8.1010	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 ›	0.91	33.0	4.68e-01	71.6%	67.4%
4l0rB00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.90	36.0	6.08e-01	79.2%	100.0%
4fxdA04	3.90.1600.10	Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain	0.88	52.0	5.76e-01	91.3%	71.9%
2qywA00	1.20.58.400	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins	0.87	36.0	5.16e-01	84.7%	78.9%
3a8pA02	6.10.140.680	Special › Helix non-globular › Helix Hairpins ›	0.86	37.0	4.80e-01	81.4%	68.4%
2ic6A00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.85	34.0	5.72e-01	79.8%	100.0%
4mtxD00	1.10.287.130	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain	0.85	32.0	4.58e-01	71.0%	70.5%
1wrdA00	1.20.58.160	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.84	31.0	4.26e-01	71.0%	65.3%
1k04A02	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.83	38.0	5.03e-01	85.2%	77.9%
4abmD00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.82	36.0	5.66e-01	78.1%	100.0%
2crbA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.81	28.0	3.90e-01	79.2%	61.9%
1ydxA02	1.10.287.1120	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein	0.79	34.0	4.91e-01	78.7%	84.4%
3r84B00	6.10.280.160	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator of RNA polymerase II transcription subunit 22	0.79	34.0	5.37e-01	79.8%	97.5%
4iggA01	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.78	31.0	5.01e-01	73.2%	100.0%
3na7A00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.77	38.0	3.41e-01	77.6%	36.7%
1i6zA00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.77	36.0	4.21e-01	88.5%	61.5%
4w4kA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.76	33.0	4.96e-01	80.3%	92.7%
4iloA00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.75	37.0	3.36e-01	78.1%	37.3%
2v6yA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.75	26.0	4.12e-01	85.2%	78.7%
4e4eA01	1.10.287.990	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain	0.74	31.0	4.82e-01	78.7%	100.0%
3nrxA00	1.20.58.1520	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.73	34.0	4.15e-01	85.2%	66.7%
4r42A01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.72	34.0	3.40e-01	85.2%	44.4%
4aflA00	6.10.140.1740	Special › Helix non-globular › Helix Hairpins ›	0.72	37.0	4.86e-01	80.9%	88.2%
3pjaJ01	1.20.58.190	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1	0.72	35.0	4.10e-01	81.4%	64.9%
2q0oC00	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.71	32.0	4.52e-01	83.1%	88.4%
2y1vA04	2.60.40.10	Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins	0.70	30.0	3.01e-01	94.0%	37.8%
3okqA00	1.20.58.1540	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Actin interacting protein 3, C-terminal domain	0.70	34.0	4.08e-01	81.4%	67.2%
4h63H01	1.20.58.1710	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.70	29.0	4.60e-01	84.7%	100.0%
1uurA01	1.20.58.240	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › STAT; domain 1	0.69	34.0	4.36e-01	84.7%	79.1%
3lbxB01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.68	32.0	4.11e-01	85.2%	75.7%
8cdaB03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.66	41.0	4.43e-01	91.8%	71.1%
3rh3A01	1.20.120.930	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF12889, N-terminal DUF3829	0.62	40.0	4.70e-01	88.5%	88.7%
1zymA02	1.10.274.10	Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › PtsI, HPr-binding domain	0.62	26.0	3.07e-01	76.5%	53.2%
3nymA00	6.10.290.10	Special › Helix non-globular › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.61	40.0	4.82e-01	86.3%	97.6%
6tqfA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.54	39.0	3.07e-01	73.8%	75.7%
1kz7A01	1.20.900.10	Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain	0.54	33.0	3.28e-01	92.9%	54.4%
2l6hA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.53	35.0	3.87e-01	86.3%	80.5%
6v9zA02	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.52	43.0	3.53e-01	87.4%	74.2%

ECOD (70)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5012672	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.93	33.0	4.92e-01	70.5%	71.1%
3619577	192.5.1.0 ↗	alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat	0.91	36.0	5.29e-01	79.8%	78.9%
3290879	3922.1.1.155 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › DUF4349	0.90	35.0	6.02e-01	80.3%	100.0%
3884649	192.5.1.1 ↗	alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1	0.88	37.0	5.36e-01	83.1%	81.1%
4024277	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.88	36.0	6.04e-01	79.8%	100.0%
3504474	192.5.1.1 ↗	alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1	0.88	36.0	5.01e-01	80.3%	74.0%
4991512	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.87	34.0	4.10e-01	72.7%	53.8%
3215342	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.87	38.0	5.39e-01	81.4%	82.1%
4062183	192.2.1.1 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2	0.87	36.0	5.95e-01	80.3%	100.0%
5026881	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.87	36.0	5.94e-01	79.8%	100.0%
3917888	192.7.1.0 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm	0.87	36.0	4.65e-01	79.2%	65.2%
3614078	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.86	35.0	4.36e-01	80.9%	60.0%
5050139	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.86	36.0	5.90e-01	80.3%	100.0%
4576287	3755.3.1.471 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Paralemmin	0.86	38.0	4.13e-01	80.3%	51.0%
3465357	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.85	36.0	4.61e-01	89.6%	66.1%
3520009	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.82	36.0	5.70e-01	80.3%	98.8%
1171038	3755.3.1.148 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › CT398_CC	0.82	37.0	3.66e-01	80.9%	41.9%
3570403	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.81	38.0	4.59e-01	82.0%	66.4%
3550436	192.7.1.0 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm	0.80	38.0	5.06e-01	76.5%	80.8%
3763454	5086.1.1.87 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › ING	0.80	39.0	4.84e-01	77.6%	72.5%
3417096	3939.1.1.0 ↗	alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain	0.80	36.0	4.69e-01	70.5%	72.7%
3487203	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.80	36.0	5.39e-01	80.3%	94.1%
5055566	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.80	38.0	4.79e-01	86.3%	73.9%
3639947	603.1.1.1 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin	0.79	38.0	3.85e-01	85.8%	47.0%
3605750	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	75.0	4.61e-01	100.0%	25.2%
4016635	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.77	39.0	5.29e-01	78.7%	90.0%
5073085	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.77	37.0	3.97e-01	78.7%	52.4%
3766400	622.4.1.0 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related	0.76	38.0	4.92e-01	80.9%	80.9%
4018440	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.76	37.0	5.18e-01	78.1%	90.5%
3706209	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.76	37.0	4.17e-01	82.0%	60.0%
4175684	3291.1.1.232 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Paralemmin	0.74	38.0	4.53e-01	80.3%	71.5%
4033755	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.73	36.0	4.13e-01	76.0%	62.1%
3273862	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.73	38.0	5.34e-01	85.8%	98.9%
4060910	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.72	40.0	5.34e-01	83.6%	97.1%
4179301	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.72	40.0	5.22e-01	84.7%	92.7%
4223425	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.71	40.0	5.34e-01	84.7%	98.1%
5048590	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.71	39.0	5.07e-01	85.2%	90.9%
3634896	622.4.1.0 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related	0.71	38.0	4.85e-01	76.0%	85.2%
4979981	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.70	39.0	5.07e-01	84.2%	91.8%
4565398	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.70	38.0	5.16e-01	77.6%	98.0%
4165448	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.70	39.0	5.15e-01	83.6%	96.2%
4219465	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.70	39.0	5.02e-01	84.7%	91.8%
4041347	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.70	38.0	4.93e-01	84.2%	90.0%
3931307	601.1.2.4 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_R4	0.69	36.0	4.03e-01	92.3%	62.1%
4221982	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.69	38.0	5.18e-01	78.7%	100.0%
3804937	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.69	37.0	4.04e-01	80.9%	62.5%
4266510	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.69	38.0	5.06e-01	85.8%	96.2%
4345287	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.68	37.0	5.08e-01	77.6%	100.0%
3988781	604.6.1.63 ↗	alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › DUF3169	0.67	36.0	4.23e-01	85.8%	71.9%
3881582	310.2.1.31 ↗	a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › DUF4455	0.67	32.0	4.17e-01	86.3%	79.0%
3996264	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.67	37.0	3.88e-01	78.7%	59.4%
3627942	3755.4.1.1 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PI3K_P85_iSH2	0.66	37.0	3.84e-01	78.7%	57.7%
4470423	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.66	39.0	4.98e-01	88.0%	94.8%
2832211	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.66	37.0	3.10e-01	77.6%	34.5%
4074458	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.66	36.0	4.92e-01	78.7%	100.0%
4971709	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.66	36.0	4.01e-01	78.7%	66.2%
3248488	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.64	36.0	3.13e-01	77.0%	36.7%
4042986	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.64	35.0	4.78e-01	85.2%	100.0%
3406218	604.7.1.0 ↗	alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A	0.62	33.0	4.17e-01	83.6%	84.5%
4029042	3939.1.1.0 ↗	alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain	0.62	37.0	3.44e-01	81.4%	47.7%
3707204	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.62	34.0	2.91e-01	78.1%	32.9%
3258488	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.62	34.0	4.59e-01	85.2%	99.0%
4429835	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.60	33.0	4.37e-01	78.7%	98.0%
3224742	3755.3.1.9 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › SH3BP5	0.58	37.0	3.51e-01	78.7%	54.9%
4155408	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.56	31.0	2.92e-01	80.9%	44.1%
5053066	192.7.1.0 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm	0.56	49.0	4.45e-01	96.2%	71.5%
3608199	1189.1.1.0 ↗	alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor	0.55	43.0	4.38e-01	86.3%	80.5%
3940953	109.4.1.623 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd1	0.53	40.0	2.70e-01	78.7%	50.8%
3796544	4177.1.1.2 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR	0.50	42.0	3.72e-01	86.3%	70.8%
3442429	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.50	38.0	3.81e-01	88.5%	76.2%

D6 medium residues 750-825

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00136.27 best	DNA_pol_B	63.1	3.00e-17	100.0%	15.4%

CATH (10)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
6muwN00	3.60.20.10	Alpha Beta › 4-Layer Sandwich › Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 › Aminohydrolase, N-terminal nucleophile (Ntn) domain	0.59	44.0	3.12e-01	78.9%	95.1%
2k7iA01	3.30.160.160	Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › YegP-like	0.59	27.0	3.31e-01	76.3%	66.7%
2plqA00	3.60.110.10	Alpha Beta › 4-Layer Sandwich › Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase › Carbon-nitrogen hydrolase	0.56	47.0	3.07e-01	93.4%	44.7%
6j7cA01	3.10.310.10	Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › Diaminopimelate Epimerase; Chain A, domain 1	0.56	47.0	3.79e-01	100.0%	71.1%
2yh9B00	3.30.1450.10	Alpha Beta › 2-Layer Sandwich › Beta-lactamase Inhibitory Protein; Chain:B, domain 1 ›	0.55	33.0	3.45e-01	86.8%	66.2%
3uueA00	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.53	46.0	3.18e-01	100.0%	82.1%
4bwkB01	1.10.510.10	Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1	0.52	39.0	2.82e-01	84.2%	44.9%
4v19S00	3.30.420.80	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribosomal protein S11/S14	0.52	40.0	3.32e-01	84.2%	61.5%
2wtzA02	3.40.1190.10	Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain	0.52	41.0	2.92e-01	86.8%	45.3%
5h8iI00	3.60.110.10	Alpha Beta › 4-Layer Sandwich › Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase › Carbon-nitrogen hydrolase	0.51	42.0	2.85e-01	92.1%	38.2%

ECOD (29)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3784383	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.93	88.0	5.43e-01	100.0%	20.8%
3705562	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.93	88.0	4.98e-01	100.0%	11.8%
4231530	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.92	87.0	6.15e-01	100.0%	37.6%
4022366	2484.1.1.161 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.92	87.0	4.97e-01	100.0%	12.0%
None	—		0.92	87.0	4.94e-01	100.0%	11.9%
3558196	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.92	87.0	5.63e-01	100.0%	27.0%
None	—		0.92	86.0	4.93e-01	100.0%	12.0%
3480546	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.91	86.0	5.69e-01	100.0%	28.7%
3628202	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.91	86.0	4.87e-01	100.0%	11.4%
4972474	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.90	85.0	4.81e-01	100.0%	11.7%
5019480	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.89	84.0	4.73e-01	100.0%	11.2%
5005286	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.88	83.0	5.35e-01	100.0%	28.9%
3575094	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.87	81.0	7.32e-01	100.0%	79.0%
1513168	809.1.1.4 ↗	a+b two layers › BLIP-like › beta-lactamase-inhibitor protein, BLIP › beta-lactamase-inhibitor protein, BLIP › DUF4309	0.63	33.0	3.49e-01	86.8%	56.7%
4474202	809.1.1.7 ↗	a+b two layers › BLIP-like › beta-lactamase-inhibitor protein, BLIP › beta-lactamase-inhibitor protein, BLIP › DUF6392	0.61	35.0	3.56e-01	86.8%	55.1%
5044837	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.61	34.0	3.71e-01	81.6%	66.7%
5045320	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.59	34.0	3.76e-01	82.9%	71.7%
5065208	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.59	32.0	3.63e-01	82.9%	70.9%
3937145	206.1.1.2 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase,Pkinase_C	0.58	44.0	2.86e-01	84.2%	40.9%
4201712	243.3.1.37 ↗	a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › DUF4901	0.58	34.0	3.60e-01	100.0%	66.2%
3494194	316.1.1.0 ↗	a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase	0.58	43.0	2.68e-01	80.3%	68.1%
3518056	206.1.1.1 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase	0.56	43.0	2.94e-01	86.8%	48.3%
4977068	375.1.1.26 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Rpr2	0.55	44.0	3.98e-01	86.8%	75.0%
3460637	5.1.4.15 ↗	beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › RPE65	0.54	41.0	2.53e-01	81.6%	82.3%
5043972	375.1.1.26 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Rpr2	0.53	41.0	3.83e-01	86.8%	78.8%
3963322	267.1.1.0 ↗	a+b complex topology › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain › Metal cation-transporting ATPase, ATP-binding domain	0.52	34.0	3.02e-01	100.0%	45.2%
3710561	4.1.1.92 ↗	beta barrels › SH3 › SH3 › SH3 › SH3_9	0.52	35.0	3.78e-01	85.5%	83.1%
4012201	2003.1.2.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain	0.51	43.0	3.76e-01	98.7%	80.8%
3707575	2484.1.1.74 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Tex_YqgF	0.50	40.0	3.27e-01	92.1%	89.4%

D7 medium residues 826-874_961-1025

PDB